Research Topics
Genomes and Genes
| Azeddine AtfiSummaryCountry: France Publications
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Detail Information
Publications
p53 brings a new twist to the Smad signaling networkAzeddine Atfi
INSERM U893, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris, France
Sci Signal 1:pe33. 2008..Thus, the discovery that p53 and TGF-beta cooperate in cell-fate decisions and cellular homeostatic mechanisms has important pathophysiological implications...- PTH battles TGF-beta in boneAzeddine Atfi
NSERM UMRS 938, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571, Paris, France
Nat Cell Biol 12:205-7. 2010..PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo... 
Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signallingNourdine Faresse
Laboratory of Cell Signaling and Carcinogenesis, INSERM U673, Paris, France
EMBO J 27:1804-15. 2008..Thus, our findings on the mode of action of PCTA provide new and important insights into the molecular mechanism underlying the antagonistic interplay between TGIF and cPML in the TGF-beta signalling network...
Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signalingSu Ryeon Seo
INSERM U673, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris
Mol Cell 23:547-59. 2006..We suggest that the interaction of TGIF with cPML through c-Jun may negatively regulate TGF-beta signaling through controlling the localization of cPML and, consequently, the assembly of the cPML-SARA complex...- The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradationSu Ryeon Seo
INSERM U 482, Hopital St Antoine, Paris, France
EMBO J 23:3780-92. 2004..These results reveal a new role for TGIF as a component of a ubiquitin ligase complex that mediates the degradation of Smad2 in response to TGF-beta signaling... - The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptorNathalie Ferrand
UPMC, université Paris 06, UMR S 938, CdR Saint Antoine, Hopital Saint Antoine, Paris, France
Cancer Res 70:8457-66. 2010..Such a mechanism may play a crucial role in tumor progression, because many tumors that express high levels of c-Ski also display impaired nuclear accumulation of Smads... - A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephalyNathalie Ferrand
INSERM U 673, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571, Paris Cedex 12, France
FASEB J 21:488-96. 2007..These results reveal an important mechanism for the degradation of TGIF through the ubiquitin-proteasome pathway, whose deregulation might contribute to the development of human holoprosencephaly... - The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptorAzeddine Atfi
Institut National de la Sante et de la Recherche Medicale, Unite 673, Hopital St Antoine, Paris, France
J Cell Biol 178:201-8. 2007..These results define ADAM12 as a new partner of TbetaRII that facilitates its trafficking to early endosomes in which activation of the Smad pathway is initiated... - A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicityChristine Demange
INSERM U, Paris, France
Mol Cell 36:1073-85. 2009.... - Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signalingOlivier Ferrigno
INSERM U532, Institut de Recherche sur la Peau, Hopital Saint Louis, Paris, France
Oncogene 21:4879-84. 2002..Together, these data provide the first evidence that YAP65 is a Smad7 partner that facilitates the recruitment of the latter to activated TbetaRI, and enhances the inhibitory activity of Smad7 against TGF-beta signaling... - Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activityRania F Zaarour
Institut Curie Unité Mixte de Recherche Centre National de la Recherche Scientifique, Paris, France
PLoS ONE 7:e37490. 2012..Given the role of Met in cell proliferation and tumorigenesis, our results may provide a mechanistic basis for understanding the role of ezrin in tumor progression... - Bcr-Abl activates the AKT/Fox O3 signalling pathway to restrict transforming growth factor-beta-mediated cytostatic signalsAzeddine Atfi
INSERM U482, 184 rue du Faubourg St Antoine, 75571 Paris, France
EMBO Rep 6:985-91. 2005..Our results show a novel mechanism of cellular transformation by the oncogenic fusion protein Bcr-Abl through suppression of the cytostatic actions of TGF-beta... - c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activityMarcia Pessah
INSERM U 482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571, Paris Cedex 12, France
J Biol Chem 277:29094-100. 2002..Thus, the formation of a c-Jun/Ski complex maintains the repressed state of Smad2-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling by the JNK cascade... - The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylationCeline Prunier
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation Cleveland, Ohio 44195, USA
J Biol Chem 278:26249-57. 2003..The ability of Ski to engage Smad proteins in nonproductive complexes provides new insights into the molecular mechanism used by Ski for disabling TGF-beta signaling... - Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulationDavid Gilot
INSERM U522, Régulation des équilibres fonctionnels du foie normal et pathologique, Avenue de la Bataille Flandre Dunkerque, Hopital Pontchaillou, 35033 Rennes, France
J Biol Chem 277:49220-9. 2002..Furthermore, in highlighting the control of apoptosis by GSTs, these data provide new insights for analyzing the complex mechanisms of hepatoprotection... - AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanismFrancois Lallemand
INSERM U482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
J Biol Chem 280:27645-53. 2005..The ability of AIP4 to enhance the inhibitory function of Smad7 independent of its ubiquitin ligase activity reveals a new mechanism by which E3 ubiquitin ligases may function to turn off TGF-beta signaling... - The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent mannerJerome Lafont
INSERM U515 and INSERM U482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
J Biol Chem 277:41220-9. 2002..In conclusion, our data provide evidence that novH is a new target of TGFbeta1; unlike other members of the CCN (cyr61, ctgf, nov) family, however, its expression is repressed rather than induced... - Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damagesFabien Milliat
Laboratory of Radiopathology, Institute for Radiological Protection and Nuclear Safety IRSN, BP17, 92262 Fontenay aux Roses, France
Am J Pathol 169:1484-95. 2006..Moreover, we demonstrate in vitro that ECs influence these fundamental mechanisms involved in radiation-induced vascular damages...