Victor Appay

Summary

Country: France

Publications

  1. ncbi Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    Bruno Salaun
    Division of Clinical Onco Immunology, Ludwig Center for Cancer Research of the University of Lausanne, Switzerland
    J Transl Med 9:44. 2011
  2. ncbi The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
    Victor Appay
    Infections and Immunity, INSERM UMR S 945, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Aging (Albany NY) 2:78-81. 2010
  3. ncbi 25 years of HIV research! ... and what about a vaccine?
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Eur J Immunol 39:1999-2003. 2009
  4. ncbi Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Paris, France
    Curr Opin HIV AIDS 6:157-62. 2011
  5. ncbi Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    Victor Appay
    INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
    AIDS 25:1813-22. 2011
  6. ncbi Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
  7. ncbi Evidence of premature immune aging in patients thymectomized during early childhood
    Delphine Sauce
    Infections and Immunity, INSERM UMRS 945, Avenir Group, Hopital Pitie Salpetriere, UPMC University of Paris 06, Paris, France
    J Clin Invest 119:3070-8. 2009
  8. ncbi HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
  9. ncbi Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    Jorge R Almeida
    Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
    J Exp Med 204:2473-85. 2007
  10. ncbi PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    AIDS 21:2005-13. 2007

Collaborators

Detail Information

Publications22

  1. ncbi Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    Bruno Salaun
    Division of Clinical Onco Immunology, Ludwig Center for Cancer Research of the University of Lausanne, Switzerland
    J Transl Med 9:44. 2011
    ..MicroRNAs have been recently shown to play a key role in the regulation of haematopoiesis in mouse, but their implication in peripheral lymphocyte differentiation in humans remains largely unknown...
  2. ncbi The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
    Victor Appay
    Infections and Immunity, INSERM UMR S 945, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Aging (Albany NY) 2:78-81. 2010
    ..These studies represent new advances in our appreciation of the role of the thymus in humans and more generally in our understanding of the development of immunosenescence...
  3. ncbi 25 years of HIV research! ... and what about a vaccine?
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Eur J Immunol 39:1999-2003. 2009
    ..HIV vaccine research discovery may only be at its dawn...
  4. ncbi Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Paris, France
    Curr Opin HIV AIDS 6:157-62. 2011
    ..We discuss why the modulation of these factors represents an interesting approach for the rational design of HIV vaccines...
  5. ncbi Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    Victor Appay
    INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
    AIDS 25:1813-22. 2011
    ....
  6. ncbi Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  7. ncbi Evidence of premature immune aging in patients thymectomized during early childhood
    Delphine Sauce
    Infections and Immunity, INSERM UMRS 945, Avenir Group, Hopital Pitie Salpetriere, UPMC University of Paris 06, Paris, France
    J Clin Invest 119:3070-8. 2009
    ..Overall, our data highlight the importance of the thymus in maintaining the integrity of T cell immunity during adult life...
  8. ncbi HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
    ..These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments...
  9. ncbi Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    Jorge R Almeida
    Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
    J Exp Med 204:2473-85. 2007
    ..Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines...
  10. ncbi PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    AIDS 21:2005-13. 2007
    ..Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans...
  11. ncbi Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults
    Delphine Sauce
    INSERM Unité Mixte de Recherche S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
    J Immunol 189:5541-8. 2012
    ..Our findings support the establishment of homeostatic regulation of naive T cell proliferation in humans. This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized patients...
  12. ncbi Accelerated immune senescence and HIV-1 infection
    Victor Appay
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Exp Gerontol 42:432-7. 2007
    ..Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation...
  13. ncbi Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineages
    Victor Appay
    Cellular Immunology Laboratory, Institut National de la Santé et de la Recherche Médical U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol 179:7406-14. 2007
    ....
  14. ncbi Cell permeabilization for the assessment of T lymphocyte polyfunctional capacity
    Laura Papagno
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol Methods 328:182-8. 2007
    ..It is important to be aware of this potential bias and to design specific application/experimental procedures in order to obtain optimal results...
  15. ncbi Escape from highly effective public CD8+ T-cell clonotypes by HIV
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 118:2138-49. 2011
    ..These findings provide refined mechanistic insights into the workings of an effective CD8(+) T-cell response against HIV...
  16. ncbi Altered thymic activity in early life: how does it affect the immune system in young adults?
    Delphine Sauce
    INSERM UMR S 945, Universite Pierre et Marie Curie PARIS6, Infections and Immunity, Hopital Pitie Salpetriere, Paris, France
    Curr Opin Immunol 23:543-8. 2011
    ..These works highlight the importance of the thymic function in preserving immune efficacy throughout life, and provide insights into the development of immune aging...
  17. ncbi CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope
    Sylvain Cardinaud
    INSERM, UMR S945, Université Pierre et Marie Curie UPMC, Paris, France
    PLoS Pathog 7:e1002049. 2011
    ..Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes...
  18. ncbi Evaluating cellular polyfunctionality with a novel polyfunctionality index
    Martin Larsen
    Institut National de la Santé et de la Recherche Médicale UMR S 945, Paris, France
    PLoS ONE 7:e42403. 2012
    ..We believe that the polyfunctionality index will render polyfunctionality an appropriate end-point measure in future studies of T cell responsiveness...
  19. ncbi Exhausted cytotoxic control of Epstein-Barr virus in human lupus
    Martin Larsen
    Institut National de la Santé et de la Recherche Médicale Inserm UMR S 945, Paris, France
    PLoS Pathog 7:e1002328. 2011
    ..We therefore propose that autoimmune B cell activation during flares drives frequent EBV reactivation, which contributes in a vicious circle to the perpetuation of immune activation in SLE patients...
  20. ncbi CD8+ T cell efficacy in vaccination and disease
    Victor Appay
    Cellular Immunology Laboratory, Institut Nationale de la Santé et de la Recherche Médicale U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 06, 91 Boulevard de l Hopital, 75013 Paris, France
    Nat Med 14:623-8. 2008
    ..This new knowledge paves the way to the design of more effective T cell vaccines and highlights the importance of comprehensive immunomonitoring...
  21. ncbi Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV
    François Boutboul
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    AIDS 19:1981-6. 2005
    ....
  22. ncbi Phenotype and function of human T lymphocyte subsets: consensus and issues
    Victor Appay
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, 75013 Paris, France
    Cytometry A 73:975-83. 2008
    ..Finally, we discuss the problems which still limit general agreement...