Djillali Annane

Summary

Country: France

Publications

  1. ncbi request reprint The effect of waiving consent on enrollment in a sepsis trial
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 30:321-4. 2004
  2. ncbi request reprint Glucocorticoids in the treatment of severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Faculté de médecine Paris Ouest, Université Versailles Saint Quentin, 92380 Garches, France
    Curr Opin Crit Care 11:449-53. 2005
  3. ncbi request reprint Corticosteroids in sepsis: from bench to bedside?
    Djillali Annane
    Raymond Poincare Hospital, School of Medicine Paris Ile de France Ouest, University of Versailles Saint Quentin en Yvelinnes, 92380 Garches, France
    Shock 20:197-207. 2003
  4. doi request reprint Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial
    Djillali Annane
    Raymond Poincare Hospital, Garches, France
    JAMA 310:1809-17. 2013
  5. doi request reprint StO₂ guided early resuscitation in subjects with severe sepsis or septic shock: a pilot randomised trial
    Olivier Nardi
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Monit Comput 27:215-21. 2013
  6. ncbi request reprint Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group
    Djillali Annane
    Service de Réanimation Médicale Hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Oncol 22:4893-900. 2004
  7. pmc Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
    Djillali Annane
    Critical Care Department, Universite de Versailles Saint Quentin en Yvelines, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Garches 92380, France
    BMJ 329:480. 2004
  8. ncbi request reprint Managing toxic shock syndrome with antibiotics
    Djillali Annane
    Intensive Care Unit Raymond Poincaré University Hospital, AP HP, School of Medicine Paris Ile de France Ouest, University Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Expert Opin Pharmacother 5:1701-10. 2004
  9. ncbi request reprint Prevalence and factors of intensive care unit conflicts: the conflicus study
    Elie Azoulay
    AP HP, Hopital Saint Louis, Medical ICU, University Paris 7 Paris Diderot, UFR de Medecine, 1 avenue Claude Vellefaux, 75010 Paris, France
    Am J Respir Crit Care Med 180:853-60. 2009
  10. pmc Cortisol replacement for severe sepsis and septic shock: what should I do?
    Djillali Annane
    Intensive Care Department, Raymond Poincare University Hospital, Garches, France
    Crit Care 6:190-1. 2002

Detail Information

Publications76

  1. ncbi request reprint The effect of waiving consent on enrollment in a sepsis trial
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 30:321-4. 2004
    ....
  2. ncbi request reprint Glucocorticoids in the treatment of severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Faculté de médecine Paris Ouest, Université Versailles Saint Quentin, 92380 Garches, France
    Curr Opin Crit Care 11:449-53. 2005
    ..This review provides opinion-based guidelines for the use of corticosteroids in severe sepsis and septic shock...
  3. ncbi request reprint Corticosteroids in sepsis: from bench to bedside?
    Djillali Annane
    Raymond Poincare Hospital, School of Medicine Paris Ile de France Ouest, University of Versailles Saint Quentin en Yvelinnes, 92380 Garches, France
    Shock 20:197-207. 2003
    ..Through these anti-inflammatory and cardiovascular effects, low doses of glucorticoids may improve septic shock survival...
  4. doi request reprint Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial
    Djillali Annane
    Raymond Poincare Hospital, Garches, France
    JAMA 310:1809-17. 2013
    ..Evidence supporting the choice of intravenous colloid vs crystalloid solutions for management of hypovolemic shock remains unclear...
  5. doi request reprint StO₂ guided early resuscitation in subjects with severe sepsis or septic shock: a pilot randomised trial
    Olivier Nardi
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Monit Comput 27:215-21. 2013
    ..This pilot study was the first randomised controlled trial using an algorithm derived from the SSC recommendations, which included StO₂ as a treatment goal. However, the protocol showed no clear trend for or against targeting StO₂...
  6. ncbi request reprint Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group
    Djillali Annane
    Service de Réanimation Médicale Hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Oncol 22:4893-900. 2004
    ..To determine the efficacy and safety of hyperbaric oxygen therapy (HBO) for overt mandibular osteoradionecrosis...
  7. pmc Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
    Djillali Annane
    Critical Care Department, Universite de Versailles Saint Quentin en Yvelines, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Garches 92380, France
    BMJ 329:480. 2004
    ..To assess the effects of corticosteroids on mortality in patients with severe sepsis and septic shock...
  8. ncbi request reprint Managing toxic shock syndrome with antibiotics
    Djillali Annane
    Intensive Care Unit Raymond Poincaré University Hospital, AP HP, School of Medicine Paris Ile de France Ouest, University Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Expert Opin Pharmacother 5:1701-10. 2004
    ..This paper aims to provide an overview of the epidemiology, pathomechanisms, and clinical presentation of TSS, and criteria for selecting drugs among available antibiotics...
  9. ncbi request reprint Prevalence and factors of intensive care unit conflicts: the conflicus study
    Elie Azoulay
    AP HP, Hopital Saint Louis, Medical ICU, University Paris 7 Paris Diderot, UFR de Medecine, 1 avenue Claude Vellefaux, 75010 Paris, France
    Am J Respir Crit Care Med 180:853-60. 2009
    ..Many sources of conflict exist in intensive care units (ICUs). Few studies recorded the prevalence, characteristics, and risk factors for conflicts in ICUs...
  10. pmc Cortisol replacement for severe sepsis and septic shock: what should I do?
    Djillali Annane
    Intensive Care Department, Raymond Poincare University Hospital, Garches, France
    Crit Care 6:190-1. 2002
    ..Similarly, in patients with severe sepsis who do not need vasopressors, the benefit/risk ratio of cortisol replacement remains to be assessed...
  11. pmc Guillain-Barré syndrome, greater Paris area
    Valérie Sivadon-Tardy
    Laboratoire de Microbiologie, Hopital Raymond Poincare, Garches, France
    Emerg Infect Dis 12:990-3. 2006
    ..The cases with no known agent (60%) peaked in winter, and half were preceded by respiratory infection, influenza-like syndrome, or gastrointestinal illness...
  12. ncbi request reprint Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
    ..The frequency of septic shock is increasing with more multiresistant strains. Its crude mortality rate is decreasing, but patients with septic shock still have a high excess risk of death than critically ill patients who are nonseptic...
  13. ncbi request reprint Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 Blvd Raymond Poincaré, 92380 Garches, France
    JAMA 288:862-71. 2002
    ..Septic shock may be associated with relative adrenal insufficiency. Thus, a replacement therapy of low doses of corticosteroids has been proposed to treat septic shock...
  14. pmc Year in review 2010: Critical Care--Multiple organ dysfunction and sepsis
    Etienne de Montmollin
    Service de Reanimation Polyvalente, hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin, 104, Bd, Raymond Poincaré, 92380 Garches, France
    Crit Care 15:236. 2011
    ..The results of these experimental studies and clinical trials are discussed in the context of the current relevant scientific and clinical background...
  15. ncbi request reprint Decompression sickness in urban divers in France
    Jacques Bessereau
    General Intensive Care Unit, Hyperbaric Medicine Department, Raymond Poincare Hospital, University of Versailles SQY, Garches, France
    Int Marit Health 63:170-3. 2012
    ..Thus, this study investigated the epidemiology and outcomes of such urban divers...
  16. doi request reprint Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review
    Djillali Annane
    Critical Care Department, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    JAMA 301:2362-75. 2009
    ..The benefit of corticosteroids in severe sepsis and septic shock remains controversial...
  17. ncbi request reprint Emerging drugs for the treatment of sepsis
    Jerome Aboab
    Intensive Care Unit, University of Versailles Saint Quentin, Hospital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    Expert Opin Emerg Drugs 11:7-22. 2006
    ..This review discusses the current management of septic shock and the potential development of new therapeutics following impressive advances in the pathomechanisms of septic shock...
  18. ncbi request reprint Diagnosis of adrenal insufficiency in severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 174:1319-26. 2006
    ..Diagnosis of adrenal insufficiency in critically ill patients has relied on random or cosyntropin-stimulated cortisol levels, and has not been corroborated by a more accurate diagnostic standard...
  19. doi request reprint Designing and conducting a randomized trial for pandemic critical illness: the 2009 H1N1 influenza pandemic
    Djillali Annane
    General ICU, Raymond Poincare Hospital, AP HP, University of Versailles SQ, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 38:29-39. 2012
    ..To analyze the hurdles in implementing a randomized trial of corticosteroids for severe 2009 H1N1 influenza infections...
  20. pmc Corticosteroids for sepsis: registry versus Cochrane systematic review!
    Djillali Annane
    General Intensive Care Unit, Raymond Poincare Hospital, University of Versailles SQY, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care 14:185. 2010
    ..In this commentary, these findings are contrasted with those of a recent Cochrane systematic review...
  21. doi request reprint Corticosteroids and human recombinant activated protein C for septic shock
    Gwenhael Colin
    Assistance Publique Hopitaux de Paris, General Intensive Care Unit, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Clin Chest Med 29:705-12, x. 2008
    ..The optimal timing for initiating these treatments is from 6 to 24 hours from onset of shock. When patients are receiving these drugs, physicians should systematically screen for superinfection and serious bleeding events...
  22. doi request reprint Effects of esmolol on systemic and pulmonary hemodynamics and on oxygenation in pigs with hypodynamic endotoxin shock
    Jerome Aboab
    Service de Reanimation, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, 104, bd Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 37:1344-51. 2011
    ..The aim of this experimental study is to investigate cardiovascular tolerance of blockade of beta-adrenergic receptors in an endotoxin model...
  23. pmc Bench-to-bedside review: Beta-adrenergic modulation in sepsis
    Etienne de Montmollin
    Service de Réanimation Polyvalente de l Hôpital Raymond Poincaré, 92380 Garches, France
    Crit Care 13:230. 2009
    ....
  24. ncbi request reprint The use of corticosteroids in severe sepsis and acute respiratory distress syndrome
    Karim Chadda
    Medical Intensive Care Unit, Raymond Poincare University Hospital, School of Medicine Paris Ile de France Ouest, 104 boulevard Raymond Poincaré, FR 92380 Garches, France
    Ann Med 34:582-9. 2002
    ..Further studies are ongoing to better identify the target population. In the meantime, cortisol replacement (i.e. 200 to 300 mg daily of hydrocortisone or equivalent) should be considered as standard care for these patients...
  25. ncbi request reprint Corticosteroids for sepsis: controversial forever?
    Djillali Annane
    Service de Reanimation, hôpital Raymonc Poincaré AP HP, Universite de Versailles Saint Quentin, 92380 Garches, France
    J Crit Care 22:329-30. 2007
  26. ncbi request reprint Relative adrenal failure in the ICU: an identifiable problem requiring treatment
    Hélène Gonzalez
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care Clin 22:105-18, vii. 2006
    ..Diagnosis relies on clinical suspicion and ACTH test results. The length of cortisol replacement therapy should be at least 7 days and the adjunction of fludrocortisone is recommended...
  27. pmc Sepsis-associated delirium: the pro and con of C5a blockade
    Djillali Annane
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care 13:135. 2009
    ..Thus, blockade of C5a may be detrimental, resulting in an attenuated response of the stress system...
  28. pmc Mechanisms of brain signaling during sepsis
    Najla Akrout
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Curr Neuropharmacol 7:296-301. 2009
    ..It is likely that an excess in nitric oxide and complement anaphylatoxin C5a contributes to DNA damage within neurons of the hippocampus and hypothalamus and subsequent brain dysfunction...
  29. ncbi request reprint Adrenal insufficiency in sepsis
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Curr Pharm Des 14:1882-6. 2008
    ....
  30. ncbi request reprint Endocrine effects of vasopressin in critically ill patients
    Tarek Sharshar
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Best Pract Res Clin Anaesthesiol 22:265-73. 2008
    ..The absence of endocrine effects of vasopressin during critical illness is unclear and may relate to an already maximal hormonal stimulation or to down-regulation of vasopressin receptors...
  31. ncbi request reprint Incidence and prognosis of sustained arrhythmias in critically ill patients
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 178:20-5. 2008
    ..Sustained arrhythmias are common in postoperative and cardiac intensive care units (ICUs), but their incidence and prognosis in general ICUs have never been reported...
  32. ncbi request reprint Sepsis-associated delirium
    Marion Ebersoldt
    Universite de Versailles Saint Quentin, Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 33:941-50. 2007
    ..This review provides an update of the diagnostic criteria and treatment strategies and the current knowledge about the mechanisms involved in sepsis associated brain dysfunction...
  33. ncbi request reprint Modafinil for the treatment of hypersomnia associated with myotonic muscular dystrophy in adults: a multicenter, prospective, randomized, double-blind, placebo-controlled, 4-week trial
    David Orlikowski
    Center for Neuromuscular Disease, Intensive Care Unit and Sleep Laboratory and Functional Exploration Department, Raymond Poincare Hospital, Paris Ile de France Ouest, Versailles Saint Quentin University, 92380 Garches, France
    Clin Ther 31:1765-73. 2009
    ..Myotonic muscular dystrophy type 1 (MMD1) is the most common form of adult MD, with a mean prevalence of 1 in 8000. Excessive daytime sleepiness (ie, hypersomnia) is a common complication of MMD1...
  34. doi request reprint The encephalopathy in sepsis
    Shidasp Siami
    General Intensive Care Unit, Raymond Poincaré Teaching Hospital AP HP, University of Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care Clin 24:67-82, viii. 2008
    ..Specific treatments for sepsis-associated encephalopathy need to be developed. Currently, treatment is mainly the management of sepsis...
  35. doi request reprint Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach
    Jerome Aboab
    Réanimation Polyvalente, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, Garches, France
    Crit Care Med 36:1481-6. 2008
    ..Septic shock may be associated with a loss in cardiovascular variability and adrenal dysfunction...
  36. pmc Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids
    Helene Prigent
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care 8:243-52. 2004
    ..Nongenomic effects are probably subsequent to cytosolic interaction between the glucocorticoid receptor and proteins, or to interaction between glucocorticoids and specific membrane binding sites...
  37. ncbi request reprint Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock
    Virginie Maxime
    Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
    J Infect Dis 191:138-44. 2005
    ..Renewed interest in glucocorticoid treatment for septic shock offers an opportunity to analyze this regulatory loop in humans...
  38. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  39. ncbi request reprint Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
    Djillali Annane
    Raymond Poincaré Hospital AP HP, University of Versailles Saint Quentin, PRES UniverSud, Paris, France
    Lancet 370:676-84. 2007
    ..However, no large comparative trial has yet been done. We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone in septic shock...
  40. pmc Cost-effectiveness of activated protein C in real-life clinical practice
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Port Royal University Hospital, AP HP, Rene Descartes University, Paris 5, Paris, France
    Crit Care 11:R99. 2007
    ..We evaluated the cost-effectiveness of rhAPC in patients with severe sepsis and multiple organ failure in real-life intensive care practice...
  41. ncbi request reprint Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis
    Yan Li
    Critical Care Medicine Department, Clinical Center, Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA
    Intensive Care Med 34:568-77. 2008
    ..We investigated whether risk of death altered the effects of hydrocortisone in a mouse pneumonia model...
  42. doi request reprint Hydrocortisone therapy for patients with septic shock
    Charles L Sprung
    Hadassah Hebrew University Medical Center, Jerusalem, Israel 91120
    N Engl J Med 358:111-24. 2008
    ....
  43. ncbi request reprint Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 34:22-30. 2006
    ..We investigated the efficacy of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome (ARDS) by post hoc analysis of a previously completed clinical trial...
  44. pmc Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Crit Care 11:R73. 2007
    ..We investigated the effects of a continuous administration of high doses of selenium in septic shock patients...
  45. ncbi request reprint Adrenal function in sepsis: the retrospective Corticus cohort study
    Diane Lipiner-Friedman
    Service de Reanimation, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, Garches, France
    Crit Care Med 35:1012-8. 2007
    ..To refine the value of baseline and adrenocorticotropin hormone (ACTH)-stimulated cortisol levels in relation to mortality from severe sepsis or septic shock...
  46. ncbi request reprint Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone
    Djillali Annane
    Crit Care Med 31:2250-1; author reply 2252-3. 2003
  47. pmc Reducing mortality in sepsis: new directions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital Free University of Brussels, Brussels, Belgium
    Crit Care 6:S1-18. 2002
    ....
  48. ncbi request reprint Time for a consensus definition of corticosteroid insufficiency in critically ill patients
    Djillali Annane
    Crit Care Med 31:1868-9. 2003
  49. ncbi request reprint Corticosteroid insufficiency in acutely ill patients
    Djillali Annane
    N Engl J Med 348:2157-9. 2003
  50. ncbi request reprint The neuropathology of septic shock
    Tarek Sharshar
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Garches, France
    Brain Pathol 14:21-33. 2004
    ..02). We conclude that septic shock is associated with diffuse cerebral damage and specific autonomic neuronal apoptosis which may be due to circulating factors particularly iNOS...
  51. ncbi request reprint Metabolism modulators in sepsis: the abnormal pituitary response
    Virginie Maxime
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 35:S596-601. 2007
    ..Summarize the current knowledge on the role of the hypothalamic pituitary axis in the development of sepsis...
  52. ncbi request reprint Multifocal necrotizing leukoencephalopathy in septic shock
    Tarek Sharshar
    Service de Réanimation Médiale, Hôpital Raymond Poincaré Faculté de Médecine Paris Ouest Université Paris, Garches, France
    Crit Care Med 30:2371-5. 2002
    ..The role of circulating cytokines has been suggested but remains to be assessed...
  53. ncbi request reprint ICU physicians should abandon the use of etomidate!
    Djillali Annane
    Intensive Care Med 31:325-6. 2005
  54. pmc Science review: The brain in sepsis--culprit and victim
    Tarek Sharshar
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care 9:37-44. 2005
    ..In parallel, damage within autonomic nervous and neuroendocrine systems may contribute to sepsis induced organ dysfunction...
  55. ncbi request reprint Circulating vasopressin levels in septic shock
    Tarek Sharshar
    Servue de Réanimation Médicale, Hopital Raymond Poincare, Faculté de médecine Paris Ile de France Ouest Université Versailles Saint Quentiun en Yvelinnes, Garches, France
    Crit Care Med 31:1752-8. 2003
    ..To assess the frequency of vasopressin deficiency in septic shock...
  56. ncbi request reprint [Pathophysiology of septic shock]
    Charles Lemaout
    Service de Reanimation Medicale, Hopital Raymond Poincare, Garches
    Presse Med 35:521-7. 2006
    ..Secretion of counterregulatory rather than proinflammatory hormones increases during sepsis. Organ dysfunctions may alter cell functions, essentially mitochondrial, as well as intertissue communication...
  57. ncbi request reprint Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update
    Steven M Hollenberg
    Crit Care Med 32:1928-48. 2004
    ..To provide the American College of Critical Care Medicine with updated guidelines for hemodynamic support of adult patients with sepsis...
  58. ncbi request reprint Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock
    Tarek Sharshar
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculté de Médecine Paris, Ile de France Ouest, Garches, France
    Lancet 362:1799-805. 2003
    ..Thus, we aimed to investigate the existence of ischaemia and apoptosis within the cerebral autonomic centres that control the cardiovascular system in patients with septic shock...
  59. pmc Clinical review: corticotherapy in sepsis
    Helene Prigent
    Service de Reanimation Medicale, Hopital Raymond Poincare, Garches, France
    Crit Care 8:122-9. 2004
    ..Finally, we propose a decision tree for diagnosis of adrenal insufficiency and institution of cortisol replacement therapy...
  60. ncbi request reprint Cardiovascular response to dopamine and early prediction of outcome in septic shock: a prospective multiple-center study
    Bruno Levy
    Réanimation Médicale, Hopital Central, Nancy Cedex, France
    Crit Care Med 33:2172-7. 2005
    ..To compare mortality rates between dopamine-sensitive (Dopa-S) and dopamine-resistant (Dopa-R) septic shock patients, the latter group defined by a mean arterial pressure <70 mm Hg despite the use of 20 mug/kg/min dopamine...
  61. ncbi request reprint Vasopressin in sepsis: a world of complexity
    Tarek Sharshar
    Pediatr Crit Care Med 7:281-2. 2006
  62. ncbi request reprint Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    ..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels...
  63. ncbi request reprint Compartmentalization of the inflammatory response in sepsis and SIRS
    Jean Marc Cavaillon
    Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 12:151-70. 2006
    ....
  64. ncbi request reprint Corticosteroids in ARDS
    Paul Marik
    N Engl J Med 355:316-7; author reply 318-9. 2006
  65. ncbi request reprint Mortality of patients with heatstroke admitted to intensive care units during the 2003 heat wave in France: a national multiple-center risk-factor study
    Benoit Misset
    Intensive Care Unit, Fondation Hopital Saint Joseph, Paris, France
    Crit Care Med 34:1087-92. 2006
    ..We examined the prognosis and risk factors for hospital mortality in patients with heatstroke admitted to an intensive care unit (ICU) during the heat wave in France in August 2003...
  66. ncbi request reprint Prognosis and risk factors of early onset pneumonia in ventilated patients with Guillain-Barré syndrome
    David Orlikowski
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, 104 boulevard Raymond Poincaré, Garches, France
    Intensive Care Med 32:1962-9. 2006
    ..Our objective was to determine the incidence, characteristics, outcomes, and risk factors of pneumonia in GBS patients receiving mechanical ventilation...
  67. ncbi request reprint Clinical and electrophysiological predictors of respiratory failure in Guillain-Barré syndrome: a prospective study
    Marie Christine Durand
    Functional Testing Department, Raymond Poincaré Teaching Hospital, Garches, France
    Lancet Neurol 5:1021-8. 2006
    ..We sought to identify clinical and electrophysiological predictors of respiratory failure in the disease...
  68. ncbi request reprint Immunotherapy for Guillain-Barré syndrome: a systematic review
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Campus, London, UK
    Brain 130:2245-57. 2007
    ..Since approximately 20% of patients die or have persistent disability despite immunotherapy, more research is needed to identify better treatment regimens and new therapeutic strategies...
  69. ncbi request reprint The hypothalamic pituitary adrenal axis in sepsis
    Andrea Polito
    Hospital Raymond Poincaré AP HP, University of Versailles SQY, 104 boulevard Raymond Poincaré, Garches 92380
    Novartis Found Symp 280:182-99; discussion 199-203. 2007
    ..This finding prompted renewed interest in a replacement therapy with low doses of corticosteroids during longer periods. We will review the key role of the hypothalamic-pituitary-adrenal axis in the host response to stress...
  70. ncbi request reprint Glucocorticoids for ARDS: Just Do It!
    Djillali Annane
    Chest 131:945-6. 2007
  71. ncbi request reprint Enlarged adrenals during septic shock
    Gerald Chanques
    Intensive Care Med 33:1671-2. 2007
  72. ncbi request reprint Using corticosteroids in intensive care
    Paul E Marik
    Arch Surg 141:946-7; author reply 947. 2006
  73. ncbi request reprint Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist
    Alain Soupart
    Department of Internal Medicine, Jolimont Tubize Nivelles Hospital, Tubize, Belgium
    Clin J Am Soc Nephrol 1:1154-60. 2006
    ..The SNa response was maintained during this time with a good tolerance. The new oral vasopressin V(2)-receptor antagonist satavaptan adequately corrects mild or moderate hyponatremia in patients with SIADH and has a good safety profile...
  74. ncbi request reprint Prohormones: novel biomarkers for corticosteroids in septic shock?
    Djillali Annane
    Intensive Care Med 34:395-6. 2008
  75. ncbi request reprint Low-dose adrenocorticotropic hormone test is not ready for routine adrenal function testing in the intensive care unit
    Djillali Annane
    Crit Care Med 33:2688-9. 2005
  76. pmc Pro-con debate: steroid use in ACTH non-responsive septic shock patients with high baseline cortisol levels
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQ, Garches, France
    Crit Care 10:210. 2006
    ..In this article, two expert groups debate the role of steroid use in a septic shock patient with arguably no clear evidence of adrenal insufficiency...