Alain Destexhe

Summary

Affiliation: Avenue de la Terrasse
Country: France

Publications

  1. pmc Inhibitory "noise"
    Alain Destexhe
    Unité de Neurosciences, Infomation et Complexité, Centre National de la Recherche Scientifique Gif sur Yvette, France
    Front Cell Neurosci 4:9. 2010
  2. doi request reprint Intracellular and computational evidence for a dominant role of internal network activity in cortical computations
    Alain Destexhe
    Unité de Neurosciences, Information et Complexité, CNRS, 91198 Gif sur Yvette, France
    Curr Opin Neurobiol 21:717-25. 2011
  3. doi request reprint Self-sustained asynchronous irregular states and Up-Down states in thalamic, cortical and thalamocortical networks of nonlinear integrate-and-fire neurons
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, UPR2191, Gif sur Yvette, France
    J Comput Neurosci 27:493-506. 2009
  4. ncbi request reprint Characterization of synaptic conductances and integrative properties during electrically induced EEG-activated states in neocortical neurons in vivo
    Michael Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Neurophysiol 94:2805-21. 2005
  5. ncbi request reprint Calculating event-triggered average synaptic conductances from the membrane potential
    Martin Pospischil
    Unite de Neurosciences Integratives et Computationnelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Neurophysiol 97:2544-52. 2007
  6. doi request reprint Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation
    Zuzanna Piwkowska
    Unite de Neurosciences Integratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    J Neurosci Methods 169:302-22. 2008
  7. doi request reprint Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons
    Martin Pospischil
    Unite de Neurosciences Integratives et Computationnelles, CNRS, Gif sur Yvette, France
    Biol Cybern 99:427-41. 2008
  8. doi request reprint Evidence for frequency-dependent extracellular impedance from the transfer function between extracellular and intracellular potentials: intracellular-LFP transfer function
    Claude Bédard
    Integrative and Computational Neuroscience Unit UNIC, UPR2191, CNRS, Gif sur Yvette, France
    J Comput Neurosci 29:389-403. 2010
  9. ncbi request reprint Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity
    Mathilde Badoual
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Int J Neural Syst 16:79-97. 2006
  10. ncbi request reprint High-resolution intracellular recordings using a real-time computational model of the electrode
    Romain Brette
    Unité de neurosciences intégratives et computationnelles UNIC, CNRS, 91198 Gif sur Yvette, France
    Neuron 59:379-91. 2008

Collaborators

Detail Information

Publications45

  1. pmc Inhibitory "noise"
    Alain Destexhe
    Unité de Neurosciences, Infomation et Complexité, Centre National de la Recherche Scientifique Gif sur Yvette, France
    Front Cell Neurosci 4:9. 2010
    ..These results argue for a determinant role for inhibitory fluctuations in evoking spikes, and do not support feed-forward modes of processing, for which opposite patterns are predicted...
  2. doi request reprint Intracellular and computational evidence for a dominant role of internal network activity in cortical computations
    Alain Destexhe
    Unité de Neurosciences, Information et Complexité, CNRS, 91198 Gif sur Yvette, France
    Curr Opin Neurobiol 21:717-25. 2011
    ..This view offers an attractive interpretation not only of dreaming activity (absence of sensory input), but also of several mental disorders...
  3. doi request reprint Self-sustained asynchronous irregular states and Up-Down states in thalamic, cortical and thalamocortical networks of nonlinear integrate-and-fire neurons
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, UPR2191, Gif sur Yvette, France
    J Comput Neurosci 27:493-506. 2009
    ..These models suggest that intrinsic properties such as adaptation and low-threshold bursting activity are crucial for the genesis and control of AI states in thalamocortical networks...
  4. ncbi request reprint Characterization of synaptic conductances and integrative properties during electrically induced EEG-activated states in neocortical neurons in vivo
    Michael Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Neurophysiol 94:2805-21. 2005
    ....
  5. ncbi request reprint Calculating event-triggered average synaptic conductances from the membrane potential
    Martin Pospischil
    Unite de Neurosciences Integratives et Computationnelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Neurophysiol 97:2544-52. 2007
    ..The procedure was also tested successfully in biological cortical neurons using conductance noise injected with dynamic clamp. This method should allow the extraction of synaptic conductances from V(m) recordings in vivo...
  6. doi request reprint Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation
    Zuzanna Piwkowska
    Unite de Neurosciences Integratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    J Neurosci Methods 169:302-22. 2008
    ....
  7. doi request reprint Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons
    Martin Pospischil
    Unite de Neurosciences Integratives et Computationnelles, CNRS, Gif sur Yvette, France
    Biol Cybern 99:427-41. 2008
    ..The selection of such cellular models constitutes a necessary step towards building network simulations of the thalamocortical system with realistic cellular dynamical properties...
  8. doi request reprint Evidence for frequency-dependent extracellular impedance from the transfer function between extracellular and intracellular potentials: intracellular-LFP transfer function
    Claude Bédard
    Integrative and Computational Neuroscience Unit UNIC, UPR2191, CNRS, Gif sur Yvette, France
    J Comput Neurosci 29:389-403. 2010
    ..This constitutes indirect evidence that the extracellular medium is non-resistive, which has many possible consequences for modeling LFPs...
  9. ncbi request reprint Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity
    Mathilde Badoual
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Int J Neural Syst 16:79-97. 2006
    ..We also make links with other well-known plasticity rules. A simplified phenomenological model is also derived, which should be useful for fast numerical simulation and analytical investigation of the impact of STDP at the network level...
  10. ncbi request reprint High-resolution intracellular recordings using a real-time computational model of the electrode
    Romain Brette
    Unité de neurosciences intégratives et computationnelles UNIC, CNRS, 91198 Gif sur Yvette, France
    Neuron 59:379-91. 2008
    ..AEC should be particularly useful to characterize fast neuronal phenomena intracellularly in vivo...
  11. ncbi request reprint Inferring network activity from synaptic noise
    Michael Rudolph
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    J Physiol Paris 98:452-66. 2004
    ..Thus, "probing the network" through intracellular V(m) activity is possible and constitutes a promising approach, but it will require a continuous effort combining theory, computational models and intracellular physiology...
  12. ncbi request reprint Tuning neocortical pyramidal neurons between integrators and coincidence detectors
    Michael Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, UPR 2191, Bat 32 33, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    J Comput Neurosci 14:239-51. 2003
    ..Thus, background activity not only sharpens cortical responses but it can also be used to tune an entire network between integration and coincidence detection modes...
  13. doi request reprint Stable learning in stochastic network states
    Sami El Boustani
    Unité de Neurosciences, Information et Complexité, CNRS, Unité Propre de Recherche 3293, 91198 Gif sur Yvette, France
    J Neurosci 32:194-214. 2012
    ..The mixed presynaptic and postsynaptic dependency of the floating plasticity threshold is justified by a cascade of known molecular pathways, which leads to experimentally testable predictions...
  14. doi request reprint Comparison of different neuron models to conductance-based post-stimulus time histograms obtained in cortical pyramidal cells using dynamic-clamp in vitro
    Martin Pospischil
    Unité de Neurosciences, Information et Complexité UNIC, CNRS, Gif sur Yvette, France
    Biol Cybern 105:167-80. 2011
    ....
  15. pmc Network-state modulation of power-law frequency-scaling in visual cortical neurons
    Sami El Boustani
    Unité de neurosciences intégratives et computationnelles UNIC, UPR CNRS 2191, Gif sur Yvette, France
    PLoS Comput Biol 5:e1000519. 2009
    ....
  16. doi request reprint Characterizing neuronal activity by describing the membrane potential as a stochastic process
    Martin Pospischil
    Integrative and Computational Neuroscience Unit, UPR, CNRS, Gif sur Yvette, France
    J Physiol Paris 103:98-106. 2009
    ..However, it does so by using a maximum-likelihood estimation, and can thus be applied to single V(m) traces. All methods were tested using controlled conductance injection in dynamic-clamp experiments...
  17. doi request reprint Topologically invariant macroscopic statistics in balanced networks of conductance-based integrate-and-fire neurons
    Pierre Yger
    Unité de Neuroscience Information et Complexité UNIC, UPR 3293 CNRS, Bat 32 33, 1 Avenue de la Terrasse, 91198, Gif sur Yvette, France
    J Comput Neurosci 31:229-45. 2011
    ..This study is an encouraging step toward a mean-field description of topological neuronal networks...
  18. pmc Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep
    Adrien Peyrache
    Unité de Neurosciences, Information, et Complexiteé, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 109:1731-6. 2012
    ..These findings provide a detailed characterization of neuronal activity, functional connectivity at the microcircuit level, and the interplay of excitation and inhibition in the human neocortex...
  19. ncbi request reprint Inhibition determines membrane potential dynamics and controls action potential generation in awake and sleeping cat cortex
    Michelle Rudolph
    Integrative and Computational Neuroscience Unit, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Neurosci 27:5280-90. 2007
    ....
  20. ncbi request reprint Oversampling method to extract excitatory and inhibitory conductances from single-trial membrane potential recordings
    Claude Bédard
    Unité de Neurosciences, Information et Complexité, CNRS, 91198 Gif sur Yvette, France
    J Neurosci Methods 210:3-14. 2012
    ..Finally, the method is evaluated using controlled conductance injection in cortical neurons in vitro using the dynamic-clamp technique. This conductance extraction method should be very useful for future in vivo applications...
  21. pmc Are corticothalamic 'up' states fragments of wakefulness?
    Alain Destexhe
    CNRS, Integrative and Computational Neuroscience Unit 1, Avenue de la Terrasse, Gif sur Yvette Cedex 91198, France
    Trends Neurosci 30:334-42. 2007
    ..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)...
  22. ncbi request reprint Neuronal computations with stochastic network states
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Science 314:85-90. 2006
    ..The understanding of the relation between network state dynamics and information representation is a major challenge that will require developing, in conjunction, specific experimental paradigms and theoretical frameworks...
  23. ncbi request reprint Kinetic models of spike-timing dependent plasticity and their functional consequences in detecting correlations
    Quan Zou
    Integrative and Computational Neuroscience Unit, CNRS, 1 Avenue de la Terrasse, 91198, Gif sur Yvette, France
    Biol Cybern 97:81-97. 2007
    ..We conclude that kinetic models generally predict soft-bound dynamics, and that such models seem ideal for detecting correlations among large numbers of inputs...
  24. doi request reprint A master equation formalism for macroscopic modeling of asynchronous irregular activity states
    Sami El Boustani
    Unite de Neurosciences Integratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    Neural Comput 21:46-100. 2009
    ....
  25. ncbi request reprint Extracting information from the power spectrum of synaptic noise
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 91198 Gif sur Yvette, France
    J Comput Neurosci 17:327-45. 2004
    ..This approach, therefore, provides a direct link between intracellular recordings in vivo and the design of models consistent with the dynamics and spectral structure of synaptic noise...
  26. ncbi request reprint Activated cortical states: experiments, analyses and models
    Sami El Boustani
    Integrative and Computational Neuroscience Unit UNIC, UPR2191, CNRS, Gif sur Yvette, France
    J Physiol Paris 101:99-109. 2007
    ..We also show how networks can approach a correct conductance state, suggesting ways by which future models will generate activity fully consistent with experimental data...
  27. pmc A modified cable formalism for modeling neuronal membranes at high frequencies
    Claude Bédard
    Integrative and Computational Neuroscience Unit UNIC, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Biophys J 94:1133-43. 2008
    ..These results suggest that cable equations based on nonideal capacitors should be used to capture the behavior of neuronal membranes at high frequencies...
  28. ncbi request reprint Analog-digital simulations of full conductance-based networks of spiking neurons with spike timing dependent plasticity
    Quan Zou
    Integrative and Computational Neuroscience Unit, CNRS, Gif sur Yvette, France
    Network 17:211-33. 2006
    ..They should be useful for any real-time application, such as hybrid systems interfacing network models with biological neurons...
  29. ncbi request reprint Generalized cable theory for neurons in complex and heterogeneous media
    Claude Bédard
    Unité de Neuroscience, Information et Complexité UNIC, CNRS, Gif sur Yvette, France
    Phys Rev E Stat Nonlin Soft Matter Phys 88:022709. 2013
    ..We conclude that the nature of intracellular and extracellular media may have a strong influence on cable filtering as well as on the passive integrative properties of neurons. ..
  30. ncbi request reprint Synaptic background activity controls spike transfer from thalamus to cortex
    Jakob Wolfart
    Unite de Neurosciences Integratives et Computationnelles, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Nat Neurosci 8:1760-7. 2005
    ..Because in thalamic neurons, background synaptic input originates mainly from cortex, these results support a determinant role of corticothalamic feedback during sensory information processing...
  31. doi request reprint Analytical integrate-and-fire neuron models with conductance-based dynamics and realistic postsynaptic potential time course for event-driven simulation strategies
    Michelle Rudolph-Lilith
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    Neural Comput 24:1426-61. 2012
    ....
  32. pmc The initiation of bursts in thalamic neurons and the cortical control of thalamic sensitivity
    Alain Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Philos Trans R Soc Lond B Biol Sci 357:1649-57. 2002
    ..These properties enable the cortex to control the sensitivity of the thalamus to inputs and are also important for understanding states such as absence seizures...
  33. ncbi request reprint A fast-conducting, stochastic integrative mode for neocortical neurons in vivo
    Michael Rudolph
    Integrative and Computational Neuroscience Unit, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Neurosci 23:2466-76. 2003
    ..Some of these predictions can be tested experimentally...
  34. pmc Comparative power spectral analysis of simultaneous elecroencephalographic and magnetoencephalographic recordings in humans suggests non-resistive extracellular media
    Nima Dehghani
    Integrative and Computational Neuroscience Unit UNIC, UPR2191, CNRS, Gif sur Yvette, France
    J Comput Neurosci 29:405-21. 2010
    ..In conclusion, there is a significant difference in frequency scaling between EEG and MEG, which can be explained if the extracellular medium (including other layers such as dura matter and skull) is globally non-resistive...
  35. ncbi request reprint Propagating waves in thalamus, cortex and the thalamocortical system: Experiments and models
    Lyle Muller
    Unité de Neurosciences, Information, et Complexité, CNRS, Gif sur Yvette, France
    J Physiol Paris 106:222-38. 2012
    ..This approach is a step towards understanding how the intrinsically-generated ongoing activity of the network affects its ability to process and propagate extrinsic input...
  36. ncbi request reprint A method to estimate synaptic conductances from membrane potential fluctuations
    Michael Rudolph
    Integrative and Computational Neuroscience Unit UNIC, Centre National de la Recherche Scientifique, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    J Neurophysiol 91:2884-96. 2004
    ....
  37. doi request reprint Correlated input reveals coexisting coding schemes in a sensory cortex
    Luc Estebanez
    Unité de Neurosciences, Information et Complexité, UPR 3293, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Nat Neurosci 15:1691-9. 2012
    ..We suggest that similar context-dependent coexisting coding strategies may be present in other sensory systems to adapt sensory integration to specific stimulus statistics...
  38. ncbi request reprint The high-conductance state of neocortical neurons in vivo
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Nat Rev Neurosci 4:739-51. 2003
  39. ncbi request reprint Generalized theory for current-source-density analysis in brain tissue
    Claude Bédard
    Unité de Neurosciences, Information et Complexité, CNRS, 1 Avenue de la Terrasse Bat 33, F 91198 Gif sur Yvette, France
    Phys Rev E Stat Nonlin Soft Matter Phys 84:041909. 2011
    ....
  40. pmc The Wilson-Cowan model, 36 years later
    Alain Destexhe
    Unité de neurosciences intégratives et computationnelles UNIC, Centre National de la Recherche Scientifique CNRS, 91198 Gif sur Yvette, France
    Biol Cybern 101:1-2. 2009
    ..These measurement techniques have revealed patterns of coherent activity that span centimetres of tissue in the cerebral cortex. Here the underlying ideas are reviewed in a historic context...
  41. pmc Inhibition recruitment in prefrontal cortex during sleep spindles and gating of hippocampal inputs
    Adrien Peyrache
    Neuroscience, Information and Complexity Unit, UPR 3293, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 108:17207-12. 2011
    ..The interplay between hippocampal and thalamic inputs may underlie a global mechanism involved in the consolidation of recently formed memory traces...
  42. ncbi request reprint Plasticity in single neuron and circuit computations
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette 91198, France
    Nature 431:789-95. 2004
    ..By linking theoretical and experimental studies, we are beginning to reveal the consequences of plasticity mechanisms for network dynamics, in both simple invertebrate circuits and the complex circuits of mammalian cerebral cortex...
  43. pmc Avalanche Analysis from Multielectrode Ensemble Recordings in Cat, Monkey, and Human Cerebral Cortex during Wakefulness and Sleep
    Nima Dehghani
    Laboratory of Computational Neuroscience, Unité de Neurosciences, Information et Complexité, CNRS Gif sur Yvette, France
    Front Physiol 3:302. 2012
    ..Collectively, these results show no clear evidence for power-law scaling or self-organized critical states in the awake and sleeping brain of mammals, from cat to man...
  44. ncbi request reprint Analytical integrate-and-fire neuron models with conductance-based dynamics for event-driven simulation strategies
    Michelle Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    Neural Comput 18:2146-210. 2006
    ..gIF models should therefore provide a useful tool for efficient and precise simulation of large-scale neuronal networks with realistic, conductance-based synaptic interactions...
  45. pmc Macroscopic models of local field potentials and the apparent 1/f noise in brain activity
    Claude Bédard
    Integrative and Computational Neuroscience Unit UNIC, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Biophys J 96:2589-603. 2009
    ..Finally, we suggest a measurement method to reveal the frequency dependence of current propagation in biological tissue, and which could be used to directly test the predictions of this formalism...