Jean Michel Azorin

Summary

Country: France

Publications

  1. doi request reprint [Management of patients with acute manic or mixed episodes and outcome at three months]
    J M Azorin
    SHU, psychiatrie adulte, CHU Sainte Marguerite, Marseille, France
    Encephale 36:226-35. 2010
  2. doi request reprint Baseline and prodromal characteristics of first- versus multiple-episode mania in a French cohort of bipolar patients
    J M Azorin
    SHU Psychiatrie Adultes, Hopital Sainte Marguerite, Assistance Publique Hopitaux de Marseille, 13274 Marseille Cedex 9, France
    Eur Psychiatry 27:557-62. 2012
  3. doi request reprint [Recommendations for the treatment of mixed episodes in current guidelines]
    J M Azorin
    SHU Psychiatrie Adultes, SOLARIS, Hopital Sainte Marguerite, 13274 Marseille Cedex 09, France Electronic address
    Encephale 39:S185-7. 2013
  4. ncbi request reprint Factors associated with borderline personality disorder in major depressive patients and their relationship to bipolarity
    J M Azorin
    SHU Psychiatrie Adultes, Sainte Marguerite Hospital, 13274 Marseille Cedex 9, France Electronic address
    Eur Psychiatry 28:463-8. 2013
  5. ncbi request reprint [Guidelines on long-acting injectable atypical antipsychotics for first-episode schizophrenia]
    J M Azorin
    SHU Psychiatrie Adultes Pavillon Solaris, Hopital Sainte Marguerite, 13274 Marseille, Cedex 09, France Electronic address
    Encephale 39:S121-3. 2013
  6. ncbi request reprint Risks associated with gender differences in bipolar I disorder
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseille, France Electronic address
    J Affect Disord 151:1033-40. 2013
  7. ncbi request reprint Characteristics and profiles of bipolar I patients according to age-at-onset: findings from an admixture analysis
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseilles, France
    J Affect Disord 150:993-1000. 2013
  8. ncbi request reprint Religious involvement in major depression: protective or risky behavior? The relevance of bipolar spectrum
    J M Azorin
    Department of Psychiatry, 270 Bd Sainte Marguerite, Sainte Marguerite Hospital, Marseille 13274, France
    J Affect Disord 150:753-9. 2013
  9. doi request reprint [Bipolar disorder: inter-episode symptoms]
    J M Azorin
    PU PH, SHU Psychiatrie Adultes, Hopital Sainte Marguerite, 270 Bd Sainte Marguerite, Marseille Cedex 09
    Encephale 38:S147-50. 2012
  10. doi request reprint Effect of asenapine on manic and depressive symptoms in bipolar I patients with mixed episodes: results from post hoc analyses
    J M Azorin
    Hospital Ste Marguerite, 270 Bd Sainte Marguerite, 13274 Marseille, France
    J Affect Disord 145:62-9. 2013

Detail Information

Publications79

  1. doi request reprint [Management of patients with acute manic or mixed episodes and outcome at three months]
    J M Azorin
    SHU, psychiatrie adulte, CHU Sainte Marguerite, Marseille, France
    Encephale 36:226-35. 2010
    ..The present report describes the acute phase outcomes of the French subgroup...
  2. doi request reprint Baseline and prodromal characteristics of first- versus multiple-episode mania in a French cohort of bipolar patients
    J M Azorin
    SHU Psychiatrie Adultes, Hopital Sainte Marguerite, Assistance Publique Hopitaux de Marseille, 13274 Marseille Cedex 9, France
    Eur Psychiatry 27:557-62. 2012
    ..To identify some of the main features of bipolar disorder for both first-episode (FE) mania and the preceding prodromal phase, in order to increase earlier recognition...
  3. doi request reprint [Recommendations for the treatment of mixed episodes in current guidelines]
    J M Azorin
    SHU Psychiatrie Adultes, SOLARIS, Hopital Sainte Marguerite, 13274 Marseille Cedex 09, France Electronic address
    Encephale 39:S185-7. 2013
    ..If some consensus may be found for the treatment of "mixed states" as a whole, recommendations for the treatment of "mixed mania" appear to be variable, whereas those for the treatment of "mixed depression" seem to be limited. ..
  4. ncbi request reprint Factors associated with borderline personality disorder in major depressive patients and their relationship to bipolarity
    J M Azorin
    SHU Psychiatrie Adultes, Sainte Marguerite Hospital, 13274 Marseille Cedex 9, France Electronic address
    Eur Psychiatry 28:463-8. 2013
    ..To analyze the interface between borderline personality disorder (BPD) and bipolarity in depressed patients comorbid with BPD...
  5. ncbi request reprint [Guidelines on long-acting injectable atypical antipsychotics for first-episode schizophrenia]
    J M Azorin
    SHU Psychiatrie Adultes Pavillon Solaris, Hopital Sainte Marguerite, 13274 Marseille, Cedex 09, France Electronic address
    Encephale 39:S121-3. 2013
    ..Pros and cons of this therapeutic option are discussed and suggestions are made for further guidelines. ..
  6. ncbi request reprint Risks associated with gender differences in bipolar I disorder
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseille, France Electronic address
    J Affect Disord 151:1033-40. 2013
    ..Previous studies have demonstrated that bipolar patients may differ in several features according to gender, but a number of the differences found remain controversial...
  7. ncbi request reprint Characteristics and profiles of bipolar I patients according to age-at-onset: findings from an admixture analysis
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseilles, France
    J Affect Disord 150:993-1000. 2013
    ..Many studies have used admixture analysis to separate age-at-onset (AAO) subgroups in bipolar patients, but few have looked at the phenomenological characteristics of these subgroups, in order to find out phenotypic markers...
  8. ncbi request reprint Religious involvement in major depression: protective or risky behavior? The relevance of bipolar spectrum
    J M Azorin
    Department of Psychiatry, 270 Bd Sainte Marguerite, Sainte Marguerite Hospital, Marseille 13274, France
    J Affect Disord 150:753-9. 2013
    ..Religiosity has been reported to be inversely related to depression and to suicide as well, but there is a lack of studies on its impact on bipolar disorder and especially, on depressed patients belonging to the bipolar spectrum...
  9. doi request reprint [Bipolar disorder: inter-episode symptoms]
    J M Azorin
    PU PH, SHU Psychiatrie Adultes, Hopital Sainte Marguerite, 270 Bd Sainte Marguerite, Marseille Cedex 09
    Encephale 38:S147-50. 2012
    ..Residual symptoms, prodromes as well as other inter-episode symptoms may respond to strategies based on cognitive-behaviour therapy, and/or psychoeducation...
  10. doi request reprint Effect of asenapine on manic and depressive symptoms in bipolar I patients with mixed episodes: results from post hoc analyses
    J M Azorin
    Hospital Ste Marguerite, 270 Bd Sainte Marguerite, 13274 Marseille, France
    J Affect Disord 145:62-9. 2013
    ..The efficacy of agents useful for mania is largely unproven in patients with mixed episodes...
  11. doi request reprint [Temperamental endophenotypes]
    J M Azorin
    SHU Psychiatrie Adultes Pavillon Solaris, Hopital Sainte Marguerite, 13274 Marseille Cedex 09, France
    Encephale 38:S70-4. 2012
    ..Finally recent studies confirmed as well, that the concept of affective temperament fulfilled the criteria required to be considered as an endophenotype...
  12. doi request reprint Self-assessment and characteristics of mixed depression in the French national EPIDEP study
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseilles 13274, France
    J Affect Disord 143:109-17. 2012
    ..Studies on mixed depression have been conducted so far on the basis of DSM-IV manic symptoms, i.e., a list of 7 symptoms which may provide limited information on the subsyndromal features associated with a full depressive episode...
  13. doi request reprint Late-onset bipolar illness: the geriatric bipolar type VI
    Jean Michel Azorin
    Pôle Universitaire de Psychiatrie Solaris, Hopital Sainte Marguerite, Cedex, France
    CNS Neurosci Ther 18:208-13. 2012
    ..More studies are also needed to better disentangle the effects of age at onset from those of age itself...
  14. doi request reprint Identifying features of bipolarity in patients with first-episode postpartum depression: findings from the international BRIDGE study
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseille, France
    J Affect Disord 136:710-5. 2012
    ..The aims of this study were to assess rates of bipolar spectrum disorders in women experiencing their first episode of postpartum depression, and to find out features indicative of bipolarity in these patients...
  15. doi request reprint [Major depression: features indicative of bipolarity?]
    J M Azorin
    Pôle universitaire de psychiatrie hôpital Ste Marguerite, 270 Bd Sainte Marguerite, 13274 Marseille Cedex 09, France
    Encephale 37:S163-8. 2011
    ..Screening instruments may also be used, to facilitate early recognition. Validation studies of these diagnostic features and instruments are underway...
  16. doi request reprint Risk factors associated with lifetime suicide attempts in bipolar I patients: findings from a French National Cohort
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseille, France
    Compr Psychiatry 50:115-20. 2009
    ..We finally propose to integrate such characteristics into a stress-diathesis model of suicidal behavior, adapted to bipolar patients...
  17. doi request reprint Correlates of first-episode polarity in a French cohort of 1089 bipolar I disorder patients: role of temperaments and triggering events
    Jean Michel Azorin
    Department of Psychiatry, Sainte Marguerite Hospital, Marseilles, France
    J Affect Disord 129:39-46. 2011
    ....
  18. ncbi request reprint [Who is Called "Schizophrenic"?]
    Jean Michel Azorin
    pôle universitaire de psychiatrie, Hopital Sainte Marguerite, Marseille, France
    Therapie 63:231-5. 2008
    ..Taking these approaches into account, at a time when naturalistic models of the illness are prevailing, is far from being of no consequence, as far as the effectiveness of our therapeutic actions is at issue...
  19. ncbi request reprint Psychopathological correlates of lifetime anxiety comorbidity in bipolar I patients: findings from a French national cohort
    Jean Michel Azorin
    Sainte Marguerite Hospital, University of Marseilles, Marseilles, France
    Psychopathology 42:380-6. 2009
    ..Despite numerous studies on the comorbidity of bipolar and anxiety disorders, there is no satisfactory psychopathological model for their overlap...
  20. doi request reprint Toward the delineation of mania subtypes in the French National EPIMAN-II Mille Cohort. Comparisons with prior cluster analytic investigations
    Jean Michel Azorin
    Adult Psychiatry Department, Ste Marguerite Hospital, 270 Bd Sainte Marguerite, 13274 Marseille Cedex 09, France
    Eur Arch Psychiatry Clin Neurosci 258:497-504. 2008
    ..Knowledge about psychopathologic presentations of mania in current clinical practice has to be refined in order to improve diagnosis and treatment...
  21. ncbi request reprint Factors associated with rapid cycling in bipolar I manic patients: findings from a French national study
    Jean Michel Azorin
    University of Aix Marseille II, and Department of Adult Psychiatry, Sainte Marguerite Hospital, Marseille Cedex 09, France
    CNS Spectr 13:780-7. 2008
    ..Despite numerous explanatory hypotheses, few studies have involved a large national clinical sample examining risk factors in the occurrence of rapid cycling during the course of bipolar illness...
  22. doi request reprint Suicidal behaviour in a French Cohort of major depressive patients: characteristics of attempters and nonattempters
    J M Azorin
    Hopital Sainte Marguerite, Marseille, France
    J Affect Disord 123:87-94. 2010
    ..Identification of risk factors is therefore essential to prevent suicide in this population...
  23. doi request reprint "Folie circulaire" vs "Folie à double forme": contribution from a French national study
    J M Azorin
    SHU Psychiatrie Adultes, Sainte Marguerite Hospital, University of Marseille, 13274 Marseille Cedex 9, France
    Eur Psychiatry 26:375-80. 2011
    ..To check whether the presence or not of free intervals between episodes could help differentiate subtypes of bipolar disorder, as suggested by the seminal controversy between Falret and Baillarger...
  24. ncbi request reprint Acute phase of schizophrenia: impact of atypical antipsychotics
    J M Azorin
    Service de Psychiatrie, Hopital Ste Marguerite, Marseilles, France
    Int Clin Psychopharmacol 15:S5-9. 2000
    ..The onset of action of amisulpride appears more rapid than that of haloperidol. Amisulpride therefore fulfils all the requirements of a first-line agent for the treatment of the acute phase of schizophrenia...
  25. doi request reprint Sertindole for the treatment of schizophrenia
    Jean Michel Azorin
    Pôle Universitaire de Psychiatrie Solaris, Hopital Ste Marguerite, Marseille, France
    Expert Opin Pharmacother 11:3053-64. 2010
    ..Sertindole, a second-generation antipsychotic with high affinity for dopamine D₂, serotonin 5-HT₂(A), 5-HT₂(C), and α₁-adrenergic receptors, is the first phenylindole-derived antipsychotic agent...
  26. ncbi request reprint Validation of a severity threshold for the Mania Rating Scale: a receiver-operating characteristic analysis
    Jean Michel Azorin
    Sainte Marguerite Hospital, University of Marseilles, Marseilles, France
    Psychopathology 40:453-60. 2007
    ..The aim of this study was to determine a cutoff score on the Mania Rating Scale (MRS), which easily allows identification of severe mania in a population of manic patients to be included in clinical trials of antimanic drugs...
  27. ncbi request reprint A double-blind comparative study of clozapine and risperidone in the management of severe chronic schizophrenia
    J M Azorin
    French Canadian Clozapine Study Group, Hôpital St Marguerite, 270 Boulevard Ste Marguerite, 13274 Marseille Cedex 09, France
    Am J Psychiatry 158:1305-13. 2001
    ..This prospective, double-blind, multicenter, parallel-group study compared the efficacy and safety of therapeutic doses of clozapine and risperidone in patients with severe chronic schizophrenia and poor previous treatment response...
  28. ncbi request reprint An update on the treatment of bipolar depression
    Jean Michel Azorin
    Pôle Universitaire de Psychiatrie Solaris, Hopital Ste Marguerite, 13274 Marseille Cedex 9, France
    Expert Opin Pharmacother 10:161-72. 2009
    ..Although depression accounts for a large part of the burden associated with bipolar disorder, its drug treatment has been under-studied...
  29. ncbi request reprint Schizophrenia: two-faced meaning of vulnerability
    Jean Michel Azorin
    Department of Psychiatry, Ste Marguerite Hospital, Marseille, France
    Am J Med Genet 114:921-2. 2002
    ..Coping strategies and resilience are core concepts of the humanistic model. Research on these protective factors may be of major importance in the current debate on prevention in schizophrenia...
  30. doi request reprint Trait-related decision-making impairment in the three phases of bipolar disorder
    Marc Adida
    Mediterranean Institute of Cognitive Neurosciences, Department of Pharmacology and Neuropsychology of Emotions Related to Risk Taking and Reward, National Research Scientific Centre, Sainte Marguerite Hospital, Mediterranean University, Marseille, France
    Biol Psychiatry 70:357-65. 2011
    ..We predicted that manic, depressed, and euthymic bipolar patients (BPs) would display impaired decision-making, and we tested whether clinical characteristics could predict patients' decision-making performance...
  31. doi request reprint Stroop and emotional Stroop interference in unaffected relatives of patients with schizophrenic and bipolar disorders: distinct markers of vulnerability?
    Nathalie Besnier
    pôle de psychiatrie, Hopital Sainte Marguerite, Marseille, France
    World J Biol Psychiatry 10:809-18. 2009
    ....
  32. doi request reprint Differential responses to emotional interference in paranoid schizophrenia and bipolar mania
    Nathalie Besnier
    Pôle Universitaire de Psychiatrie Adultes, CHU Sainte Marguerite, Marseille, France
    Psychopathology 44:1-11. 2011
    ....
  33. ncbi request reprint Risperidone versus haloperidol for facial affect recognition in schizophrenia: findings from a randomised study
    Eric Fakra
    Department of Psychiatry, University of Marseille, Marseille, France
    World J Biol Psychiatry 10:719-28. 2009
    ..We conclude that risperidone may specifically act on the processing of emotion-laden information...
  34. ncbi request reprint The mood-instability hypothesis in the origin of mood-congruent versus mood-incongruent psychotic distinction in mania: validation in a French National Study of 1090 patients
    Jean Michel Azorin
    Ste Marguerite Hospital, University of Marseilles, Marseilles, France
    J Affect Disord 96:215-23. 2006
    ..Although included in successive editions of the DSM since its introduction in the IIIrd, the subtyping of manic episode into 'with mood-congruent (MCP) versus mood-incongruent (MIP) psychotic features' is yet to be fully validated...
  35. ncbi request reprint [Selecting material to develop an emotional Stroop test adapted to schizophrenia and bipolar disorders]
    Nathalie Besnier
    Service du Pr Azorin, SHU de Psychiatrie Adultes, Hopital Sainte Marguerite, Marseille, France
    Can J Psychiatry 53:177-88. 2008
    ..This study aims to develop a version of the emotional Stroop test adapted to paranoid schizophrenia and bipolar disorder...
  36. pmc Evaluation of patients on sertindole treatment after failure of other antipsychotics: a retrospective analysis
    Jean Michel Azorin
    Department of Psychiatry, CHU Sainte Marguerite, Marseilles, France
    BMC Psychiatry 8:16. 2008
    ..The purpose of this study was to determine if a subset of patients with psychotic illness exists which particularly benefits from sertindole treatment after failure of other antipsychotic drugs, including atypical antipsychotics...
  37. ncbi request reprint Rates and correlates of employment in people with schizophrenia in the UK, France and Germany
    Steven Marwaha
    Department of Mental Health Sciences, Royal Free and University College London Medical School, 48 Riding House Street, London W1W 7EY, UK, and Psychiatrie Adultes, Hospital Sainte Marguerite, Marseille, France
    Br J Psychiatry 191:30-7. 2007
    ..Little is known about international variations in employment rates among people with schizophrenia or about the factors associated with employment in this disorder...
  38. ncbi request reprint Blunted activation in right ventrolateral prefrontal cortex during motor response inhibition in schizophrenia
    Arthur Kaladjian
    Equipe Imagerie Cérébrale en Psychiatrie, CNRS, IFR 131, Marseille, France
    Schizophr Res 97:184-93. 2007
    ....
  39. ncbi request reprint [A randomized controlled study on the impact of pharmacoeducation on a French patient population with schizophrenic and schizoaffective disorders]
    Muriele Maurel
    Pôle Universitaire de Psychiatrie Adultes, Centre hospitalier universitaire Sainte Marguerite, Marseille, France
    Can J Psychiatry 55:329-37. 2010
    ..To evaluate the impact of a pharmacoeducation module both on hospital stay and on clinical and functional state in a French patient population with schizophrenic and schizoaffective disorders...
  40. ncbi request reprint A double-blind, controlled study of sertindole versus risperidone in the treatment of moderate-to-severe schizophrenia
    Jean Michel Azorin
    Hopital Sainte Marguerite, Service de Psychiatrie, Marseille, France
    Int Clin Psychopharmacol 21:49-56. 2006
    ..05). In conclusion, sertindole was well tolerated and demonstrated clinically relevant efficacy advantages over risperidone...
  41. ncbi request reprint Depressive residual symptoms are associated with lower adherence to medication in bipolar patients without substance use disorder: results from the FACE-BD cohort
    Raoul Belzeaux
    pôle de psychiatrie, Hopital Sainte Marguerite, Assistance Publique Hopitaux de Marseille, France Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 cedex 15, Marseille, France Fondation FondaMental, Creteil, France Electronic address
    J Affect Disord 151:1009-15. 2013
    ..Several factors are associated with poor adherence but previous studies included heterogeneous cohorts of patients with and without current mood episode, with and without SUD...
  42. ncbi request reprint Impact of switching or initiating antipsychotic treatment on body weight during a 6-month follow-up in a cohort of patients with schizophrenia
    Jean Pierre Schuster
    Assistance Publique Hopitaux de Paris, Department of Psychiatry, Corentin Celton Hospital, Issy les Moulineaux, France
    J Clin Psychopharmacol 32:672-7. 2012
    ..We aimed to evaluate the impact of switching antipsychotics on body mass index (BMI) during a 6-month follow-up period in a large cohort of patients with schizophrenia...
  43. doi request reprint Lack of insight may predict impaired decision making in manic patients
    Marc Adida
    Centre National de la Recherche Scientifique, IFR131, Equipe Imagerie Cérébrale en Psychiatrie, University Department of Psychiatry, SOLARIS, Sainte Marguerite Hospital, Marseille, France
    Bipolar Disord 10:829-37. 2008
    ..The aim of this study was to establish whether this characteristic can be quantified with a laboratory measure of decision making [the Iowa Gambling Task (IGT)] and to determine clinical correlates of the IGT performance in mania...
  44. ncbi request reprint Is psychosis in DSM-IV mania due to severity? The relevance of selected demographic and comorbid social-phobic features
    J M Azorin
    Ste Marguerite Hospital, University of Marseilles, Marseilles, France
    Acta Psychiatr Scand 115:29-34. 2007
    ..We tested whether factors other than episode severity contributed to psychosis in mania...
  45. doi request reprint Body mass index and prevalence of obesity in a French cohort of patients with schizophrenia
    F Limosin
    Department of Psychiatry, University of Reims, Reims, France
    Acta Psychiatr Scand 118:19-25. 2008
    ..To evaluate the distributions of body mass index in a large sample of patients with schizophrenia, and to examine the association between body weight and antipsychotic drugs...
  46. ncbi request reprint Clinical and psychometric characterization of depression in mixed mania: a report from the French National Cohort of 1090 manic patients
    E G Hantouche
    Mood Center, Adult Psychiatry Department, Pitie Salpetriere Hospital, 47 bd de l Hopital, 75013 Paris Cedex 13, France
    J Affect Disord 96:225-32. 2006
    ..This work eventually led to the Kraepelinian synthesis of all manic, mixed, and depressive states into the unitary rubric of "manic-depressive insanity (1899/1921)...
  47. doi request reprint Clozapine for the treatment of schizophrenia
    Eric Fakra
    Pôle Universitaire de Psychiatrie Solaris, Hopital Sainte Marguerite, Marseille, France
    Expert Opin Pharmacother 13:1923-35. 2012
    ..Clozapine , a D(2)-5HT(2) antagonist, was the first antipsychotic to demonstrate efficacy in treatment-resistant patients, and to be associated with the lowest risk of death...
  48. pmc Mixed states vs. pure mania in the French sample of the EMBLEM study: results at baseline and 24 months--European mania in bipolar longitudinal evaluation of medication
    Jean Michel Azorin
    Neurosciences Medical department, Eli Lilly and Company, Suresnes, France
    BMC Psychiatry 9:33. 2009
    ..To describe the clinical course and treatment patterns over 24 months of patients experiencing an acute manic/mixed episode within the standard course of care...
  49. pmc Relapse according to antipsychotic treatment in schizophrenic patients: a propensity-adjusted analysis
    Aurelie Millier
    Department of Public Health, EA 3279 Research Unit, University Hospital, Boulevard Jean Moulin 13385 Marseille, France
    BMC Psychiatry 11:24. 2011
    ..To compare the rate of relapse as a function of antipsychotic treatment (monotherapy vs. polypharmacy) in schizophrenic patients over a 2-year period...
  50. doi request reprint [Affective disorders and repetitive transcranial magnetic stimulation: Therapeutic innovations]
    R Richieri
    pôle universitaire de psychiatrie, Hôpital S te Marguerite, 270 Bd Sainte Marguerite, 13274 Marseille Cedex 09, France
    Encephale 36:S197-201. 2010
    ..Nevertheless it demonstrates the importance of developing maintenance protocols to maintain the clinical improvement achieved at the end of the acute treatment. New techniques to improve the effectiveness of rTMS are already appearing...
  51. doi request reprint [Affective disorders, antipsychotics and mood stabilizers: Therapeutic innovations]
    M Adida
    pôle universitaire de psychiatrie, Hôpital S te Marguerite, 13274 Marseille Cedex 09, France
    Encephale 36:S188-96. 2010
    ....
  52. doi request reprint [Affective disorders and antidepressant drugs: Therapeutic innovations]
    E Fakra
    pôle universitaire de psychiatrie, Hôpital S te Marguerite, 270 bd de S te Marguerite, 13274 Marseille Cedex 09, France
    Encephale 36:S183-7. 2010
    ..It thus seems that antidepressant agents have the ability to opposite the impact of stress through molecular actions, which directly or indirectly influence neuroplasticity...
  53. doi request reprint [Bipolar disorder: Continuity from child to adult?]
    D Da Fonseca
    Service de Pédopsychiatrie, Bd Sainte Marguerite 13009 Marseille, France
    Encephale 36:S173-7. 2010
    ..Studies on the childhood of bipolar adults, as well as studies on the children of bipolar parents will be reviewed, in an attempt to identify the psychopathological substrates of bipolar disorders...
  54. doi request reprint [Bipolar affective disorders: Models and assessment of psychological treatments]
    M Maurel
    pôle universitaire de psychiatrie, Hôpital S te Marguerite, 270 bd de S te Marguerite 13274 Marseille cedex 9
    Encephale 36:S202-5. 2010
    ..These robust and corroborating results should probably be integrated in future guidelines for the management of bipolar disorders...
  55. doi request reprint [Depressive onset episode of bipolar disorder: clinical and prognostic considerations]
    N Besnier
    Pôle de Psychiatrie Adultes, CHU Sainte Marguerite, 13009 Marseille
    Encephale 36:S18-22. 2010
    ..The impact of a high risk of bipolarity on drug prescription is unclear ; however, one can strongly recommend to intensifying clinical monitoring and to proposing adjunctive psychoeducation...
  56. doi request reprint [Treatment of a first manic episode]
    M Maurel
    Pôle de Psychiatrie Adultes, CHU Sainte Marguerite, 13009 Marseille
    Encephale 36:S23-6. 2010
    ..Clinical studies are needed in order to provide more information about the most suitable preventative treatment in this population...
  57. doi request reprint [Prodromal phase in bipolar disorder]
    E Fakra
    pôle universitaire de psychiatrie, Hopital Ste Marguerite, 13274 Marseille Cedex 09
    Encephale 36:S8-12. 2010
    ....
  58. doi request reprint Effect of risperidone versus haloperidol on emotional responding in schizophrenic patients
    E Fakra
    CIC UPCET et Pharmacologie Clinique, Hopital de la Timone, UMR CNRS 6193 Institut des Neurosciences Cognitives de la Méditerranée, Marseille, France
    Psychopharmacology (Berl) 200:261-72. 2008
    ..However, studies have rarely controlled the nature of antipsychotic medication. Yet, the influence of these drugs on emotional response is uncertain and could vary depending on their pharmacological profile...
  59. doi request reprint [In Alzheimer's disease, the clinical expression of behavioral and psychological signs and symptoms is early and specific of neuropathological stages]
    B F Michel
    Unité de Neurogériatrie, Hopital Sainte Marguerite, 270, boulevard de Sainte Marguerite, 13009 Marseille, France
    Encephale 36:314-25. 2010
    ..The early diagnosis of Alzheimer's disease is a new challenge. This study concerns 50 patients, 34 females (68 %) and 16 males (32 %) with Alzheimer (AD), according to NINCDS-ADRDA diagnostic criteria...
  60. doi request reprint [Manic polarity of the onset episode of bipolar disorder: clinical and prognostic considerations]
    A Kaladjian
    pôle universitaire de psychiatrie, SHU Psychiatrie Adultes, Hopital Ste Marguerite, 13274 Marseille cedex 9 France
    Encephale 36:S13-7. 2010
    ....
  61. doi request reprint [Psychometric properties of the Activities Daily Life Scale (ADL)]
    L Boyer
    pôle de santé publique, Hopital La Timone, Assistance Publique Hopitaux de Marseille, 264, rue Saint Pierre, 13385 Marseille Cedex 5, France
    Encephale 36:408-16. 2010
    ..There is a pressing need for detailed examination of its performance. The aim of this study was to explore ADL psychometric properties in a sample of hospitalized patients in a psychiatric ward...
  62. ncbi request reprint [Depression and circadian rhythm]
    J M Azorin
    Hopital Sainte Marguerite, Service de Psychiatrie Adulte, 270, Bld Sainte Marguerite, 13274 Marseille Cedex 9
    Encephale 35:S68-71. 2009
    ..The question determining whether these adverse changes are a cause or effect of depressive behaviour is unresolved...
  63. doi request reprint Natural speech comprehension in bipolar disorders: an event-related brain potential study among manic patients
    Michel Cermolacce
    Département universitaire de psychiatrie, CHU Sainte Marguerite and Aix Marseille Université, Marseille, France Unité de neurophysiologie, Psychophysiologie et Neurophénoménologie UNPN, UF 4817, CHU Sainte Marguerite, Marseille, France Laboratoire de Neurosciences Cognitives, UMR CNRS 7291 and Aix Marseille Université, Fédération 3C, Marseille, France Electronic address
    J Affect Disord 158:161-71. 2014
    ..The aim of our study was to explore N400 and LPC among patients with BD in natural speech conditions...
  64. pmc Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism
    Jean Michel Azorin
    Department of Psychiatry, CHU Sainte Marguerite, Marseilles, France
    Neuropsychiatr Dis Treat 6:37-46. 2010
    ..In conclusion, randomized, controlled research is still needed to provide guidelines for possible use of valproate and other agents in patients with a dual diagnosis of bipolar disorder and substance abuse or dependence...
  65. ncbi request reprint Possible involvement of the dopamine D3 receptor locus in subtypes of bipolar affective disorder
    P Chiaroni
    Service de Psychiatrie 2, CHU Timone, Marseille, France
    Psychiatr Genet 10:43-9. 2000
    ..01) was then noted, the bipolar females being preferentially heterozygous, and the males homozygous. These results could involve the dopamine D3 receptor locus as a minor effect gene in the manic depression condition...
  66. doi request reprint Mixed states with predominant manic or depressive symptoms: baseline characteristics and 24-month outcomes of the EMBLEM cohort
    Jean Michel Azorin
    SHU Psychiatrie Adulte, CHU Ste Marguerite, Marseille, France
    J Affect Disord 146:369-77. 2013
    ..We describe and compare baseline characteristics and 24-month clinical course of mixed states with predominant depressive symptoms (MSDS) and mixed states with predominant manic symptoms (MSMS)...
  67. doi request reprint Reduced brain activation in euthymic bipolar patients during response inhibition: an event-related fMRI study
    Arthur Kaladjian
    CNRS, IFR 131, Equipe Imagerie Cérébrale en Psychiatrie, Marseille, France
    Psychiatry Res 173:45-51. 2009
    ..Further research should ascertain the role that such deficits may play in the emergence of impulsive behaviors that characterize bipolar disorder...
  68. ncbi request reprint Valproate use in children and adolescents with bipolar disorder
    Jean Michel Azorin
    Hopital de Sainte Marguerite, Marseille, France
    CNS Drugs 21:1019-33. 2007
    ..Furthermore, clinical studies are required to clarify the efficacy and tolerability profile of valproate in comparison with other agents used in paediatric and adolescent bipolar disorder...
  69. ncbi request reprint The cyclothymic temperament in healthy controls and familially at risk individuals for mood disorder: endophenotype for genetic studies?
    Pierre Chiaroni
    Service de Psychiatrie, Hopital Sainte Marguerite, Bd Sainte Marguerite, 13009 Marseille, France
    J Affect Disord 85:135-45. 2005
    ..As bipolar disorder is a familial illness, an examination of cyclothymic temperament (CT) in controls and relatives of bipolar patients is of major relevance...
  70. doi request reprint Insight in schizophrenia: from conceptualization to neuroscience
    Mounir Ouzir
    Laboratory of Clinical Neuroscience and Mental Health, Faculty of Medicine and Pharmacy, Casablanca, Morocco
    Psychiatry Clin Neurosci 66:167-79. 2012
    ..The extensive literature on the cognitive consequences of lack of insight and the contribution of neuroimaging techniques to elucidating neurological etiology of insight deficits, is also reviewed...
  71. ncbi request reprint A differential role for interleukin-6 and tumor necrosis factor-alpha in schizophrenia?
    J Naudin
    service hospitalo universitaire de psychiatrie, CHU Sainte Marguerite, Marseille, France
    Schizophr Res 26:227-33. 1997
    ..e. illness duration. These data suggest a specific cytokine-mediated syndrome in schizophrenia. We hypothesize that TNF alpha and IL-6 reflect the genetic background of disease suceptibility...
  72. ncbi request reprint A prospective study of Quality of life in schizophrenia in three European countries
    Dirk Heider
    Department of Psychiatry, University of Leipzig, Johannisalle 20, 04317 Leipzig, Germany
    Schizophr Res 93:194-202. 2007
    ..However, changes in individual's characteristics and circumstances did not relate as strongly as expected to changes in QoL, suggesting effective intervention may be difficult...
  73. doi request reprint Correlates of subjective quality of life in people with schizophrenia: findings from the EuroSC study
    Steven Marwaha
    Department of Mental Health Sciences, Royal Free and University College London Medical School, University College London, London, United Kingdom
    J Nerv Ment Dis 196:87-94. 2008
    ..Differences in mental health service provision in the United Kingdom and Germany may in part explain variations in the QOL of people with schizophrenia resident there...
  74. ncbi request reprint Residential area and social contacts in schizophrenia. Results from the European Schizophrenia Cohort (EuroSC)
    Georg Schomerus
    Dept of Psychiatry, Leipzig University, Johannisallee 20, 04317, Leipzig, Germany
    Soc Psychiatry Psychiatr Epidemiol 42:617-22. 2007
    ..Social isolation is associated with poor prognosis in schizophrenia. We aim to determine the effect of rural or urban residence on frequency of social and family contacts...
  75. ncbi request reprint The European sertindole safety and exposure survey: a follow-up study of 8600 patients
    Joseph Peuskens
    University Psychiatric Centre, Campus St Jozef Kortenberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Pharmacoepidemiol Drug Saf 16:804-11. 2007
    ..A regulatory signal suggested that sertindole was associated with a 10-fold increased risk of death. This observational study aimed to identify deaths and their causes in patients treated with sertindole...
  76. doi request reprint The architecture of cognitive control in schizophrenia
    Valerian Chambon
    Centre de Neuroscience Cognitive, Universite de Lyon, Lyon, France
    Brain 131:962-70. 2008
    ....
  77. ncbi request reprint Validating antidepressant-associated hypomania (bipolar III): a systematic comparison with spontaneous hypomania (bipolar II)
    Hagop S Akiskal
    International Mood Center, University of California at San Diego and VA Psychiatry Service 116 A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 73:65-74. 2003
    ..According to DSM-IV and ICD-10, hypomania which occurs solely during antidepressant treatment does not belong to the category of bipolar II (BP-II)...
  78. ncbi request reprint Burden on caregivers of people with schizophrenia: comparison between Germany and Britain
    Christiane Roick
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Br J Psychiatry 190:333-8. 2007
    ..Burden on the relatives of patients with schizophrenia may be influenced not only by patient and caregiver characteristics, but also by differences in mental health service provision...
  79. ncbi request reprint The European Schizophrenia Cohort (EuroSC): a naturalistic prognostic and economic study
    Paul E Bebbington
    Dept Mental Health Sciences Bloomsbury Campus, Royal Free and University College Medical School, UCL, London, W1W 7EY, UK
    Soc Psychiatry Psychiatr Epidemiol 40:707-17. 2005
    ..Secondary objectives include the assessment of treatment needs in relation to outcome, the calculation of resource consumption associated with different methods of care, and the identification of prognostic factors...