Victor Appay

Summary

Country: France

Publications

  1. ncbi request reprint Naive T cells: the crux of cellular immune aging?
    Victor Appay
    Sorbonne Universités, Universite Pierre et Marie Curie, CR7, Centre d Immunologie et des Maladies Infectieuses CIMI, F 75013, Paris, France Electronic address
    Exp Gerontol 54:90-3. 2014
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  3. pmc Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    Bruno Salaun
    Division of Clinical Onco Immunology, Ludwig Center for Cancer Research of the University of Lausanne, Switzerland
    J Transl Med 9:44. 2011
  4. pmc The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
    Victor Appay
    Infections and Immunity, INSERM UMR S 945, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Aging (Albany NY) 2:78-81. 2010
  5. doi request reprint 25 years of HIV research! ... and what about a vaccine?
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Eur J Immunol 39:1999-2003. 2009
  6. doi request reprint Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    Victor Appay
    INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
    AIDS 25:1813-22. 2011
  7. doi request reprint Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Paris, France
    Curr Opin HIV AIDS 6:157-62. 2011
  8. doi request reprint Differential impact of age and cytomegalovirus infection on the γδ T cell compartment
    Antoine Roux
    INSERM Unité Mixte de Recherche S945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
    J Immunol 191:1300-6. 2013
  9. pmc Evidence of premature immune aging in patients thymectomized during early childhood
    Delphine Sauce
    Infections and Immunity, INSERM UMRS 945, Avenir Group, Hopital Pitie Salpetriere, UPMC University of Paris 06, Paris, France
    J Clin Invest 119:3070-8. 2009
  10. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Naive T cells: the crux of cellular immune aging?
    Victor Appay
    Sorbonne Universités, Universite Pierre et Marie Curie, CR7, Centre d Immunologie et des Maladies Infectieuses CIMI, F 75013, Paris, France Electronic address
    Exp Gerontol 54:90-3. 2014
    ..Increasing focus on the study of naïve T cells (in particular CD8(+)) in old humans are needed to fill the gaps in our understanding of reduced cellular immunity with aging. ..
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  3. pmc Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    Bruno Salaun
    Division of Clinical Onco Immunology, Ludwig Center for Cancer Research of the University of Lausanne, Switzerland
    J Transl Med 9:44. 2011
    ..MicroRNAs have been recently shown to play a key role in the regulation of haematopoiesis in mouse, but their implication in peripheral lymphocyte differentiation in humans remains largely unknown...
  4. pmc The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
    Victor Appay
    Infections and Immunity, INSERM UMR S 945, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Aging (Albany NY) 2:78-81. 2010
    ..These studies represent new advances in our appreciation of the role of the thymus in humans and more generally in our understanding of the development of immunosenescence...
  5. doi request reprint 25 years of HIV research! ... and what about a vaccine?
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    Eur J Immunol 39:1999-2003. 2009
    ..HIV vaccine research discovery may only be at its dawn...
  6. doi request reprint Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
    Victor Appay
    INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
    AIDS 25:1813-22. 2011
    ....
  7. doi request reprint Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
    Victor Appay
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Paris, France
    Curr Opin HIV AIDS 6:157-62. 2011
    ..We discuss why the modulation of these factors represents an interesting approach for the rational design of HIV vaccines...
  8. doi request reprint Differential impact of age and cytomegalovirus infection on the γδ T cell compartment
    Antoine Roux
    INSERM Unité Mixte de Recherche S945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
    J Immunol 191:1300-6. 2013
    ..This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens. ..
  9. pmc Evidence of premature immune aging in patients thymectomized during early childhood
    Delphine Sauce
    Infections and Immunity, INSERM UMRS 945, Avenir Group, Hopital Pitie Salpetriere, UPMC University of Paris 06, Paris, France
    J Clin Invest 119:3070-8. 2009
    ..Overall, our data highlight the importance of the thymus in maintaining the integrity of T cell immunity during adult life...
  10. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  11. doi request reprint Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults
    Delphine Sauce
    INSERM Unité Mixte de Recherche S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
    J Immunol 189:5541-8. 2012
    ..Our findings support the establishment of homeostatic regulation of naive T cell proliferation in humans. This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized patients...
  12. doi request reprint CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation
    Antoine Roux
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, 75013 Paris, France
    Clin Immunol 148:16-26. 2013
    ..These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection...
  13. pmc HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
    ..These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments...
  14. pmc Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    Jorge R Almeida
    Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
    J Exp Med 204:2473-85. 2007
    ..Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines...
  15. ncbi request reprint PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    AIDS 21:2005-13. 2007
    ..Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans...
  16. ncbi request reprint Accelerated immune senescence and HIV-1 infection
    Victor Appay
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Exp Gerontol 42:432-7. 2007
    ..Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation...
  17. ncbi request reprint The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
    Anna Lissina
    aINSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, Paris, France bInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France Anna Lissina and Solène Fastenackels contributed equally to this writing of this work Current address Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    AIDS 28:477-86. 2014
    ....
  18. doi request reprint Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Immunol Lett 149:119-22. 2013
    ..These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope...
  19. pmc Evaluating cellular polyfunctionality with a novel polyfunctionality index
    Martin Larsen
    Institut National de la Santé et de la Recherche Médicale UMR S 945, Paris, France
    PLoS ONE 7:e42403. 2012
    ..We believe that the polyfunctionality index will render polyfunctionality an appropriate end-point measure in future studies of T cell responsiveness...
  20. doi request reprint Altered thymic activity in early life: how does it affect the immune system in young adults?
    Delphine Sauce
    INSERM UMR S 945, Universite Pierre et Marie Curie PARIS6, Infections and Immunity, Hopital Pitie Salpetriere, Paris, France
    Curr Opin Immunol 23:543-8. 2011
    ..These works highlight the importance of the thymic function in preserving immune efficacy throughout life, and provide insights into the development of immune aging...
  21. pmc Escape from highly effective public CD8+ T-cell clonotypes by HIV
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 118:2138-49. 2011
    ..These findings provide refined mechanistic insights into the workings of an effective CD8(+) T-cell response against HIV...
  22. ncbi request reprint Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineages
    Victor Appay
    Cellular Immunology Laboratory, Institut National de la Santé et de la Recherche Médical U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol 179:7406-14. 2007
    ....
  23. ncbi request reprint Cell permeabilization for the assessment of T lymphocyte polyfunctional capacity
    Laura Papagno
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol Methods 328:182-8. 2007
    ..It is important to be aware of this potential bias and to design specific application/experimental procedures in order to obtain optimal results...
  24. ncbi request reprint Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV
    François Boutboul
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    AIDS 19:1981-6. 2005
    ....
  25. doi request reprint Monitoring cellular immune markers in HIV infection: from activation to exhaustion
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Paris, France
    Curr Opin HIV AIDS 8:125-31. 2013
    ..The thorough study of HIV pathogenesis is increasingly more challenging...
  26. pmc CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope
    Sylvain Cardinaud
    INSERM, UMR S945, Université Pierre et Marie Curie UPMC, Paris, France
    PLoS Pathog 7:e1002049. 2011
    ..Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes...
  27. pmc Exhausted cytotoxic control of Epstein-Barr virus in human lupus
    Martin Larsen
    Institut National de la Santé et de la Recherche Médicale Inserm UMR S 945, Paris, France
    PLoS Pathog 7:e1002328. 2011
    ..We therefore propose that autoimmune B cell activation during flares drives frequent EBV reactivation, which contributes in a vicious circle to the perpetuation of immune activation in SLE patients...
  28. doi request reprint CD8+ T cell efficacy in vaccination and disease
    Victor Appay
    Cellular Immunology Laboratory, Institut Nationale de la Santé et de la Recherche Médicale U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 06, 91 Boulevard de l Hopital, 75013 Paris, France
    Nat Med 14:623-8. 2008
    ..This new knowledge paves the way to the design of more effective T cell vaccines and highlights the importance of comprehensive immunomonitoring...
  29. doi request reprint Phenotype and function of human T lymphocyte subsets: consensus and issues
    Victor Appay
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, 75013 Paris, France
    Cytometry A 73:975-83. 2008
    ..Finally, we discuss the problems which still limit general agreement...