Research Topics
Genomes and Genes | Mehdi KabaniSummaryAffiliation: Avenue de la Terrasse Country: France Publications
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Publications
Yeast prions assembly and propagation: contributions of the prion and non-prion moieties and the nature of assembliesMehdi Kabani
Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
Prion 5:277-84. 2011....
Structural and functional diversity among eukaryotic Hsp70 nucleotide exchange factorsMehdi Kabani
Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
Protein Pept Lett 16:623-60. 2009..Here, I summarize our current knowledge of their mechanisms of action, regulations and cellular functions as well as their relevance for human diseases such as cystic fibrosis or amyloidoses...
A mutation within the C-terminal domain of Sup35p that affects [PSI+] prion propagationMehdi Kabani
Laboratoire d Enzymologie et Biochimie Structurales, CNRS, Bat 34, Avenue de la Terrasse, F 91190 Gif sur Yvette, France
Mol Microbiol 81:640-58. 2011..Our results clearly demonstrate that Sup35p C-terminal domain plays a critical role in prion propagation and provide new insights into the mechanism of prion conversion...
Swa2p-dependent clathrin dynamics is critical for Flo11p processing and 'Mat' formation in the yeast Saccharomyces cerevisiaeCéline N Martineau
Laboratoire d Enzymologie et Biochimie Structurales LEBS, CNRS, Gif sur Yvette, France
FEBS Lett 584:1149-55. 2010..Both the TPR and J-domains of Swa2p, but not its clathrin-binding and ubiquitin-association motifs, are required for its function in Flo11p processing...
Hsc70 protein interaction with soluble and fibrillar alpha-synucleinSamantha Pemberton
Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
J Biol Chem 286:34690-9. 2011..Hsc70 may therefore significantly affect the cellular propagation of α-Syn aggregates and their spread throughout the central nervous system in Parkinson disease...
Molecular and functional characterization of the only known hemiascomycete ortholog of the carboxyl terminus of Hsc70-interacting protein CHIP in the yeast Yarrowia lipolyticaCéline N Martineau
Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
Cell Stress Chaperones 17:229-41. 2012..Chn1p/Ssa1p/Sse1p ternary complex. Finally, we show that, similar to Sse1p, Yl.Chn1p can act as a "holdase" to prevent the aggregation of a heat-denatured protein...
Flo11p-independent control of "mat" formation by hsp70 molecular chaperones and nucleotide exchange factors in yeastCéline N Martineau
Laboratoire de Microbiologie et Genetique Moleculaire, CNRS, INRA, AgroParisTech, 78850 Thiverval Grignon, France
Genetics 177:1679-89. 2007..Importantly, these mutations did not compromise invasive growth or Flo11p expression, suggesting that Flo11p-independent pathways are necessary to form mats...
Multiple hsp70 isoforms in the eukaryotic cytosol: mere redundancy or functional specificity?Mehdi Kabani
Laboratoire d Enzymologie et Biochimie Structurales LEBS, CNRS, Bat 34, Avenue de la Terrasse, 91198 Gif sur Yvette, France
Curr Genomics 9:338-248. 2008..We summarize here our current knowledge of the functions and regulations of these molecular chaperones, and shed light on the known functional specificities among isoforms...
