A Destexhe

Summary

Affiliation: Avenue de la Terrasse
Country: France

Publications

  1. pmc Interactions between membrane conductances underlying thalamocortical slow-wave oscillations
    A Destexhe
    Unité de Neurosciences Intégratives et Computation nelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Physiol Rev 83:1401-53. 2003
  2. ncbi request reprint The high-conductance state of neocortical neurons in vivo
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Nat Rev Neurosci 4:739-51. 2003
  3. ncbi request reprint Extracting information from the power spectrum of synaptic noise
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 91198 Gif sur Yvette, France
    J Comput Neurosci 17:327-45. 2004
  4. ncbi request reprint Plasticity in single neuron and circuit computations
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette 91198, France
    Nature 431:789-95. 2004
  5. ncbi request reprint Neuronal computations with stochastic network states
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Science 314:85-90. 2006
  6. pmc Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Gif sur Yvette, France
    Neuroscience 107:13-24. 2001
  7. ncbi request reprint Modelling corticothalamic feedback and the gating of the thalamus by the cerebral cortex
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Avenue de la Terrasse, 91198, Gif sur Yvette, France
    J Physiol Paris 94:391-410. 2000
  8. ncbi request reprint Nonlinear thermodynamic models of voltage-dependent currents
    A Destexhe
    Department of Physiology, Laval University, Quebec, Canada
    J Comput Neurosci 9:259-70. 2000
  9. ncbi request reprint Do neocortical pyramidal neurons display stochastic resonance?
    M Rudolph
    Unite de Neurosciences Integratives et Computationnelles, CNRS, Bat 33, Avenue de la Terrasse 1, 91198 Gif sur Yvette, France
    J Comput Neurosci 11:19-42. 2001
  10. ncbi request reprint The discharge variability of neocortical neurons during high-conductance states
    M Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, Bat 32 33, Avenue de la Terrasse, 91198, Gif sur Yvette, France
    Neuroscience 119:855-73. 2003

Collaborators

Detail Information

Publications42

  1. pmc Interactions between membrane conductances underlying thalamocortical slow-wave oscillations
    A Destexhe
    Unité de Neurosciences Intégratives et Computation nelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Physiol Rev 83:1401-53. 2003
    ..This framework suggests physiological roles for the highly synchronized oscillations of slow-wave sleep...
  2. ncbi request reprint The high-conductance state of neocortical neurons in vivo
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Nat Rev Neurosci 4:739-51. 2003
  3. ncbi request reprint Extracting information from the power spectrum of synaptic noise
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, 91198 Gif sur Yvette, France
    J Comput Neurosci 17:327-45. 2004
    ..This approach, therefore, provides a direct link between intracellular recordings in vivo and the design of models consistent with the dynamics and spectral structure of synaptic noise...
  4. ncbi request reprint Plasticity in single neuron and circuit computations
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette 91198, France
    Nature 431:789-95. 2004
    ..By linking theoretical and experimental studies, we are beginning to reveal the consequences of plasticity mechanisms for network dynamics, in both simple invertebrate circuits and the complex circuits of mammalian cerebral cortex...
  5. ncbi request reprint Neuronal computations with stochastic network states
    Alain Destexhe
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Science 314:85-90. 2006
    ..The understanding of the relation between network state dynamics and information representation is a major challenge that will require developing, in conjunction, specific experimental paradigms and theoretical frameworks...
  6. pmc Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Gif sur Yvette, France
    Neuroscience 107:13-24. 2001
    ..We conclude that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically...
  7. ncbi request reprint Modelling corticothalamic feedback and the gating of the thalamus by the cerebral cortex
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Avenue de la Terrasse, 91198, Gif sur Yvette, France
    J Physiol Paris 94:391-410. 2000
    ..We suggest mechanisms by which different modes of corticothalamic interaction would allow oscillations of very different spatiotemporal coherence to coexist in the thalamocortical system...
  8. ncbi request reprint Nonlinear thermodynamic models of voltage-dependent currents
    A Destexhe
    Department of Physiology, Laval University, Quebec, Canada
    J Comput Neurosci 9:259-70. 2000
    ..We illustrate their applicability to fit experimental data by considering the case of the T-type calcium current in thalamic neurons...
  9. ncbi request reprint Do neocortical pyramidal neurons display stochastic resonance?
    M Rudolph
    Unite de Neurosciences Integratives et Computationnelles, CNRS, Bat 33, Avenue de la Terrasse 1, 91198 Gif sur Yvette, France
    J Comput Neurosci 11:19-42. 2001
    ..We suggest that this type of resonance may be relevant to information processing in the cerebral cortex...
  10. ncbi request reprint The discharge variability of neocortical neurons during high-conductance states
    M Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, Bat 32 33, Avenue de la Terrasse, 91198, Gif sur Yvette, France
    Neuroscience 119:855-73. 2003
    ..We conclude that the fluctuating high-conductance state caused by the ongoing activity in the cortical network in vivo may be viewed as a natural determinant of the highly variable discharges of these neurons...
  11. ncbi request reprint Cortical feedback controls the frequency and synchrony of oscillations in the visual thalamus
    T Bal
    Unite de Neurosciences Integratives et Computationnelles, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2191, Institut de Neurobiologie A Fessard, 91 198, Gif sur Yvette Cedex, France
    J Neurosci 20:7478-88. 2000
    ..This modulation may have implications for a better understanding of the descending control of thalamic nuclei by the cortex, and the genesis of pathological rhythmical activity, such as absence seizures...
  12. ncbi request reprint Correlation detection and resonance in neural systems with distributed noise sources
    M Rudolph
    Department of Physiology, Laval University, , Canada
    Phys Rev Lett 86:3662-5. 2001
    ..Remarkably, the neuron could detect weak correlations among the distributed inputs within millisecond time scales...
  13. ncbi request reprint Does the 1/f frequency scaling of brain signals reflect self-organized critical states?
    C Bedard
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Phys Rev Lett 97:118102. 2006
    ..We propose a model of 1/f scaling which does not rely on critical states, and which is testable experimentally...
  14. doi request reprint Extracting synaptic conductances from single membrane potential traces
    M Pospischil
    Integrative and Computational Neuroscience Unit UNIC, UPR 2191, CNRS, Bat 32 33, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Neuroscience 158:545-52. 2009
    ..The VmT method holds promises for extracting conductances from single-trial measurements, which has a high potential for in vivo applications...
  15. ncbi request reprint Model of low-pass filtering of local field potentials in brain tissue
    C Bedard
    Departement de Physique, Universite Laval, Quebec, Quebec G1K 7P4, Canada
    Phys Rev E Stat Nonlin Soft Matter Phys 73:051911. 2006
    ..Experimentally testable predictions are provided allowing us to verify the validity of this model...
  16. ncbi request reprint Prediction of spatiotemporal patterns of neural activity from pairwise correlations
    O Marre
    Unité de neurosciences intégratives et computationnelles UNIC, UPR CNRS 2191, Gif sur Yvette, France
    Phys Rev Lett 102:138101. 2009
    ..This approach can also be used to generate surrogates that reproduce the spatial and temporal correlations of a given data set...
  17. ncbi request reprint Can GABAA conductances explain the fast oscillation frequency of absence seizures in rodents?
    A Destexhe
    Department de Physiologie, Universite Laval, Quebec, Canada
    Eur J Neurosci 11:2175-81. 1999
    ..Experiments are proposed to test this mechanism...
  18. ncbi request reprint Characterization of subthreshold voltage fluctuations in neuronal membranes
    M Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    Neural Comput 15:2577-618. 2003
    ..Because the steady-state membrane potential distribution is easily obtained experimentally, this approach provides a possible method to estimate the mean and variance of synaptic conductances in real neurons...
  19. ncbi request reprint An extended analytic expression for the membrane potential distribution of conductance-based synaptic noise
    M Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    Neural Comput 17:2301-15. 2005
    ..These extended expressions should enable finer characterization of the stochasticity of synaptic currents by analyzing experimentally recorded Vm distributions and may be applicable to other classes of stochastic processes as well...
  20. ncbi request reprint Analog-digital simulations of full conductance-based networks of spiking neurons with spike timing dependent plasticity
    Quan Zou
    Integrative and Computational Neuroscience Unit, CNRS, Gif sur Yvette, France
    Network 17:211-33. 2006
    ..They should be useful for any real-time application, such as hybrid systems interfacing network models with biological neurons...
  21. pmc Are corticothalamic 'up' states fragments of wakefulness?
    Alain Destexhe
    CNRS, Integrative and Computational Neuroscience Unit 1, Avenue de la Terrasse, Gif sur Yvette Cedex 91198, France
    Trends Neurosci 30:334-42. 2007
    ..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)...
  22. ncbi request reprint Kinetic models of spike-timing dependent plasticity and their functional consequences in detecting correlations
    Quan Zou
    Integrative and Computational Neuroscience Unit, CNRS, 1 Avenue de la Terrasse, 91198, Gif sur Yvette, France
    Biol Cybern 97:81-97. 2007
    ..We conclude that kinetic models generally predict soft-bound dynamics, and that such models seem ideal for detecting correlations among large numbers of inputs...
  23. pmc Simulation of networks of spiking neurons: a review of tools and strategies
    Romain Brette
    Ecole Normale Superieure, Paris, France
    J Comput Neurosci 23:349-98. 2007
    ..The ultimate goal of this review is to provide a resource to facilitate identifying the appropriate integration strategy and simulation tool to use for a given modeling problem related to spiking neural networks...
  24. pmc A modified cable formalism for modeling neuronal membranes at high frequencies
    Claude Bédard
    Integrative and Computational Neuroscience Unit UNIC, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Biophys J 94:1133-43. 2008
    ..These results suggest that cable equations based on nonideal capacitors should be used to capture the behavior of neuronal membranes at high frequencies...
  25. ncbi request reprint Activated cortical states: experiments, analyses and models
    Sami El Boustani
    Integrative and Computational Neuroscience Unit UNIC, UPR2191, CNRS, Gif sur Yvette, France
    J Physiol Paris 101:99-109. 2007
    ..We also show how networks can approach a correct conductance state, suggesting ways by which future models will generate activity fully consistent with experimental data...
  26. doi request reprint Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation
    Zuzanna Piwkowska
    Unite de Neurosciences Integratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    J Neurosci Methods 169:302-22. 2008
    ....
  27. doi request reprint High-resolution intracellular recordings using a real-time computational model of the electrode
    Romain Brette
    Unité de neurosciences intégratives et computationnelles UNIC, CNRS, 91198 Gif sur Yvette, France
    Neuron 59:379-91. 2008
    ..AEC should be particularly useful to characterize fast neuronal phenomena intracellularly in vivo...
  28. ncbi request reprint Calculating event-triggered average synaptic conductances from the membrane potential
    Martin Pospischil
    Unite de Neurosciences Integratives et Computationnelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Neurophysiol 97:2544-52. 2007
    ..The procedure was also tested successfully in biological cortical neurons using conductance noise injected with dynamic clamp. This method should allow the extraction of synaptic conductances from V(m) recordings in vivo...
  29. ncbi request reprint On the use of analytical expressions for the voltage distribution to analyze intracellular recordings
    Michelle Rudolph
    Neural Comput 18:2917-22. 2006
    ..In this note, we provide a comparison of the different approximations available, with an aim of delineating which expression is most suitable for analyzing experimental data...
  30. pmc Modeling extracellular field potentials and the frequency-filtering properties of extracellular space
    Claude Bédard
    Departement de Physique, Universite Laval, Quebec, Quebec G1K 7P4, Canada
    Biophys J 86:1829-42. 2004
    ..This simple model can be used to obtain frequency-dependent extracellular field potentials without taking into account explicitly the complex folding of extracellular space...
  31. ncbi request reprint A method to estimate synaptic conductances from membrane potential fluctuations
    Michael Rudolph
    Integrative and Computational Neuroscience Unit UNIC, Centre National de la Recherche Scientifique, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    J Neurophysiol 91:2884-96. 2004
    ....
  32. ncbi request reprint Tuning neocortical pyramidal neurons between integrators and coincidence detectors
    Michael Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, UPR 2191, Bat 32 33, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    J Comput Neurosci 14:239-51. 2003
    ..Thus, background activity not only sharpens cortical responses but it can also be used to tune an entire network between integration and coincidence detection modes...
  33. ncbi request reprint Characterization of synaptic conductances and integrative properties during electrically induced EEG-activated states in neocortical neurons in vivo
    Michael Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Neurophysiol 94:2805-21. 2005
    ....
  34. ncbi request reprint Synaptic background activity controls spike transfer from thalamus to cortex
    Jakob Wolfart
    Unite de Neurosciences Integratives et Computationnelles, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Nat Neurosci 8:1760-7. 2005
    ..Because in thalamic neurons, background synaptic input originates mainly from cortex, these results support a determinant role of corticothalamic feedback during sensory information processing...
  35. ncbi request reprint A fast-conducting, stochastic integrative mode for neocortical neurons in vivo
    Michael Rudolph
    Integrative and Computational Neuroscience Unit, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Neurosci 23:2466-76. 2003
    ..Some of these predictions can be tested experimentally...
  36. ncbi request reprint Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity
    Mathilde Badoual
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Int J Neural Syst 16:79-97. 2006
    ..We also make links with other well-known plasticity rules. A simplified phenomenological model is also derived, which should be useful for fast numerical simulation and analytical investigation of the impact of STDP at the network level...
  37. ncbi request reprint Analytical integrate-and-fire neuron models with conductance-based dynamics for event-driven simulation strategies
    Michelle Rudolph
    Unité de Neuroscience Intégratives et Computationnelles, CNRS, 91198 Gif sur Yvette, France
    Neural Comput 18:2146-210. 2006
    ..gIF models should therefore provide a useful tool for efficient and precise simulation of large-scale neuronal networks with realistic, conductance-based synaptic interactions...
  38. pmc The initiation of bursts in thalamic neurons and the cortical control of thalamic sensitivity
    Alain Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Philos Trans R Soc Lond B Biol Sci 357:1649-57. 2002
    ..These properties enable the cortex to control the sensitivity of the thalamus to inputs and are also important for understanding states such as absence seizures...
  39. ncbi request reprint Inferring network activity from synaptic noise
    Michael Rudolph
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    J Physiol Paris 98:452-66. 2004
    ..Thus, "probing the network" through intracellular V(m) activity is possible and constitutes a promising approach, but it will require a continuous effort combining theory, computational models and intracellular physiology...
  40. ncbi request reprint Inhibition determines membrane potential dynamics and controls action potential generation in awake and sleeping cat cortex
    Michelle Rudolph
    Integrative and Computational Neuroscience Unit, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Neurosci 27:5280-90. 2007
    ....
  41. doi request reprint Methods for computational neuroscience
    Alain Destexhe
    J Neurosci Methods 169:269-70. 2008
  42. pmc Hyperpolarization-activated graded persistent activity in the prefrontal cortex
    Milena Winograd
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    Proc Natl Acad Sci U S A 105:7298-303. 2008
    ....