Patrick J Babin
Ouadah Boussouf N, Babin P. Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin. Toxicol Appl Pharmacol. 2016;294:32-42 pubmed publisher
..Together, the present results suggest that TBT may induce the promotion of triacylglycerol storage in adipocytes via RXR-dependent pathways without necessary using PPAR isoforms. ..
Knoll Gellida A, André M, Gattegno T, Forgue J, Admon A, Babin P. Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals. BMC Genomics. 2006;7:46 pubmed
..The molecular phenotype described provides groundwork for future experimental approaches aimed at identifying functionally important stored maternal transcripts and proteins involved in oogenesis and early stages of embryo development. ..
Babin P, Goizet C, Raldua D. Zebrafish models of human motor neuron diseases: advantages and limitations. Prog Neurobiol. 2014;118:36-58 pubmed publisher
..Positive hits obtained by phenotype-based small-molecule screening using zebrafish may potentially be effective drugs for treatment of human MNDs. ..
Esteves A, Knoll Gellida A, Canclini L, Silvarrey M, AndrÃ© M, Babin P. Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei. J Lipid Res. 2016;57:219-32 pubmed publisher
..These data suggest that dietary FAs complexed with FABPs are able to reach the enterocyte nucleus with the potential to modulate nuclear activity. ..
Babin P. Conservation of a vitellogenin gene cluster in oviparous vertebrates and identification of its traces in the platypus genome. Gene. 2008;413:76-82 pubmed publisher
Tingaud Sequeira A, RaldÃºa D, Lavie J, Mathieu G, Bordier M, Knoll Gellida A, et al
. Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiol Dis. 2017;98:36-51 pubmed publisher
..Zebrafish may provide a suitable vertebrate model for ABHD12 insufficiency and the study of functional impairment and potential therapeutic rescue of this rare, neurodegenerative disease. ..