Azeddine Atfi

Summary

Country: France

Publications

  1. doi request reprint PTH battles TGF-beta in bone
    Azeddine Atfi
    NSERM UMRS 938, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571, Paris, France
    Nat Cell Biol 12:205-7. 2010
  2. doi request reprint p53 brings a new twist to the Smad signaling network
    Azeddine Atfi
    INSERM U893, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris, France
    Sci Signal 1:pe33. 2008
  3. pmc Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling
    Nourdine Faresse
    Laboratory of Cell Signaling and Carcinogenesis, INSERM U673, Paris, France
    EMBO J 27:1804-15. 2008
  4. ncbi request reprint Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling
    Su Ryeon Seo
    INSERM U673, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris
    Mol Cell 23:547-59. 2006
  5. pmc The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
    Su Ryeon Seo
    INSERM U 482, Hopital St Antoine, Paris, France
    EMBO J 23:3780-92. 2004
  6. pmc Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation
    Yigit Erker
    Laboratory of Cell Signaling and Carcinogenesis, INSERM UMR938, Paris, France
    Mol Cell Biol 33:2163-77. 2013
  7. doi request reprint The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor
    Nathalie Ferrand
    UPMC, université Paris 06, UMR S 938, CdR Saint Antoine, Hopital Saint Antoine, Paris, France
    Cancer Res 70:8457-66. 2010
  8. ncbi request reprint A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly
    Nathalie Ferrand
    INSERM U 673, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571, Paris Cedex 12, France
    FASEB J 21:488-96. 2007
  9. doi request reprint A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity
    Christine Demange
    INSERM U, Paris, France
    Mol Cell 36:1073-85. 2009
  10. ncbi request reprint Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling
    Olivier Ferrigno
    INSERM U532, Institut de Recherche sur la Peau, Hopital Saint Louis, Paris, France
    Oncogene 21:4879-84. 2002

Collaborators

Detail Information

Publications20

  1. doi request reprint PTH battles TGF-beta in bone
    Azeddine Atfi
    NSERM UMRS 938, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571, Paris, France
    Nat Cell Biol 12:205-7. 2010
    ..PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo...
  2. doi request reprint p53 brings a new twist to the Smad signaling network
    Azeddine Atfi
    INSERM U893, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris, France
    Sci Signal 1:pe33. 2008
    ..Thus, the discovery that p53 and TGF-beta cooperate in cell-fate decisions and cellular homeostatic mechanisms has important pathophysiological implications...
  3. pmc Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling
    Nourdine Faresse
    Laboratory of Cell Signaling and Carcinogenesis, INSERM U673, Paris, France
    EMBO J 27:1804-15. 2008
    ..Thus, our findings on the mode of action of PCTA provide new and important insights into the molecular mechanism underlying the antagonistic interplay between TGIF and cPML in the TGF-beta signalling network...
  4. ncbi request reprint Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling
    Su Ryeon Seo
    INSERM U673, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris
    Mol Cell 23:547-59. 2006
    ..We suggest that the interaction of TGIF with cPML through c-Jun may negatively regulate TGF-beta signaling through controlling the localization of cPML and, consequently, the assembly of the cPML-SARA complex...
  5. pmc The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
    Su Ryeon Seo
    INSERM U 482, Hopital St Antoine, Paris, France
    EMBO J 23:3780-92. 2004
    ..These results reveal a new role for TGIF as a component of a ubiquitin ligase complex that mediates the degradation of Smad2 in response to TGF-beta signaling...
  6. pmc Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation
    Yigit Erker
    Laboratory of Cell Signaling and Carcinogenesis, INSERM UMR938, Paris, France
    Mol Cell Biol 33:2163-77. 2013
    ..Altogether, these results identify Arkadia to be a novel STUBL that can trigger degradation of signal-induced polysumoylated proteins...
  7. doi request reprint The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor
    Nathalie Ferrand
    UPMC, université Paris 06, UMR S 938, CdR Saint Antoine, Hopital Saint Antoine, Paris, France
    Cancer Res 70:8457-66. 2010
    ..Such a mechanism may play a crucial role in tumor progression, because many tumors that express high levels of c-Ski also display impaired nuclear accumulation of Smads...
  8. ncbi request reprint A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly
    Nathalie Ferrand
    INSERM U 673, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571, Paris Cedex 12, France
    FASEB J 21:488-96. 2007
    ..These results reveal an important mechanism for the degradation of TGIF through the ubiquitin-proteasome pathway, whose deregulation might contribute to the development of human holoprosencephaly...
  9. doi request reprint A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity
    Christine Demange
    INSERM U, Paris, France
    Mol Cell 36:1073-85. 2009
    ....
  10. ncbi request reprint Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling
    Olivier Ferrigno
    INSERM U532, Institut de Recherche sur la Peau, Hopital Saint Louis, Paris, France
    Oncogene 21:4879-84. 2002
    ..Together, these data provide the first evidence that YAP65 is a Smad7 partner that facilitates the recruitment of the latter to activated TbetaRI, and enhances the inhibitory activity of Smad7 against TGF-beta signaling...
  11. pmc The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor
    Azeddine Atfi
    Institut National de la Sante et de la Recherche Medicale, Unite 673, Hopital St Antoine, Paris, France
    J Cell Biol 178:201-8. 2007
    ..These results define ADAM12 as a new partner of TbetaRII that facilitates its trafficking to early endosomes in which activation of the Smad pathway is initiated...
  12. doi request reprint Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation
    Asma Ettahar
    Laboratory of Cell Signaling and Carcinogenesis, INSERM UMRS938, 184 rue du Faubourg St Antoine, 75571 Paris, France
    Cell Rep 4:530-41. 2013
    ..These findings unveil a paradigm behind inactivation of the cPML tumor suppressor network in human malignancies. ..
  13. pmc Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity
    Rania F Zaarour
    Institut Curie Unité Mixte de Recherche Centre National de la Recherche Scientifique, Paris, France
    PLoS ONE 7:e37490. 2012
    ..Given the role of Met in cell proliferation and tumorigenesis, our results may provide a mechanistic basis for understanding the role of ezrin in tumor progression...
  14. pmc Bcr-Abl activates the AKT/Fox O3 signalling pathway to restrict transforming growth factor-beta-mediated cytostatic signals
    Azeddine Atfi
    INSERM U482, 184 rue du Faubourg St Antoine, 75571 Paris, France
    EMBO Rep 6:985-91. 2005
    ..Our results show a novel mechanism of cellular transformation by the oncogenic fusion protein Bcr-Abl through suppression of the cytostatic actions of TGF-beta...
  15. ncbi request reprint c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity
    Marcia Pessah
    INSERM U 482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571, Paris Cedex 12, France
    J Biol Chem 277:29094-100. 2002
    ..Thus, the formation of a c-Jun/Ski complex maintains the repressed state of Smad2-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling by the JNK cascade...
  16. ncbi request reprint The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation
    Celine Prunier
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation Cleveland, Ohio 44195, USA
    J Biol Chem 278:26249-57. 2003
    ..The ability of Ski to engage Smad proteins in nonproductive complexes provides new insights into the molecular mechanism used by Ski for disabling TGF-beta signaling...
  17. ncbi request reprint Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation
    David Gilot
    INSERM U522, Régulation des équilibres fonctionnels du foie normal et pathologique, Avenue de la Bataille Flandre Dunkerque, Hopital Pontchaillou, 35033 Rennes, France
    J Biol Chem 277:49220-9. 2002
    ..Furthermore, in highlighting the control of apoptosis by GSTs, these data provide new insights for analyzing the complex mechanisms of hepatoprotection...
  18. pmc Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages
    Fabien Milliat
    Laboratory of Radiopathology, Institute for Radiological Protection and Nuclear Safety IRSN, BP17, 92262 Fontenay aux Roses, France
    Am J Pathol 169:1484-95. 2006
    ..Moreover, we demonstrate in vitro that ECs influence these fundamental mechanisms involved in radiation-induced vascular damages...
  19. ncbi request reprint AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism
    Francois Lallemand
    INSERM U482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    J Biol Chem 280:27645-53. 2005
    ..The ability of AIP4 to enhance the inhibitory function of Smad7 independent of its ubiquitin ligase activity reveals a new mechanism by which E3 ubiquitin ligases may function to turn off TGF-beta signaling...
  20. ncbi request reprint The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent manner
    Jerome Lafont
    INSERM U515 and INSERM U482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    J Biol Chem 277:41220-9. 2002
    ..In conclusion, our data provide evidence that novH is a new target of TGFbeta1; unlike other members of the CCN (cyr61, ctgf, nov) family, however, its expression is repressed rather than induced...