Robert A Arkowitz

Summary

Country: France

Publications

  1. pmc A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth
    Aurélia Vernay
    Institute of Biology Valrose, université Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    J Cell Biol 198:711-30. 2012
  2. doi request reprint Cell polarity: wanderful exploration in yeast sex
    Robert A Arkowitz
    université Nice Sophia Antipolis, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France
    Curr Biol 23:R10-2. 2013
  3. doi request reprint Polarized growth in fungi: symmetry breaking and hyphal formation
    Robert A Arkowitz
    Centre National de la Recherche Scientifique and Université de Nice Sophia Antipolis, Institute of Developmental Biology and Cancer, CNRS UMR6543 Faculté des Sciences, Nice, France
    Semin Cell Dev Biol 22:806-15. 2011
  4. pmc Chemical gradients and chemotropism in yeast
    Robert A Arkowitz
    Institute of Developmental Biology and Cancer, Université de Nice Sophia Antipolis CNRS UMR6543, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Cold Spring Harb Perspect Biol 1:a001958. 2009
  5. ncbi request reprint Cell polarity: connecting to the cortex
    R A Arkowitz
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre de Biochimie, Université de Nice Faculté des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Curr Biol 11:R610-2. 2001
  6. ncbi request reprint Oligomerization regulates the localization of Cdc24, the Cdc42 activator in Saccharomyces cerevisiae
    Cyril Mionnet
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    J Biol Chem 283:17515-30. 2008
  7. pmc Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating
    Sophie Barale
    Institute of Signaling, Developmental Biology, and Cancer, Centre National de la Recherche Scientifique UMR 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Mol Biol Cell 17:2824-38. 2006
  8. pmc Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans
    Hannah Hope
    Institute of Developmental Biology and Cancer, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Mol Biol Cell 19:3638-51. 2008
  9. pmc Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth
    Martine Bassilana
    Institute of Signaling, Developmental Biology, and Cancer, UMR 6543 Centre National de la Recherche Scientifique, Centre de Biochimie, University of Nice, 06108 Nice, France
    Eukaryot Cell 4:588-603. 2005
  10. ncbi request reprint The Candida albicans ELMO homologue functions together with Rac1 and Dck1, upstream of the MAP Kinase Cek1, in invasive filamentous growth
    Hannah Hope
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Universite de Nice Sophia Antipolis, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Mol Microbiol 76:1572-90. 2010

Collaborators

  • Martine Bassilana
  • Danièle Stalder
  • Hannah Hope
  • Isabelle Guillas
  • Aurélia Vernay
  • Sophie Barale
  • Stéphanie Bogliolo
  • Vincent Corvest
  • Romain Vauchelles
  • Peter J Follette
  • Cyril Mionnet
  • Derek McCusker
  • Peter Follette
  • Jean Jacques Vitagliano
  • Sebastien Schaub
  • Christian Schmauch
  • Thomas Botton

Detail Information

Publications17

  1. pmc A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth
    Aurélia Vernay
    Institute of Biology Valrose, université Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    J Cell Biol 198:711-30. 2012
    ..Furthermore, we propose that slow membrane diffusion of PI(4,5)P(2) contributes to the maintenance of such a gradient...
  2. doi request reprint Cell polarity: wanderful exploration in yeast sex
    Robert A Arkowitz
    université Nice Sophia Antipolis, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France
    Curr Biol 23:R10-2. 2013
    ..Two new studies reveal that polarity proteins are highly dynamic in yeast cells responding to a pheromone gradient and suggest that this behavior is important for robust directional growth...
  3. doi request reprint Polarized growth in fungi: symmetry breaking and hyphal formation
    Robert A Arkowitz
    Centre National de la Recherche Scientifique and Université de Nice Sophia Antipolis, Institute of Developmental Biology and Cancer, CNRS UMR6543 Faculté des Sciences, Nice, France
    Semin Cell Dev Biol 22:806-15. 2011
    ..This review discusses how cells break symmetry using the yeast S. cerevisiae paradigm and how polarized growth is initiated and maintained to result in dramatic morphological changes during C. albicans hyphal growth...
  4. pmc Chemical gradients and chemotropism in yeast
    Robert A Arkowitz
    Institute of Developmental Biology and Cancer, Université de Nice Sophia Antipolis CNRS UMR6543, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Cold Spring Harb Perspect Biol 1:a001958. 2009
    ....
  5. ncbi request reprint Cell polarity: connecting to the cortex
    R A Arkowitz
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre de Biochimie, Université de Nice Faculté des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Curr Biol 11:R610-2. 2001
    ..The GDP--GTP exchange factor of this module, Bud5, has now been localized to sites of cell division and shown to interact with a transmembrane protein that marks these sites...
  6. ncbi request reprint Oligomerization regulates the localization of Cdc24, the Cdc42 activator in Saccharomyces cerevisiae
    Cyril Mionnet
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    J Biol Chem 283:17515-30. 2008
    ..Together, our results suggest that Cdc24p oligomerization regulates Cdc42p activation via its localization...
  7. pmc Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating
    Sophie Barale
    Institute of Signaling, Developmental Biology, and Cancer, Centre National de la Recherche Scientifique UMR 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Mol Biol Cell 17:2824-38. 2006
    ..Taken together, our results indicate that Cdc42p GDP-GTP cycling is critical for efficient cell fusion...
  8. pmc Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans
    Hannah Hope
    Institute of Developmental Biology and Cancer, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Mol Biol Cell 19:3638-51. 2008
    ..We conclude that specific exchange factors, together with the G proteins they activate, are required for morphological changes in response to different stimuli...
  9. pmc Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth
    Martine Bassilana
    Institute of Signaling, Developmental Biology, and Cancer, UMR 6543 Centre National de la Recherche Scientifique, Centre de Biochimie, University of Nice, 06108 Nice, France
    Eukaryot Cell 4:588-603. 2005
    ..These results suggest that a positive feedback loop between Cdc24 and Tec1 contributes to an increase in active Cdc42 at the tip of the germ tube which is important for hypha formation...
  10. ncbi request reprint The Candida albicans ELMO homologue functions together with Rac1 and Dck1, upstream of the MAP Kinase Cek1, in invasive filamentous growth
    Hannah Hope
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Universite de Nice Sophia Antipolis, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Mol Microbiol 76:1572-90. 2010
    ..We conclude that the requirement of ELMO/CED12 family members for Rac1 function is conserved from fungi to humans...
  11. pmc Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans
    Martine Bassilana
    Institute of Signaling, Developmental Biology, and Cancer, UMR 6543 Centre National de la Recherche Scientifique, University of Nice, 06108 Nice, France
    Eukaryot Cell 2:9-18. 2003
    ..These results indicate that a specific regulation of Cdc24/Cdc42 activity is required for invasive hyphal growth and suggest that these proteins are required for pathogenicity of C. albicans...
  12. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate is required for invasive growth in Saccharomyces cerevisiae
    Isabelle Guillas
    université Nice Sophia Antipolis, Institute of Biology Valrose, 06108 Nice Cedex 2, France
    J Cell Sci 126:3602-14. 2013
    ..Taken together, our results indicate that plasma membrane PtdIns(4,5)P2 is crucial for yeast invasive growth and suggest that this phospholipid functions upstream of the cAMP-dependent protein kinase A signaling pathway...
  13. doi request reprint Spatiotemporal regulation of Rho1 and Cdc42 activity during Candida albicans filamentous growth
    Vincent Corvest
    université Nice Sophia Antipolis, Institute of Biology Valrose, Parc Valrose, 06108, Nice Cedex 2, France
    Mol Microbiol 89:626-48. 2013
    ..Together, our results point towards different regulation of Cdc42 and Rho1 activity during initiation and maintenance of filamentous growth. ..
  14. pmc Rac1 and Cdc42 have different roles in Candida albicans development
    Martine Bassilana
    Institute of Signaling, Developmental Biology, and Cancer, CNRS UMR 6543, Universite de Nice, Faculté des Sciences Parc Valrose, 06108 Nice Cedex 2, France
    Eukaryot Cell 5:321-9. 2006
    ..Thus, Rac1 and Cdc42, although highly similar to one another, have different roles in C. albicans development...
  15. pmc The exchange factor Cdc24 is required for cell fusion during yeast mating
    Sophie Barale
    Institute of Signaling, Developmental Biology, and Cancer, CNRS UMR 6543, Faculté des Sciences Parc Valrose, Universite de Nice, 06108 Nice Cedex 2, France
    Eukaryot Cell 3:1049-61. 2004
    ..Our results indicate that the exchange factor Cdc24p is necessary for maintaining or restricting specific proteins required for cell fusion to the cell contact region during mating...
  16. doi request reprint Chemotropism during yeast mating
    Peter J Follette
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, University of Nice Sophia Antipolis, Nice, France
    Methods Mol Biol 571:99-110. 2009
    ..Two methods of assessing the ability of yeast strains to respond to pheromone gradients are presented here...
  17. pmc Rac1 dynamics in the human opportunistic fungal pathogen Candida albicans
    Romain Vauchelles
    Institute of Developmental Biology and Cancer, Centre National de la Recherche Scientifique UMR 6543, Universite de Nice, Faculté des Sciences Parc Valrose, Nice, France
    PLoS ONE 5:e15400. 2010
    ..albicans Rac1. Taken together our results indicate that Rac1 nuclear accumulation is an inherent property of this G-protein and suggest that the requirements for its nucleo-cytoplasmic shuttling are conserved from fungi to humans...