Victor Appay

Summary

Country: France

Publications

  1. ncbi request reprint New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Immunol 177:1670-8. 2006
  2. ncbi request reprint Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Eur J Immunol 36:1805-14. 2006
  3. ncbi request reprint Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples
    Victor Appay
    Immunology Group, Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Immunol Methods 309:192-9. 2006
  4. ncbi request reprint Accelerated immune senescence and HIV-1 infection
    Victor Appay
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Exp Gerontol 42:432-7. 2007
  5. ncbi request reprint Immune activation and inflammation in HIV-1 infection: causes and consequences
    V Appay
    Cellular Immunology Laboratory, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Pathol 214:231-41. 2008
  6. doi request reprint Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    Victor Appay
    INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
    AIDS 25:1813-22. 2011
  7. ncbi request reprint Combination of transient lymphodepletion with busulfan and fludarabine and peptide vaccination in a phase I clinical trial for patients with advanced melanoma
    Victor Appay
    Multidisciplinary Oncology Center, University of Lausanne Hospitals CHUV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunother 30:240-50. 2007
  8. doi request reprint Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor
    Verena Voelter
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Int Immunol 20:1087-96. 2008
  9. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
  10. doi request reprint Impact of 3 different short-term chemotherapy regimens on lymphocyte-depletion and reconstitution in melanoma patients
    Julien Laurent
    Multidisciplinary Oncology Center, University of Lausanne Hospitals, Ludwig Institute for Cancer Research Ltd, University of Lausanne, Switzerland
    J Immunother 33:723-34. 2010

Detail Information

Publications43

  1. ncbi request reprint New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Immunol 177:1670-8. 2006
    ....
  2. ncbi request reprint Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Eur J Immunol 36:1805-14. 2006
    ..Importantly, these cells are tumor-reactive...
  3. ncbi request reprint Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples
    Victor Appay
    Immunology Group, Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Immunol Methods 309:192-9. 2006
    ..While the need to purify and cryopreserve PBMC for subsequent studies is obvious, the use of whole blood has the advantage of providing unbiased results and only small amounts of blood are used...
  4. ncbi request reprint Accelerated immune senescence and HIV-1 infection
    Victor Appay
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Exp Gerontol 42:432-7. 2007
    ..Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation...
  5. ncbi request reprint Immune activation and inflammation in HIV-1 infection: causes and consequences
    V Appay
    Cellular Immunology Laboratory, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Pathol 214:231-41. 2008
    ..A simplified model of HIV pathogenesis is proposed, which links together the three major facets of HIV-1 infection: the massive depletion of CD4(+) T cells, the paradoxical immune activation and the exhaustion of regenerative capacity...
  6. doi request reprint Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    Victor Appay
    INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
    AIDS 25:1813-22. 2011
    ....
  7. ncbi request reprint Combination of transient lymphodepletion with busulfan and fludarabine and peptide vaccination in a phase I clinical trial for patients with advanced melanoma
    Victor Appay
    Multidisciplinary Oncology Center, University of Lausanne Hospitals CHUV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunother 30:240-50. 2007
    ..Overall, these data provide further ground for the development of immunotherapeutic approaches to be both effective against melanoma and applicable in clinic...
  8. doi request reprint Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor
    Verena Voelter
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Int Immunol 20:1087-96. 2008
    ..Finally, we discuss potential perspectives regarding the role of such cells in heterologous immunity, by influencing the balance between protective immunity and pathology, e.g. in the case of melanoma development...
  9. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  10. doi request reprint Impact of 3 different short-term chemotherapy regimens on lymphocyte-depletion and reconstitution in melanoma patients
    Julien Laurent
    Multidisciplinary Oncology Center, University of Lausanne Hospitals, Ludwig Institute for Cancer Research Ltd, University of Lausanne, Switzerland
    J Immunother 33:723-34. 2010
    ..We conclude that short-term chemotherapy promoted homeostatic lymphocyte proliferation depending on the intensity of lymphocyte depletion, however without preferential expansion of tumor antigen-specific T cells...
  11. doi request reprint Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults
    Delphine Sauce
    INSERM Unité Mixte de Recherche S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
    J Immunol 189:5541-8. 2012
    ..Our findings support the establishment of homeostatic regulation of naive T cell proliferation in humans. This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized patients...
  12. pmc Evidence of premature immune aging in patients thymectomized during early childhood
    Delphine Sauce
    Infections and Immunity, INSERM UMRS 945, Avenir Group, Hopital Pitie Salpetriere, UPMC University of Paris 06, Paris, France
    J Clin Invest 119:3070-8. 2009
    ..Overall, our data highlight the importance of the thymus in maintaining the integrity of T cell immunity during adult life...
  13. doi request reprint Differential impact of age and cytomegalovirus infection on the γδ T cell compartment
    Antoine Roux
    INSERM Unité Mixte de Recherche S945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
    J Immunol 191:1300-6. 2013
    ..This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens. ..
  14. pmc HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
    ..These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments...
  15. ncbi request reprint PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    AIDS 21:2005-13. 2007
    ..Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans...
  16. pmc The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
    Victor Appay
    Infections and Immunity, INSERM UMR S 945, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Aging (Albany NY) 2:78-81. 2010
    ..These studies represent new advances in our appreciation of the role of the thymus in humans and more generally in our understanding of the development of immunosenescence...
  17. pmc Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    Jorge R Almeida
    Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
    J Exp Med 204:2473-85. 2007
    ..Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines...
  18. ncbi request reprint Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineages
    Victor Appay
    Cellular Immunology Laboratory, Institut National de la Santé et de la Recherche Médical U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol 179:7406-14. 2007
    ....
  19. doi request reprint CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation
    Antoine Roux
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, 75013 Paris, France
    Clin Immunol 148:16-26. 2013
    ..These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection...
  20. doi request reprint CD8+ T cell efficacy in vaccination and disease
    Victor Appay
    Cellular Immunology Laboratory, Institut Nationale de la Santé et de la Recherche Médicale U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 06, 91 Boulevard de l Hopital, 75013 Paris, France
    Nat Med 14:623-8. 2008
    ..This new knowledge paves the way to the design of more effective T cell vaccines and highlights the importance of comprehensive immunomonitoring...
  21. doi request reprint Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Immunol Lett 149:119-22. 2013
    ..These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope...
  22. pmc Evaluating cellular polyfunctionality with a novel polyfunctionality index
    Martin Larsen
    Institut National de la Santé et de la Recherche Médicale UMR S 945, Paris, France
    PLoS ONE 7:e42403. 2012
    ..We believe that the polyfunctionality index will render polyfunctionality an appropriate end-point measure in future studies of T cell responsiveness...
  23. doi request reprint Altered thymic activity in early life: how does it affect the immune system in young adults?
    Delphine Sauce
    INSERM UMR S 945, Universite Pierre et Marie Curie PARIS6, Infections and Immunity, Hopital Pitie Salpetriere, Paris, France
    Curr Opin Immunol 23:543-8. 2011
    ..These works highlight the importance of the thymic function in preserving immune efficacy throughout life, and provide insights into the development of immune aging...
  24. pmc Escape from highly effective public CD8+ T-cell clonotypes by HIV
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 118:2138-49. 2011
    ..These findings provide refined mechanistic insights into the workings of an effective CD8(+) T-cell response against HIV...
  25. doi request reprint Monitoring cellular immune markers in HIV infection: from activation to exhaustion
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Paris, France
    Curr Opin HIV AIDS 8:125-31. 2013
    ..The thorough study of HIV pathogenesis is increasingly more challenging...
  26. pmc Exhausted cytotoxic control of Epstein-Barr virus in human lupus
    Martin Larsen
    Institut National de la Santé et de la Recherche Médicale Inserm UMR S 945, Paris, France
    PLoS Pathog 7:e1002328. 2011
    ..We therefore propose that autoimmune B cell activation during flares drives frequent EBV reactivation, which contributes in a vicious circle to the perpetuation of immune activation in SLE patients...
  27. ncbi request reprint Cell permeabilization for the assessment of T lymphocyte polyfunctional capacity
    Laura Papagno
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol Methods 328:182-8. 2007
    ..It is important to be aware of this potential bias and to design specific application/experimental procedures in order to obtain optimal results...
  28. doi request reprint Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Paris, France
    Curr Opin HIV AIDS 6:157-62. 2011
    ..We discuss why the modulation of these factors represents an interesting approach for the rational design of HIV vaccines...
  29. pmc CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope
    Sylvain Cardinaud
    INSERM, UMR S945, Université Pierre et Marie Curie UPMC, Paris, France
    PLoS Pathog 7:e1002049. 2011
    ..Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes...
  30. ncbi request reprint Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV
    François Boutboul
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    AIDS 19:1981-6. 2005
    ....
  31. doi request reprint Phenotype and function of human T lymphocyte subsets: consensus and issues
    Victor Appay
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, 75013 Paris, France
    Cytometry A 73:975-83. 2008
    ..Finally, we discuss the problems which still limit general agreement...
  32. doi request reprint 25 years of HIV research! ... and what about a vaccine?
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Eur J Immunol 39:1999-2003. 2009
    ..HIV vaccine research discovery may only be at its dawn...
  33. ncbi request reprint The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Immunol Methods 268:9-19. 2002
    ..Understanding how antigen-specific cells develop and function in different circumstances and pathologies will be the key to unravelling the secrets of our cellular immune system...
  34. pmc Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation
    Robert Thimme
    Institute for Medical Microbiology and Hygiene, Department of Immunology, Hermann Herder Str 11, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 79:12112-6. 2005
    ..Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation...
  35. ncbi request reprint Correlates of delayed disease progression in HIV-1-infected Kenyan children
    Rana Chakraborty
    Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
    J Immunol 174:8191-9. 2005
    ..As HIV-1-specific helper cells support anti-HIV-1 effector responses in active disease, their presence may be important in delaying disease progression...
  36. ncbi request reprint Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    AIDS 16:161-70. 2002
    ..It leads to significant reductions of plasma viremia, often to undetectable levels, but it can also be linked with the reduction and disappearance of detectable HIV-specific CD8 T-cell responses...
  37. pmc HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor
    Tao Dong
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS UK
    J Exp Med 200:1547-57. 2004
    ..Selection of Vbeta13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome...
  38. ncbi request reprint Premature ageing of the immune system: the cause of AIDS?
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DS
    Trends Immunol 23:580-5. 2002
    ..This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus...
  39. pmc Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    Laura Papagno
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Biol 2:E20. 2004
    ..It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system...
  40. pmc Mature CD8(+) T lymphocyte response to viral infection during fetal life
    Arnaud Marchant
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 111:1747-55. 2003
    ..The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens...
  41. ncbi request reprint Dynamics of T cell responses in HIV infection
    Victor Appay
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:3660-6. 2002
    ..These observations have significant implications for our understanding of T cell responses in human viral infections in general and indicate that the definition of effector and memory subsets in humans may need revision...
  42. ncbi request reprint Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Victor Appay
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Med 8:379-85. 2002
    ..These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate...
  43. ncbi request reprint Characterization of CD4(+) CTLs ex vivo
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:5954-8. 2002
    ..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...