D Annane

Summary

Country: France

Publications

  1. ncbi Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
  2. ncbi Science review: The brain in sepsis--culprit and victim
    Tarek Sharshar
    , , , , Garches, France
    Crit Care 9:37-44. 2005
  3. ncbi Clinical review: corticotherapy in sepsis
    Helene Prigent
    , , Garches, France
    Crit Care 8:122-9. 2004
  4. ncbi A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin
    D Annane
    Department of Intensive Care Unit, Hospital Raymond Poincare, School of Medicine of Paris Ouest, Garches, France
    JAMA 283:1038-45. 2000
  5. ncbi Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group
    Djillali Annane
    Service de Réanimation Médicale Hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Oncol 22:4893-900. 2004
  6. ncbi Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
    Djillali Annane
    Critical Care Department, Universite de Versailles Saint Quentin en Yvelines, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Garches 92380, France
    BMJ 329:480. 2004
  7. ncbi Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
  8. ncbi Managing toxic shock syndrome with antibiotics
    Djillali Annane
    Intensive Care Unit Raymond Poincaré University Hospital, AP HP, School of Medicine Paris Ile de France Ouest, University Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Expert Opin Pharmacother 5:1701-10. 2004
  9. ncbi Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review
    Djillali Annane
    Critical Care Department, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    JAMA 301:2362-75. 2009
  10. ncbi Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 Blvd Raymond Poincaré, 92380 Garches, France
    JAMA 288:862-71. 2002

Detail Information

Publications97

  1. ncbi Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
    ..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
  2. ncbi Science review: The brain in sepsis--culprit and victim
    Tarek Sharshar
    , , , , Garches, France
    Crit Care 9:37-44. 2005
    ..In parallel, damage within autonomic nervous and neuroendocrine systems may contribute to sepsis induced organ dysfunction...
  3. ncbi Clinical review: corticotherapy in sepsis
    Helene Prigent
    , , Garches, France
    Crit Care 8:122-9. 2004
    ..Finally, we propose a decision tree for diagnosis of adrenal insufficiency and institution of cortisol replacement therapy...
  4. ncbi A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin
    D Annane
    Department of Intensive Care Unit, Hospital Raymond Poincare, School of Medicine of Paris Ouest, Garches, France
    JAMA 283:1038-45. 2000
    ..The hypothalamic-pituitary-adrenal axis is a major determinant of the host response to stress. The relationship between its activation and patient outcome is not known...
  5. ncbi Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group
    Djillali Annane
    Service de Réanimation Médicale Hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Oncol 22:4893-900. 2004
    ..To determine the efficacy and safety of hyperbaric oxygen therapy (HBO) for overt mandibular osteoradionecrosis...
  6. ncbi Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
    Djillali Annane
    Critical Care Department, Universite de Versailles Saint Quentin en Yvelines, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Garches 92380, France
    BMJ 329:480. 2004
    ..To assess the effects of corticosteroids on mortality in patients with severe sepsis and septic shock...
  7. ncbi Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
    ..The frequency of septic shock is increasing with more multiresistant strains. Its crude mortality rate is decreasing, but patients with septic shock still have a high excess risk of death than critically ill patients who are nonseptic...
  8. ncbi Managing toxic shock syndrome with antibiotics
    Djillali Annane
    Intensive Care Unit Raymond Poincaré University Hospital, AP HP, School of Medicine Paris Ile de France Ouest, University Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Expert Opin Pharmacother 5:1701-10. 2004
    ..This paper aims to provide an overview of the epidemiology, pathomechanisms, and clinical presentation of TSS, and criteria for selecting drugs among available antibiotics...
  9. ncbi Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review
    Djillali Annane
    Critical Care Department, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    JAMA 301:2362-75. 2009
    ..The benefit of corticosteroids in severe sepsis and septic shock remains controversial...
  10. ncbi Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 Blvd Raymond Poincaré, 92380 Garches, France
    JAMA 288:862-71. 2002
    ..Septic shock may be associated with relative adrenal insufficiency. Thus, a replacement therapy of low doses of corticosteroids has been proposed to treat septic shock...
  11. ncbi Cortisol replacement for severe sepsis and septic shock: what should I do?
    Djillali Annane
    Intensive Care Department, Raymond Poincare University Hospital, Garches, France
    Crit Care 6:190-1. 2002
    ..Similarly, in patients with severe sepsis who do not need vasopressors, the benefit/risk ratio of cortisol replacement remains to be assessed...
  12. ncbi The effect of waiving consent on enrollment in a sepsis trial
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 30:321-4. 2004
    ....
  13. ncbi Compartmentalised inducible nitric-oxide synthase activity in septic shock
    D Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine, France
    Lancet 355:1143-8. 2000
    ..Previous experimental studies support a role for inducible nitric-oxide synthase (iNOS) in the pathogenesis of severe sepsis. The aim of the study was to characterise iNOS activity in different tissues in patients with septic shock...
  14. ncbi Corticosteroids for septic shock
    D Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculté de médecine Paris Ouest, University Paris V, Garches, France
    Crit Care Med 29:S117-20. 2001
    ..To gather the data to provide a rationale for using replacement therapy with hydrocortisone in septic shock patients...
  15. ncbi [Corticotherapy in severe infectious states]
    D Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104, Boulevard Raymond Poincare, 92380 Garches
    Bull Acad Natl Med 184:1631-40; discussion 1640-2. 2000
    ..These trials strongly suggested that this strategy of corticotherapy reduced the morbidity of septic shock and may favourably affect survival from septic shock...
  16. ncbi Replacement therapy with hydrocortisone in catecholamine-dependent septic shock
    D Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculté de médecine Paris Ouest, Universite Paris V, Garches, France
    J Endotoxin Res 7:305-9. 2001
    ..These trials strongly suggest that this replacement therapy reduces the morbidity of septic shock and may favorably affect survival from septic shock...
  17. ncbi Psychostimulants for hypersomnia (excessive daytime sleepiness) in myotonic dystrophy
    D Annane
    Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Critical Care Department, 104 boulevard Raymond Poincaré, Garches, Ile de France, France 92380
    Cochrane Database Syst Rev 3:CD003218. 2006
    ..Excessive daytime sleepiness is a common symptom of myotonic dystrophy. Psychostimulants are drugs increasingly used to treat hypersomnia in myotonic dystrophy...
  18. ncbi Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 34:22-30. 2006
    ..We investigated the efficacy of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome (ARDS) by post hoc analysis of a previously completed clinical trial...
  19. ncbi Cardiac variability in critically ill adults: influence of sepsis
    M Korach
    , , , Garches, France
    Crit Care Med 29:1380-5. 2001
    ..47. CONCLUSIONS: This work suggests that impaired cardiac variability and notably sympathovagal balance (i.e., a low-frequency/high-frequency ratio <1.0) may be a diagnostic test for sepsis...
  20. ncbi Effect of hydrocortisone on phenylephrine--mean arterial pressure dose-response relationship in septic shock
    E Bellissant
    Laboratoire de Pharmacologie Experimentale et Clinique, Faculte de Medecine, Universite de Rennes I, France
    Clin Pharmacol Ther 68:293-303. 2000
    ....
  21. ncbi Glucocorticoids in the treatment of severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Faculté de médecine Paris Ouest, Université Versailles Saint Quentin, 92380 Garches, France
    Curr Opin Crit Care 11:449-53. 2005
    ..This review provides opinion-based guidelines for the use of corticosteroids in severe sepsis and septic shock...
  22. ncbi Glucocorticoid treatment in patients with septic shock: effects on vasopressor use and mortality
    A Boyer
    Critical Care Department, CHU Bordeaux, Bordeaux, France
    Int J Clin Pharmacol Ther 44:309-18. 2006
    ..64 - 0.90; p = 0.002) without heterogeneity across the trials (p = 0.28). In conclusion, in severe sepsis, high doses of corticosteroids should not be given. Septic shock should be treated with a replacement dose of hydrocortisone...
  23. ncbi Plasma cortisol levels in Guillain-Barré syndrome
    Julian Strauss
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, Garches, France
    Crit Care Med 37:2436-40. 2009
    ..One third of patients with Guillain-Barré syndrome develop respiratory failure, which is predicted by few early indicators. Adrenal function has rarely been studied in Guillain-Barré syndrome...
  24. ncbi Glucocorticoids and sepsis
    J Allary
    Department of Anesthesiology and Critical Care, , University of Medicine, Paris Ile de France Ouest, Garches, France
    Minerva Anestesiol 71:759-68. 2005
    ..This article summarises why, when and how glucocorticoids should be used in the management of septic shock...
  25. ncbi Supine fall in lung volumes in the assessment of diaphragmatic weakness in neuromuscular disorders
    C Fromageot
    Service de Physiologie-Explorations Fonctionnelles, , Garches, France
    Arch Phys Med Rehabil 82:123-8. 2001
    ..0001). These factors contributed 52% and 14% of the Pdi sniff variance, respectively. CONCLUSIONS: Simple VC measurement in the sitting and supine positions may be helpful in detecting severe or predominant diaphragmatic weakness...
  26. ncbi Guillain-Barré syndrome, greater Paris area
    Valérie Sivadon-Tardy
    Laboratoire de Microbiologie, Hopital Raymond Poincare, Garches, France
    Emerg Infect Dis 12:990-3. 2006
    ..The cases with no known agent (60%) peaked in winter, and half were preceded by respiratory infection, influenza-like syndrome, or gastrointestinal illness...
  27. ncbi Prevalence and factors of intensive care unit conflicts: the conflicus study
    Elie Azoulay
    AP HP, Hopital Saint Louis, Medical ICU, University Paris 7 Paris Diderot, UFR de Medecine, 1 avenue Claude Vellefaux, 75010 Paris, France
    Am J Respir Crit Care Med 180:853-60. 2009
    ..Many sources of conflict exist in intensive care units (ICUs). Few studies recorded the prevalence, characteristics, and risk factors for conflicts in ICUs...
  28. ncbi Adrenal insufficiency in sepsis
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Curr Pharm Des 14:1882-6. 2008
    ....
  29. ncbi Corticosteroids in sepsis: from bench to bedside?
    Djillali Annane
    Raymond Poincare Hospital, School of Medicine Paris Ile de France Ouest, University of Versailles Saint Quentin en Yvelinnes, 92380 Garches, France
    Shock 20:197-207. 2003
    ..Through these anti-inflammatory and cardiovascular effects, low doses of glucorticoids may improve septic shock survival...
  30. ncbi [Heart involvement in sarcoglycanopathies]
    A Fayssoil
    Réanimation Médicale, Université Versailles SQY, CHU Raymond Poincaré, 104, Boulevard Raymond Poincare, 92380 Garches, France Electronic address
    Rev Neurol (Paris) 168:779-82. 2012
    ..Clinical pictures include muscle weakness affecting mainly the proximal limb girdle musculature. We review heart involvement in this group of disease...
  31. ncbi [Xigris and corticoids: what are the perspectives for the patient with severe sepsis?]
    D Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Ann Fr Anesth Reanim 22:43-5. 2003
  32. ncbi [Corticotropic axis in septic shock]
    M Kloeckner
    , , , 104, boulevard Raymond-Poincar, 92380 Garches, France
    Ann Endocrinol (Paris) 68:281-9. 2007
  33. ncbi Tongue weakness is associated with respiratory failure in patients with severe Guillain-Barré syndrome
    D Orlikowski
    Services de Réanimation Médicale, Physiologie Explorations Fonctionnelles, Centre d Innovations Technologiques, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Acta Neurol Scand 119:364-70. 2009
    ..We prospectively evaluate how tongue weakness could be associated to bulbar dysfunction and respiratory weakness in severe GBS patients...
  34. ncbi Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids
    Helene Prigent
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care 8:243-52. 2004
    ..Nongenomic effects are probably subsequent to cytosolic interaction between the glucocorticoid receptor and proteins, or to interaction between glucocorticoids and specific membrane binding sites...
  35. ncbi Diagnosis of adrenal insufficiency in severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 174:1319-26. 2006
    ..Diagnosis of adrenal insufficiency in critically ill patients has relied on random or cosyntropin-stimulated cortisol levels, and has not been corroborated by a more accurate diagnostic standard...
  36. ncbi Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach
    Jerome Aboab
    Réanimation Polyvalente, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, Garches, France
    Crit Care Med 36:1481-6. 2008
    ..Septic shock may be associated with a loss in cardiovascular variability and adrenal dysfunction...
  37. ncbi Adrenal function in sepsis: the retrospective Corticus cohort study
    Diane Lipiner Friedman
    Service de Reanimation, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, Garches, France
    Crit Care Med 35:1012-8. 2007
    ..To refine the value of baseline and adrenocorticotropin hormone (ACTH)-stimulated cortisol levels in relation to mortality from severe sepsis or septic shock...
  38. ncbi Emerging drugs for the treatment of sepsis
    Jerome Aboab
    Intensive Care Unit, University of Versailles Saint Quentin, Hospital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    Expert Opin Emerg Drugs 11:7-22. 2006
    ..This review discusses the current management of septic shock and the potential development of new therapeutics following impressive advances in the pathomechanisms of septic shock...
  39. ncbi Resurrection of steroids for sepsis resuscitation
    D Annane
    , , , , Garches, France. djillali.anane.rpc.ap-hop-paris.fr
    Minerva Anestesiol 68:127-31. 2002
    ..The rational for a replacement therapy with hydrocortisone in catecholamines-dependent septic shock grows stronger...
  40. ncbi Prognostic factors in unintentional mild carbon monoxide poisoning
    D Annane
    , , , , 92380 Garches, France
    Intensive Care Med 27:1776-81. 2001
    ....
  41. ncbi Corticosteroids for sepsis: controversial forever?
    Djillali Annane
    Service de Reanimation, hôpital Raymonc Poincaré AP HP, Universite de Versailles Saint Quentin, 92380 Garches, France
    J Crit Care 22:329-30. 2007
  42. ncbi Corticosteroids and human recombinant activated protein C for septic shock
    Gwenhael Colin
    Assistance Publique Hopitaux de Paris, General Intensive Care Unit, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Clin Chest Med 29:705-12, x. 2008
    ..The optimal timing for initiating these treatments is from 6 to 24 hours from onset of shock. When patients are receiving these drugs, physicians should systematically screen for superinfection and serious bleeding events...
  43. ncbi Relative adrenal failure in the ICU: an identifiable problem requiring treatment
    Hélène Gonzalez
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care Clin 22:105-18, vii. 2006
    ..Diagnosis relies on clinical suspicion and ACTH test results. The length of cortisol replacement therapy should be at least 7 days and the adjunction of fludrocortisone is recommended...
  44. ncbi Adrenal insufficiency in septic shock
    Virginie Maxime
    Assistance Publique Hopitaux de Paris, Université de Versailles SQY UniverSud Paris, Hopital Raymond Poincare, Service de Reanimation, Garches, France
    Clin Chest Med 30:17-27, vii. 2009
    ..This article focuses on actual knowledge, mechanisms, definitions, and therapeutic recommendations, as well as on areas of uncertainty relative to adrenal gland insufficiency in septic shock...
  45. ncbi The use of corticosteroids in severe sepsis and acute respiratory distress syndrome
    Karim Chadda
    Medical Intensive Care Unit, , School of Medicine Paris Ile de France Ouest, 104 Boulevard Raymond Poincar, FR-92380 Garches, France
    Ann Med 34:582-9. 2002
    ..Further studies are ongoing to better identify the target population. In the meantime, cortisol replacement (i.e. 200 to 300 mg daily of hydrocortisone or equivalent) should be considered as standard care for these patients...
  46. ncbi Detection of Campylobacter jejuni by culture and real-time PCR in a French cohort of patients with Guillain-Barre syndrome
    Valérie Sivadon-Tardy
    Laboratoire de Microbiologie, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne Billancourt, France
    J Clin Microbiol 48:2278-81. 2010
    ..We provide evidence that diverse serotypes and genotypes of C. jejuni are a major trigger of GBS in France...
  47. ncbi Cost-effectiveness of activated protein C in real-life clinical practice
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Port Royal University Hospital, AP HP, Rene Descartes University, Paris 5, Paris, France
    Crit Care 11:R99. 2007
    ..We evaluated the cost-effectiveness of rhAPC in patients with severe sepsis and multiple organ failure in real-life intensive care practice...
  48. ncbi Bedside adherence to clinical practice guidelines in the intensive care unit: the TECLA study
    Jean Pierre Quenot
    Service de Reanimation Medicale, hôpital Bocage, 21079, Dijon, France
    Intensive Care Med 34:1393-400. 2008
    ..To assess adherence to clinical practice guidelines for three interventions routinely used in critical care medicine...
  49. ncbi Complete atrioventricular block in Duchenne muscular dystrophy
    A Fayssoil
    Cardiology, European Hospital Georges Pompidou, AP HP, Paris, France
    Europace 10:1351-2. 2008
    ..Heart is involved leading to heart failure. Conduction abnormalities are unusual. We report a case of complete atrio-ventricular block in a DMD patient...
  50. ncbi Metabolism modulators in sepsis: the abnormal pituitary response
    Virginie Maxime
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 35:S596-601. 2007
    ..Summarize the current knowledge on the role of the hypothalamic pituitary axis in the development of sepsis...
  51. ncbi Masseter muscle oxygen saturation is associated with central venous oxygen saturation in patients with severe sepsis
    Olivier Nardi
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380, Garches, France
    J Clin Monit Comput 24:289-93. 2010
    ....
  52. ncbi Long-term outcome of iatrogenic gas embolism
    Jacques Bessereau
    General Intensive Care Unit, Hyperbaric Centre, Raymond Poincaré Hospital AP HP, University of Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380, Garches, France
    Intensive Care Med 36:1180-7. 2010
    ..To establish the incidence and long-term prognosis of iatrogenic gas embolism...
  53. ncbi Endocrine effects of vasopressin in critically ill patients
    Tarek Sharshar
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Best Pract Res Clin Anaesthesiol 22:265-73. 2008
    ..The absence of endocrine effects of vasopressin during critical illness is unclear and may relate to an already maximal hormonal stimulation or to down-regulation of vasopressin receptors...
  54. ncbi Incidence and prognosis of sustained arrhythmias in critically ill patients
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 178:20-5. 2008
    ..Sustained arrhythmias are common in postoperative and cardiac intensive care units (ICUs), but their incidence and prognosis in general ICUs have never been reported...
  55. ncbi Prognosis and risk factors of early onset pneumonia in ventilated patients with Guillain-Barré syndrome
    David Orlikowski
    Medical Intensive Care Unit, , 104 Boulevard Raymond Poincar, Garches, France
    Intensive Care Med 32:1962-9. 2006
    ..CONCLUSIONS: Early-onset pneumonia is a common and severe complication that is related to aspiration in patients with GBS. Delaying intubation may increase the risk of early-onset pneumonia...
  56. ncbi Sepsis-associated delirium
    Marion Ebersoldt
    Universite de Versailles Saint Quentin, Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 33:941-50. 2007
    ..This review provides an update of the diagnostic criteria and treatment strategies and the current knowledge about the mechanisms involved in sepsis associated brain dysfunction...
  57. ncbi [Pathophysiology of septic shock]
    Charles Lemaout
    , , Garches
    Presse Med 35:521-7. 2006
    ..Secretion of counterregulatory rather than proinflammatory hormones increases during sepsis. Organ dysfunctions may alter cell functions, essentially mitochondrial, as well as intertissue communication...
  58. ncbi Pro-con debate: steroid use in ACTH non-responsive septic shock patients with high baseline cortisol levels
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQ, Garches, France
    Crit Care 10:210. 2006
    ..In this article, two expert groups debate the role of steroid use in a septic shock patient with arguably no clear evidence of adrenal insufficiency...
  59. ncbi Multifocal necrotizing leukoencephalopathy in septic shock
    Tarek Sharshar
    , , Garches, France
    Crit Care Med 30:2371-5. 2002
    ..CONCLUSION: Septic shock is a newly described cause of multifocal necrotizing leukoencephalopathy, probably mediated by an excessive systemic inflammatory response...
  60. ncbi The neuropathology of septic shock
    Tarek Sharshar
    , , , Garches, France
    Brain Pathol 14:21-33. 2004
    ..02). We conclude that septic shock is associated with diffuse cerebral damage and specific autonomic neuronal apoptosis which may be due to circulating factors particularly iNOS...
  61. ncbi Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock
    Tarek Sharshar
    , , , Ile de France Ouest, Garches, France
    Lancet 362:1799-805. 2003
    ..INTERPRETATION: Septic shock is associated with neuronal and glial apoptosis within the autonomic centres, which is strongly associated with endothelial iNOS expression...
  62. ncbi Improving clinical trials in the critically ill: unique challenge--sepsis
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Universite de Versailles SQY, Paris, France
    Crit Care Med 37:S117-28. 2009
    ..This article aimed at providing suggestions to improve the success rate of future sepsis trials...
  63. ncbi Circulating vasopressin levels in septic shock
    Tarek Sharshar
    , , , Garches, France
    Crit Care Med 31:1752-8. 2003
    ..CONCLUSIONS: Plasma vasopressin levels are almost always increased at the initial phase of septic shock and decrease afterward. Relative vasopressin deficiency is seen in approximately one-third of late septic shock patients...
  64. ncbi Clinical and electrophysiological predictors of respiratory failure in Guillain-Barré syndrome: a prospective study
    Marie-Christine Durand
    Functional Testing Department, , Garches, France
    Lancet Neurol 5:1021-8. 2006
    ..6% conduction block of the common peroneal nerve and a 20% reduction in vital capacity...
  65. ncbi Septic shock
    Djillali Annane
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Lancet 365:63-78. 2005
    ..Other therapeutic strategies are under investigation, including those that target late proinflammatory mediators, endothelium, or the neuroendocrine system...
  66. ncbi The encephalopathy in sepsis
    Shidasp Siami
    General Intensive Care Unit, Raymond Poincaré Teaching Hospital AP HP, University of Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care Clin 24:67-82, viii. 2008
    ..Specific treatments for sepsis-associated encephalopathy need to be developed. Currently, treatment is mainly the management of sepsis...
  67. ncbi Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia
    Djillali Annane
    Department of General Critical Care Medicine Division of Acute Medicine and Surgery, University of Versailles SQY Raymond Poincaré Hospital, Garches, France
    Am J Med Sci 337:28-36. 2009
    ..This placebo-controlled, randomized, double-blind multicenter study evaluated the efficacy and safety of oral conivaptan, a V1A/V2-receptor antagonist, in patients with euvolemic or hypervolemic hyponatremia...
  68. ncbi Brain lesions in septic shock: a magnetic resonance imaging study
    Tarek Sharshar
    Service de Reanimation Medicale, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104, Boulevard Raymond Poincare, 92380, Garches, France
    Intensive Care Med 33:798-806. 2007
    ..Understanding of sepsis-induced brain dysfunction remains poor, and relies mainly on data from animals or post-mortem studies in patients. The current study provided findings from magnetic resonance imaging of the brain in septic shock...
  69. ncbi Sepsis-associated delirium: the pro and con of C5a blockade
    Djillali Annane
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care 13:135. 2009
    ..Thus, blockade of C5a may be detrimental, resulting in an attenuated response of the stress system...
  70. ncbi The hypothalamic pituitary adrenal axis in sepsis
    Andrea Polito
    Hospital Raymond Poincaré AP HP, University of Versailles SQY, 104 boulevard Raymond Poincaré, Garches 92380
    Novartis Found Symp 280:182-99; discussion 199-203. 2007
    ..This finding prompted renewed interest in a replacement therapy with low doses of corticosteroids during longer periods. We will review the key role of the hypothalamic-pituitary-adrenal axis in the host response to stress...
  71. ncbi Bench-to-bedside review: Beta-adrenergic modulation in sepsis
    Etienne de Montmollin
    Service de Réanimation Polyvalente de l Hôpital Raymond Poincaré, 92380 Garches, France
    Crit Care 13:230. 2009
    ....
  72. ncbi Modafinil for the treatment of hypersomnia associated with myotonic muscular dystrophy in adults: a multicenter, prospective, randomized, double-blind, placebo-controlled, 4-week trial
    David Orlikowski
    Center for Neuromuscular Disease, Intensive Care Unit and Sleep Laboratory and Functional Exploration Department, Raymond Poincare Hospital, Paris Ile de France Ouest, Versailles Saint Quentin University, 92380 Garches, France
    Clin Ther 31:1765-73. 2009
    ..Myotonic muscular dystrophy type 1 (MMD1) is the most common form of adult MD, with a mean prevalence of 1 in 8000. Excessive daytime sleepiness (ie, hypersomnia) is a common complication of MMD1...
  73. ncbi Reducing mortality in sepsis: new directions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital Free University of Brussels, Brussels, Belgium
    Crit Care 6:S1-18. 2002
    ....
  74. ncbi Corticosteroid insufficiency in acutely ill patients
    Djillali Annane
    N Engl J Med 348:2157-9. 2003
  75. ncbi Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone
    Djillali Annane
    Crit Care Med 31:2250-1; author reply 2252-3. 2003
  76. ncbi Hydrocortisone therapy for patients with septic shock
    Charles L Sprung
    Hadassah Hebrew University Medical Center, Jerusalem, Israel 91120
    N Engl J Med 358:111-24. 2008
    ....
  77. ncbi Time for a consensus definition of corticosteroid insufficiency in critically ill patients
    Djillali Annane
    Crit Care Med 31:1868-9. 2003
  78. ncbi Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  79. ncbi Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock
    Virginie Maxime
    Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
    J Infect Dis 191:138-44. 2005
    ..Glucocorticoid treatment normalized the release of MIF by circulating PBMCs from patients with septic shock...
  80. ncbi Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis
    Yan Li
    Critical Care Medicine Department, Clinical Center, Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA
    Intensive Care Med 34:568-77. 2008
    ..We investigated whether risk of death altered the effects of hydrocortisone in a mouse pneumonia model...
  81. ncbi Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
    Djillali Annane
    Raymond Poincaré Hospital AP HP, University of Versailles Saint Quentin, PRES UniverSud, Paris, France
    Lancet 370:676-84. 2007
    ..However, no large comparative trial has yet been done. We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone in septic shock...
  82. ncbi Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Crit Care 11:R73. 2007
    ..We investigated the effects of a continuous administration of high doses of selenium in septic shock patients...
  83. ncbi Enlarged adrenals during septic shock
    Gerald Chanques
    Intensive Care Med 33:1671-2. 2007
  84. ncbi Glucocorticoids for ARDS: Just Do It!
    Djillali Annane
    Chest 131:945-6. 2007
  85. ncbi Corticosteroids in ARDS
    Paul Marik
    N Engl J Med 355:316-7; author reply 318-9. 2006
  86. ncbi Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist
    Alain Soupart
    Department of Internal Medicine, Jolimont Tubize Nivelles Hospital, Tubize, Belgium
    Clin J Am Soc Nephrol 1:1154-60. 2006
    ..The SNa response was maintained during this time with a good tolerance. The new oral vasopressin V(2)-receptor antagonist satavaptan adequately corrects mild or moderate hyponatremia in patients with SIADH and has a good safety profile...
  87. ncbi Immunotherapy for Guillain-Barré syndrome: a systematic review
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Campus, London, UK
    Brain 130:2245-57. 2007
    ..Since approximately 20% of patients die or have persistent disability despite immunotherapy, more research is needed to identify better treatment regimens and new therapeutic strategies...
  88. ncbi Cardiovascular response to dopamine and early prediction of outcome in septic shock: a prospective multiple-center study
    Bruno Levy
    , , Nancy Cedex, France
    Crit Care Med 33:2172-7. 2005
    ..CONCLUSIONS: Dopamine sensitivity is associated with decreased mortality rate. Early recognition of dopamine resistant septic shock could allow for better screening of patients with an ominous prognosis...
  89. ncbi Vasopressin in sepsis: a world of complexity
    Tarek Sharshar
    Pediatr Crit Care Med 7:281-2. 2006
  90. ncbi Prohormones: novel biomarkers for corticosteroids in septic shock?
    Djillali Annane
    Intensive Care Med 34:395-6. 2008
  91. ncbi Compartmentalization of the inflammatory response in sepsis and SIRS
    Jean Marc Cavaillon
    Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 12:151-70. 2006
    ....
  92. ncbi Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    ..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels...
  93. ncbi Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update
    Steven M Hollenberg
    Crit Care Med 32:1928-48. 2004
    ..Using this approach, specific recommendations for fluid resuscitation, vasopressor therapy, and inotropic therapy of septic in adult patients were promulgated...
  94. ncbi Low-dose adrenocorticotropic hormone test is not ready for routine adrenal function testing in the intensive care unit
    Djillali Annane
    Crit Care Med 33:2688-9. 2005
  95. ncbi Mortality of patients with heatstroke admitted to intensive care units during the 2003 heat wave in France: a national multiple-center risk-factor study
    Benoit Misset
    Intensive Care Unit, Fondation Hopital Saint Joseph, Paris, France
    Crit Care Med 34:1087-92. 2006
    ..We examined the prognosis and risk factors for hospital mortality in patients with heatstroke admitted to an intensive care unit (ICU) during the heat wave in France in August 2003...
  96. ncbi ICU physicians should abandon the use of etomidate!
    Djillali Annane
    Intensive Care Med 31:325-6. 2005
  97. ncbi Using corticosteroids in intensive care
    Paul E Marik
    Arch Surg 141:946-7; author reply 947. 2006