Research Topics
| I ArnulfSummaryCountry: France Publications
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Publications
Hyperoxia increases paradoxical sleep rhythm in the pontine catI Arnulf
UPRESS EA2397, Pitie Salpetriere Hospital, Paris, France
Brain Res 807:160-6. 1998..These findings show that PS is exquisitely sensitive to conditions that impair oxidative metabolism. The role of cholinergic executive PS systems as putative metabolic-sensitive neurons remains to be established...
[Kleine-Levin syndrome: state of the art]I Arnulf
Centre de référence maladies rares narcolepsie, hypersomnie et syndrome de Kleine Levin, France
Rev Neurol (Paris) 164:658-68. 2008..Case-reports, small series, meta-analysis and a recent large, prospective trio study are consistent with a homogeneous, genuine disease entity...- Kleine-Levin syndrome: a systematic review of 186 cases in the literatureI Arnulf
Stanford University Center for Narcolepsy, Palo Alto, CA, USA
Brain 128:2763-76. 2005..In conclusion, KLS is a unique disease which may be more severe in female and secondary cases... - Parkinson's disease and sleepiness: an integral part of PDI Arnulf
Fédération des pathologies du sommeil, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
Neurology 58:1019-24. 2002..To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents... - [Respiratory disorders during sleep in degenerative diseases of the brain stem]I Arnulf
Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, 75013 Paris
Rev Neurol (Paris) 157:S148-51. 2001..During amyotrophic lateral sclerosis, the progressive loss of phrenic nerve leads to a diaphragmatic dysfunction, dyspnea and a lesser survival. Adequate ventilation is jeopardized during REM sleep with a consequent loss of this state... - Severe restless legs syndrome presenting as intractable insomniaI Arnulf
, , , 75651 Paris Cedex 13, France
Neurology 62:E19. 2004 - Improvement of sleep architecture in PD with subthalamic nucleus stimulationI Arnulf
centre d investigation clinique, Fédération de Neurologie and INSERM U289, Paris, France
Neurology 55:1732-4. 2000..Total sleep time increased by 47%; wakefulness after sleep onset decreased by 51 minutes. Insomnia in patients with PD may predominantly result from nighttime motor disability... - Excessive daytime sleepiness in parkinsonismIsabelle Arnulf
Fédération des pathologies du sommeil, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Sleep Med Rev 9:185-200. 2005..EDS (and sometimes the narcolepsy-like phenotype) may also affect patients with atypical parkinsonism, such as dementia with Lewy bodies, multiple-system atrophy, and progressive supranuclear palsy... - Effect of low and high frequency thalamic stimulation on sleep in patients with Parkinson's disease and essential tremorI Arnulf
centre d investigation clinique, Fédération de Neurologie and INSERM U 289, Paris, France
J Sleep Res 9:55-62. 2000..Our results also suggest that low frequency stimulation applied in the region of the reticular nuclei does not induce sleep... - Sleep disorders and diaphragmatic function in patients with amyotrophic lateral sclerosisI Arnulf
Service de Pneumologie, UPRES EA 2397, Explorations Fonctionnelles Respiratoires, Neurologie et Explorations Fonctionnelles du Systeme Nerveux, Groupe Hospitalier Pitie Salpetriere, Paris, France
Am J Respir Crit Care Med 161:849-56. 2000..Median survival time was dramatically shorter (217 d) in Group 1 than in Group 2 (619 d, p = 0.015)... - Mid-morning tryptophan depletion delays REM sleep onset in healthy subjectsIsabelle Arnulf
AP HP, centre d investigation clinique, Fédération des Pathologies du Sommeil et UPRES EA 2397, Paris, France
Neuropsychopharmacology 27:843-51. 2002.... - Clinical predictive factors of subthalamic stimulation in Parkinson's diseaseM L Welter
Centre d'Investigation Clinique and INSERM U 289, , Paris, France
Brain 125:575-83. 2002.... - Hallucinations, REM sleep, and Parkinson's disease: a medical hypothesisI Arnulf
centre d investigation clinique, Fédération de Neurologie and INSERM U 289
Neurology 55:281-8. 2000..Patients with PD can have disabling visual hallucinations associated with dopaminergic therapy. Sleep disorders, including vivid dreams and REM sleep with motor behaviors (RBD), are frequent in these patients... - Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson diseaseV Mesnage
Centre d'Investigation Clinique, , Paris, France
Clin Neuropharmacol 27:108-10. 2004..In this exploratory randomized, double-blind, placebo-controlled study, at the dose used, the drugs tested were well tolerated and could not improve parkinsonian motor disability... - Residual sleepiness in obstructive sleep apnoea: phenotype and related symptomsC Vernet
Sleep Disorders Unit, UMR 975, National Reference Centre for Narcolepsy and Hypersomnia, Paris, France
Eur Respir J 38:98-105. 2011..The association between RES, periodic leg movements, apathy and depressive mood parallels the post-hypoxic lesions in noradrenaline, dopamine and serotonin systems in animals exposed to intermittent hypoxia... - Unawareness of naps in Parkinson's disease and in disorders with excessive daytime sleepinessM Merino-Andreu
, , , Paris, France
Neurology 60:1553-4. 2003 - Chronic hiccups and sleepI Arnulf
Service de Pneumologie et Laboratoire du Sommeil, , Paris, France
Sleep 19:227-31. 1996..Hiccups themselves were not responsible for any arousals or awakenings. We conclude that neural mechanisms responsible for hiccups are strongly influenced by sleep state and that hiccups disrupt sleep onset but not established sleep... - [Narcolepsy with cataplexy in the child: clinical evaluation and therapeutical management]M Lecendreux
centre pédiatrique des pathologies du sommeil, Hopital Robert Debre, Paris, France
Rev Neurol (Paris) 164:646-57. 2008.... - Does clinical rapid eye movement behavior disorder predict worse outcomes in Parkinson's disease?S Lavault
Unité des pathologies du sommeil, Assistance Publique Hopitaux de Paris APHP, Paris, France
J Neurol 257:1154-9. 2010..The fluctuation and disappearance of clinical RBD in some patients may be due to functional abnormalities rather than lesions... - [REM sleep behavior disorder: an overt access to motor and cognitive control during sleep]I Arnulf
Unité des pathologies du sommeil, Hopital Pitie Salpetriere, Groupe Hospitalier de la Pitié Salpêtrière, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Neurol (Paris) 166:785-92. 2010.... - The 'scanning hypothesis' of rapid eye movements during REM sleep: a review of the evidenceI Arnulf
Unité des pathologies du sommeil, Hopital Pitie Salpetriere, Paris, France
Arch Ital Biol 149:367-82. 2011..These results are consistent with the model of a brainstem generator activating simultaneously images, sounds, limbs movements and REMs in a coordinated parallel manner, as in a virtual reality... 
Parkinson's disease with camptocormiaF Bloch
, , Paris, France
J Neurol Neurosurg Psychiatry 77:1223-8. 2006....- Vivid dreams, hallucinations, psychosis and REM sleep in Guillain-Barré syndromeV Cochen
, , , Paris, France
Brain 128:2535-45. 2005..Sleep studies suggest that mental status abnormalities are wakeful dreams caused by a sleep and dream-associated disorder (status dissociatus)... - Effects of levodopa on pulmonary function in Parkinson's diseaseB Herer
Service de Pneumologie, Centre Médical de Forcilles, Ferolles Attilly, France
Chest 119:387-93. 2001..To investigate the effects of oral intake of levodopa on pulmonary function and UAO criteria in patients with PD, we studied 22 patients with PD... - [Sleep disorders during synucleopathies and taupathies]I Arnulf
Fédération des pathologies du sommeil, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris
Rev Neurol (Paris) 159:6S77-82. 2003..Recent evidences suggest that they may result from non dopaminergic lesions, including cholinergic neurons in the locus subcoeruleus and orexinergic neurons in the lateral hypothalamus... - [Normal and disordered sleep]I Arnulf
Fédération des pathologies du sommeil, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Boulevard de l Hopital, F 75651 Paris Cedex 13
Ann Pharm Fr 65:239-50. 2007..g. psychiatric insomnia, restless legs syndrome)... - [Restless-legs syndrome]E Karroum
UF pathologies du sommeil, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Pavillon Marguerite Bottard, Paris Cedex, France
Rev Neurol (Paris) 164:701-21. 2008..In severe, refractory or neuropathy-associated RLS, antiepileptic (gabapentin, pregabalin) or opioid (oxycodone, tramadol) drugs can be used... - Nonviolent elaborate behaviors may also occur in REM sleep behavior disorderD Oudiette
Sleep Disorders Unit, Pitie Salpetriere Hospital, APHP, Team 106, CRicm, and Paris 6 University, France
Neurology 72:551-7. 2009..To document unusual, nonviolent behaviors during REM sleep behavior disorder (RBD) and evaluate their frequency in Parkinson disease (PD)... - [Psychic disorders and somnolence]J L Houeto
, Centre d'Investigation Clinique, , Paris, France
Rev Neurol (Paris) 158:S102-7. 2002.... - [Acute exacerbation of restless legs syndrome during perioperative procedures: case reports and suggested management]E G Karroum
Unité des pathologies du sommeil, Groupe Hospitalier Pitie Salpetriere, AP HP, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Ann Fr Anesth Reanim 29:920-4. 2010.... - Effect of genetically caused excess of brain gamma-hydroxybutyric acid and GABA on sleepIsabelle Arnulf
Fédération des pathologies du sommeil, Hopital Pitie Salpetriere
Sleep 28:418-24. 2005..Exogenous gamma-hydroxybutyrate (GHB) increases slow-wave sleep and reduces daytime sleepiness and cataplexy in patients with primary narcolepsy... - REM sleep behavior disorder in patients with guadeloupean parkinsonism, a tauopathyValerie Cochen De Cock
Service de Neurologie, Hopital Saint Antoine, Paris, France
Sleep 30:1026-32. 2007..It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons... - An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patientsJian Sheng Lin
INSERM U628, 69373 Lyon, France Faculté de Médecine, Universite Claude Bernard, 69373 Lyon, France
Neurobiol Dis 30:74-83. 2008..H(3)-receptor inverse agonists could constitute a novel effective treatment of EDS, particularly when associated with modafinil... - Rapid eye movement sleep disturbances in Huntington diseaseIsabelle Arnulf
Pathologies du Sommeil, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris AP HP, and U106, University Pierre and Marie Curie, Paris Cedex 13, France
Arch Neurol 65:482-8. 2008..Sleep disorders including insomnia, movements during sleep, and daytime sleepiness are common but poorly studied in Huntington disease (HD)... - Kleine-Levin syndrome: a systematic study of 108 patientsIsabelle Arnulf
Stanford Center for Narcolepsy and Howard Hughes Medical Institute, Stanford University, Palo Alto, CA, USA
Ann Neurol 63:482-93. 2008..Kleine-Levin syndrome is a rare disorder characterized by relapsing-remitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality... - Abnormal sleep and sleepiness in Parkinson's diseaseIsabelle Arnulf
Sleep Disorders Unit, Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, and team 106, CRIMS, Pierre and Marie Curie University, Paris, France
Curr Opin Neurol 21:472-7. 2008..Recent data provide major advances in the mechanisms and consequences of rapid eye movement sleep behavior disorders, insomnia and narcolepsy-like daytime sleepiness... - Iron deficiency in children with attention-deficit/hyperactivity disorderEric Konofal
Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris, France
Arch Pediatr Adolesc Med 158:1113-5. 2004..Iron deficiency causes abnormal dopaminergic neurotransmission and may contribute to the physiopathology of attention-deficit/hyperactivity disorder (ADHD)... - Expiratory-synchronized sleep in a quadriplegic patient using inspiratory neck muscles to breatheIsabelle Arnulf
Service de Pneumologie, , , and UPRES EA 397, , Paris, France
Sleep Breath 7:143-6. 2003..This case report illustrates the powerful adaptability of the respiratory and sleep control systems to maintain each vital function... - Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in childrenEric Konofal
Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
Sleep Med 8:711-5. 2007..To date, the impact of iron deficiency, RLS and familial history of RLS on ADHD severity has been scarcely examined in children. These issues are addressed in the present study... - Sleep and sex: what can go wrong? A review of the literature on sleep related disorders and abnormal sexual behaviors and experiencesCarlos H Schenck
Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, USA
Sleep 30:683-702. 2007..To formulate the first classification of sleep related disorders and abnormal sexual behaviors and experiences... - REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsyIsabelle Arnulf
Fédération des Pathologies du Sommeil and Upres EA 2397, Paris, France
Sleep 28:349-54. 2005.... - Stages 1-2 non-rapid eye movement sleep behavior disorder associated with dementia: a new parasomnia?Isabelle Arnulf
Fédération des pathologies du sommeil, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
Mov Disord 20:1223-8. 2005..This newly described stages 1--2 non-REM sleep behavior disorder suggests that central motor pattern generators were disinhibited during non-REM sleep... - Effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorderEric Konofal
Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris, France
Pediatrics 116:e732-4. 2005..The Conners' Parent and Teacher Rating Scale raw total scores decreased to 19 and 13, respectively. This is the first report of the effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder... - Ropinirole in a child with attention-deficit hyperactivity disorder and restless legs syndromeEric Konofal
Service de Psychopathologie de l'Enfant et de l'Adolescent, , Paris, France
Pediatr Neurol 32:350-1. 2005..Treatment with the dopamine agonist ropinirole resulted in a significant improvement in both his attention-deficit hyperactivity disorder symptoms and sleep problems... - Effects of iron supplementation on attention deficit hyperactivity disorder in childrenEric Konofal
Hopital Robert Debre, Service de Psychopathologie de l Enfant et de l Adolescent, Paris, France
Pediatr Neurol 38:20-6. 2008..Iron therapy was well tolerated and effectiveness is comparable to stimulants... - Restoration of normal motor control in Parkinson's disease during REM sleepValerie Cochen De Cock
Service de Neurologie, Hopital Saint Antoine, Paris, France
Brain 130:450-6. 2007..These movements would eventually be transmitted to lower motor neurons because of brainstem lesions interrupting the pontomedullary pathways which mediate the REM sleep atonia... - Functional imaging of cataplexy during status cataplecticusDorothee Chabas
INSERM UMR 546 AVENIR, Paris, France
Sleep 30:153-6. 2007..To identify the neural structures and pathways underlying cataplexy during status cataplecticus in a narcoleptic patient, using brain perfusion single photon emission computed tomography (SPECT)... - Narcolepsy with cataplexyYves Dauvilliers
Neurologie, CHU Montpellier Hôpital Gui de Chauliac and INSERM U888, Montpellier France
Lancet 369:499-511. 2007..Because narcolepsy is an under-recognised disease, it is important that general practitioners and other primary health-care workers identify abnormal daytime sleepiness early... - English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentaryCarlos H Schenck
Minnesota Regional Sleep Disorders Center, Department of Psychiatry, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN 55415, USA
J Clin Sleep Med 3:301-11. 2007..To publish the first English translations, with commentary, of the original reports describing narcolepsy and cataplexy by Westphal in German (1877) and by Gélineau in French (1880)... - Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literatureSamuele Cortese
Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris, France
Sleep 28:1007-13. 2005.... - Genetics of restless legs syndrome (RLS): State-of-the-art and future directionsJuliane Winkelmann
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:S449-58. 2007..One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies... - Eating disorder and metabolism in narcoleptic patientsDorothee Chabas
Fédération des Maladies du Système Nerveux, Programme AVENIR, INSERM U546, France
Sleep 30:1267-73. 2007..To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy... - Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humansSelma Mehiri
Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, , , Paris, France
Respir Physiol Neurobiol 154:406-18. 2006.... - Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexyIsabelle Arnulf
Sleep 27:1242-3. 2004 - CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?Isabelle Arnulf
Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
Sleep 29:1017-24. 2006..To determine if hypocretin deficiency is associated with abnormally low serum leptin levels, a putative cause of increased body mass index in narcoleptics... - Family-based association study of the restless legs syndrome loci 2 and 3 in a European populationDavid Kemlink
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:207-12. 2007..0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS... - Sleep disturbances in patients with parkinsonismValerie Cochen De Cock
National Center for MSA, Sleep Department, Purpan Hospital, Toulouse, France
Nat Clin Pract Neurol 4:254-66. 2008..The use of dopamine agonists increases the risk of sleep attacks, especially when driving, suggesting a drug-disease interaction... - Diagnostic indicators of restless legs syndrome in primary care consultations: the DESYR studyAnne Crochard
Laboratoire GlaxoSmithKline, Marly le Roi, France
Mov Disord 22:791-7; quiz 907. 2007..7% a hypnotic, and 41.5% an anxiolytic. Complaints of sleep or leg symptoms are frequently associated with a diagnosis of RLS, and their presence should alert the physician to the possibility of a differential diagnosis of RLS...