Brigitte Autran

Summary

Country: France

Publications

  1. ncbi request reprint Therapeutic vaccines for chronic infections
    Brigitte Autran
    Laboratoire d Immunologie Cellulaire and INSERM Unit 543, Centre Hospitalier Universitaire Pitie Salpetriere, Universite Pierre et Marie Curie, 75013 Paris, France
    Science 305:205-8. 2004
  2. ncbi request reprint Evaluating therapeutic vaccines in patients infected with HIV
    Brigitte Autran
    Laboratoire d Immunologie Cellulaire and INSERM U 543, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Expert Rev Vaccines 3:S169-77. 2004
  3. ncbi request reprint Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection
    Sabine Kinloch-de Loes
    Department of Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:607-17. 2005
  4. pmc A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection
    Charline Bacchus
    Pierre and Marie Curie University Paris 06, Laboratory Immunity and Infection UMR_S 945, F 75013, Paris, France
    PLoS ONE 8:e64219. 2013
  5. doi request reprint Immune control of HIV-1 reservoirs
    Brigitte Autran
    Laboratory Immunity and Infection, UMR S 945 UPMC INSERM, University Pierre et Marie Curie, Paris, France
    Curr Opin HIV AIDS 8:204-10. 2013
  6. pmc Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    Bruno Salaun
    Division of Clinical Onco Immunology, Ludwig Center for Cancer Research of the University of Lausanne, Switzerland
    J Transl Med 9:44. 2011
  7. pmc T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals
    Valerie Martinez
    Laboratoire d Immunologie Cellulaire, INSERM U543, Hopital Pitie Salpetriere, Paris Cedex 13, France
    BMC Infect Dis 7:83. 2007
  8. doi request reprint Elite controllers as a model of functional cure
    Brigitte Autran
    Laboratory Immunity and Infection, Pierre and Marie Curie University, INSERM UMRS 945, France
    Curr Opin HIV AIDS 6:181-7. 2011
  9. doi request reprint Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)
    Brigitte Autran
    UPMC Univ Paris 06, UMR_543, France
    AIDS 22:1313-22. 2008
  10. ncbi request reprint Proliferative, IFNgamma and IL-2-producing T-cell responses to HIV-2 in untreated HIV-2 infection
    Nadia Alatrakchi
    Laboratoire d Immunologie Cellulaire, INSERM U 543, Hopital Pitie Salpetriere, Paris, France
    AIDS 20:29-34. 2006

Detail Information

Publications81

  1. ncbi request reprint Therapeutic vaccines for chronic infections
    Brigitte Autran
    Laboratoire d Immunologie Cellulaire and INSERM Unit 543, Centre Hospitalier Universitaire Pitie Salpetriere, Universite Pierre et Marie Curie, 75013 Paris, France
    Science 305:205-8. 2004
    ....
  2. ncbi request reprint Evaluating therapeutic vaccines in patients infected with HIV
    Brigitte Autran
    Laboratoire d Immunologie Cellulaire and INSERM U 543, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Expert Rev Vaccines 3:S169-77. 2004
    ..The design and end-points of clinical trials, and the clinical settings in which these new strategies should be evaluated and will be of benefit, have yet to be defined and are the focus of this review...
  3. ncbi request reprint Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection
    Sabine Kinloch-de Loes
    Department of Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:607-17. 2005
    ..Our trial design appears to be feasible and safe for testing future immune-boosting strategies...
  4. pmc A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection
    Charline Bacchus
    Pierre and Marie Curie University Paris 06, Laboratory Immunity and Infection UMR_S 945, F 75013, Paris, France
    PLoS ONE 8:e64219. 2013
    ....
  5. doi request reprint Immune control of HIV-1 reservoirs
    Brigitte Autran
    Laboratory Immunity and Infection, UMR S 945 UPMC INSERM, University Pierre et Marie Curie, Paris, France
    Curr Opin HIV AIDS 8:204-10. 2013
    ..To discuss the recent major advances in the understanding of how host immune defenses contribute to HIV reservoir control...
  6. pmc Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    Bruno Salaun
    Division of Clinical Onco Immunology, Ludwig Center for Cancer Research of the University of Lausanne, Switzerland
    J Transl Med 9:44. 2011
    ..MicroRNAs have been recently shown to play a key role in the regulation of haematopoiesis in mouse, but their implication in peripheral lymphocyte differentiation in humans remains largely unknown...
  7. pmc T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals
    Valerie Martinez
    Laboratoire d Immunologie Cellulaire, INSERM U543, Hopital Pitie Salpetriere, Paris Cedex 13, France
    BMC Infect Dis 7:83. 2007
    ..Cellular and humoral immune responses to Erp (Exported repetitive protein)--a recently identified M. tuberculosis protein--have not yet been investigated in humans and may contribute to this aim...
  8. doi request reprint Elite controllers as a model of functional cure
    Brigitte Autran
    Laboratory Immunity and Infection, Pierre and Marie Curie University, INSERM UMRS 945, France
    Curr Opin HIV AIDS 6:181-7. 2011
    ....
  9. doi request reprint Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)
    Brigitte Autran
    UPMC Univ Paris 06, UMR_543, France
    AIDS 22:1313-22. 2008
    ..Evaluate immunogenicity and clinical efficacy of two immunization strategies with the ALVAC-HIV-recombinant canarypox vaccine (vCP1452) in treated HIV-infected patients...
  10. ncbi request reprint Proliferative, IFNgamma and IL-2-producing T-cell responses to HIV-2 in untreated HIV-2 infection
    Nadia Alatrakchi
    Laboratoire d Immunologie Cellulaire, INSERM U 543, Hopital Pitie Salpetriere, Paris, France
    AIDS 20:29-34. 2006
    ..To evaluate HIV-2-specific proliferative, interferon (IFN)gamma- and interleukin (IL)-2-producing T-cell responses in HIV-2 infection and their relationship with plasma HIV-2 RNA...
  11. doi request reprint Tuberculosis-associated immune restoration syndrome in HIV-1-infected patients involves tuberculin-specific CD4 Th1 cells and KIR-negative gammadelta T cells
    Anne Bourgarit
    Laboratory of Cellular Immunology, INSERM, Pitie Salpetriere Hospital, Assistance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    J Immunol 183:3915-23. 2009
    ..Higher proportions of Vdelta2(+)TCRgammadelta(+) T cells lacking KIR expression are present as baseline and distinguish patients who will develop IRS from those who will not...
  12. ncbi request reprint IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia
    Guislaine Carcelain
    Laboratoire d Immunologie Cellulaire, INSERM U543, Paris, France
    AIDS 17:841-50. 2003
    ..To investigate this effect, we quantified T-cell receptor rearrangement excision circles (TREC) in CD4 T cells from lymphopenic AIDS patients treated with highly active antiretroviral therapy and IL-2...
  13. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  14. ncbi request reprint High-dose therapy plus autologous hematopoietic stem cell transplantation for human immunodeficiency virus (HIV)-related lymphoma: results and impact on HIV disease
    Jean Gabarre
    Service d Hematologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Haematologica 89:1100-8. 2004
    ....
  15. ncbi request reprint Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells
    Amelie Guihot
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie Paris 6, Paris, France
    Blood 111:1387-95. 2008
    ..Their differentiation increases with HHV-8 viral load. These results offer new insight into the pathophysiology of MCD...
  16. ncbi request reprint Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients
    Cedric Lecureuil
    INSERM U543, Assistance Publique Hopitaux de Paris, Faculte de Medecine, Universite Pierre et Marie Curie Paris 6, Paris, France
    Blood 109:3649-57. 2007
    ....
  17. ncbi request reprint Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease
    Assia Samri
    Laboratoire d Immunologie Cellulaire, AP HP, Hopital Pitie Salpetriere, Paris, France
    Antivir Ther 12:553-8. 2007
    ..The long-term immunological benefit of protease inhibitor (PI)-sparing antiretroviral therapy (ART) using non-nucleoside reverse transcriptase inhibitors (NNRTIs) remains poorly investigated...
  18. pmc Control of vaccinia virus skin lesions by long-term-maintained IFN-gamma+TNF-alpha+ effector/memory CD4+ lymphocytes in humans
    Bénédicte Puissant-Lubrano
    INSERM U945, Paris, France
    J Clin Invest 120:1636-44. 2010
    ....
  19. doi request reprint Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells
    Benjamin Descours
    Immunity and Infection Laboratory, Pierre and Marie Curie University, INSERM UMRS 945, Pitie Salpetriere Hospital, Paris, France
    Clin Infect Dis 54:1495-503. 2012
    ....
  20. doi request reprint Anticardiolipin antibodies in HIV infection are independently associated with antibodies to the membrane proximal external region of gp41 and with cell-associated HIV DNA and immune activation
    Valerie Martinez
    Laboratory of Cellular Immunology, UMR INSERM 543, Paris, France
    Clin Infect Dis 48:123-32. 2009
    ..The demonstration of in vitro cardiolipin reactivity with 2 human immunodeficiency virus (HIV)-specific, broadly neutralizing antibodies (2F5 and 4E10) has prompted reevaluation of autoimmune manifestations in HIV infection...
  21. doi request reprint Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy
    Amelie Guihot
    UPMC Univ Paris 06, INSERM, UMR945, AP HP, Laboratoire d Immunologie Cellulaire et Tissulaire, Hopital Pitie Salpetriere, Paris, France
    AIDS 24:614-7. 2010
    ..Long-term and efficient antiretroviral therapy provides continuous benefits both on the immune system and on the HIV reservoirs...
  22. ncbi request reprint Increase of HIV-1 pro-viral DNA per million peripheral blood mononuclear cells in patients with advanced HIV disease (CD4<200 cells/mm3) receiving interleukin 2 combined with HAART versus HAART alone (ANRS-082 trial)
    Constance Delaugerre
    Department of Virology EA2387, Pitie Salpetriere Hospital, Paris, France
    Antivir Ther 8:233-7. 2003
    ..To assess the effect of interleukin (IL)-2 combined with highly active antiretroviral therapy (HAART) on HIV-1 pro-viral DNA quantification in HIV-1-infected patients with CD4<200/mm3...
  23. pmc Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial
    Behazine Combadiere
    Institut National de Santé et de Recherche Médicale, INSERM U945, Paris, France
    PLoS ONE 5:e10818. 2010
    ....
  24. doi request reprint Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients
    Benjamin Descours
    UPMC University Paris 06, INSERM, UMRs945, AP HP, Hopital Pitie Salpetriere, Laboratoire d Immunologie Cellulaire et Tissulaire, Paris, France
    J Acquir Immune Defic Syndr 62:255-9. 2013
    ....
  25. ncbi request reprint Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression
    Valerie Martinez
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Universite Pierre et Marie Curie, Hopital Pitie Salpetriere, Paris, France
    J Infect Dis 191:2053-63. 2005
    ....
  26. ncbi request reprint Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma
    Amelie Guihot
    Laboratoire d Immunologie Cellulaire et Tissulaire du Pr Debre, INSERM UMR S 543, Batiment CERVI, Hopital Pitie Salpetriere, 47 bd de l Hopital, 75013, Paris, France
    J Infect Dis 194:1078-88. 2006
    ..We hypothesized that KS is linked to deficiencies in specific anti-HHV-8 T cell immunity...
  27. pmc HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
    ..These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments...
  28. ncbi request reprint Acute hepatitis C in HIV-infected patients: rare spontaneous clearance correlates with weak memory CD4 T-cell responses to hepatitis C virus
    Aurelie Schnuriger
    INSERM, UMRS 945, Paris, France
    AIDS 23:2079-89. 2009
    ..To explore the parameters of specific immunity to hepatitis C virus (HCV) associated with virus clearance during acute HCV infection in HIV coinfection...
  29. ncbi request reprint Therapeutic immunization with a human immunodeficiency virus (HIV) type 1-recombinant canarypox vaccine in chronically HIV-infected patients: The Vacciter Study (ANRS 094)
    Roland Tubiana
    Departement des Maladies Infectieuses et Tropicales, INSERM E0214, Hopital Pitie Salpetriere, Paris, France
    Vaccine 23:4292-301. 2005
    ..Detection of such LPR response at the time of treatment interruption was significantly associated with the probability of remaining off therapy. These results provide rationale for future randomized trials exploring this strategy...
  30. ncbi request reprint Decreased frequencies of virus-specific T helper type 1 cells during interferon alpha plus ribavirin treatment in HIV-hepatitis C virus co-infection
    Nadia Alatrakchi
    Laboratoire d Immunologie Cellulaire et Tissulaire INSERM U543, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    AIDS 18:121-3. 2004
    ..This suggests that IFN+R therapy might compromise virus-specific immune defenses in immunosuppressed patients...
  31. ncbi request reprint Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients
    Anne Bourgarit
    Laboratory of Cellular Immunology, Pitie Salpetriere Hospital, Universite Pierre et Marie Curie, Paris, France
    AIDS 20:F1-7. 2006
    ..To test the hypothesis that an acute exacerbation of mycobacteria-specific Th1 response after HIV infection control by HAART causes immune restoration syndrome (IRS) in HIV-tuberculosis (TB) coinfected patients...
  32. doi request reprint Distinct differentiation profiles of HIV-Gag and Nef-specific central memory CD8+ T cells associated with HLA-B57/5801 and virus control
    Jing Xie
    Laboratoire d Immunité et Infections, INSERM, UMR S 945, Hopital Pitie Salpetriere, UPMC Univ Paris, Paris, France
    AIDS 24:2323-9. 2010
    ..To further elucidate this protective effect, we compared the multifunctional and differentiation characteristics of CD8(+) T cells specific for HIV-Gag and Nef in HLA-B57/5801-positive and negative nonprogressors...
  33. ncbi request reprint Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV
    François Boutboul
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    AIDS 19:1981-6. 2005
    ....
  34. ncbi request reprint The chemokine receptor CX3CR1 controls homing and anti-viral potencies of CD8 effector-memory T lymphocytes in HIV-infected patients
    Behazine Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Faculté de Médecine Pitié Salpêtière, Paris, France
    AIDS 17:1279-90. 2003
    ..In order to understand the mechanism by which CX3CR1 participates in the regulation of HIV-immune responses, we investigated its expression and role on T lymphocytes in HIV-infected patients...
  35. pmc Escape from highly effective public CD8+ T-cell clonotypes by HIV
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 118:2138-49. 2011
    ..These findings provide refined mechanistic insights into the workings of an effective CD8(+) T-cell response against HIV...
  36. ncbi request reprint Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: the ILSTIM study--ANRS 082
    Christine Katlama
    Service for Infectious and Tropical Diseases, Paris, France
    AIDS 16:2027-34. 2002
    ..The addition of interleukin-2, a cytokine that stimulates CD4 T lymphocyte helper cells, may benefit patients with discordant responses...
  37. ncbi request reprint PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    AIDS 21:2005-13. 2007
    ..Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans...
  38. doi request reprint Immune reconstitution after a decade of combined antiretroviral therapies for human immunodeficiency virus
    Amelie Guihot
    UPMC Univ Paris 06, INSERM, UM 5945, AP HP, Hopital Pitie Salpetriere, Immunitiet infection F 75013, Paris, France
    Trends Immunol 32:131-7. 2011
    ..Immune restoration during HAART can, however, have adverse effects. Immune restoration syndrome occurs in some patients as a result of successful but unbalanced immunity...
  39. doi request reprint Factors associated with a low HIV reservoir in patients with prolonged suppressive antiretroviral therapy
    Slim Fourati
    INSERM UMR S 943, Paris, France
    J Antimicrob Chemother 69:753-6. 2014
    ..The objective of this study was to determine factors that influence the establishment of low-level HIV DNA in long-term treated patients (excluding treatment since acute infection)...
  40. doi request reprint MHC-driven HIV-1 control on the long run is not systematically determined at early times post-HIV-1 infection
    Guillemette Antoni
    Epidemiology and Public Health Service, APHP, Hôpital du Kremlin Bicêtre, Universite Paris Sud, Paris, France
    AIDS 27:1707-16. 2013
    ..This effect is observed early after infection. Clarification needs to be established concerning the moment of action for the other HLA-B or HLA-C alleles...
  41. ncbi request reprint Accelerated immune senescence and HIV-1 infection
    Victor Appay
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Exp Gerontol 42:432-7. 2007
    ..Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation...
  42. pmc Distinct time effects of vaccination on long-term proliferative and IFN-gamma-producing T cell memory to smallpox in humans
    Behazine Combadiere
    Laboratoire d Immunologie Cellulaire, INSERM U543, Paris, France
    J Exp Med 199:1585-93. 2004
    ..Such long-term maintenance of vaccinia-specific immune memory in the absence of smallpox virus modifies our understanding of the mechanism of persistence of long-term memory to poxviruses and challenges vaccination strategies...
  43. ncbi request reprint Cell permeabilization for the assessment of T lymphocyte polyfunctional capacity
    Laura Papagno
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol Methods 328:182-8. 2007
    ..It is important to be aware of this potential bias and to design specific application/experimental procedures in order to obtain optimal results...
  44. ncbi request reprint The Th1 immune response against HIV-1 Gag p24-derived peptides in mice expressing HLA-A02.01 and HLA-DR1
    Anthony Pajot
    Unité d Immunité Cellulaire Antivirale, Departement d Immunologie, Institut Pasteur, Paris, France
    Eur J Immunol 37:2635-44. 2007
    ..A T helper effect was demonstrated in all cases, and was particularly strong with epitopes Gag(301-320),Gag(321-340 )and Gag(271-290), which should, therefore, be considered in the design of new vaccines...
  45. doi request reprint Maraviroc does not affect humoral response to the pandemic influenza A-H1N1v 2009 adjuvanted vaccine in HIV-1-infected patients
    Ana Canestri
    AP HP, Hopital Pitie Salpetriere, Service des Maladies Infectieuses et Tropicales, Paris, France
    AIDS 24:2887-9. 2010
    ..Seroprotection, seroconversion, and geometric mean titer ratio of specific antibody titers did not differ between groups. These results suggest that maraviroc does not significantly affect the immune response to this adjuvanted vaccine...
  46. ncbi request reprint No influence of human herpesvirus 8 infection on the progression of HIV-1 infection in initially asymptomatic patients
    Zaina Ait-Arkoub
    Department of aVirology EA 2387, Paris, France
    AIDS 17:1394-6. 2003
  47. doi request reprint Immune interventions in HIV infection
    Guislaine Carcelain
    UPMC Univ Paris 06, UMR S945, Laboratory of Immunity and Infection, Paris, France
    Immunol Rev 254:355-71. 2013
    ..Results from these first series of IBTs have been so far somewhat disappointing in terms of clinical relevance, but have provided lessons that are discussed in light of the future combined strategies to be developed toward an HIV cure...
  48. ncbi request reprint The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
    Anna Lissina
    aINSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, Paris, France bInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France Anna Lissina and Solène Fastenackels contributed equally to this writing of this work Current address Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    AIDS 28:477-86. 2014
    ....
  49. pmc Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
    Christine Katlama
    Department of Infectious Diseases, Pierre and Marie Curie University, Pitie Salpetriere Hospital, Paris, France
    Lancet 381:2109-17. 2013
    ....
  50. pmc CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope
    Sylvain Cardinaud
    INSERM, UMR S945, Université Pierre et Marie Curie UPMC, Paris, France
    PLoS Pathog 7:e1002049. 2011
    ..Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes...
  51. pmc Quality control assessment of human immunodeficiency virus type 2 (HIV-2) viral load quantification assays: results from an international collaboration on HIV-2 infection in 2006
    Florence Damond
    APHP, Hopital Bichat Claude Bernard, Laboratoire de Virologie, Paris, 75018 France
    J Clin Microbiol 46:2088-91. 2008
    ..Quantification varied between laboratories, and international standardization of quantification assays is strongly needed...
  52. pmc Demographic and clinical factors associated with response to smallpox vaccine in preimmunized volunteers
    Philippe Bossi
    Department of Infectious Diseases, University Pierre and Marie Curie, Paris VI, Paris, France
    PLoS ONE 3:e4087. 2008
    ..This program included the establishment of a preoutbreak national team that could be revaccinated against smallpox...
  53. doi request reprint T cells subtypes in a patient with interferon-alpha induced sarcoidosis
    Jean Jacques Monsuez
    AP HP, Hopital Paul Brousse, Department of Internal Medicine, Universite Paris Sud 11, Faculté de Médecine de Bicêtre, Villejuif Cedex, France
    Am J Med Sci 337:60-2. 2009
    ..This activation process also improved over time, but more slowly than clinical symptoms...
  54. doi request reprint The tyrosine kinase inhibitor Dasatinib blocks in-vitro HIV-1 production by primary CD4+ T cells from HIV-1 infected patients
    Manuela Pogliaghi
    aUPMC Univ Paris 06, UMR S945 bInserm, U945, Laboratory of Immunity and Infection, Paris, France cUniversità Vita Salute, San Raffaele Scientific Institute, Milan, Italy dORVACS, Hospital Pitié Salpêtrière eUPMC Univ Paris 06, UMR S943, Epidemiology, Therapeutics Strategies and Clinical Virology in HIV Infection, Paris, France fINSERM, U943, Epidemiology, Therapeutics Strategies and Clinical Virology in HIV Infection gAP HP, Hospital Pitié Salpêtrière Hospital, Department of Virology hAP HP, Hospital Pitié Salpêtrière Hospital, Department of Infectious and Tropical Diseases, Paris, France
    AIDS 28:278-81. 2014
    ..This molecule deserves to be investigated further for HIV cure strategies to hinder persistent immune activation and residual viral production. ..
  55. pmc Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    PLoS Pathog 9:e1003211. 2013
    ..Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure...
  56. doi request reprint [HIV controllers: a new evolutionary entity of HIV infection?]
    Valerie Martinez
    Laboratoire d Immunologie Cellulaire et Tissulaire, Universite Pierre et Marie Curie Paris 6, Paris, France
    Med Sci (Paris) 24:7-9. 2008
  57. ncbi request reprint Evidence for naive T-cell repopulation despite thymus irradiation after autologous transplantation in adults with multiple myeloma: role of ex vivo CD34+ selection and age
    Marion Malphettes
    Laboratoire d Immunologie Cellulaire et Tissulaire URA CNRS 625, Hopital de la Pitie Salpetriere, Paris, France
    Blood 101:1891-7. 2003
    ..Our results provide evidence that infusing PBSCs depleted of T cells after TBI in adults delays T-cell reconstitution but accelerates thymic regeneration...
  58. ncbi request reprint Strong CD4 Th1 responses to HIV and hepatitis C virus in HIV-infected long-term non-progressors co-infected with hepatitis C virus
    Nadia Alatrakchi
    Laboratoire d Immunologie Cellulaire, GH Pitié Salpétrière, Paris, France
    AIDS 16:713-7. 2002
    ..To compare the T-cell responses to hepatitis C virus (HCV) and HIV in HIV-infected long-term non-progressors (LT-NP) and HIV-positive progressors co-infected with HCV and in HIV-negative HCV-infected patients...
  59. ncbi request reprint Severe herpes virus (HSV-2) infection in two patients with myelodysplasia and undetectable NK cells and plasmacytoid dendritic cells in the blood
    Ali Dalloul
    Laboratoire d Imunologie Hôpital de la Pitié, Paris, France
    J Clin Virol 30:329-36. 2004
    ....
  60. ncbi request reprint Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection
    Amelie Guihot
    1 Laboratory of Immunity and Infection, UPMC Univ Paris 06, UMR S945, Paris, France
    Am J Respir Crit Care Med 189:1240-9. 2014
    ..The biology of fatal pandemic influenza infection remains undefined...
  61. doi request reprint Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients
    Nathalie Dhedin
    Service d Hématologie Adolescents Jeunes Adultes, Hopital Saint Louis, AP HP, Paris, France Service d hématologie, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris, France Electronic address
    Vaccine 32:585-91. 2014
    ....
  62. doi request reprint Effect of two injections of non-adjuvanted influenza A H1N1pdm2009 vaccine in renal transplant recipients: INSERM C09-32 TRANSFLUVAC trial
    Nicole Le Corre
    INSERM UMRS 945, Laboratoire Immunité et Infection, Groupe Hospitalier Pitié Salpêtrière Paris, France
    Vaccine 30:7522-8. 2012
    ..We therefore investigated the immunogenicity and safety of a double dose non-adjuvanted vaccination regimen against influenza H1N1pdm2009 in kidney transplant adult recipients...
  63. ncbi request reprint Therapeutic vaccines against HIV need international partnerships
    Brigitte Autran
    Laboratoire d Immunologie Cellulaire, Centre Hospitalier Universitaire Pitie Salpetriere, 75651 Paris, France
    Nat Rev Immunol 3:503-8. 2003
    ....
  64. ncbi request reprint Plasticity of lymphoid compartments during HIV infection and treatments: hopes and limits
    Behazine Combadiere
    Laboratoire d Immunologie Cellulaire et Tissulaire, Unité Inserm 543, Hopital Pitie Salpetriere, 83, Boulevard de l Hopital, 75013 Paris, France
    Microbes Infect 4:575-80. 2002
    ....
  65. ncbi request reprint Antibodies to conserved epitopes of the HIV-1 envelope in sera from long-term non-progressors: prevalence and association with neutralizing activity
    Martine Braibant
    Laboratoire de Virologie, Universite Francois Rabelais, INSERM ERI 19, 37044 Tours Cedex, France
    AIDS 20:1923-30. 2006
    ....
  66. ncbi request reprint Strategies toward restoration of immunity to HIV
    Brigitte Autran
    AIDS 16:4-6. 2002
  67. ncbi request reprint A patient with HIV-1 superinfection
    Stephanie Jost
    Division of Infectious Diseases, University of Geneva, Geneva
    N Engl J Med 347:731-6. 2002
  68. ncbi request reprint Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection
    Cécile Chouquet
    INSERM EMI 0214, Laboratoire d Immunologie Cellulaire et Tissulaire, Centre Hospitalier Pitié Salpétrière, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    AIDS 16:2399-407. 2002
    ..The correlations between the breadth and specificities of memory CTL and virus production and disease progression are still unknown, but are of major importance for vaccine strategies...
  69. ncbi request reprint A simplified flow cytometry method of CD4 and CD8 cell counting based on thermoresistant reagents: implications for large scale monitoring of HIV-infected patients in resource-limited settings
    Silva Barbesti
    BIO D Srl, Valenzano, Italy
    Cytometry B Clin Cytom 68:43-51. 2005
    ..To validate a simplified flow cytometry assay for CD4 and CD8 T cell counting based on monoclonal antibodies which are made resistant to high temperatures (simplified thermoresistant assay (STRA))...
  70. pmc Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    Jorge R Almeida
    Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
    J Exp Med 204:2473-85. 2007
    ..Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines...
  71. ncbi request reprint Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro
    Emi E Nakayama
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka, Japan
    Immunogenetics 59:511-5. 2007
    ..Our epidemiological and molecular biological findings clearly indicate H43Y has a very minor effect on anti-HIV-1 activity of TRIM5alpha, suggesting that this allele is immaterial, at least in HIV-1-infected Europeans and Asians...
  72. ncbi request reprint Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase
    Jay A Levy
    AIDS 17:1119. 2003
  73. ncbi request reprint Hepatitis C virus infection in long-term nonprogressor HIV-1-infected subjects
    Vincent Thibault
    J Acquir Immune Defic Syndr 29:204-6. 2002
  74. ncbi request reprint [Evaluation of residual immune response against human pox virus before and after revaccination in healthy volunteers]
    Francois Bricaire
    Service des Maladies Infectieuses et Tropicales, G H Pitié Salpêtrière, 47 83 boulevard de l Hopital, 75013 Paris
    Bull Acad Natl Med 190:1035-46; discussion 1046-9. 2006
    ..Three-quarters of the subjects had a proliferative response. This response was lower after the age of 55 years but could be reactivated by revaccination...
  75. doi request reprint Characteristics of the env genes of HIV type 1 quasispecies in long-term nonprogressors with broadly neutralizing antibodies
    Martine Braibant
    Universite Francois Rabelais, Tours, France
    J Acquir Immune Defic Syndr 47:274-84. 2008
    ..In addition, a higher proportion of defective clones was found among the env genes of NAb- patients (25% to 93%)-particularly those with lower viral loads and low levels of env diversity-than among those of NAb+ patients (7% to 19%)...
  76. ncbi request reprint Transcutaneous anti-influenza vaccination promotes both CD4 and CD8 T cell immune responses in humans
    Annika Vogt
    Clinical Research Center for Hair and Skin Physiology, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    J Immunol 180:1482-9. 2008
    ..This study proposes new perspectives for the development of vaccination strategies that trigger T cell immune responses in humans...
  77. ncbi request reprint T-cell subset counting and the fight against AIDS: reflections over a 20-year struggle
    Francis Mandy
    National HIV Immunology Laboratory, Health Canada, LCDC 0603B1, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
    Cytometry 50:39-45. 2002
    ..It is clear that an effective attack on the human immunodeficiency virus (HIV) epidemic has to embrace resource-poor regions. Reducing the cost of the assay while improving reliability and durability is a move in the right direction...
  78. pmc A triple-mutated allele of granzyme B incapable of inducing apoptosis
    Dorian McIlroy
    Laboratoire d Immunologie Cellulaire et Tissulaire, Institut National de la Sante et de la Recherche Medicale U543, Faculté de Médecine Pitié Salpêtrière, 75013 Paris, France
    Proc Natl Acad Sci U S A 100:2562-7. 2003
    ....
  79. pmc Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease
    Karim Sacre
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, 75013 Paris, France
    J Exp Med 201:1999-2010. 2005
    ....
  80. ncbi request reprint Differential requirement of caspases during naive T cell proliferation
    Alexandre Boissonnas
    Faculté de Médicine Pitié Salpêtrière, Laboratoire d Immunologie Cellulaire, INSERM U543, 91 Boulevard de l Hopital, F 75643 Paris Cedex 13, France
    Eur J Immunol 32:3007-15. 2002
    ..These data reveal a novel facet of antigenic caspase regulation during naive CD4 T cell proliferation and provide insights into the function of caspases during T cell homeostasis...
  81. pmc Yeast-derived human immunodeficiency virus type 1 p55(gag) virus-like particles activate dendritic cells (DCs) and induce perforin expression in Gag-specific CD8(+) T cells by cross-presentation of DCs
    Yasuko Tsunetsugu-Yokota
    Department of Immunology, National Institute of Infectious Diseases, Shinjuku ku, Japan
    J Virol 77:10250-9. 2003
    ....