E Autret-Leca

Summary

Country: France

Publications

  1. ncbi request reprint Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study
    Elisabeth Autret-Leca
    University Francois Rabelais, Tours, France
    Curr Med Res Opin 23:2205-11. 2007
  2. doi request reprint [Neonatal risks of drugs exposure at the end of pregnancy]
    Elisabeth Autret-Leca
    Centre Régional de Pharmacovigilance et d Information sur le Médicament, Tours, France
    Therapie 66:431-6. 2011
  3. doi request reprint [Pharmacovigilance in children]
    E Autret-Leca
    Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
    Arch Pediatr 19:848-55. 2012
  4. pmc A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shock
    Annick Legras
    Department of Intensive Care Unit, University Hospital of Tours, boulevard Tonnelle, 37044 Tours, France
    Crit Care 13:R43. 2009
  5. ncbi request reprint Vitamin K in neonates: how to administer, when and to whom
    E Autret-Leca
    Department of Clinical Pharmacology, H pital Bretonneau, University Francois Rabelais, Tours, France
    Paediatr Drugs 3:1-8. 2001
  6. ncbi request reprint [Vaccines pharmacovigilance]
    Elisabeth Autret-Leca
    Service de pharmacologie clinique et Centre regional de pharmacovigilance et d informations sur le médicament, CHRU, 37044 Tours
    Rev Prat 54:526-31. 2004
  7. doi request reprint [Drug news]
    E Autret-Leca
    Department of Pharmacology, Hospital Bretonneau, CHRU of Tours, 2 boulevard Tonnelle, Tours Cedex 9, France
    Arch Pediatr 15:1349-55. 2008
  8. ncbi request reprint [Prescriptions and children]
    E Autret-Leca
    Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, Hopital Bretonneau, Universite Francois Rabelais de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 09, France
    Arch Pediatr 13:181-5. 2006
  9. ncbi request reprint [Drug news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, France
    Arch Pediatr 12:1148-52. 2005
  10. ncbi request reprint [DRESS syndrome, a drug reaction which remains bad known from paediatricians]
    E Autret-Leca
    Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, Hopital Bretonneau, CHRU de Tours, Tours Cedex 09, France
    Arch Pediatr 14:1439-41. 2007

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study
    Elisabeth Autret-Leca
    University Francois Rabelais, Tours, France
    Curr Med Res Opin 23:2205-11. 2007
    ..The main objective of this study was to compare the single-dose efficacy of 15 mg/kg paracetamol (acetaminophen) versus 10 mg/kg ibuprofen in a general practice setting...
  2. doi request reprint [Neonatal risks of drugs exposure at the end of pregnancy]
    Elisabeth Autret-Leca
    Centre Régional de Pharmacovigilance et d Information sur le Médicament, Tours, France
    Therapie 66:431-6. 2011
    ....
  3. doi request reprint [Pharmacovigilance in children]
    E Autret-Leca
    Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
    Arch Pediatr 19:848-55. 2012
    ..D.E.C(®), rotavirus vaccines, growth hormone, cisapride) have been less frequent than in adults...
  4. pmc A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shock
    Annick Legras
    Department of Intensive Care Unit, University Hospital of Tours, boulevard Tonnelle, 37044 Tours, France
    Crit Care 13:R43. 2009
    ..We aimed to establish whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during evolving bacterial community-acquired infection in adults is associated with severe sepsis or septic shock...
  5. ncbi request reprint Vitamin K in neonates: how to administer, when and to whom
    E Autret-Leca
    Department of Clinical Pharmacology, H pital Bretonneau, University Francois Rabelais, Tours, France
    Paediatr Drugs 3:1-8. 2001
    ..After neonatal prophylaxis, as for infants at high risk of haemorrhage, doses need to be repeated at a rate and route of administration decided for each dose, according to the clotting factor profile specific for each infant...
  6. ncbi request reprint [Vaccines pharmacovigilance]
    Elisabeth Autret-Leca
    Service de pharmacologie clinique et Centre regional de pharmacovigilance et d informations sur le médicament, CHRU, 37044 Tours
    Rev Prat 54:526-31. 2004
    ..Thus it must be intensive and systematic...
  7. doi request reprint [Drug news]
    E Autret-Leca
    Department of Pharmacology, Hospital Bretonneau, CHRU of Tours, 2 boulevard Tonnelle, Tours Cedex 9, France
    Arch Pediatr 15:1349-55. 2008
  8. ncbi request reprint [Prescriptions and children]
    E Autret-Leca
    Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, Hopital Bretonneau, Universite Francois Rabelais de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 09, France
    Arch Pediatr 13:181-5. 2006
    ..Off labeling prescription should be based on a supposed benefit, which had to be justified if a severe side effect occurred...
  9. ncbi request reprint [Drug news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, France
    Arch Pediatr 12:1148-52. 2005
  10. ncbi request reprint [DRESS syndrome, a drug reaction which remains bad known from paediatricians]
    E Autret-Leca
    Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, Hopital Bretonneau, CHRU de Tours, Tours Cedex 09, France
    Arch Pediatr 14:1439-41. 2007
    ..DRESS syndrome is a well described disease that occurs during treatment with a number drugs, particularly anti-epileptic drugs. Steroid therapy and immunoglobulins are proposed for treatment but have not been evaluated...
  11. ncbi request reprint [Drugs news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, 37004 Tours cedex 01, France
    Arch Pediatr 12:1392-4. 2005
  12. ncbi request reprint [Drugs news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, 2, boulevard Tonnelé, 37004 Tours cedex 09, France
    Arch Pediatr 14:1451-7. 2007
  13. ncbi request reprint [Pharmacovigilance of vaccines]
    E Autret-Leca
    Service de Pharmacologie, Hopital Bretonneau, Universite Francois Rabelais de Tours, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours, Cedex 09, France
    Arch Pediatr 13:175-80. 2006
    ..This surveillance is made through reporting of ADRs to the PVRC. However, an active and intensive surveillance of ADRs as the one set up from the marketing of Prevenar should be systematic...
  14. ncbi request reprint [Drugs news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 09, France
    Arch Pediatr 14:917-22. 2007
  15. ncbi request reprint [Drugs news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, 2, boulevard Tonnelé, 37004 Tours cedex 09, France
    Arch Pediatr 14:287-91. 2007
  16. ncbi request reprint [Drug news]
    E Autret-Leca
    Service de Pharmacologie, centre hospitalier régional de Tours, 2, boulevard Tonnelle, 37044 Tours Cedex 01, France
    Arch Pediatr 10:540-3. 2003
  17. pmc Amoxicillin/clavulanic acid is ineffective at preventing otitis media in children with presumed viral upper respiratory infection: a randomized, double-blind equivalence, placebo-controlled trial
    Elisabeth Autret-Leca
    Department of Clinical Pharmacology, Hospital Bretonneau and University François Rabelais, Tours, France
    Br J Clin Pharmacol 54:652-6. 2002
    ..To assess the equivalence of amoxicillin/clavulanic acid and placebo in the prevention of acute otitis media in children at high risk of acute otitis media who develop upper respiratory tract infection...
  18. ncbi request reprint Incidence of Reye's syndrome in France: a hospital-based survey
    E Autret-Leca
    Department of Clinical Pharmacology, Hôpital Bretonneau University François Rabelais, Tours, France
    J Clin Epidemiol 54:857-62. 2001
    ....
  19. doi request reprint [Glucocorticoide therapy in premature infants: French practices in 2006]
    E Autret-Leca
    Service de Pharmacologie Clinique, centre régional de pharmacovigilance et d information sur médicament, Hopital Bretonneau, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
    Arch Pediatr 16:999-1004. 2009
    ..The effects of early postnatal dexamethasone therapy on pulmonary outcome in premature infants with respiratory distress syndrome: a 2-year follow-up study. Acta Paediatr 2005;94:310-16]...
  20. ncbi request reprint [Treatment of febrile convulsions]
    E Autret-Leca
    Service de Pediatrie, Centre Hospitalier Regional Universitaire, 2, boulevard Tonnelle, 37044 Tours, France
    Arch Pediatr 9:91-5. 2002
    ..Due to its several inconveniences, oral diazepam as an intermittent prophylaxis should be only considered in case of multiple reoccurrences. There is little place for continuous anticonvulsant treatment...
  21. doi request reprint [Most innovative drugs labelled during the last years in paediatrics: does the paediatrician have the tools for their identification?]
    E Autret-Leca
    Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 9, France
    Arch Pediatr 17:1237-42. 2010
    ..The need to know and to follow therapeutic recommendations is the evidence based medicine. The opinions of the Transparency Commission are one of those recommendations...
  22. doi request reprint Drug exposure during the periconceptional period: a study of 1793 women
    Elisabeth Autret-Leca
    CHRU de Tours, Service de Pharmacologie Clinique, Centre Rgional de Pharmacovigilance et dInformation sur le Mdicament, Tours, France
    Paediatr Drugs 13:317-24. 2011
    ..Many studies have described the prescribing of drugs to pregnant women, but only very few have data concerning the periconceptional period specifically...
  23. ncbi request reprint [Drugs associated with acute generalized exanthematic pustulosis]
    E H Saissi
    Service de Pharmacologie, CHRU de Tours
    Ann Dermatol Venereol 130:612-8. 2003
    ..The aim of this study was to compare drugs suspected of causing acute generalized exanthematous pustulosis reported to French Pharmacovigilance centres and those reported in the literature...
  24. ncbi request reprint [Neonatal consequences of benzodiazepines used during the last month of pregnancy]
    D Swortfiguer
    Centre Régional de Pharmacovigilance et d Information sur le Médicament, Service de Pharmacologie
    Arch Pediatr 12:1327-31. 2005
    ..The purpose of our study was to evaluate the neonatal consequences of BZD used at the end of pregnancy and to analysed if our recommendations were taken into account and if they were appropriate...
  25. ncbi request reprint [Neonatal outcome after exposure to selective serotonin reuptake inhibitors late in pregnancy]
    H Cissoko
    Centre Régional de Pharmacovigilance et d Information sur le Médicament, Service de Pharmacologie, CHRU, Tours, France
    Arch Pediatr 12:1081-4. 2005
    ..To analyse neonatal effects after in utero selective serotonin reuptake inhibitors exposure and the pertinence of recommendations delivered by our team...
  26. ncbi request reprint Are incorrectly used drugs more frequently involved in adverse drug reactions? A prospective study
    A P Jonville-Bera
    Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital, CHRU, 2 boulevard Tonnelle, 37044, Tours Cedex 09, France
    Eur J Clin Pharmacol 61:231-6. 2005
    ....
  27. ncbi request reprint Relationship between calcineurin inhibition and plasma endothelin concentrations in cyclosporine-A-treated kidney transplant patients
    M Buchler
    Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
    Eur J Clin Pharmacol 60:703-8. 2004
    ..However, there is obviously also an inter-individual pharmacodynamic variability, which might be explored by the measurement of biomarkers of CsA effects...
  28. ncbi request reprint [Issues in therapeutic drug monitoring evaluation]
    G Paintaud
    Laboratoire de Pharmacologie et de Toxicologie, Service de Pharmacologie, Hopital Bretonneau, 2 bis Boulevard Tonnelle, 37044 Tours, France
    Therapie 56:245-9. 2001
    ..Factors which limit the setting up of such studies are: the number of subjects to include, the often imprecise measurement of drug exposure and poor knowledge of the pharmacokinetic-pharmacodynamic relationship and its variability...
  29. ncbi request reprint [Post licensure safety surveillance for Prevenar]
    L Bensouda-Grimaldi
    Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours cedex 09, France
    Arch Pediatr 14:870-4. 2007
    ..A pharmacovigilance survey was required by the French drug agency (Afssaps) to the regional pharmacovigilance centre of Tours (France)...
  30. ncbi request reprint [Clinical relevance of N-acetyltransferase type 2 (NAT2) genetic polymorphism]
    Y Furet
    Service de Pharmacologie, Centre Hospitalier et Universitaire, Tours, France
    Therapie 57:427-31. 2002
    ..Parkinson's disease may be more frequent among slow acetylators, but again, data have shown contradictory results. Finally, a poor acetylator phenotype may predispose to atopic diseases...
  31. ncbi request reprint Ciprofloxacin pharmacokinetics in young cystic fibrosis patients after repeated oral doses
    F Odoul
    Department of Pharmacology, Tours University Hospital, Bretonneau Hospital, , F-37044 Tours, France
    Therapie 56:519-24. 2001
    ..A higher dose, administered from a specific formulation to ensure precise dosing, must be given in order to obtain adequate concentrations in cystic fibrosis children...
  32. ncbi request reprint Therapeutic drug monitoring of HIV protease inhibitors using high-performance liquid chromatography with ultraviolet or photodiode array detection
    P Leibenguth
    Department of Pharmacology, Tours University Hospital, Tours, France
    Ther Drug Monit 23:679-88. 2001
    ..Concentration-controlled studies should now be used to select proper target concentrations for each protease inhibitor, either prescribed alone or in combination...
  33. ncbi request reprint [Pharmacokinetic studies in neonatology: regulatory and methodologic problems]
    C Le Guellec
    Service de Pharmacologie, , CHRU, , 37044 Tours, France
    Therapie 56:663-8. 2001
    ..Most studies performed with neonates have involved drugs with a narrow safety margin and cleared by renal or metabolic routes to study the impact of immaturity on drug concentrations and on clinical effects...
  34. ncbi request reprint [Neonatal outcome after exposure to beta adrenergic blockers late in pregnancy]
    H Cissoko
    Centre Regional de Pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Service de Pharmacologie, CHRU, 2, boulevard Tonnelle, 37044 Tours Cedex 01, France
    Arch Pediatr 12:543-7. 2005
    ..To analyse neonatal effects after in utero betablockers exposure and the pertinence of recommendations delivered by our team...
  35. ncbi request reprint [Isotretinoin: compliance with recommendations in childbearing women]
    L Bensouda-Grimaldi
    Service de Pharmacologie, Centre Régional de Pharmacovigilance et d Information sur le Médicament, Universite Francois Rabelais, Hopital Bretonneau, Tours
    Ann Dermatol Venereol 132:415-23. 2005
    ..The aim of this survey is to ascertain if the incidence of isotretinoin exposed pregnancies was reduced by the late recommendations of prescription and issue (AMM modification on 06/08/2001 and 25/09/2001)...
  36. ncbi request reprint [Insertion problems, removal problems, and contraception failures with Implanon]
    L Bensouda-Grimaldi
    Service de Pharmacologie, Hopital Bretonneau, Universite Francois Rabelais, Centre Régional de Pharmacovigilance et d Information sur le Médicament, Tours, France
    Gynecol Obstet Fertil 33:986-90. 2005
    ..Analysis of the results of a national pharmacovigilance study on Implanon, a contraceptive implant containing 68 mg of etonogestrel...
  37. ncbi request reprint [Porphyria and drugs]
    C Jarry
    Service de Pharmacologie, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours, France
    Arch Pediatr 9:422-8. 2002
    ..In any case it is necessary to verify any prescription before giving a drug to a patient with porphyria...
  38. ncbi request reprint [New antiepileptic drugs in pregnancy: outcome of 12 exposed pregnancies]
    H Cissoko
    Centre Régional de Pharmacovigilance et d Information sur le Médicament, Service de Pharmacologie, CHRU, Tours, France
    Therapie 57:397-401. 2002
    ..Consequently, strict adherence to current recommendations relating to drug use during pregnancy is essential. The treatment of all patients wishing to become pregnant should be discussed...
  39. ncbi request reprint [Methadone blood assay by the FPIA technique: application to the monitoring of patients in maintenance treatment to opiates]
    C Boglione-Kerrien
    Service de Pharmacologie, CHRU de Tours, Tours
    Ann Biol Clin (Paris) 65:51-7. 2007
    ..We describe some clinical cases from the Methadone Treatment Center of Tours (Centre Port-Bretagne), which showed that methadone blood concentration measurement may be helpful to achieve the optimal dose of methadone in each patient...
  40. doi request reprint [Psychiatric disorders associated with montelukast: data from the National Pharmacovigilance Database]
    M S Marchand
    Service de Pharmacologie Clinique, Centre Régional de Pharmacovigilance et d Information sur le Médicament, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours, Cedex 9, France
    Arch Pediatr 20:269-73. 2013
    ..The potential severity of these events prompts physicians to seek the existence of psychiatric disorders before prescribing the drug and to carefully monitor the occurrence of AEs during treatment...
  41. ncbi request reprint Population pharmacokinetics of cisapride in neonates
    F Odoul
    Department of Pharmacology, Tours University Hospital, Tours, France
    Eur J Clin Pharmacol 58:507-13. 2002
    ..We conducted a population pharmacokinetic analysis of cisapride in neonates to study whether metabolic immaturity in this population may lead to increased concentrations...
  42. ncbi request reprint Microalbuminuria in hypertensive nonproteinuric renal transplant recipients: influence of previous acute rejection episodes and sodium intake
    J M Halimi
    Service de néphrologie immunologie clinique, Hopital Bretonneau, Tours, France
    Transplant Proc 34:801-2. 2002
  43. ncbi request reprint [Risk medications in case of glucose-6-phosphate dehydrogenase deficiency]
    L Bensouda
    Service de Pharmacologie, CHRU de Tours, 2, Bd Tonnelle, 37044 Tours, France
    Arch Pediatr 9:316-9. 2002
    ....
  44. ncbi request reprint [Alveolo-interstitial pneumonia due to Temozolamide]
    L Guilleminault
    Service de Pneumologie, CHU de Tours, Universite Francois Rabelais de Tours, France
    Rev Mal Respir 25:880-4. 2008
    ..Temozolomide is an alkylating agent approved for treatment of glioblastoma in association with radiotherapy...
  45. ncbi request reprint Prescription of drugs contraindicated in children: a national community survey
    Lamiae Bensouda-Grimaldi
    Eur J Clin Pharmacol 63:99-101. 2007
  46. ncbi request reprint Antipyretic drug use in children in French office based medical practice
    Jean Deligne
    CANAM, Caisse Nationale d Assurance Maladie des Professions Indépendantes, France
    Pharmacoepidemiol Drug Saf 16:812-7. 2007
    ..To analyse antipyretics (APs) prescriptions profile in children, particularly the frequency of AP combinations...
  47. ncbi request reprint Lack of association between rifampicin plasma concentration and treatment-related side effects in osteoarticular infections
    France Roblot
    CHRU de Tours, Service des Maladies Infectieuses, 2 boulevard Tonnelle, 37044 Tours Cedex, France
    Fundam Clin Pharmacol 21:363-9. 2007
    ..GSE occur frequently in patients receiving rifampicin for osteoarticular infection but without an association with rifampicin plasma concentrations. Thus, therapeutic drug monitoring of rifampicin is irrelevant in the management of GSE...
  48. pmc Frequency of adverse drug reactions in children: a prospective study
    Annie Pierre Jonville-Bera
    Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 Boulevard Tonellé, 37044 Tours Cedex, France
    Br J Clin Pharmacol 53:207-10. 2002
    ..To assess the frequency of adverse drug reactions (ADRs) in children in France...
  49. ncbi request reprint [Hepatitis B vaccine tolerance: spontaneous reporting and pharmacoepidemiologic studies]
    Elisabeth Autret-Leca
    Presse Med 36:563-4. 2007
  50. ncbi request reprint [Homage to Professor Michel Breteau]
    Elisabeth Autret-Leca
    Therapie 61:87-8. 2006
  51. ncbi request reprint Reporting of drug tolerance in randomized clinical trials: when data conflict with authors' conclusions
    Annie Pierre Jonville-Bera
    Ann Intern Med 144:306-7. 2006
  52. ncbi request reprint Upper gastrointestinal complications associated with NSAIDs in children
    Elisabeth Autret-Leca
    CHRU of Tours, Regional Centre of Pharmacovigilance, Department of Pharmacology, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    Therapie 62:173-6. 2007
    ..To analyse serious upper gastrointestinal (UGI) complications associated with non-salicylate non-steroidal anti-inflammatory drugs (NSAIDs) in children...
  53. ncbi request reprint Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Paediatr Anaesth 15:282-92. 2005
    ..The aim of this study was to describe propacetamol pharmacokinetics in children in order to predict concentrations after a standard dosing regimen of propacetamol 30 mg x kg(-1) (15 mg x kg(-1) paracetamol) 6 h...
  54. pmc Assessing general practitioners' prescribing behaviour in elderly patients with concealed renal failure
    Annie Pierre Jonville-Bera
    Br J Clin Pharmacol 65:961-3. 2008
  55. pmc A well-tolerated 5-FU-based treatment subsequent to severe capecitabine-induced toxicity in a DPD-deficient patient
    Helene Blasco
    Br J Clin Pharmacol 65:966-70. 2008
  56. ncbi request reprint Prevalence and patterns of methylphenidate use in French children and adolescents
    Anne Laure Knellwolf
    Clinical Research Unit, Department of Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
    Eur J Clin Pharmacol 64:311-7. 2008
    ..The aim of the study was to describe the prevalence and utilization patterns of methylphenidate (MPH) in children and adolescents in France...