Samir Attoub

Summary

Country: France

Publications

  1. ncbi The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy
    Samir Attoub
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Cancer Res 62:4879-83. 2002
  2. ncbi Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells
    Sylvie Rodrigues
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, , 75571 Paris, France
    Oncogene 22:4488-97. 2003
  3. ncbi Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth
    Christine Rivat
    Institut National de la Sante et de la Recherche Medicale U482, Hopital Saint Antoine, Paris, France
    Cancer Res 65:195-202. 2005
  4. ncbi Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts
    Quang De Nguyen
    Institut National de la Sante et de la Recherche Medicale U673, Universite Pierre et Marie Curie Paris 6, Molecular and Clinical Oncology of Solid Tumors, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Mol Cancer Ther 5:2070-7. 2006
  5. ncbi Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes
    Christine Rivat
    INSERM U 482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, , 184 rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France
    Oncogene 23:3317-27. 2004
  6. ncbi Trefoil factor family (TFF) peptides and cancer progression
    Shahin Emami
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Peptides 25:885-98. 2004
  7. ncbi Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling
    Sylvie Rodrigues
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, , 75571 Paris Cedex 12, France
    FASEB J 17:7-16. 2003
  8. ncbi Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion
    Christine Rivat
    INSERM U 482, Hopital Saint Antoine, 75571, Paris Cedex 12, France
    FASEB J 17:1721-3. 2003
  9. ncbi Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression
    Frédérique Souazé
    Institut National de la Sante et de la Recherche Medicale U673 and UPMC, Hopital Saint Antoine, France
    Cancer Res 66:6243-9. 2006
  10. ncbi Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex
    Gregoire P Prevost
    Ipsen Institut Henri Beaufour, Les Ulis, France
    Cancer Res 66:9227-34. 2006

Collaborators

Detail Information

Publications14

  1. ncbi The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy
    Samir Attoub
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Cancer Res 62:4879-83. 2002
    ....
  2. ncbi Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells
    Sylvie Rodrigues
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, , 75571 Paris, France
    Oncogene 22:4488-97. 2003
    ..It is concluded that although pS2, SP and ITF belong to the same family of inflammation- and cancer-associated regulatory peptides, they do not control identical signaling networks...
  3. ncbi Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth
    Christine Rivat
    Institut National de la Sante et de la Recherche Medicale U482, Hopital Saint Antoine, Paris, France
    Cancer Res 65:195-202. 2005
    ..We also validate new therapeutic strategies targeting STAT3 signaling by pharmacologic inhibitors and RNA interference for the treatment of colorectal cancer patients...
  4. ncbi Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts
    Quang De Nguyen
    Institut National de la Sante et de la Recherche Medicale U673, Universite Pierre et Marie Curie Paris 6, Molecular and Clinical Oncology of Solid Tumors, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Mol Cancer Ther 5:2070-7. 2006
    ....
  5. ncbi Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes
    Christine Rivat
    INSERM U 482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, , 184 rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France
    Oncogene 23:3317-27. 2004
    ..Disruption of this cascade by Y705F reveals the proinvasive potential of altered forms of STAT3 as a persistent signaling adaptor in cytokine/transforming growth factor receptor scaffolds and oncogenic pathways...
  6. ncbi Trefoil factor family (TFF) peptides and cancer progression
    Shahin Emami
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Peptides 25:885-98. 2004
    ..As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors...
  7. ncbi Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling
    Sylvie Rodrigues
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, , 75571 Paris Cedex 12, France
    FASEB J 17:7-16. 2003
    ....
  8. ncbi Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion
    Christine Rivat
    INSERM U 482, Hopital Saint Antoine, 75571, Paris Cedex 12, France
    FASEB J 17:1721-3. 2003
    ..This mechanism may thereby contribute to cellular invasion during the early-stage adenoma/adenocarcinoma conversion and the metastatic process of digestive tumors...
  9. ncbi Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression
    Frédérique Souazé
    Institut National de la Sante et de la Recherche Medicale U673 and UPMC, Hopital Saint Antoine, France
    Cancer Res 66:6243-9. 2006
    ..These strategies would increase the range of therapeutic approaches and be beneficial for specific patients...
  10. ncbi Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex
    Gregoire P Prevost
    Ipsen Institut Henri Beaufour, Les Ulis, France
    Cancer Res 66:9227-34. 2006
    ..Our data validate the feasibility of targeting heterotrimeric G-protein functions downstream the GPCRs to improve anticancer chemotherapy...
  11. ncbi Captopril as a potential inhibitor of lung tumor growth and metastasis
    Samir Attoub
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1138:65-72. 2008
    ..In view of these experimental findings, we conclude that captopril could be a promising option for the treatment of lung cancer...
  12. ncbi The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion
    Samir Attoub
    INSERM U 673, Molecular and Clinical Oncology of Solid Tumors, University Pierre et Marie Curie Paris VI, Hospital Saint Antoine, Paris, France
    Ann N Y Acad Sci 1138:204-13. 2008
    ....
  13. ncbi Gamma-synuclein and the progression of cancer
    Mushfika Ahmad
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates, Al Ain, PO Box 17666, United Arab Emirates
    FASEB J 21:3419-30. 2007
    ..This review will discuss the involvement of gamma-syn in cancer progression, metastasis and its potential as a marker...
  14. ncbi Attenuated bacteria as effectors in cancer immunotherapy
    Basel K al-Ramadi
    Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1138:351-7. 2008
    ..This supports the notion of using cytokine-expressing attenuated Salmonella organisms in cancer therapy...