Research Topics
Species | E Autret-LecaSummaryCountry: France Publications
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Publications
Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded studyElisabeth Autret-Leca
University Francois Rabelais, Tours, France
Curr Med Res Opin 23:2205-11. 2007..The main objective of this study was to compare the single-dose efficacy of 15 mg/kg paracetamol (acetaminophen) versus 10 mg/kg ibuprofen in a general practice setting...
[Neonatal risks of drugs exposure at the end of pregnancy]Elisabeth Autret-Leca
Centre Régional de Pharmacovigilance et d Information sur le Médicament, Tours, France
Therapie 66:431-6. 2011....- [Pharmacovigilance in children]E Autret-Leca
Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
Arch Pediatr 19:848-55. 2012..D.E.C(®), rotavirus vaccines, growth hormone, cisapride) have been less frequent than in adults... 
A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shockAnnick Legras
Department of Intensive Care Unit, University Hospital of Tours, boulevard Tonnelle, 37044 Tours, France
Crit Care 13:R43. 2009..We aimed to establish whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during evolving bacterial community-acquired infection in adults is associated with severe sepsis or septic shock...- [Drugs news]E Autret-Leca
Service de Pharmacologie, , 2, boulevard Tonnel, 37004 Tours cedex 09, France
Arch Pediatr 14:287-91. 2007 - [Drug news]E Autret-Leca
Service de Pharmacologie, , France
Arch Pediatr 12:1148-52. 2005 - [Drugs news]E Autret-Leca
Service de Pharmacologie, , 37004 Tours cedex 01, France
Arch Pediatr 12:1392-4. 2005 - [Prescriptions and children]E Autret-Leca
Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, Hopital Bretonneau, Universite Francois Rabelais de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 09, France
Arch Pediatr 13:181-5. 2006..Off labeling prescription should be based on a supposed benefit, which had to be justified if a severe side effect occurred... - [Pharmacovigilance of vaccines]E Autret-Leca
Service de Pharmacologie, Hopital Bretonneau, Universite Francois Rabelais de Tours, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours, Cedex 09, France
Arch Pediatr 13:175-80. 2006..This surveillance is made through reporting of ADRs to the PVRC. However, an active and intensive surveillance of ADRs as the one set up from the marketing of Prevenar should be systematic... - [Drugs news]E Autret-Leca
Service de Pharmacologie, , 2, boulevard Tonnell, 37044 Tours cedex 09, France
Arch Pediatr 14:917-22. 2007 - [Drugs news]E Autret-Leca
Service de Pharmacologie, , 2, boulevard Tonnel, 37004 Tours cedex 09, France
Arch Pediatr 14:1451-7. 2007 - [Drug news]E Autret-Leca
Department of Pharmacology, Hospital Bretonneau, CHRU of Tours, 2 boulevard Tonnelle, Tours Cedex 9, France
Arch Pediatr 15:1349-55. 2008 - [DRESS syndrome, a drug reaction which remains bad known from paediatricians]E Autret-Leca
Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, Hopital Bretonneau, CHRU de Tours, Tours Cedex 09, France
Arch Pediatr 14:1439-41. 2007..DRESS syndrome is a well described disease that occurs during treatment with a number drugs, particularly anti-epileptic drugs. Steroid therapy and immunoglobulins are proposed for treatment but have not been evaluated... - [Glucocorticoide therapy in premature infants: French practices in 2006]E Autret-Leca
Service de Pharmacologie Clinique, centre régional de pharmacovigilance et d information sur médicament, Hopital Bretonneau, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
Arch Pediatr 16:999-1004. 2009..The effects of early postnatal dexamethasone therapy on pulmonary outcome in premature infants with respiratory distress syndrome: a 2-year follow-up study. Acta Paediatr 2005;94:310-16]... - [Most innovative drugs labelled during the last years in paediatrics: does the paediatrician have the tools for their identification?]E Autret-Leca
Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
Arch Pediatr 17:1237-42. 2010..The need to know and to follow therapeutic recommendations is the evidence based medicine. The opinions of the Transparency Commission are one of those recommendations... - Drug exposure during the periconceptional period: a study of 1793 womenElisabeth Autret-Leca
CHRU de Tours, Service de Pharmacologie Clinique, Centre Rgional de Pharmacovigilance et dInformation sur le Mdicament, Tours, France
Paediatr Drugs 13:317-24. 2011..Many studies have described the prescribing of drugs to pregnant women, but only very few have data concerning the periconceptional period specifically... - [Vaccines pharmacovigilance]Elisabeth Autret-Leca
Service de pharmacologie clinique et Centre regional de pharmacovigilance et d informations sur le médicament, CHRU, 37044 Tours
Rev Prat 54:526-31. 2004..Thus it must be intensive and systematic... - Incidence of Reye's syndrome in France: a hospital-based surveyE Autret-Leca
Department of Clinical Pharmacology, Hôpital Bretonneau University François Rabelais, Tours, France
J Clin Epidemiol 54:857-62. 2001.... - [Treatment of febrile convulsions]E Autret-Leca
Service de Pediatrie, Centre Hospitalier Regional Universitaire, 2, boulevard Tonnelle, 37044 Tours, France
Arch Pediatr 9:91-5. 2002..Due to its several inconveniences, oral diazepam as an intermittent prophylaxis should be only considered in case of multiple reoccurrences. There is little place for continuous anticonvulsant treatment... - Vitamin K in neonates: how to administer, when and to whomE Autret-Leca
Department of Clinical Pharmacology, H pital Bretonneau, University Francois Rabelais, Tours, France
Paediatr Drugs 3:1-8. 2001..After neonatal prophylaxis, as for infants at high risk of haemorrhage, doses need to be repeated at a rate and route of administration decided for each dose, according to the clotting factor profile specific for each infant... - [Drug news]E Autret-Leca
Service de Pharmacologie, , 2, boulevard Tonnell, 37044 Tours Cedex 01, France
Arch Pediatr 10:540-3. 2003 - Amoxicillin/clavulanic acid is ineffective at preventing otitis media in children with presumed viral upper respiratory infection: a randomized, double-blind equivalence, placebo-controlled trialElisabeth Autret-Leca
Department of Clinical Pharmacology, Hospital Bretonneau and University François Rabelais, Tours, France
Br J Clin Pharmacol 54:652-6. 2002..To assess the equivalence of amoxicillin/clavulanic acid and placebo in the prevention of acute otitis media in children at high risk of acute otitis media who develop upper respiratory tract infection... - [Drugs associated with acute generalized exanthematic pustulosis]E H Saissi
Service de Pharmacologie, CHRU de Tours
Ann Dermatol Venereol 130:612-8. 2003..The aim of this study was to compare drugs suspected of causing acute generalized exanthematous pustulosis reported to French Pharmacovigilance centres and those reported in the literature... - Are incorrectly used drugs more frequently involved in adverse drug reactions? A prospective studyA P Jonville-Bera
Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital, CHRU, 2 boulevard Tonnelle, 37044, Tours Cedex 09, France
Eur J Clin Pharmacol 61:231-6. 2005.... - Relationship between calcineurin inhibition and plasma endothelin concentrations in cyclosporine-A-treated kidney transplant patientsM Buchler
Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
Eur J Clin Pharmacol 60:703-8. 2004..However, there is obviously also an inter-individual pharmacodynamic variability, which might be explored by the measurement of biomarkers of CsA effects... - [Neonatal outcome after exposure to selective serotonin reuptake inhibitors late in pregnancy]H Cissoko
, Service de Pharmacologie, CHRU, Tours, France
Arch Pediatr 12:1081-4. 2005..The risk of hemorrhagic symptoms or hyponatremia, not well known by pediatricians, deserves to be recalled to medical teams who take in charge newborns exposed to SSRI... - [Post licensure safety surveillance for Prevenar]L Bensouda Grimaldi
Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 09, France
Arch Pediatr 14:870-4. 2007..A pharmacovigilance survey was required by the French drug agency (Afssaps) to the regional pharmacovigilance centre of Tours (France)... - [Issues in therapeutic drug monitoring evaluation]G Paintaud
Laboratoire de Pharmacologie et de Toxicologie, Service de Pharmacologie, Hopital Bretonneau, 2 bis Boulevard Tonnelle, 37044 Tours, France
Therapie 56:245-9. 2001..Factors which limit the setting up of such studies are: the number of subjects to include, the often imprecise measurement of drug exposure and poor knowledge of the pharmacokinetic-pharmacodynamic relationship and its variability... - Ciprofloxacin pharmacokinetics in young cystic fibrosis patients after repeated oral dosesF Odoul
Department of Pharmacology, Tours University Hospital, Bretonneau Hospital, , F-37044 Tours, France
Therapie 56:519-24. 2001..A higher dose, administered from a specific formulation to ensure precise dosing, must be given in order to obtain adequate concentrations in cystic fibrosis children... - Therapeutic drug monitoring of HIV protease inhibitors using high-performance liquid chromatography with ultraviolet or photodiode array detectionP Leibenguth
Department of Pharmacology, Tours University Hospital, Tours, France
Ther Drug Monit 23:679-88. 2001..Concentration-controlled studies should now be used to select proper target concentrations for each protease inhibitor, either prescribed alone or in combination... - [Clinical relevance of N-acetyltransferase type 2 (NAT2) genetic polymorphism]Y Furet
Service de Pharmacologie, Centre Hospitalier et Universitaire, Tours, France
Therapie 57:427-31. 2002..Parkinson's disease may be more frequent among slow acetylators, but again, data have shown contradictory results. Finally, a poor acetylator phenotype may predispose to atopic diseases... - [Pharmacokinetic studies in neonatology: regulatory and methodologic problems]C Le Guellec
Service de Pharmacologie, , CHRU, , 37044 Tours, France
Therapie 56:663-8. 2001..Most studies performed with neonates have involved drugs with a narrow safety margin and cleared by renal or metabolic routes to study the impact of immaturity on drug concentrations and on clinical effects... - [Neonatal outcome after exposure to beta adrenergic blockers late in pregnancy]H Cissoko
, , Service de Pharmacologie, CHRU, 2, boulevard Tonnell, 37044 Tours Cedex 01, France
Arch Pediatr 12:543-7. 2005..Atenolol often provider of intrauterine growth retardation and labetalol more often at the origin of neonatal adverse effects are probably to avoid during pregnancy... - [Insertion problems, removal problems, and contraception failures with Implanon]L Bensouda-Grimaldi
Service de Pharmacologie, , , , Tours, France
Gynecol Obstet Fertil 33:986-90. 2005..That is why a real and strict training is highly recommended to physicians... - [Isotretinoin: compliance with recommendations in childbearing women]L Bensouda-Grimaldi
Service de Pharmacologie, , , , Tours
Ann Dermatol Venereol 132:415-23. 2005..It estimates that the administrative authority must intensify information by dermatologists, general practitioners and pharmacists, about measures to take to avoid an exposure to isotretinoin during pregnancy... - [Porphyria and drugs]C Jarry
Service de Pharmacologie, CHRU de Tours, 2, boulevard Tonnell, 37044 Tours, France
Arch Pediatr 9:422-8. 2002..In any case it is necessary to verify any prescription before giving a drug to a patient with porphyria... - [New antiepileptic drugs in pregnancy: outcome of 12 exposed pregnancies]H Cissoko
, Service de Pharmacologie, CHRU, Tours, France
Therapie 57:397-401. 2002..Consequently, strict adherence to current recommendations relating to drug use during pregnancy is essential. The treatment of all patients wishing to become pregnant should be discussed... - [Psychiatric disorders associated with montelukast: data from the National Pharmacovigilance Database]M S Marchand
Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours, Cedex 9, France
Arch Pediatr 20:269-73. 2013..The potential severity of these events prompts physicians to seek the existence of psychiatric disorders before prescribing the drug and to carefully monitor the occurrence of AEs during treatment... - Population pharmacokinetics of cisapride in neonatesF Odoul
Department of Pharmacology, Tours University Hospital, Tours, France
Eur J Clin Pharmacol 58:507-13. 2002..This study indicates that no clinically relevant maturational changes in cisapride clearance have to be considered during the first quadrimester of life... - Microalbuminuria in hypertensive nonproteinuric renal transplant recipients: influence of previous acute rejection episodes and sodium intakeJ-M Halimi
, , Tours, France
Transplant Proc 34:801-2. 2002 - [Methadone blood assay by the FPIA technique: application to the monitoring of patients in maintenance treatment to opiates]C Boglione Kerrien
Service de Pharmacologie, CHRU de Tours, Tours
Ann Biol Clin (Paris) 65:51-7. 2007..We describe some clinical cases from the Methadone Treatment Center of Tours (Centre Port-Bretagne), which showed that methadone blood concentration measurement may be helpful to achieve the optimal dose of methadone in each patient... - [Risk medications in case of glucose-6-phosphate dehydrogenase deficiency]L Bensouda
Service de Pharmacologie, CHRU de Tours, 2, bd Tonnell, 37044 Tours, France
Arch Pediatr 9:316-9. 2002.... - [Alveolo-interstitial pneumonia due to Temozolamide]L Guilleminault
Service de Pneumologie, CHU de Tours, Universite Francois Rabelais de Tours, France
Rev Mal Respir 25:880-4. 2008..Temozolomide is an alkylating agent approved for treatment of glioblastoma in association with radiotherapy... - Antipyretic drug use in children in French office based medical practiceJean Deligne
CANAM, Caisse Nationale d Assurance Maladie des Professions Indépendantes, France
Pharmacoepidemiol Drug Saf 16:812-7. 2007..To analyse antipyretics (APs) prescriptions profile in children, particularly the frequency of AP combinations... - Prescription of drugs contraindicated in children: a national community surveyLamiae Bensouda-Grimaldi
Eur J Clin Pharmacol 63:99-101. 2007 - Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysisBrian J Anderson
Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
Paediatr Anaesth 15:282-92. 2005..The aim of this study was to describe propacetamol pharmacokinetics in children in order to predict concentrations after a standard dosing regimen of propacetamol 30 mg x kg(-1) (15 mg x kg(-1) paracetamol) 6 h... - Upper gastrointestinal complications associated with NSAIDs in childrenElisabeth Autret-Leca
CHRU of Tours, Regional Centre of Pharmacovigilance, Department of Pharmacology, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
Therapie 62:173-6. 2007..To analyse serious upper gastrointestinal (UGI) complications associated with non-salicylate non-steroidal anti-inflammatory drugs (NSAIDs) in children... - Reporting of drug tolerance in randomized clinical trials: when data conflict with authors' conclusionsAnnie Pierre Jonville-Bera
Ann Intern Med 144:306-7. 2006 - [Homage to Professor Michel Breteau]Elisabeth Autret-Leca
Therapie 61:87-8. 2006 - Frequency of adverse drug reactions in children: a prospective studyAnnie Pierre Jonville-Bera
Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 Boulevard Tonellé, 37044 Tours Cedex, France
Br J Clin Pharmacol 53:207-10. 2002..To assess the frequency of adverse drug reactions (ADRs) in children in France... - Lack of association between rifampicin plasma concentration and treatment-related side effects in osteoarticular infectionsFrance Roblot
CHRU de Tours, Service des Maladies Infectieuses, 2 boulevard Tonnelle, 37044 Tours Cedex, France
Fundam Clin Pharmacol 21:363-9. 2007..GSE occur frequently in patients receiving rifampicin for osteoarticular infection but without an association with rifampicin plasma concentrations. Thus, therapeutic drug monitoring of rifampicin is irrelevant in the management of GSE... - Assessing general practitioners' prescribing behaviour in elderly patients with concealed renal failureAnnie Pierre Jonville-Bera
Br J Clin Pharmacol 65:961-3. 2008 - A well-tolerated 5-FU-based treatment subsequent to severe capecitabine-induced toxicity in a DPD-deficient patientHelene Blasco
Br J Clin Pharmacol 65:966-70. 2008 - Prevalence and patterns of methylphenidate use in French children and adolescentsAnne Laure Knellwolf
Clinical Research Unit, Department of Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
Eur J Clin Pharmacol 64:311-7. 2008..The aim of the study was to describe the prevalence and utilization patterns of methylphenidate (MPH) in children and adolescents in France... - [Hepatitis B vaccine tolerance: spontaneous reporting and pharmacoepidemiologic studies]Elisabeth Autret-Leca
Presse Med 36:563-4. 2007