Research Topics
Species | Victor AppaySummaryCountry: France Publications
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Publications
Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samplesVictor Appay
Immunology Group, Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
J Immunol Methods 309:192-9. 2006..While the need to purify and cryopreserve PBMC for subsequent studies is obvious, the use of whole blood has the advantage of providing unbiased results and only small amounts of blood are used...
Phenotype and function of human T lymphocyte subsets: consensus and issuesVictor Appay
Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, 75013 Paris, France
Cytometry A 73:975-83. 2008..Finally, we discuss the problems which still limit general agreement...- CD8+ T cell efficacy in vaccination and diseaseVictor Appay
Cellular Immunology Laboratory, Institut Nationale de la Santé et de la Recherche Médicale U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 06, 91 Boulevard de l Hopital, 75013 Paris, France
Nat Med 14:623-8. 2008..This new knowledge paves the way to the design of more effective T cell vaccines and highlights the importance of comprehensive immunomonitoring... - Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patientsVictor Appay
INSERM UMR S, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie Paris, Hopital Pitie Salpetriere, France
AIDS 25:1813-22. 2011.... 
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activityJorge R Almeida
Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
Blood 113:6351-60. 2009....- Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adultsDelphine Sauce
INSERM Unité Mixte de Recherche S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, 75013 Paris, France
J Immunol 189:5541-8. 2012..Our findings support the establishment of homeostatic regulation of naive T cell proliferation in humans. This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized patients... - Evidence of premature immune aging in patients thymectomized during early childhoodDelphine Sauce
Infections and Immunity, INSERM UMRS 945, Avenir Group, Hopital Pitie Salpetriere, UPMC University of Paris 06, Paris, France
J Clin Invest 119:3070-8. 2009..Overall, our data highlight the importance of the thymus in maintaining the integrity of T cell immunity during adult life... - Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnoverJorge R Almeida
Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
J Exp Med 204:2473-85. 2007..Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines... - PD-1 expression on human CD8 T cells depends on both state of differentiation and activation statusDelphine Sauce
Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
AIDS 21:2005-13. 2007..Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans... - The role of the thymus in immunosenescence: lessons from the study of thymectomized individualsVictor Appay
Infections and Immunity, INSERM UMR S 945, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
Aging (Albany NY) 2:78-81. 2010..These studies represent new advances in our appreciation of the role of the thymus in humans and more generally in our understanding of the development of immunosenescence... - HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesisDelphine Sauce
INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
Blood 117:5142-51. 2011..These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments... - Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineagesVictor Appay
Cellular Immunology Laboratory, Institut National de la Santé et de la Recherche Médical U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
J Immunol 179:7406-14. 2007.... - Altered thymic activity in early life: how does it affect the immune system in young adults?Delphine Sauce
INSERM UMR S 945, Universite Pierre et Marie Curie PARIS6, Infections and Immunity, Hopital Pitie Salpetriere, Paris, France
Curr Opin Immunol 23:543-8. 2011..These works highlight the importance of the thymic function in preserving immune efficacy throughout life, and provide insights into the development of immune aging... - Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequencyMaria Candela Iglesias
INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
Immunol Lett 149:119-22. 2013..These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope... - Accelerated immune senescence and HIV-1 infectionVictor Appay
Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
Exp Gerontol 42:432-7. 2007..Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation... - Escape from highly effective public CD8+ T-cell clonotypes by HIVMaria Candela Iglesias
INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
Blood 118:2138-49. 2011..These findings provide refined mechanistic insights into the workings of an effective CD8(+) T-cell response against HIV... - Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV controlVictor Appay
INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Paris, France
Curr Opin HIV AIDS 6:157-62. 2011..We discuss why the modulation of these factors represents an interesting approach for the rational design of HIV vaccines... - New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor siteVictor Appay
Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
J Immunol 177:1670-8. 2006.... - Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptideVictor Appay
Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
Eur J Immunol 36:1805-14. 2006..Importantly, these cells are tumor-reactive... - Cell permeabilization for the assessment of T lymphocyte polyfunctional capacityLaura Papagno
Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
J Immunol Methods 328:182-8. 2007..It is important to be aware of this potential bias and to design specific application/experimental procedures in order to obtain optimal results... - 25 years of HIV research! ... and what about a vaccine?Victor Appay
INSERM UMR S 945, Infections and Immunity, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
Eur J Immunol 39:1999-2003. 2009..HIV vaccine research discovery may only be at its dawn... - Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMVFrançois Boutboul
Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
AIDS 19:1981-6. 2005.... - Dynamics of T cell responses in HIV infectionVictor Appay
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 168:3660-6. 2002..These observations have significant implications for our understanding of T cell responses in human viral infections in general and indicate that the definition of effector and memory subsets in humans may need revision... - Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infectionsVictor Appay
MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Nat Med 8:379-85. 2002..These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate... - HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptorTao Dong
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS UK
J Exp Med 200:1547-57. 2004..Selection of Vbeta13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome... - The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular stainingVictor Appay
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
J Immunol Methods 268:9-19. 2002..Understanding how antigen-specific cells develop and function in different circumstances and pathologies will be the key to unravelling the secrets of our cellular immune system... - Premature ageing of the immune system: the cause of AIDS?Victor Appay
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DS
Trends Immunol 23:580-5. 2002..This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus... - Mature CD8(+) T lymphocyte response to viral infection during fetal lifeArnaud Marchant
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Clin Invest 111:1747-55. 2003..The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens... - Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infectionLaura Papagno
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
PLoS Biol 2:E20. 2004..It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system... - Combination of transient lymphodepletion with busulfan and fludarabine and peptide vaccination in a phase I clinical trial for patients with advanced melanomaVictor Appay
Multidisciplinary Oncology Center, University of Lausanne Hospitals CHUV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Immunother 30:240-50. 2007..Overall, these data provide further ground for the development of immunotherapeutic approaches to be both effective against melanoma and applicable in clinic... - Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulationRobert Thimme
Institute for Medical Microbiology and Hygiene, Department of Immunology, Hermann Herder Str 11, University of Freiburg, D 79104 Freiburg, Germany
J Virol 79:12112-6. 2005..Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation... - Correlates of delayed disease progression in HIV-1-infected Kenyan childrenRana Chakraborty
Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
J Immunol 174:8191-9. 2005..As HIV-1-specific helper cells support anti-HIV-1 effector responses in active disease, their presence may be important in delaying disease progression... - Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppressionVictor Appay
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
AIDS 16:161-70. 2002..It leads to significant reductions of plasma viremia, often to undetectable levels, but it can also be linked with the reduction and disappearance of detectable HIV-specific CD8 T-cell responses... - Characterization of CD4(+) CTLs ex vivoVictor Appay
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 168:5954-8. 2002..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...