J Badaut


Country: France


  1. Hirt L, Fukuda A, Ambadipudi K, Rashid F, Binder D, Verkman A, et al. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. J Cereb Blood Flow Metab. 2017;37:277-290 pubmed
    ..Our data suggest that the lack of AQP4 confers an overall beneficial role at long term with improved neuronal survival and reduced neuroinflammation, but without a direct effect on edema formation. ..
  2. Jullienne A, Fukuda A, Ichkova A, Nishiyama N, Aussudre J, Obenaus A, et al. Modulating the water channel AQP4 alters miRNA expression, astrocyte connectivity and water diffusion in the rodent brain. Sci Rep. 2018;8:4186 pubmed publisher
    ..This could be one potential molecular mechanism responsible for the effect of siAQP4 on Cx43 expression, and the resultant decrease in astrocyte connectivity and dramatic effects on ADC values and water mobility. ..
  3. Badaut J, Ajao D, Sorensen D, Fukuda A, Pellerin L. Caveolin expression changes in the neurovascular unit after juvenile traumatic brain injury: signs of blood-brain barrier healing?. Neuroscience. 2015;285:215-26 pubmed publisher
  4. Ichkova A, Rodriguez Grande B, Bar C, Villega F, Konsman J, Badaut J. Vascular impairment as a pathological mechanism underlying long-lasting cognitive dysfunction after pediatric traumatic brain injury. Neurochem Int. 2017;111:93-102 pubmed publisher
    ..Finally, since no effective treatments are currently available, understanding the unique pathophysiological mechanisms of pediatric TBI is crucial for the development of new therapeutic options. ..
  5. Rodriguez Grande B, Ichkova A, Lemarchant S, Badaut J. Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development. AAPS J. 2017;19:1615-1625 pubmed publisher