Jean Michel Arrang

Summary

Country: France

Publications

  1. ncbi request reprint Constitutive activity of the histamine H3 receptor
    Jean Michel Arrang
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U 573, Centre Paul Broca, 75014 Paris, France
    Trends Pharmacol Sci 28:350-7. 2007
  2. ncbi request reprint [The histamine H3 receptor: a new target for the treatment of arousal and cognitive disorders]
    J M Arrang
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U 573, Centre Paul Broca, 2 ter, rue d Alésia F 75014 Paris
    Ann Pharm Fr 65:275-84. 2007
  3. ncbi request reprint N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain
    Raphaël Faucard
    INSERM, U573, Centre Paul Broca, Paris, France
    J Neurochem 98:1487-96. 2006
  4. pmc Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives
    Florence Gbahou
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U573, Centre Paul Broca, 2 ter rue d Alesia, 75014 Paris, France
    Br J Pharmacol 147:744-54. 2006
  5. pmc Protean agonism at histamine H3 receptors in vitro and in vivo
    Florence Gbahou
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l Institut National de la Santé et de la Recherche Médicale, Centre Paul Broca, 75014 Paris, France
    Proc Natl Acad Sci U S A 100:11086-91. 2003
  6. ncbi request reprint Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms
    Agnès Rouleau
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l INSERM, Centre Paul Broca, Paris, France
    J Neurochem 90:1331-8. 2004
  7. doi request reprint Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo
    Marie Humbert-Claude
    Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Centre de Psychiatrie et Neurosciences CPN, U 894, INSERM, 2 ter rue d Alesia, 75014 Paris, France
    Psychopharmacology (Berl) 220:225-41. 2012
  8. ncbi request reprint Histamine H3 and dopamine D2 receptor-mediated [35S]GTPgamma[S] binding in rat striatum: evidence for additive effects but lack of interactions
    Marie Humbert-Claude
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U573, Centre Paul Broca, 75014 Paris, France
    Biochem Pharmacol 73:1172-81. 2007
  9. doi request reprint CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease
    Mouhammad Motawaj
    INSERM, Centre de psychiatrie et Neurosciences, Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Paris, France
    J Alzheimers Dis 22:861-71. 2010
  10. doi request reprint Ciproxifan, a histamine H₃-receptor antagonist / inverse agonist, modulates methamphetamine-induced sensitization in mice
    Mouhammad Motawaj
    INSERM, Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Centre de Psychiatrie et Neurosciences CPN, U 894, Paris, France
    Eur J Neurosci 33:1197-204. 2011

Collaborators

  • Holger Stark
  • Jean Charles Schwartz
  • Jian Sheng Lin
  • Sven Grassmann
  • Xavier Ligneau
  • Florence Gbahou
  • Marie Humbert-Claude
  • Walter Schunack
  • C Robin Ganellin
  • Mouhammad Motawaj
  • Catherine Pillot
  • Anne Héron
  • Tibor Mikó
  • Agnès Rouleau
  • Heinz H Pertz
  • Ludwig Vincent
  • Raphaël Faucard
  • Véronique Cochois
  • Séverine Morisset
  • Regis Parmentier
  • Joel Tardivel-Lacombe
  • Nadia Pelloux-Léon
  • Galina Meier
  • Astrid Sasse
  • Joachim Apelt
  • Elisabeth Davenas
  • Katell Peoc'h
  • Jacques Callebert
  • Marilyne Uguen
  • Emmanuel Denis
  • Aude Burban
  • Christelle Anaclet
  • David Perrin
  • Philippe Robert
  • Johanne Piriou
  • Laurent Landais
  • Claude Chabret
  • Vincent Armand
  • Antonia Piripitsi
  • Annette Hüls
  • Abdellatif Fkyerat
  • Michael Krause
  • Monique Garbarg
  • Wasyl Tertiuk
  • Sylvain Crochet
  • Sophie Ridray
  • Jordi Ortiz
  • Sigurd Elz

Detail Information

Publications22

  1. ncbi request reprint Constitutive activity of the histamine H3 receptor
    Jean Michel Arrang
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U 573, Centre Paul Broca, 75014 Paris, France
    Trends Pharmacol Sci 28:350-7. 2007
    ..Consistent with its physiological and therapeutic relevance, the constitutive activity of H(3)R thus has a major function in the brain and regulates the activity of H(3)R-targeted drugs...
  2. ncbi request reprint [The histamine H3 receptor: a new target for the treatment of arousal and cognitive disorders]
    J M Arrang
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U 573, Centre Paul Broca, 2 ter, rue d Alésia F 75014 Paris
    Ann Pharm Fr 65:275-84. 2007
    ....
  3. ncbi request reprint N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain
    Raphaël Faucard
    INSERM, U573, Centre Paul Broca, Paris, France
    J Neurochem 98:1487-96. 2006
    ....
  4. pmc Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives
    Florence Gbahou
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U573, Centre Paul Broca, 2 ter rue d Alesia, 75014 Paris, France
    Br J Pharmacol 147:744-54. 2006
    ..In conclusion, although the pharmacological profiles of the human H3R and H4R overlap, the structure-activity relationships of histamine derivatives at both receptors strongly differ and lead to the identification of selective compounds...
  5. pmc Protean agonism at histamine H3 receptors in vitro and in vivo
    Florence Gbahou
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l Institut National de la Santé et de la Recherche Médicale, Centre Paul Broca, 75014 Paris, France
    Proc Natl Acad Sci U S A 100:11086-91. 2003
    ....
  6. ncbi request reprint Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms
    Agnès Rouleau
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l INSERM, Centre Paul Broca, Paris, France
    J Neurochem 90:1331-8. 2004
    ..However, the autoradiographic and cellular expression patterns observed in several brain areas such as the thalamus or hippocampus reveal important differences between the two species...
  7. doi request reprint Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo
    Marie Humbert-Claude
    Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Centre de Psychiatrie et Neurosciences CPN, U 894, INSERM, 2 ter rue d Alesia, 75014 Paris, France
    Psychopharmacology (Berl) 220:225-41. 2012
    ..The basis of the unique clinical profile of the antipsychotic clozapine is not yet elucidated. Brain histamine receptors may play a role in schizophrenia and its treatment, but their involvement in the profile of clozapine remained unknown...
  8. ncbi request reprint Histamine H3 and dopamine D2 receptor-mediated [35S]GTPgamma[S] binding in rat striatum: evidence for additive effects but lack of interactions
    Marie Humbert-Claude
    INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire U573, Centre Paul Broca, 75014 Paris, France
    Biochem Pharmacol 73:1172-81. 2007
    ..Such a postsynaptic mechanism may underlie the antipsychotic-like effects of H(3)R inverse agonists and supports their therapeutic interest, alone or as adjunctive treatment with neuroleptics...
  9. doi request reprint CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease
    Mouhammad Motawaj
    INSERM, Centre de psychiatrie et Neurosciences, Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Paris, France
    J Alzheimers Dis 22:861-71. 2010
    ....
  10. doi request reprint Ciproxifan, a histamine H₃-receptor antagonist / inverse agonist, modulates methamphetamine-induced sensitization in mice
    Mouhammad Motawaj
    INSERM, Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Centre de Psychiatrie et Neurosciences CPN, U 894, Paris, France
    Eur J Neurosci 33:1197-204. 2011
    ..The reversal by CPX of BDNF and NR1 mRNAs in the hippocampus of sensitized animals further strengthens the interest of H₃-receptor inverse agonists for the long-term treatment of cognitive deficits of patients with schizophrenia...
  11. ncbi request reprint Histamine and schizophrenia
    Jean Michel Arrang
    INSERM, U573, Unité de Neurobiologie et Pharmacologie Moléculaire, Centre Paul Broca, 2 ter rue d Alesia, 75014 Paris, France
    Int Rev Neurobiol 78:247-87. 2007
    ....
  12. ncbi request reprint 4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists
    Galina Meier
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195 Berlin, Germany
    J Med Chem 47:2678-87. 2004
    ..Additionally, selected compounds were functionally investigated in vitro on isolated organs of the guinea-pig at H(3), H(1), and H(2) receptors...
  13. ncbi request reprint Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain
    Nadia Pelloux-Léon
    Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, England, UK
    J Med Chem 47:3264-74. 2004
    ....
  14. ncbi request reprint Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties
    Astrid Sasse
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195 Berlin, Germany
    J Med Chem 45:4000-10. 2002
    ..07-0.1 mg/kg depending on tissue)...
  15. ncbi request reprint Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649
    Xavier Ligneau
    Bioprojet Biotech, Saint Gregoire Cedex, France
    Biochem Pharmacol 73:1215-24. 2007
    ..These observations suggest that H(3)-receptor inverse agonists/antagonists deserve attention as a novel class of antipsychotic drugs endowed with pro-cognitive properties...
  16. ncbi request reprint Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives
    Sven Grassmann
    Institut fur Pharmazie, Institut fur Pharmazie, Berlin, Germany
    Arch Pharm (Weinheim) 337:533-45. 2004
    ..In this study, new hybrid compounds with a dual mode biological action were developed. These pharmacological agents are valuable leads for further development and candidates for treatment of histamine-dependent disorders...
  17. ncbi request reprint Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists
    Tibor Mikó
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195 Berlin, Germany
    Bioorg Med Chem 12:2727-36. 2004
    ..In vivo only the inverse phenyl benzyl ether (3) showed worthwhile antagonist potencies...
  18. ncbi request reprint Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds
    Tibor Mikó
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, Germany
    J Med Chem 46:1523-30. 2003
    ..Unexpectedly, some of the novel antagonists also showed a slight preference for the human histamine H(3) receptor compared to their affinities for the guinea-pig H(3) receptor...
  19. ncbi request reprint Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum
    Catherine Pillot
    Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    Eur J Neurosci 17:307-14. 2003
    ..They suggest that endogenous histamine and dopamine cooperate to modulate the activity of striatal projection neurons and strengthen the interest of H3-receptors as new targets for the treatment of psychotic disorders and drug abuse...
  20. ncbi request reprint Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat
    Catherine Pillot
    Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    J Neurosci 22:7272-80. 2002
    ..The potentiation of the effects of haloperidol by ciproxifan strengthens the potential interest of H3-receptor antagonists/inverse agonists to improve the symptomatic treatment of schizophrenia...
  21. ncbi request reprint Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists
    Sven Grassmann
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195, Germany
    Eur J Pharm Sci 15:367-78. 2002
    ..Thus, these novel H(3)-receptor antagonists are interesting leads for further development...
  22. ncbi request reprint Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity
    Joachim Apelt
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195 Berlin, Germany
    J Med Chem 45:1128-41. 2002
    ....