Beverley Balkau

Summary

Country: France

Publications

  1. doi request reprint Type 2 diabetes treatment intensification in general practice in France in 2008-2009: the DIAttitude Study
    B Balkau
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, obesity and chronic kidney disease over the lifecourse and determinants of early nutrition, Villejuif, France
    Diabetes Metab 38:S29-35. 2012
  2. pmc Physical activity and insulin sensitivity: the RISC study
    Beverley Balkau
    INSERM 780, Villejuif, University Paris Sud, Orsay, France
    Diabetes 57:2613-8. 2008
  3. pmc Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Beverley Balkau
    INSERM U780 IFR69, Villejuif, France University Paris Sud, Orsay, France
    Diabetes Care 31:2056-61. 2008
  4. pmc Nine-year incident diabetes is predicted by fatty liver indices: the French D.E.S.I.R. study
    Beverley Balkau
    INSERM CESP Center for Research in Epidemiology and Population Health, Villejuif, France
    BMC Gastroenterol 10:56. 2010
  5. pmc High baseline insulin levels associated with 6-year incident observed sleep apnea
    Beverley Balkau
    Institut Nationale de la Santé et de la Recherché Médicale, CESP Centre for research in Epidemiology and Population Health, Unité 1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the lifecourse, Villejuif, France
    Diabetes Care 33:1044-9. 2010
  6. pmc Are the same clinical risk factors relevant for incident diabetes defined by treatment, fasting plasma glucose, and HbA1c?
    Beverley Balkau
    INSERM, CESP Center for Research in Epidemiology and Population Health, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the lifecourse, U1018, Villejuif, France
    Diabetes Care 34:957-9. 2011
  7. ncbi request reprint Dairy products and the metabolic syndrome in a prospective study, DESIR
    Frederic Fumeron
    INSERM, U695, Genetic Determinants of Type 2 Diabetes and Its Vascular Complications, Univ Paris Diderot, Sorbonne Paris Cité, UMRS 695, UFR de Medecine Site Bichat, Paris 75018, France
    J Am Coll Nutr 30:454S-63S. 2011
  8. ncbi request reprint Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Peggy Drouillet
    INSERM U780 IFR69, Villejuif, France
    Nutr Metab Cardiovasc Dis 17:486-92. 2007
  9. doi request reprint Anthropometrics, body shape over 12 years and risk of cancer events in pre- and post-menopausal women
    Guy Fagherazzi
    INSERM, Centre for Research in Epidemiology and Population Health CESP, CESP U1018, Nutrition, Hormones and Women s Health Team, F 94805, Villejuif, France
    Int J Cancer 133:740-8. 2013
  10. doi request reprint HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R
    Soraya Soulimane
    Universite Paris Sud 11, UMRS 1018, Villejuif, France
    Diabetes Res Clin Pract 96:392-9. 2012

Detail Information

Publications80

  1. doi request reprint Type 2 diabetes treatment intensification in general practice in France in 2008-2009: the DIAttitude Study
    B Balkau
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, obesity and chronic kidney disease over the lifecourse and determinants of early nutrition, Villejuif, France
    Diabetes Metab 38:S29-35. 2012
    ..To evaluate the current procedures in French general practice of intensifying hypoglycaemic treatment in orally treated type 2 diabetic patients, according to the French recommendations...
  2. pmc Physical activity and insulin sensitivity: the RISC study
    Beverley Balkau
    INSERM 780, Villejuif, University Paris Sud, Orsay, France
    Diabetes 57:2613-8. 2008
    ..Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelerometry...
  3. pmc Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Beverley Balkau
    INSERM U780 IFR69, Villejuif, France University Paris Sud, Orsay, France
    Diabetes Care 31:2056-61. 2008
    ..To provide a simple clinical diabetes risk score and to identify characteristics that predict later diabetes using variables available in the clinic setting as well as biological variables and polymorphisms...
  4. pmc Nine-year incident diabetes is predicted by fatty liver indices: the French D.E.S.I.R. study
    Beverley Balkau
    INSERM CESP Center for Research in Epidemiology and Population Health, Villejuif, France
    BMC Gastroenterol 10:56. 2010
    ..e.s.i.r)...
  5. pmc High baseline insulin levels associated with 6-year incident observed sleep apnea
    Beverley Balkau
    Institut Nationale de la Santé et de la Recherché Médicale, CESP Centre for research in Epidemiology and Population Health, Unité 1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the lifecourse, Villejuif, France
    Diabetes Care 33:1044-9. 2010
    ..We evaluate risk factors for incident observed sleep apnea in a general population not selected for sleep disturbances...
  6. pmc Are the same clinical risk factors relevant for incident diabetes defined by treatment, fasting plasma glucose, and HbA1c?
    Beverley Balkau
    INSERM, CESP Center for Research in Epidemiology and Population Health, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the lifecourse, U1018, Villejuif, France
    Diabetes Care 34:957-9. 2011
    ..To compare incidences and risk factors for diabetes using seven definitions, with combinations of pharmacological treatment, fasting plasma glucose (FPG) ≥7.0 mmol/L, and HbA(1c) ≥6.5%...
  7. ncbi request reprint Dairy products and the metabolic syndrome in a prospective study, DESIR
    Frederic Fumeron
    INSERM, U695, Genetic Determinants of Type 2 Diabetes and Its Vascular Complications, Univ Paris Diderot, Sorbonne Paris Cité, UMRS 695, UFR de Medecine Site Bichat, Paris 75018, France
    J Am Coll Nutr 30:454S-63S. 2011
    ....
  8. ncbi request reprint Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Peggy Drouillet
    INSERM U780 IFR69, Villejuif, France
    Nutr Metab Cardiovasc Dis 17:486-92. 2007
    ..In this study we have examined the relationship between dietary calcium and the established parameters of the insulin resistance syndrome...
  9. doi request reprint Anthropometrics, body shape over 12 years and risk of cancer events in pre- and post-menopausal women
    Guy Fagherazzi
    INSERM, Centre for Research in Epidemiology and Population Health CESP, CESP U1018, Nutrition, Hormones and Women s Health Team, F 94805, Villejuif, France
    Int J Cancer 133:740-8. 2013
    ..20 (1.10-1.30)], respectively as was long birth length in post-menopausal women [HR: 1.18 (1.07-1.30) compared to medium birth length]. These results suggest independent roles of height and WC on cancer risk, through different pathways...
  10. doi request reprint HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R
    Soraya Soulimane
    Universite Paris Sud 11, UMRS 1018, Villejuif, France
    Diabetes Res Clin Pract 96:392-9. 2012
    ..With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases...
  11. ncbi request reprint Weight, the metabolic syndrome, and coronary heart disease in type 2 diabetes: associations among a national French sample of adults with diabetes-the ENTRED study
    Teresa A Hillier
    Institut National de la Santé et de la Recherche Médicale U258 IFR69, University Paris XI, Villejuif, France
    J Cardiometab Syndr 1:318-25. 2006
    ..8-2.9). The authors suggest that obesity alone--and particularly when the MS is present--increases CHD risk in patients with T2DM. High levels of high-density lipoprotein may modify this relationship...
  12. pmc Metabolic syndrome in a sub-Saharan African setting: central obesity may be the key determinant
    Leopold Fezeu
    INSERM U780 IFR69, Epidemiological and Biostatistical Research, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
    Atherosclerosis 193:70-6. 2007
    ....
  13. ncbi request reprint The impact of 3-year changes in lifestyle habits on metabolic syndrome parameters: the D.E.S.I.R study
    Beverley Balkau
    INSERM U780 IFR69, Villejuif, France
    Eur J Cardiovasc Prev Rehabil 13:334-40. 2006
    ..The effect of lifestyle changes in cohorts of free-living populations has been surprisingly little evaluated...
  14. doi request reprint The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study
    Amel Lamri
    INSERM, U695, Genetic Determinants of Type 2 Diabetes and Its Vascular Complications, Paris, France Univ Paris Diderot, Sorbonne Paris Cité, UMRS 695, UFR de Medecine Site Bichat, Paris, France
    Metabolism 62:1323-9. 2013
    ..Our aim was to test in this study, the association of rs4988235 with BMI and related metabolic diseases, in interaction with dairy product consumption...
  15. ncbi request reprint Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Istvan S Vari
    Institut National de la Sante et de la Recherche Medicale, unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:1795-801. 2007
    ..The aim of this work was to study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities...
  16. pmc Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort
    Blandine de Lauzon-Guillain
    INSERM, ERI 20, EA 4045, Institut Gustave Roussy, Villejuif, France
    Diabetes Care 33:298-303. 2010
    ..Low birth weight is also associated with a higher diabetes incidence. We aimed to examine to what extent the evolution of body shape, from childhood to adulthood, is related to incident diabetes in late adulthood...
  17. doi request reprint Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus. Results from the D.E.S.I.R. prospective cohort
    Marie Christine Alessi
    U626, INSERM, Marseille, France
    Thromb Haemost 106:416-22. 2011
    ..0009). In conclusion, baseline plasma vitronectin is a marker of incident MetS at nine years. Its predictive ability for MetS and T2DM should not be assessed independently of PAI-1 levels...
  18. doi request reprint Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height
    Nabila Bouatia-Naji
    INSERM, Unité 690, Robert Debre Hospital, Paris F 75019, France
    Eur J Endocrinol 160:557-60. 2009
    ..Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs1042725) in the high mobility group A2 gene (HMGA2) that consistently associates with height variability but its interaction with SGA is unknown...
  19. doi request reprint Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort
    Guy Fagherazzi
    Center for Research in Epidemiology and Population Health, Villejuif, France
    Am J Clin Nutr 97:517-23. 2013
    ..It has been extensively shown, mainly in US populations, that sugar-sweetened beverages (SSBs) are associated with increased risk of type 2 diabetes (T2D), but less is known about the effects of artificially sweetened beverages (ASBs)...
  20. doi request reprint Center effect on ankle-brachial index measurement when using the reference method (Doppler and manometer): results from a large cohort study
    Emilie Vierron
    INSERM, CIC 202, Tours, France
    Am J Hypertens 22:718-22. 2009
    ..We aimed to assess, in a French multicenter cohort, the center effect associated with arterial pressure (AP) and ABI measurements using the reference method and using a semiautomatic device...
  21. doi request reprint Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study
    Suliya Maimaitiming
    INSERM, U695, Paris, France
    J Hypertens 28:1230-3. 2010
    ....
  22. ncbi request reprint Consequences of change in waist circumference on cardiometabolic risk factors over 9 years: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Beverley Balkau
    Institut National de la Sante et de la Recherche Medicale, unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:1901-3. 2007
  23. ncbi request reprint The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance
    Riphed Jaziri
    INSERM, U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Diabetes 55:1157-62. 2006
    ..Cumulative rather than synergistic effects of PPARG Pro12Ala and APM1 SNPs on diabetes risk are suggested...
  24. ncbi request reprint Association between socioeconomic status and adiposity in urban Cameroon
    Leopold Fezeu
    INSERM Unité 258, Villejuif, France
    Int J Epidemiol 35:105-11. 2006
    ..As the relation between socioeconomic status (SES) and obesity may depend on the stage of development of a country, this relation is assessed in adults from urban Cameroon...
  25. ncbi request reprint Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort
    Philippe Andre
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:2355-61. 2007
    ..Our aim was to study the association of GGT with the development of the metabolic syndrome (MetS)...
  26. pmc International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries
    Beverley Balkau
    INSERM U780 IFR69, Research in Epidemiology and Biostatistics, 16 Ave Paul Vaillant Couturier, 94807 Villejuif, France
    Circulation 116:1942-51. 2007
    ....
  27. ncbi request reprint Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study
    Frederic Fumeron
    EA 3516, Interactions Gènes Environnement dans les Pathologies Métaboliques à Risque Cardiovasculaire, Faculte Xavier Bichat, Paris, France
    Diabetes 53:1150-7. 2004
    ..Adiponectin gene SNPs may have several phenotypic effects that co-occur with the development of the metabolic syndrome...
  28. doi request reprint Associations of the -344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in a French population
    Naïma Muñoz Bellili
    Institut National de la Santé et de la Recherche Médicale INSERM U695, Déterminants Génétiques du Diabète de Type 2 et de ses Complications Cardiovasculaires, Faculte Xavier Bichat, Universite Denis Diderot Paris 7, Paris, France
    Am J Hypertens 23:660-7. 2010
    ..We assessed the association of two polymorphisms -344 T>C and the 3097 G>A in the aldosterone synthase gene (CYP11B2) with prevalent and incident hypertension (HT), type 2 diabetes (T2D), and the metabolic syndrome (MetS)...
  29. ncbi request reprint Contribution of the metabolic syndrome to sudden death risk in asymptomatic men: the Paris Prospective Study I
    Jean Philippe Empana
    INSERM Avenir, Epidemiology of Sudden Death in the Population, Paris XI University, Paris, France
    Eur Heart J 28:1149-54. 2007
    ..To compare the risk of sudden death and non-sudden death from myocardial infarction associated with the metabolic syndrome (MetS) in asymptomatic men...
  30. ncbi request reprint A pharmacoepidemiological assessment of the effect of statins and fibrates on fibrinogen concentration
    Patrick Maison
    Service de Pharmacologie Clinique, Hopital Henri Mondor, AP HP, 94010 Creteil Cedex, France
    Atherosclerosis 160:155-60. 2002
    ..In conclusion, fibrates in contrast with statins may combine lipid-lowering with a beneficial effect on fibrinogen. This effect is independent of changes in cholesterol and triglyceride concentrations...
  31. pmc Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a french prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Frederic Fumeron
    1INSERM U695, Paris, France
    Diabetes Care 34:813-7. 2011
    ..We assess the influence of dairy products on 9-year incident MetS and on impaired fasting glycemia and/or type 2 diabetes (IFG/T2D)...
  32. ncbi request reprint Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Frederic Fumeron
    INSERM U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Diabetes Care 29:2090-4. 2006
    ....
  33. ncbi request reprint Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome
    Beverley Balkau
    INSERM Unit 258, Villejuif Cedex, France
    Diabetes Metab 28:364-76. 2002
    ....
  34. doi request reprint Ten-year changes in central obesity and BMI in rural and urban Cameroon
    Leopold K Fezeu
    Health of Population in Transition Research Group, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    Obesity (Silver Spring) 16:1144-7. 2008
    ..To compare the 10-year changes in the distribution of adiposity in rural and urban Cameroonian populations...
  35. ncbi request reprint Alcohol consumption and insulin resistance syndrome parameters: associations and evolutions in a longitudinal analysis of the French DESIR cohort
    Michel Vernay
    INSERM U258 IFR69, Universite Paris XI, Villejuif, France
    Ann Epidemiol 14:209-14. 2004
    ..To determine the effects of average alcohol consumption and changes in alcohol intake on the insulin resistance syndrome parameters in a 3-year follow-up study...
  36. ncbi request reprint Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-
    Julie Anne Nazare
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Am J Clin Nutr 96:714-26. 2012
    ..Ethnic differences in cardiometabolic risk (CMR) may be related to patterns of ethnic-specific body fat distribution...
  37. pmc The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population
    Martine Vaxillaire
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 57:2253-7. 2008
    ..We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk...
  38. pmc Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    PLoS ONE 3:e2031. 2008
    ..Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal glucose tolerant (NGT) individuals...
  39. doi request reprint A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Santé University, 59019 Lille, France
    Science 320:1085-8. 2008
    ..We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells...
  40. ncbi request reprint The metabolic syndrome
    Beverley Balkau
    Lancet 366:1921; author reply 1923-4. 2005
  41. pmc Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians
    Konsta Duesing
    Section of Genomic Medicine, Imperial College London, Hammersmith Campus, London, U K
    Diabetes 57:1992-6. 2008
    ....
  42. pmc The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
    Stephane Cauchi
    CNRS UMR8090, Institut de Biologie de Lille, Génomique et Physiologie Moléculaire des Maladies Métaboliques, Lille, France
    BMC Med Genet 9:45. 2008
    ....
  43. doi request reprint Urinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance. The DESIR Study
    Jean Michel Halimi
    Francois Rabelais University, CHRU Tours, Service de néphrologie immunologie clinique, Tours, France
    J Hypertens 26:2198-206. 2008
    ..Whether UAE predicts the development of diabetes mellitus, independently of the presence or the development of the metabolic syndrome, is unclear, in particular, in women...
  44. ncbi request reprint Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women
    Gang Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Arch Intern Med 164:1066-76. 2004
    ..This study examined the age- and sex-specific prevalence of the metabolic syndrome and its association with all-cause and cardiovascular mortality in nondiabetic European men and women...
  45. ncbi request reprint The prevalence of and factors associated with diabetic retinopathy in the Australian population
    Robyn J Tapp
    The International Diabetes Institute, Melbourne, Vic, Australia
    Diabetes Care 26:1731-7. 2003
    ..To determine the prevalence and factors associated with diabetic retinopathy in the Australian population and to estimate the time difference between disease onset and clinical diagnosis of type 2 diabetes...
  46. ncbi request reprint Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a Metaanalysis of Blinded, Randomized, Placebo-Controlled Trials
    Patrick Maison
    Clinical Pharmacology, Clinical Research Unit, Assistance Pubique Hôpitaux de Paris, Henri Mondor University Hospital, F 94010 Creteil, France
    J Clin Endocrinol Metab 89:2192-9. 2004
    ..The global cardiovascular benefit remains to be determined in large trials with appropriate clinical endpoints...
  47. ncbi request reprint Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts
    Qing Qiao
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:1770-80. 2003
    ..To report the age- and sex-specific prevalence of diabetes and impaired glucose regulation (IGR) according to revised World Health Organization criteria for diabetes in Asian populations...
  48. ncbi request reprint The fasting plasma glucose cut-point predicting a diabetic 2-h OGTT glucose level depends on the phenotype
    Tomoko Nakagami
    Diabetes Res Clin Pract 55:35-43. 2002
    ..1 mmol/l. There seems to be ethnic differences with respect to optimal FPG cut-point, and different screening strategies may be necessary in different parts of the world...
  49. ncbi request reprint Albuminuria is evident in the early stages of diabetes onset: results from the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)
    Robyn J Tapp
    International Diabetes Institute, Melbourne, Australia
    Am J Kidney Dis 44:792-8. 2004
    ..We determined the prevalence of and factors associated with albuminuria in an Australian population and examined the association of albuminuria with glucose tolerance...
  50. doi request reprint The burden of diabetes-related mortality in France in 2002: an analysis using both underlying and multiple causes of death
    Isabelle Romon
    French Institute for Public Health Surveillance, institut de veille sanitaire InVS, 12 Rue du Val d Osne, 94415 Saint Maurice Cedex, France
    Eur J Epidemiol 23:327-34. 2008
    ..To describe the burden of diabetes-related mortality in France...
  51. doi request reprint Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
    Michael Benzinou
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 17:1916-21. 2008
    ..As CB1 is a drug target for obesity, a pharmacogenetic analysis of the endocannabinoid blockade obesity treatment may be of interest to identify best responders...
  52. ncbi request reprint Association of glucose metabolism, smoking and cardiovascular risk factors with incident peripheral arterial disease: the DESIR study
    Robyn J Tapp
    INSERM Unite 258 IFR69, University Paris XI, Villejuif, France Department of Epidemiology and Preventive Medicine, Monash University, Australia
    Atherosclerosis 190:84-9. 2007
    ..We determined the 6-year incidence of peripheral arterial disease (PAD) in a French population and assessed the association of glucose metabolism, smoking, cardiovascular risk factors and physical activity with incident PAD...
  53. ncbi request reprint Insulin resistance, insulin response, and obesity as indicators of metabolic risk
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:2885-92. 2007
    ..Moreover, the differential impact of IR viz. insulin response has not been evaluated...
  54. ncbi request reprint Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
    ..The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses...
  55. ncbi request reprint Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR Study
    Fabrice Bonnet
    Department of Diabetology Endocrinology, CRNH, Hospital Edouard Herriot, INSERM U 449, Lyon, France
    J Hypertens 24:1157-63. 2006
    ..We investigated in both sexes whether an elevated waist circumference (WC) or the presence of the metabolic syndrome (MetS) predict the development of elevated albuminuria at 6 years...
  56. ncbi request reprint EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families
    Claire Cheyssac
    CNRS UMR 8090, Biology Institute and Pasteur Institute of Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille, France
    Diabetes 55:1171-6. 2006
    ..The potential role of EIF4A2 in glucose homeostasis and its putative contribution to type 2 diabetes in the presence of metabolic stress will require further investigation...
  57. ncbi request reprint A genome-wide association study identifies novel risk loci for type 2 diabetes
    Robert Sladek
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada
    Nature 445:881-5. 2007
    ..These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits...
  58. ncbi request reprint Comment on "A common genetic variant is associated with adult and childhood obesity"
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Science 315:187; author reply 187. 2007
    ..We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity...
  59. ncbi request reprint ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study
    Isabelle Porchay
    Institut National de la Sante et de la Recherche Medicale, Unité 695, Xavier Bichat School of Medicine, Paris, France
    Obesity (Silver Spring) 14:1874-9. 2006
    ..This study suggests that ABCA1 gene polymorphisms modulate HDL-C concentrations, in interaction with BMI, and, thus, they might influence cardiovascular risk in the general population...
  60. ncbi request reprint TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Stephane Cauchi
    Imperial College, Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Diabetes 55:3189-92. 2006
    ..We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion...
  61. ncbi request reprint Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes
    Stephane Cauchi
    CNRS Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 55:2903-8. 2006
    ..These data provide evidence that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis...
  62. ncbi request reprint Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians
    Michael Benzinou
    Section of Genomic Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Diabetes 55:2876-82. 2006
    ..g., dyslipidemia, hyperglycemia), a complication previously described in BBS patients. In summary, our preliminary data suggest that variations at BBS genes are associated with risk of common obesity...
  63. pmc Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population
    Claire Cheyssac
    CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur, 59019 Lille, France
    BMC Med Genet 7:44. 2006
    ....
  64. ncbi request reprint Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Celine Droumaguet
    INSERM U258 IFR69, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Diabetes Care 29:1619-25. 2006
    ..The predictive value of A1C, in comparison to FPG, is evaluated for 6-year incident diabetes...
  65. ncbi request reprint Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene
    Fanny Stutzmann
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 16:1837-44. 2007
    ..These results also emphasize the importance of the MC4R signalling tonus to prevent obesity, even in the context of our current obesogenic environment...
  66. pmc Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity
    Nabila Bouatia-Naji
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    BMC Med Genet 8:44. 2007
    ..The aim of this study is to analyze associations of SGNE1 genetic variation with obesity and metabolism related quantitative traits...
  67. doi request reprint R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 17:1798-802. 2008
    ..In contrast, R125W variant was neither associated with BMI nor with obesity in a large population-based cohort. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition...
  68. pmc Evaluating the association of common PBX1 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    BMC Med Genet 9:14. 2008
    ..PBX1 is a biological candidate gene for type 2 diabetes at the 1q21-q24 susceptibility locus. The aim of this study was to evaluate the association of common PBX1 variants with type 2 diabetes in French Caucasian subjects...
  69. doi request reprint Effects of TCF7L2 polymorphisms on obesity in European populations
    Stephane Cauchi
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Obesity (Silver Spring) 16:476-82. 2008
    ..Furthermore, our data suggest that the rs7903146 T allele may be possibly functional and associated with a nominal decrease in TCF7L2 expression in adipose tissue of individuals under calorie restriction...
  70. doi request reprint Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
    Fabrice Bonnet
    Department of Medicine, Endocrinology Unit, Centre Hospitalier Universitaire, université Rennes, Rennes, France
    Diabetes Care 31:789-94. 2008
    ..The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects...
  71. doi request reprint Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    J Mol Med (Berl) 86:341-8. 2008
    ..E.S.I.R. prospective cohort. However, in contrast to TCF7L2, the contribution of novel loci to T2D incidence seems only modest in the general middle-aged French population and should be replicated in larger cohorts...
  72. ncbi request reprint Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study
    Martine Vaxillaire
    UMR8090 and Institute of Biology, Lille 2 University, CNRS and Pasteur Institute, Lille, France
    Diabetes 57:244-54. 2008
    ..However, the relevance of these genes for disease prediction has not been extensively tested...
  73. pmc Analysis of KLF transcription factor family gene variants in type 2 diabetes
    Ruth Gutierrez-Aguilar
    UMR8090, CNRS, Institute of Biologie Institute Pasteur de Lille, Lille, France
    BMC Med Genet 8:53. 2007
    ..Moreover, several of these proteins have been implicated in glucose homeostasis, making them candidate genes for involvement in type 2 diabetes (T2D)...
  74. ncbi request reprint ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity
    Nabila Bouatia-Naji
    Centre National de la Recherche Scientifique UMR8090, Pasteur Institute of Lille, France
    Diabetes 55:545-50. 2006
    ..In summary, our study suggests that variations at the ACDC/adiponectin gene are associated with risk of severe forms of obesity. However, the mechanisms underlying these possible associations are not fully understood...
  75. pmc Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees
    Fanny Stutzmann
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 57:2511-8. 2008
    ..However, there is uncertainty regarding the degree of penetrance of this condition, and the putative impact of the environment on the development of obesity in MC4R mutation carriers is unknown...
  76. doi request reprint Common nonsynonymous variants in PCSK1 confer risk of obesity
    Michael Benzinou
    Genomic Medicine, Imperial College London, Hammersmith Hospital, London W120NN, UK
    Nat Genet 40:943-5. 2008
    ..27 x 10(-8) and P = 2.31 x 10(-12), respectively). Functional analysis showed a significant impairment of the N221D-mutant PC1/3 protein catalytic activity...
  77. pmc Screening for diabetes
    Beverley Balkau
    Diabetes Care 31:1084-5. 2008
  78. ncbi request reprint Screen-detected diabetes, hypertension and hypercholesterolemia as predictors of cardiovascular mortality in five populations of Asian origin: the DECODA study
    Tomoko Nakagami
    Diabetes Center, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Cardiovasc Prev Rehabil 13:555-61. 2006
    ..The aims of this study were to assess the predictive value of glucose tolerance status as a risk factor for CVD and identify a high-risk group for fatal CVD in population-based studies of Asians...
  79. ncbi request reprint Habitual physical activity and vascular aging in a young to middle-age population at low cardiovascular risk
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Stroke 38:2549-55. 2007
    ..The aim of this study was to evaluate the influence of age and habitual physical activity on carotid artery wall thickness and stiffness in a population of young to middle-age subjects at low cardiovascular risk...
  80. ncbi request reprint Diabetes care in an Australian population: frequency of screening examinations for eye and foot complications of diabetes
    Robyn J Tapp
    International Diabetes Institute, Melbourne, Australia
    Diabetes Care 27:688-93. 2004
    ..The aim of this work was to study the frequency of examining for diabetic eye and foot complications in an Australian population and to study factors associated with regular screening...