Marie Line Andreola

Summary

Country: France

Publications

  1. ncbi request reprint Closely related antiretroviral agents as inhibitors of two HIV-1 enzymes, ribonuclease H and integrase: "killing two birds with one stone"
    Marie Line Andreola
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Curr Pharm Des 10:3713-23. 2004
  2. pmc Yeast and the AIDS virus: the odd couple
    Marie Line Andreola
    Laboratoire Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR 5234 CNRS, Université Bordeaux Segalen, 146 rue Leo Saignat, SFR TransBioMed, 33076 Bordeaux, France
    J Biomed Biotechnol 2012:549020. 2012
  3. ncbi request reprint Towards the selection of phosphorothioate aptamers optimizing in vitro selection steps with phosphorothioate nucleotides
    M L Andreola
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, Bordeaux, France Institut Fédératif de Recherches Pathologies Infectieuses IFR 66, Bordeaux, France
    Eur J Biochem 267:5032-40. 2000
  4. ncbi request reprint DNA aptamers selected against the HIV-1 RNase H display in vitro antiviral activity
    M L Andreola
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Biochemistry 40:10087-94. 2001
  5. ncbi request reprint HIV-1 integrase and RNase H activities as therapeutic targets
    M L Andreola
    Laboratory of Replication and Expression of Eukaryotic and Retroviral Genomes, UMR 5097, CNRS Université Victor Segalen Bordeaux 2, France
    Expert Opin Ther Targets 6:433-46. 2002
  6. ncbi request reprint Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase
    M L Andreola
    UMR 5234 CNRS, Universite Victor Segalen Bordeaux 2, France
    Curr Pharm Des 15:2508-19. 2009
  7. ncbi request reprint Selection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro
    Pantxika Bellecave
    UMR 5097 CNRS, Institut Fédératif de Recherches Pathologies Infectieuses et Cancer IFR 66, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Oligonucleotides 13:455-63. 2003
  8. doi request reprint Activation of GCN2 upon HIV-1 infection and inhibition of translation
    Ophélie Cosnefroy
    UMR 5234 CNRS, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Cell Mol Life Sci 70:2411-21. 2013
  9. ncbi request reprint Targeting HIV-1 integrase with aptamers selected against the purified RNase H domain of HIV-1 RT
    Mathieu Metifiot
    UMR 5097 CNRS, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Biochimie 87:911-9. 2005
  10. doi request reprint The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration
    Aurélie Faure-Perraud
    UMR, CNRS, Universite Victor Segalen, Bordeaux, France
    Antivir Ther 16:383-94. 2011

Collaborators

  • Thérèse Astier-Gin
  • Jean Jacques Toulmé
  • Rodolphe Thiebaut
  • V Parissi
  • J Michel
  • L Tarrago-Litvak
  • Lieven J Stuyver
  • Linda Wittkop
  • Sandrine Reigadas
  • Michel Ventura
  • Mathieu Metifiot
  • Ophélie Cosnefroy
  • Christina Calmels
  • Herve Fleury
  • Simon Litvak
  • Pantxika Bellecave
  • Paul Lesbats
  • Aurélie Faure-Perraud
  • Patricia Recordon-Pinson
  • Bernard Masquelier
  • Guerric Anies
  • Frédéric Pileur
  • V R de Soultrait
  • Anaïs Jaspart
  • Cedric Vaillant
  • Marc Lavigne
  • Alain Arneodo
  • Guillaume Chevereau
  • Yair Botbol
  • Aurelie Faure
  • Véronique Guyonnet-Duperat
  • Oscar Leon
  • Hirofumi Yamada
  • Serge Moreau
  • Christian Cazenave
  • Robert J Crouch
  • Sergei A Gaidamakov
  • Sergei Gryaznov
  • Eric Dausse
  • Ralf Altmeyer
  • S Litvak
  • Pierre Yves Lozach

Detail Information

Publications18

  1. ncbi request reprint Closely related antiretroviral agents as inhibitors of two HIV-1 enzymes, ribonuclease H and integrase: "killing two birds with one stone"
    Marie Line Andreola
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Curr Pharm Des 10:3713-23. 2004
    ..This suggests that prototype structures can be exploited to develop inhibitors of two related enzymes, such as the RNase H and integrase activities of HIV-1 RT...
  2. pmc Yeast and the AIDS virus: the odd couple
    Marie Line Andreola
    Laboratoire Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR 5234 CNRS, Université Bordeaux Segalen, 146 rue Leo Saignat, SFR TransBioMed, 33076 Bordeaux, France
    J Biomed Biotechnol 2012:549020. 2012
    ....
  3. ncbi request reprint Towards the selection of phosphorothioate aptamers optimizing in vitro selection steps with phosphorothioate nucleotides
    M L Andreola
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, Bordeaux, France Institut Fédératif de Recherches Pathologies Infectieuses IFR 66, Bordeaux, France
    Eur J Biochem 267:5032-40. 2000
    ..In the course of this work, we have showed that the PS-dGTP is a strong inhibitor of thermostable DNA polymerases as well as of HIV-1 RT...
  4. ncbi request reprint DNA aptamers selected against the HIV-1 RNase H display in vitro antiviral activity
    M L Andreola
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Biochemistry 40:10087-94. 2001
    ..Oligonucleotides described here may serve as leading compounds for the development of specific inhibitors of this key retroviral enzyme activity...
  5. ncbi request reprint HIV-1 integrase and RNase H activities as therapeutic targets
    M L Andreola
    Laboratory of Replication and Expression of Eukaryotic and Retroviral Genomes, UMR 5097, CNRS Université Victor Segalen Bordeaux 2, France
    Expert Opin Ther Targets 6:433-46. 2002
    ..Some IN inhibitors have been recently reported and are available demonstrating the potential of IN as an antiviral target. This paper is an overview of the inhibitors of RNase H and IN and describes the most promising inhibitors...
  6. ncbi request reprint Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase
    M L Andreola
    UMR 5234 CNRS, Universite Victor Segalen Bordeaux 2, France
    Curr Pharm Des 15:2508-19. 2009
    ..Finally, a new promising class of peptide inhibitors is emerging called "shiftides", which interfere with the ability of IN to adopt an oligomeric active state...
  7. ncbi request reprint Selection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro
    Pantxika Bellecave
    UMR 5097 CNRS, Institut Fédératif de Recherches Pathologies Infectieuses et Cancer IFR 66, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Oligonucleotides 13:455-63. 2003
    ....
  8. doi request reprint Activation of GCN2 upon HIV-1 infection and inhibition of translation
    Ophélie Cosnefroy
    UMR 5234 CNRS, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Cell Mol Life Sci 70:2411-21. 2013
    ....
  9. ncbi request reprint Targeting HIV-1 integrase with aptamers selected against the purified RNase H domain of HIV-1 RT
    Mathieu Metifiot
    UMR 5097 CNRS, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Biochimie 87:911-9. 2005
    ..In contrast to RNase H, the HIV-1 integrase was inhibited by these aptamers. Our results point out that prototype structures can be exploited to develop inhibitors of two related enzymes...
  10. doi request reprint The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration
    Aurélie Faure-Perraud
    UMR, CNRS, Universite Victor Segalen, Bordeaux, France
    Antivir Ther 16:383-94. 2011
    ..Moreover, low nanomolar concentrations of ODN 93del have been shown to inhibit HIV-1 replication in infected cells...
  11. ncbi request reprint Inhibitors of HIV-1 reverse transcriptase and integrase: classical and emerging therapeutical approaches
    Laura Tarrago-Litvak
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Curr Pharm Des 8:595-614. 2002
    ..Some of these antiviral agents have been known for several years while others are emerging as new promising strategies based on the use of oligonucleotides with special emphasis on the SELEX approach, peptides and retrovirucides...
  12. pmc The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions
    Sandrine Reigadas
    Laboratoire de Virologie, CHU de Bordeaux, EA 2968, Universite Victor Segalen, Bordeaux, France
    PLoS ONE 5:e10311. 2010
    ..An FC of 2 was observed only for IN Y143R in the strand transfer assay. In concerted integration, integrases were less sensitive to RAL than in ST or 3'P but mutants were more resistant to RAL than WT...
  13. ncbi request reprint DNA aptamers derived from HIV-1 RNase H inhibitors are strong anti-integrase agents
    V R de Soultrait
    UMR 5097, CNRS Université Victor Segalen Bordeaux 2, 146 rue Leo Saignat, Bordeaux, France
    J Mol Biol 324:195-203. 2002
    ..Moreover, cell fusion assays showed that these agents do not block viral cell entry at concentrations where viral replication is stopped...
  14. ncbi request reprint An oligonucleotide complementary to the SL-B1 domain in the 3'-end of the minus-strand RNA of the hepatitis C virus inhibits in vitro initiation of RNA synthesis by the viral polymerase
    Sandrine Reigadas
    UMR 5097 CNRS Université Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 3307 Bordeaux Cedex, France
    Virology 314:206-20. 2003
    ..Our data demonstrate that ODN7 inhibits the initiation process, most probably by modifying structural features present at the 3'-end of the minus-strand RNA...
  15. pmc Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes
    Paul Lesbats
    Laboratoire MCMP, UMR 5234 CNRS Université Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS Pathog 7:e1001280. 2011
    ..Our data indicate that some chromatin structures can be refractory for integration and that coupling between nucleosome remodeling and HIV-1 integration is required to overcome this natural barrier...
  16. ncbi request reprint Cellular uptake of ODNs in HIV-1 human-infected cells: a role for viral particles in DNA delivery?
    Mathieu Metifiot
    UMR 5097 CNRS, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Oligonucleotides 17:151-65. 2007
    ..When HIV-1 virions were present a sharp increase in cellular fluorescence was observed. These results strongly suggest a role for HIV-1 virions in the uptake of certain ODNs...
  17. doi request reprint Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells
    Sandrine Reigadas
    Laboratory of Virology, EA2968, University of Bordeaux 2, Bordeaux, France
    J Antimicrob Chemother 65:434-7. 2010
    ..Our aim was to analyse the evolution of HIV-1 2-long terminal repeat (2-LTR) circular DNA in vitro and ex vivo in the presence of raltegravir...
  18. pmc Selective inhibitory DNA aptamers of the human RNase H1
    Frédéric Pileur
    INSERM U386, IFR Pathologies Infectieuses, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Nucleic Acids Res 31:5776-88. 2003
    ..Finally, the inhibitory aptamers were capable of completely abolishing the action of an antisense oligonucleotide in a rabbit reticulocyte lysate supplemented with human RNase H1, with IC50 ranging from 50 to 100 nM...