M Arock

Summary

Country: France

Publications

  1. ncbi request reprint [Mastocytosis, classification, biological diagnosis and therapy]
    M Arock
    Unité CNRS UMR 8147, Laboratoire d hématologie cellulaire et moléculaire, Faculte de Pharmacie, Paris
    Ann Biol Clin (Paris) 62:657-69. 2004
  2. ncbi request reprint [Mastocytosis: advances in molecular diagnosis and therapeutics]
    M Arock
    Laboratoire d hématologie cellulaire et moléculaire, Unité CNRS UMR 8147, Faculte de Pharmacie 4, avenue de l Observatoire, F75270 Paris Cedex
    Ann Pharm Fr 62:233-43. 2004
  3. ncbi request reprint Differentiation of human basophils: an overview of recent advances and pending questions
    Michel Arock
    Department of Cellular and Molecular Hematology, UPRES EA 2509, Faculty of Pharmacy, Paris, France
    J Leukoc Biol 71:557-64. 2002
  4. ncbi request reprint MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation
    P Poncet
    Unite d Immuno Allergie, Institut Pasteur, Paris, France
    J Leukoc Biol 66:105-12. 1999
  5. pmc Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France
    J Clin Invest 95:577-85. 1995
  6. ncbi request reprint Thrombopoietin induces histidine decarboxylase gene expression in c-mpl transfected UT7 cells
    M Pacilio
    CNRS UMR 8603, Paris V University, Necker Hospital, Paris, France
    Biochem Biophys Res Commun 285:1095-101. 2001
  7. ncbi request reprint Mast cells as a source and target for nitric oxide
    M Bidri
    Department of Cellular and Molecular Hematology, UPRES-EA 2509, Faculty of Pharmaceutical and Biological Sciences, Paris, France
    Int Immunopharmacol 1:1543-58. 2001
  8. ncbi request reprint Trends in histamine research: new functions during immune responses and hematopoiesis
    Elke Schneider
    CNRS UMR 8603 Université René Descartes Paris V, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Trends Immunol 23:255-63. 2002
  9. ncbi request reprint Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines
    Françoise Féménia
    UMR BIPAR, INRA ENVA AFSSA Paris XII, Ecole Nationale Veterinaire d Alfort, 94704 Maisons Alfort cedex, France
    Life Sci 77:808-23. 2005
  10. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004

Collaborators

  • S Latour
  • P Poncet
  • Elke Schneider
  • M Dy
  • W R Sperr
  • P Valent
  • Cem Akin
  • Dean D Metcalfe
  • Luis Escribano
  • Alberto Orfao
  • Stephan C Bischoff
  • M Triggiani
  • Karin Hartmann
  • Hans Peter Horny
  • K Sotlar
  • G Marone
  • K Brockow
  • Frédéric Feger
  • Nadine Ben Hamouda
  • Olivier Hermine
  • Patrice Dubreuil
  • Antoine Ribadeau Dumas
  • Jacques P Zappulla
  • Olivier Lortholary
  • Ying Yang
  • Cedric Baude
  • Laurence Leriche
  • Sonia Varadaradjalou
  • Katia Hanssens
  • David Ghez
  • Annick Cohen-Akenine
  • Alain Moussy
  • Felipe Suarez
  • Frédérique Soppelsa
  • Philippe Casassus
  • Hagay Sobol
  • Fabienne Palmerini
  • Fanny Lanternier
  • Adeline Catteau
  • Stephane Barete
  • Odile Malbec
  • Christine Bodemer
  • Veronique Godot
  • Marc Daëron
  • Marion Gabillot-Carré
  • Sébastien Letard
  • Françoise Féménia
  • Petra Kempna
  • Roland S Liblau
  • M Bidri
  • M Pacilio
  • Beatrice Sans
  • Richard Delarue
  • Beatrix Sans
  • Yael Zermati
  • Sylvie Fraytag
  • Phillip S Leventhal
  • Jean Pierre Kinet
  • Jean Marie Launay
  • Danièle Canioni
  • Sylvie Fraitag
  • Marc Humbert
  • Dominique Emilie
  • Bruno Iannascoli
  • Cecile Schiffer
  • Carine Flys
  • Gilles Garcia
  • Karine Roget
  • Francis Capel
  • Jean Pierre Zappulla
  • François Machavoine
  • Emmanuel Morelon
  • Guy Laurent
  • Antoine Ribadeau-Dumas
  • Yves Lepelletier
  • Aurélie Hermant
  • Paulo de Sepuvelda
  • Martine Humbert
  • Jacques Vargaftig
  • Roland Liblau
  • Christian Recher
  • Claude Delouis
  • Annie Alliot
  • Thomas Lilin
  • Georges Delsol
  • Alain Pinton
  • Nathalie Iannucceli
  • Gaelle Millet
  • Pascal Boireau
  • André Laurent Parodi

Detail Information

Publications26

  1. ncbi request reprint [Mastocytosis, classification, biological diagnosis and therapy]
    M Arock
    Unité CNRS UMR 8147, Laboratoire d hématologie cellulaire et moléculaire, Faculte de Pharmacie, Paris
    Ann Biol Clin (Paris) 62:657-69. 2004
    ..The current review provides an overview of mastocytosis and its subvariants, the new classification of these diseases, a practical guide for the biological diagnosis and advances and future directions in therapy of these pathologies...
  2. ncbi request reprint [Mastocytosis: advances in molecular diagnosis and therapeutics]
    M Arock
    Laboratoire d hématologie cellulaire et moléculaire, Unité CNRS UMR 8147, Faculte de Pharmacie 4, avenue de l Observatoire, F75270 Paris Cedex
    Ann Pharm Fr 62:233-43. 2004
    ..Finally, it would be possible to design, in the very next future, new tyrosine kinase inhibitors targeting specifically the mutant forms of c-Kit found in patients suffering from systemic mastocytosis...
  3. ncbi request reprint Differentiation of human basophils: an overview of recent advances and pending questions
    Michel Arock
    Department of Cellular and Molecular Hematology, UPRES EA 2509, Faculty of Pharmacy, Paris, France
    J Leukoc Biol 71:557-64. 2002
    ....
  4. ncbi request reprint MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation
    P Poncet
    Unite d Immuno Allergie, Institut Pasteur, Paris, France
    J Leukoc Biol 66:105-12. 1999
    ..e., MHC class II-dependent activation of CD4+ T cells, may be critical in subsequent cellular activation events because colocalization of mast and T cells is frequently observed at sites of antigen entry...
  5. pmc Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France
    J Clin Invest 95:577-85. 1995
    ..This regulation of Fc epsilon RI-mediated mast cell activation is of potential interest in mast cell physiology and in allergic pathology...
  6. ncbi request reprint Thrombopoietin induces histidine decarboxylase gene expression in c-mpl transfected UT7 cells
    M Pacilio
    CNRS UMR 8603, Paris V University, Necker Hospital, Paris, France
    Biochem Biophys Res Commun 285:1095-101. 2001
    ..Both PMA- and TPO-induced histamine synthesis was reduced by PKC and MEKs inhibitors, indicating that the induction occurred through a common signalling pathway...
  7. ncbi request reprint Mast cells as a source and target for nitric oxide
    M Bidri
    Department of Cellular and Molecular Hematology, UPRES-EA 2509, Faculty of Pharmaceutical and Biological Sciences, Paris, France
    Int Immunopharmacol 1:1543-58. 2001
    ....
  8. ncbi request reprint Trends in histamine research: new functions during immune responses and hematopoiesis
    Elke Schneider
    CNRS UMR 8603 Université René Descartes Paris V, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Trends Immunol 23:255-63. 2002
  9. ncbi request reprint Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines
    Françoise Féménia
    UMR BIPAR, INRA ENVA AFSSA Paris XII, Ecole Nationale Veterinaire d Alfort, 94704 Maisons Alfort cedex, France
    Life Sci 77:808-23. 2005
    ....
  10. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004
    ..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians...
  11. pmc Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
    Jacques P Zappulla
    Institut National de la Sante et de la Recherche Medicale U563, Centre de Physiopathologie de Toulouse Purpan, Purpan Hospital, 31000 Toulouse, France
    J Exp Med 202:1635-41. 2005
    ..These results demonstrate a causal link in vivo between the Asp816Val Kit mutation and MC neoplasia and suggest a basis for the clinical heterogeneity of human mastocytosis...
  12. ncbi request reprint Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
    Marion Gabillot-Carré
    CNRS UMR 8147, Universite Rene Descartes Paris V, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Blood 108:1065-72. 2006
    ..The data presented here provide a rationale to test whether rapamycin could be a possible treatment for SM and other hematologic malignancies with the D816V mutation...
  13. ncbi request reprint Peritoneal cell-derived mast cells: an in vitro model of mature serosal-type mouse mast cells
    Odile Malbec
    Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Institut Pasteur, Paris, France
    J Immunol 178:6465-75. 2007
    ..These properties make PCMC a useful new model for understanding the physiopathology of mast cells in IgE- and IgG-dependent tissue inflammation...
  14. ncbi request reprint H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12
    Veronique Godot
    Institut National de la Sante et de la Recherche Medicale, Universite Paris Sud 11, Faculte de Medecine Paris Sud, Institut Fédératif de Recherche 13, Clamart, France
    J Allergy Clin Immunol 120:827-34. 2007
    ..The pleiotropic effects of CXCL12 are enhanced by cofactors specific to the target cell...
  15. pmc Phenotypic and genotypic characteristics of mastocytosis according to the age of onset
    Fanny Lanternier
    Universite Paris V, Service de Maladies Infectieuses et Tropicales, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    PLoS ONE 3:e1906. 2008
    ..001). In conclusion, pathogenesis of mastocytosis significantly differs according to the age of disease's onset. Our data may have major therapeutic relevance when considering c-kit-targeted therapy...
  16. doi request reprint Ex vivo and in vitro primary mast cells
    Michel Arock
    Ecole Normale Superieure de Cachan, Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquées, Cachan, France
    Methods Mol Biol 415:241-54. 2008
    ....
  17. ncbi request reprint Mastocytosis: pathology, genetics, and current options for therapy
    Peter Valent
    Department of Internal Medicine I, Medical Univeristy of Vienna, Austria
    Leuk Lymphoma 46:35-48. 2005
    ..Examples include the use of STI571 in patients with SM plus hypereosinophilic syndrome (SM-HES) and the FIPL1/PDGFRA fusion gene target, or chemotherapy for eradication of AML in patients with SM-AML...
  18. ncbi request reprint Establishment and characterization of a new human erythroleukemic cell line, ERY-1
    Antoine Ribadeau Dumas
    Unité CNRS UMR 8147, Faculté de Pharmacie et Hôpital Necker 4, Avenue de l Observatoire 75006, Paris, France
    Leuk Res 28:1329-39. 2004
    ..In conclusion, ERY-1 is a new growth factor-independent human erythroleukemic cell line with a relatively mature phenotype that may be useful to study the molecular events involved in erythroblastic differentiation...
  19. ncbi request reprint Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    J Biol Chem 279:50700-9. 2004
    ..Inhibition of proliferation and PKB signaling in HMC-1 cells by vitamin E suggests a role in preventing diseases with mast cell involvement, such as allergies, atherosclerosis, and tumorigenesis...
  20. ncbi request reprint Diagnosis and treatment of systemic mastocytosis: state of the art
    Peter Valent
    Department of Internal Medicine I, Division of Haematology, University of Vienna, Austria
    Br J Haematol 122:695-717. 2003
  21. ncbi request reprint Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells
    Sonia Varadaradjalou
    CNRS FRE 2444, Faculty of Pharmacy, Paris V University, Paris, France
    Eur J Immunol 33:899-906. 2003
    ....
  22. ncbi request reprint Mast cells: new targets for multiple sclerosis therapy?
    Jacques P Zappulla
    INSERM U546, Pitie Salpetriere Hospital, 105 Boulevard de l Hôpital, 75634 Cedex 13, Paris, France
    J Neuroimmunol 131:5-20. 2002
    ..In addition to changing our views on the pathophysiology of multiple sclerosis, the concept that mast cells are critical for the outcome of the disease could have an important impact on the development of new therapeutic approaches...
  23. ncbi request reprint Signal transduction-associated and cell activation-linked antigens expressed in human mast cells
    Peter Valent
    Department of Internal Medicine I, University of Vienna, Austria
    Int J Hematol 75:357-62. 2002
    ..The current article gives an overview on signal transduction-associated and activation-linked antigens expressed in human MCs. Wherever possible the functional implication of signaling pathways and antigen expression are discussed...
  24. ncbi request reprint Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts
    Frédéric Feger
    Cellular and Molecular Hematology Unit, Faculty of Pharmacy, Paris, France
    Int Arch Allergy Immunol 127:110-4. 2002
    ..Such mutations are probably involved in the abnormal (SCF-independent) proliferation of MC in these patients. New therapeutic strategies may be envisaged to inhibit the deregulated kinase activity of these mutant forms of c-kit...
  25. ncbi request reprint The role of mast cells in host defense and their subversion by bacterial pathogens
    Frédéric Feger
    Dept of Cellular and Molecular Hematology, UPRES EA 2509, Faculty of Pharmacy, 4 avenue de l Observatoire, 75006, Paris, France
    Trends Immunol 23:151-8. 2002
    ..Elucidating how pathogens subvert the activities of MCs could provide clues to limiting the pathological activities of these cells during infectious diseases...
  26. pmc Case-control cohort study of patients' perceptions of disability in mastocytosis
    Olivier Hermine
    Service de Dermatologie, Centre de référence sur la mastocytose, Hopital Necker, Paris, France
    PLoS ONE 3:e2266. 2008
    ..We therefore performed a case-control cohort study to examine self-reported disability and impact of symptoms on the quality of life in patients with mastocytosis...