Jean Francois Bach

Summary

Country: France

Publications

  1. ncbi request reprint Are there unique autoantigens triggering autoimmune diseases?
    J F Bach
    INSERM U 25, Hopital Necker, Paris, France
    Immunol Rev 164:139-55. 1998
  2. ncbi request reprint The protective effect of infections on immune disorders
    Jean Francois Bach
    INSERM, Hopital Necker, Paris, France
    J Pediatr Gastroenterol Nutr 40:S8. 2005
  3. ncbi request reprint [Health research matters in the next ten years]
    J F Bach
    Groupe Hospitalier Necker Enfants Malades, Bâtiment Sevres, 149 161, rue de Sevres, 75015 Paris, France
    Transfus Clin Biol 11:261-5. 2004
  4. ncbi request reprint Autoimmune diseases as the loss of active "self-control"
    Jean Francois Bach
    Hopital Necker, INSERM U580, 75015 Paris, France
    Ann N Y Acad Sci 998:161-77. 2003
  5. ncbi request reprint [Prevent and cure insulin-dependent diabetes]
    J F Bach
    INSERM U25, Hopital Necker, 161, rue de Sevres, 75743 Paris, Cedex 15, France
    Pathol Biol (Paris) 51:151-5. 2003
  6. ncbi request reprint Regulatory T cells under scrutiny
    Jean Francois Bach
    Hopital Necker, INSERM U580, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Nat Rev Immunol 3:189-98. 2003
  7. ncbi request reprint Infections and autoimmune diseases
    Jean Francois Bach
    Laboratoire d Immunologie, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Autoimmun 25:74-80. 2005
  8. ncbi request reprint Induction of immunological tolerance using monoclonal antibodies: applications to organ transplantation and autoimmune disease
    Jean Francois Bach
    INSERM U580, Hopital Necker, 161, rue de Sevres, 75015 Paris, France
    C R Biol 329:260-2. 2006
  9. ncbi request reprint [Immunological aging]
    Jean Francois Bach
    INSERM U25, Hopital Necker, 161, rue de Sevres, 75015 Paris, France
    C R Biol 325:751-3. 2002
  10. ncbi request reprint The effect of infections on susceptibility to autoimmune and allergic diseases
    Jean Francois Bach
    INSERM Unité 25, Institut de Recherches Necker Enfants Malades, Hopital Necker, Paris, France
    N Engl J Med 347:911-20. 2002

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Are there unique autoantigens triggering autoimmune diseases?
    J F Bach
    INSERM U 25, Hopital Necker, Paris, France
    Immunol Rev 164:139-55. 1998
    ..The respective roles of genetic and environmental factors in these triggering events remain to be determined...
  2. ncbi request reprint The protective effect of infections on immune disorders
    Jean Francois Bach
    INSERM, Hopital Necker, Paris, France
    J Pediatr Gastroenterol Nutr 40:S8. 2005
  3. ncbi request reprint [Health research matters in the next ten years]
    J F Bach
    Groupe Hospitalier Necker Enfants Malades, Bâtiment Sevres, 149 161, rue de Sevres, 75015 Paris, France
    Transfus Clin Biol 11:261-5. 2004
  4. ncbi request reprint Autoimmune diseases as the loss of active "self-control"
    Jean Francois Bach
    Hopital Necker, INSERM U580, 75015 Paris, France
    Ann N Y Acad Sci 998:161-77. 2003
    ..A central question is to determine whether immune dysregulation precedes the burst of pathogenic autoimmunity...
  5. ncbi request reprint [Prevent and cure insulin-dependent diabetes]
    J F Bach
    INSERM U25, Hopital Necker, 161, rue de Sevres, 75743 Paris, Cedex 15, France
    Pathol Biol (Paris) 51:151-5. 2003
    ..These strategies, initially developed in the NOD mouse, have been proven to be efficacious in recently diagnosed diabetics...
  6. ncbi request reprint Regulatory T cells under scrutiny
    Jean Francois Bach
    Hopital Necker, INSERM U580, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Nat Rev Immunol 3:189-98. 2003
    ..Other cell types, however, contribute to immunoregulation also, whether they arise spontaneously during ontogeny or during the course of an adaptive immune response...
  7. ncbi request reprint Infections and autoimmune diseases
    Jean Francois Bach
    Laboratoire d Immunologie, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Autoimmun 25:74-80. 2005
    ..Numerous experimental data are already available in several models. Preliminary results have also been reported in atopic dermatitis using bacterial extracts and probiotics...
  8. ncbi request reprint Induction of immunological tolerance using monoclonal antibodies: applications to organ transplantation and autoimmune disease
    Jean Francois Bach
    INSERM U580, Hopital Necker, 161, rue de Sevres, 75015 Paris, France
    C R Biol 329:260-2. 2006
    ....
  9. ncbi request reprint [Immunological aging]
    Jean Francois Bach
    INSERM U25, Hopital Necker, 161, rue de Sevres, 75015 Paris, France
    C R Biol 325:751-3. 2002
    ..This is, however, an important challenge in view of the possible therapeutic perspectives of immunotherapy of aged subjects...
  10. ncbi request reprint The effect of infections on susceptibility to autoimmune and allergic diseases
    Jean Francois Bach
    INSERM Unité 25, Institut de Recherches Necker Enfants Malades, Hopital Necker, Paris, France
    N Engl J Med 347:911-20. 2002
  11. ncbi request reprint Tolerance to islet autoantigens in type 1 diabetes
    J F Bach
    INSERM U 25, Hopital Necker, 161 rue de Sevres, Paris Cedex 15, 75743 France
    Annu Rev Immunol 19:131-61. 2001
    ..Protection can also be obtained by NK T cell stimulation. Administration of beta cell antigens or CD3 antibodies is now being tested in clinical trials in prediabetics and/or recently diagnosed diabetes...
  12. ncbi request reprint Protective role of infections and vaccinations on autoimmune diseases
    J F Bach
    INSERM U 25, Hopital Necker, Paris, France
    J Autoimmun 16:347-53. 2001
    ..It is interesting that the frequency of these diseases has been increasing in developed countries over the last 20 years but not in undeveloped ones...
  13. ncbi request reprint Non-Th2 regulatory T-cell control of Th1 autoimmunity
    J F Bach
    INSERM U 25, Hopital Necker, Paris, France
    Scand J Immunol 54:21-9. 2001
    ..The hypothesis is proposed that CD25 CD62L T cells mediate the physiologic regulation of self regulation whereas Th2 and Th3 cells are essentially induced following sensitization against autoantigens...
  14. ncbi request reprint Immunotherapy of insulin-dependent diabetes mellitus
    J F Bach
    Institut National de la Santé et de la Recherche Médicale INSERM U 25, Hopital Necker, 161 rue de Sevres, 75743 Cedex 15, Paris, France
    Curr Opin Immunol 13:601-5. 2001
    ..These approaches have reached the clinical arena. At the experimental level, strategies are being developed that use or target cytokines (with gene therapy) or stimulate regulatory T cells...
  15. ncbi request reprint [Therapeutic monoclonal antibodics]
    J F Bach
    INSERM U580, Hopital Necker Enfants Malades, 161, rue de Sevres, F 75015 Paris
    Ann Pharm Fr 64:308-11. 2006
    ....
  16. pmc Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases
    Jean Francois Bach
    INSERM U 25, Hopital Necker, Paris, France
    Arthritis Res 4:S3-15. 2002
    ..Most of the concepts and strategies derived from this model apply to other autoimmune diseases, for which no such diversified data are available...
  17. ncbi request reprint Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells
    Sylvaine You
    INSERM U580, Paris, France
    Diabetes 54:1415-22. 2005
    ..We propose that progression to overt disease correlates with the pathogenic T-cell's escape from TGF-beta-dependent T-cell-mediated regulation...
  18. pmc Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases
    Marie Alexandra Alyanakian
    Institut National de la Santé et de la Recherche Médicale U580, and Institut Fédératif Necker Enfants Malades, Faculté Necker Enfants Malades, 161 rue de Sevres, 75015 Paris, France
    Proc Natl Acad Sci U S A 100:15806-11. 2003
    ..Collectively, these data point to the diversity and organ selectivity of regulatory T cells controlling distinct autoimmune diseases whatever the underlying mechanisms...
  19. ncbi request reprint Transforming growth factor-beta and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes
    Marie Alexandra Alyanakian
    INSERM U580, Hopital Necker Enfants Malades, 161 rue de Sevres, 75015 Paris, France
    Diabetes 55:179-85. 2006
    ..Lipopolysaccharide is excluded, but other Toll-like receptor (TLR) agonists could be involved because OM-85 stimulated dendritic cells and induced TGF-beta production by splenocytes in a TLR-2-, TLR-4-, and MyD88-dependent fashion...
  20. ncbi request reprint Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells
    Hassen Kared
    DSC, INSERM U580, Necker Institute, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Diabetes 54:78-84. 2005
    ..They also provide a rationale for a protective role of the endogenous G-CSF produced during infections in early diabetes...
  21. pmc Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice
    Sylvaine You
    Institut National de la Santé et de la Recherche Médicale U580, Paris, France
    Proc Natl Acad Sci U S A 101:14580-5. 2004
    ....
  22. ncbi request reprint TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    Meriam Belghith
    INSERM U580, IRNEM, Hopital Necker, 161 rue de Sevres, 75015 Paris, France
    Nat Med 9:1202-8. 2003
    ..These data explain the intriguing tolerogenic effect of CD3-specific antibodies and position them as the first clinically applicable pharmacological stimulant of TGF-beta-producing regulatory CD4+ T cells...
  23. ncbi request reprint Resetting the functional capacity of regulatory T cells: a novel immunotherapeutic strategy to promote immune tolerance
    Lucienne Chatenoud
    Faculté René Descartes Paris 5, INSERM U580, Hopital Necker, 161 rue de Sevres, 75015 Paris, France
    Expert Opin Biol Ther 5:S73-81. 2005
    ....
  24. ncbi request reprint Long-term reversal of established autoimmunity upon transient blockade of the LFA-1/intercellular adhesion molecule-1 pathway
    Lydia Bertry-Coussot
    Institut National de la Sante et de la Recherche Medicale, Unité 25, Equipe 0016, Universite Rene Descartes, Paris, France
    J Immunol 168:3641-8. 2002
    ..Rather, sICAM-1/Ig induced active tolerance, as assessed by the persistence of diabetogenic T cells in protected mice and the reversal of protection by immunosuppression with cyclophosphamide...
  25. pmc The role of innate immunity in autoimmunity
    Jean Francois Bach
    INSERM U580, Hopital Necker, Paris, France
    J Exp Med 200:1527-31. 2004
    ....
  26. ncbi request reprint [Immunoregulation and autoimmunity]
    Jean Francois Bach
    INSERM U25, Hopital Necker, 161, rue de Sevres, 75743 Paris
    J Soc Biol 196:255-8. 2002
    ..These various cells, whether related to innate or adaptive immunity, can be used to advantage as new therapeutic targets...
  27. pmc Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes
    Sylvaine You
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France Institut National de la Santé et de la Recherche Médicale, Unité 1013, Paris, France
    PLoS ONE 8:e77296. 2013
    ..In conclusion, treatment with a selective S1P1 modulator in combination with CD3 antibody represents a promising therapeutic approach for the treatment of autoimmune diabetes. ..
  28. pmc On the mechanisms of the protective effect of infections on type 1 diabetes
    Hélène Feillet
    Necker Hospital, INSERM U580, 161 rue de Sevres, 75015 Paris, France
    Clin Dev Immunol 11:191-4. 2004
    ..This article presents a review of epidemiological data and of the main putative underlying cellular and molecular mechanisms...
  29. pmc Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    Sylvaine You
    Universite Paris Descartes, 75015 Paris, France
    Proc Natl Acad Sci U S A 104:6335-40. 2007
    ....
  30. ncbi request reprint Transforming growth factor-beta and T-cell-mediated immunoregulation in the control of autoimmune diabetes
    Sylvaine You
    Universite Rene Descartes Paris 5, Institut National de la Santé et de la Recherche Médicale U580 and Hôpital Necker Enfants Malades, Paris, France
    Immunol Rev 212:185-202. 2006
    ..Herein we discuss these results and the working hypothesis they evoke in the context of the present literature, where the role of TGF-beta-dependent T-cell-mediated immunoregulation is still debated...
  31. pmc Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target
    Sylvaine You
    Universite Paris Descartes, Paris, France
    PLoS ONE 4:e7848. 2009
    ..In this study, we examined the role of GITR/GITRLigand interaction in the progression of autoimmune diabetes...
  32. ncbi request reprint Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
    Hassen Kared
    Centre National de la Recherche Scientifique CNRS UMR 8147, université Paris V René Descartes, Necker Institute, 75743 Paris Cedex 15, France
    Immunity 25:823-34. 2006
    ..They open therapeutic perspectives for autologous transplantation of Jagged2(+) LSK progenitors to promote Treg cell expansion in T cell-mediated diseases...
  33. pmc Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice
    Aude Aumeunier
    Universite Paris Descartes, Paris, France
    PLoS ONE 5:e11484. 2010
    ..We have tested whether Toll-like receptor (TLR) stimulation can recapitulate the protective effect of infectious agents on allergy and autoimmunity...
  34. ncbi request reprint G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation
    Flora Zavala
    Institut National de la Sante et de la Recherche Medical, Unité 25 and Unité 345, Necker Hospital, Paris, France Sanofi Synthelabo, Bagneux, France
    J Immunol 168:2011-9. 2002
    ..These findings support the potential application of G-CSF in the treatment of human autoimmune diseases such as multiple sclerosis, taking advantage of the wide clinical favorable experience with this molecule...
  35. ncbi request reprint Six questions about the hygiene hypothesis
    Jean Francois Bach
    Hopital Necker Enfants Malades, Service d Immunologie, 149 rue de Sevres, Paris, France
    Cell Immunol 233:158-61. 2005
    ....
  36. pmc Adaptive human regulatory T cells: myth or reality?
    Lucienne Chatenoud
    Universite Rene Descartes Paris 5, INSERM U580, Hopital Necker Enfants Malades, Paris, France
    J Clin Invest 116:2325-7. 2006
    ..It is thus unlikely that all CD4+ CD25hi Foxp3+ Tregs are generated as a separate lineage in the thymus. The authors propose that during adulthood, Tregs essentially emerge at the periphery from the memory T cell pool...
  37. ncbi request reprint Chair's introduction. Generation and effector functions of regulatory lymphocytes
    Jean Francois Bach
    Laboratoire d Immunologie, Hopital Necker, 161 Ra de Sèvres, 75743 Paris, Cedex 15, France
    Novartis Found Symp 252:1-5; discussion 106-14. 2003
  38. ncbi request reprint Regulatory T cells in the control of autoimmune diabetes: the case of the NOD mouse
    Lucienne Chatenoud
    Universite Rene Descartes, INSERM U580 Hôpital Necker, Paris, France
    Int Rev Immunol 24:247-67. 2005
    ....
  39. doi request reprint The etiology of autoimmune diseases: the case of myasthenia gravis
    Jean Francois Bach
    Academie des sciences, Paris, France
    Ann N Y Acad Sci 1274:33-9. 2012
    ..In this article I will attempt to analyze the various factors that have a triggering or protecting role, with particular reference to myasthenia gravis...
  40. doi request reprint Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance
    Chantal Kuhn
    Universite Paris Descartes, INSERM, 75015 Paris, France
    Sci Transl Med 3:68ra10. 2011
    ..This model should enable the evaluation of anti-human CD3 antibodies to determine their potential clinical utility...
  41. ncbi request reprint Normal renal function 8 to 13 years after cyclosporin A therapy in 285 diabetic patients
    Roger Assan
    Service de Diabetologie, Hopital Bichat, Paris, France
    Diabetes Metab Res Rev 18:464-72. 2002
    ..Advantage was taken of a large cohort of diabetic patients treated for several months using moderate CyA dosage to evaluate the long-term evolution of renal function in such patients...
  42. ncbi request reprint The elusive case for a role of mimicry in autoimmune diseases
    Jean Marie Fourneau
    INSERM U580, Necker Institut, 161 rue de Sevres, 75015 Paris, France
    Mol Immunol 40:1095-102. 2004
    ..Based on these considerations, we contend that the mimicry concept remains largely hypothetical, and that novel carefully designed animal models are needed to make a convincing case for a role of mimicry in autoimmune diseases...
  43. pmc The hygiene hypothesis: an explanation for the increased frequency of insulin-dependent diabetes
    Jean Francois Bach
    Universite Paris Descartes, 75015 Paris, France INSERM, Unité 1013, 75015 Paris, France
    Cold Spring Harb Perspect Med 2:a007799. 2012
    ..These considerations might have interesting therapeutic applications for the prevention of the disease...
  44. pmc Immunoregulatory pathways controlling progression of autoimmunity in NOD mice
    Sylvaine You
    INSERM U580, Hopital Necker Enfants Malades, Paris, France
    Ann N Y Acad Sci 1150:300-10. 2008
    ..Moreover, data are presented that simultaneous blockade of CTLA4 and TGF-beta further impairs immunoregulatory circuits that control disease progression...
  45. pmc Genetic control of hepatitis A severity and susceptibility to allergy
    Lucienne Chatenoud
    Universite Paris Descartes, INSERM, Paris, France
    J Clin Invest 121:848-50. 2011
    ..Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals...
  46. doi request reprint A historical view from thirty eventful years of immunotherapy in autoimmune diabetes
    Jean Francois Bach
    Universite Paris Descartes, 75015 Paris, France
    Semin Immunol 23:174-81. 2011
    ....
  47. ncbi request reprint Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice
    Diego Laderach
    INSERM U25, Hopital Necker, 161 rue de Sevres, 75743 Cedex 15, Paris, France
    J Autoimmun 20:161-70. 2003
    ....
  48. ncbi request reprint [Immunological expectations at the dawn of the XXIth century]
    Jean Francois Bach
    Service de Nephrologie, Hopital Necker, 149, rue de Sevres, 75743 Paris Cedex 15
    Presse Med 33:Sp73-4. 2004