Marie-Laure Ancelin

Summary

Affiliation: Inserm U1061
Location: Montpellier, France
URL: http://www.montp.inserm.fr/u1061/index.htm
Summary:
Senior Researcher (Research Director Inserm "National Institute of Health and Medical Research"); PhD.
MAIN EXPERTISE: Psychiatry and Mental Health; Cognition and Neuropsychology
APPLICATIONS: Epidemiology, Biochemistry, Endocrinology, Pharmacology
RESEARCH ACTIVITIES: Endocrine and metabolic approach to stress-related neuropsychiatric disorders

Publications

  1. doi Estrogen receptor gene variants are associated with anxiety disorders in older women
    Joanne Ryan
    INSERM, U1061, Nervous System Pathologies Epidemiological and Clinical Research, Hôpital La Colombière, Montpellier, France
    Psychoneuroendocrinology 36:1582-6. 2011
  2. pmc Caffeine, cognitive functioning, and white matter lesions in the elderly: establishing causality from epidemiological evidence
    Karen Ritchie
    INSERM, U888, Montpellier, France and University of Montpellier 1, Montpellier, France
    J Alzheimers Dis 20:S161-6. 2010
  3. pmc Characteristics of hormone therapy, cognitive function, and dementia: the prospective 3C Study
    J Ryan
    INSERM U888, Nervous System Pathologies Epidemiological and Clinical Research, Hôpital La Colombière, BP 34493, 34093 Montpellier Cedex 5, France
    Neurology 73:1729-37. 2009
  4. pmc Neurological signs and late-life depressive symptoms in a community population: the ESPRIT study
    Mishael Soremekun
    King s College London, Institute of Psychiatry, London, UK
    Int J Geriatr Psychiatry 25:672-8. 2010
  5. pmc A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people
    I Beluche
    INSERM, U888, University of Montpellier 1, Montpellier, France
    Psychol Med 40:1039-49. 2010
  6. pmc Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study
    Isabelle Carriere
    INSERM, U888, Universite Montpellier 1, Montpellier, France
    Arch Intern Med 169:1317-24. 2009
  7. doi Social activity and improvement in depressive symptoms in older people: a prospective community cohort study
    Vivian Isaac
    King s College London, Institute of Psychiatry, Section of Epidemiology, London, UK
    Am J Geriatr Psychiatry 17:688-96. 2009
  8. pmc Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression
    Karen Ritchie
    INSERM, U888, Montpellier, France
    J Clin Psychiatry 70:1281-8. 2009
  9. pmc Modelling complex pathways between late-life depression and disability: evidence for mediating and moderating factors
    I Carriere
    Psychol Med 39:1587-90. 2009
  10. doi Comparison of health insurance claims and patient interviews in assessing drug use: data from the Three-City (3C) Study
    Pernelle Noize
    INSERM, Unit 657, Pharmaco épidémiologie et évaluation de l impact des produits de santé sur les populations, Bordeaux, France
    Pharmacoepidemiol Drug Saf 18:310-9. 2009

Collaborators

Detail Information

Publications47

  1. doi Estrogen receptor gene variants are associated with anxiety disorders in older women
    Joanne Ryan
    INSERM, U1061, Nervous System Pathologies Epidemiological and Clinical Research, Hôpital La Colombière, Montpellier, France
    Psychoneuroendocrinology 36:1582-6. 2011
    ..This study investigated whether ESR1 and ESR2 gene variants were associated with specific anxiety disorders in postmenopausal women and evaluated the potential modifying effect of hormone treatment (HT) on these associations...
  2. pmc Caffeine, cognitive functioning, and white matter lesions in the elderly: establishing causality from epidemiological evidence
    Karen Ritchie
    INSERM, U888, Montpellier, France and University of Montpellier 1, Montpellier, France
    J Alzheimers Dis 20:S161-6. 2010
    ..The significant relationship observed between caffeine intake in women and lower cognitive decline is highly likely to be a true causal relationship and not a spurious association...
  3. pmc Characteristics of hormone therapy, cognitive function, and dementia: the prospective 3C Study
    J Ryan
    INSERM U888, Nervous System Pathologies Epidemiological and Clinical Research, Hôpital La Colombière, BP 34493, 34093 Montpellier Cedex 5, France
    Neurology 73:1729-37. 2009
    ..To examine the association between hormone therapy (HT) and cognitive performance or dementia, focusing on the duration and type of treatment used, as well as the timing of initiation of HT in relation to the menopause...
  4. pmc Neurological signs and late-life depressive symptoms in a community population: the ESPRIT study
    Mishael Soremekun
    King s College London, Institute of Psychiatry, London, UK
    Int J Geriatr Psychiatry 25:672-8. 2010
    ....
  5. pmc A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people
    I Beluche
    INSERM, U888, University of Montpellier 1, Montpellier, France
    Psychol Med 40:1039-49. 2010
    ..However, the causal relationship between stress and subsequent cognitive impairment remains unclear, notably because of the small number of gender-stratified prospective studies...
  6. pmc Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study
    Isabelle Carriere
    INSERM, U888, Universite Montpellier 1, Montpellier, France
    Arch Intern Med 169:1317-24. 2009
    ..Despite the high intake of medications with anticholinergic properties by community-dwelling elderly persons, the effects on cognitive decline and dementia have rarely been evaluated...
  7. doi Social activity and improvement in depressive symptoms in older people: a prospective community cohort study
    Vivian Isaac
    King s College London, Institute of Psychiatry, Section of Epidemiology, London, UK
    Am J Geriatr Psychiatry 17:688-96. 2009
    ....
  8. pmc Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression
    Karen Ritchie
    INSERM, U888, Montpellier, France
    J Clin Psychiatry 70:1281-8. 2009
    ..Little is known, however, about the persistence of this vulnerability across the life span, although clinical studies of adult populations suggest that gene-environment interaction may diminish with aging...
  9. pmc Modelling complex pathways between late-life depression and disability: evidence for mediating and moderating factors
    I Carriere
    Psychol Med 39:1587-90. 2009
    ....
  10. doi Comparison of health insurance claims and patient interviews in assessing drug use: data from the Three-City (3C) Study
    Pernelle Noize
    INSERM, Unit 657, Pharmaco épidémiologie et évaluation de l impact des produits de santé sur les populations, Bordeaux, France
    Pharmacoepidemiol Drug Saf 18:310-9. 2009
    ..Drug exposure is often presumed from health insurance claims but this may not correspond exactly to what subjects actually take. This study was designed to investigate French reimbursement databases in assessing drug use...
  11. doi Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (the ESPRIT study)
    Marie Laure Ancelin
    Institut de la Santé et de la Recherche Médicale Inserm and University of Montpellier 1, Hôpital La Colombière, Centre hospitalier universitaire CHU, Montpellier, France
    Biol Psychiatry 68:125-32. 2010
    ..Lipids appear to mediate depressive vulnerability in the elderly; however, sex differences and genetic vulnerability have not been taken into account in previous prospective studies...
  12. pmc Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors
    K Ritchie
    INSERM, U888 Nervous System Pathologies Epidemiological and Clinical Research, La Colombière Hospital, 34093 Montpellier Cedex 5, France
    BMJ 341:c3885. 2010
    ..To estimate the percentage reduction in incidence of dementia that would be obtained if specific risk factors were eliminated...
  13. pmc Retrospective identification and characterization of mild cognitive impairment from a prospective population cohort
    Karen Ritchie
    INSERM U, Universite de Montpellier, France
    Am J Geriatr Psychiatry 18:692-700. 2010
    ..This study retrospectively identifies cases of MCI and determines baseline criteria giving the highest discriminability. The ability of these criteria to increase current case detection specificity is estimated...
  14. doi Late life depression and incident activity limitations: influence of gender and symptom severity
    Isabelle Carriere
    INSERM, U1061, Hôpital La Colombière, Montpellier, F 34093, France
    J Affect Disord 133:42-50. 2011
    ..Previous research has been limited partly due to the failure to take into account sub-syndromal states and the very large number of candidate mediating and confounding factors...
  15. doi Adverse childhood environment and late-life cognitive functioning
    Karen Ritchie
    INSERM, U888, Montpellier, France
    Int J Geriatr Psychiatry 26:503-10. 2011
    ..Clinical studies suggest that childhood maltreatment may cause nervous system changes and consequent cognitive disorder. The persistence of this association in late-life is examined...
  16. pmc Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study
    Tasnime N Akbaraly
    Institut National de la Santé et de la Recherche Médicale INSERM U1061, F 34000 Montpellier, France
    Diabetes Care 34:904-9. 2011
    ....
  17. pmc Long-term post-operative cognitive decline in the elderly: the effects of anesthesia type, apolipoprotein E genotype, and clinical antecedents
    Marie Laure Ancelin
    INSERM, Montpellier, France
    J Alzheimers Dis 22:105-13. 2010
    ....
  18. pmc A prospective study of hormone therapy and depression in community-dwelling elderly women: the Three City Study
    Jacqueline Scali
    Institut National de la Santé et de la Recherche Médicale U888, Montpellier, France
    J Clin Psychiatry 71:1673-9. 2010
    ..The potential benefits of hormone therapy (HT) in treating depressed postmenopausal women are controversial, and data on depression (re)emergence in the context of HT discontinuation are lacking...
  19. pmc Metabolic syndrome, its components, and mortality in the elderly
    Tasnime N Akbaraly
    Institut National de la Santé et de la Recherche Médicale INSERM Unité U 888, Universite Montpellier, Montpellier, France
    J Clin Endocrinol Metab 95:E327-32. 2010
    ..Our objectives were 1) to examine the association of MetS with the risk of all-cause and cause-specific mortality in a French elderly community-dweller cohort and 2) to determine the main components driving these associations...
  20. pmc Insomnia symptoms in older adults: associated factors and gender differences
    Isabelle Jaussent
    INSERM, U888, Univ Montpellier 1, Montpellier, INSERM, U897, Univ Bordeaux 2, Bordeaux, France
    Am J Geriatr Psychiatry 19:88-97. 2011
    ..g., difficulty with initiating sleep (DIS), difficulty with maintaining sleep (DMS), and early morning awakening (EMA)...
  21. pmc A prospective study of the association between endogenous hormones and depressive symptoms in postmenopausal women
    Joanne Ryan
    Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Menopause 16:509-17. 2009
    ..Across a woman's lifetime, variations in hormone levels are known to influence mood and well-being. Whether absolute or changes in hormone levels over time are associated with depression among postmenopausal women remains unclear...
  22. doi Persistence of abnormal cortisol levels in elderly persons after recovery from major depression
    Isabelle Beluche
    INSERM, U888, Montpellier, France
    J Psychiatr Res 43:777-83. 2009
    ....
  23. ncbi Hormonal therapy and depression: are we overlooking an important therapeutic alternative?
    Marie Laure Ancelin
    INSERM, U888, Montpellier, France
    J Psychosom Res 62:473-85. 2007
    ..This review aimed to examine evidence for the role of hormonal changes in the onset and course of depressive symptomatology and to assess the possible future role of hormonal therapies in the treatment of depression...
  24. ncbi [Epidemiology of mental diseases in the elderly]
    S Artero
    INSERM E361, Universite Montpellier 1, 34000 Montpellier, Hôpital La Colombière, Pavillon 42, 39, Avenue Charles Flahault, BP 34493, 34093 Montpellier Cedex 5, France
    Encephale 32:S1091-4. 2006
  25. ncbi [The Esprit Project: a longitudinal general population study of psychiatric disorders in France in subjects over 65 years old]
    M L Ancelin
    INSERM, E361, Montpellier, F 34093 France, Univ Montpellier 1, Montpellier, F 34000 France
    Encephale 32:S615-21. 2006
  26. pmc Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study
    Marie L Ancelin
    INSERM, E361, Pathologies of the Nervous System, 34093 Montpellier, France
    BMJ 332:455-9. 2006
    ..To assess the potential of anticholinergic drugs as a cause of non-degenerative mild cognitive impairment in elderly people...
  27. ncbi Lifelong endocrine fluctuations and related cognitive disorders
    M L Ancelin
    INSERM, E361, Montpellier, F 34093 France
    Curr Pharm Des 11:4229-52. 2005
    ....
  28. ncbi Prevalence of DSM-IV psychiatric disorder in the French elderly population
    K Ritchie
    Institut National de la Sante et de la Recherche Medicale INSERM, E 0361 Pathologies of the Nervous System, Montpellier, France
    Br J Psychiatry 184:147-52. 2004
    ..France has high rates of psychotropic drug consumption and suicide in the elderly population, but it has not yet been possible to determine whether this is due to exceptionally high morbidity rates...
  29. ncbi A class of potent antimalarials and their specific accumulation in infected erythrocytes
    Kai Wengelnik
    CNRS UMR 5539, CP 107, CNRS UMR 5810, CP 22, Universite Montpellier II, Place E Bataillon, 34095 Montpellier Cedex 5, France
    Science 295:1311-4. 2002
    ..falciparum and P. cynomolgi...
  30. ncbi Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly
    M L Ancelin
    INSERM EPI-9930, Epidemiology and Clinical Research in Nervous System Pathologies, CLRC Val d'Aurelle, Bat. Rech. Rdc, , 34298 Montpellier Cedex 5, France
    Br J Psychiatry 178:360-6. 2001
    ..CONCLUSIONS: Cognitive functions are not equally affected, type of impairment being determined by the risk factors described above and anaesthesia type...
  31. ncbi [Anesthesia and postoperative cognitive dysfunction in the elderly: a review of clinical and epidemiological observations]
    M L Ancelin
    INSERM EPI 9930 Pathologies du Système Nerveux Recherche Epidémiologique et Clinique, CRLC Val d Aurelle, Bat Rech Rdc, Parc Euromedecine, 34298 Montpellier Cedex 5
    Rev Epidemiol Sante Publique 48:459-72. 2000
    ..It is concluded that the complex interaction of etiological factors makes it difficult to determine at this point of time to what extent POCD may be attributed specifically to anesthetic agents...
  32. ncbi Is antioxidant therapy a viable alternative for mild cognitive impairment? Examination of the evidence
    Marie Laure Ancelin
    INSERM, U888, University of Montpellier 1, Montpellier, France
    Dement Geriatr Cogn Disord 24:1-19. 2007
    ....
  33. ncbi The neuroprotective effects of caffeine: a prospective population study (the Three City Study)
    K Ritchie
    INSERM U888 Nervous System Pathologies, Epidemiological and Clinical Research, La Colombière Hospital, Montpellier, France
    Neurology 69:536-45. 2007
    ..To examine the association between caffeine intake, cognitive decline, and incident dementia in a community-based sample of subjects aged 65 years and over...
  34. doi Life-time estrogen exposure and cognitive functioning in later life
    Joanne Ryan
    INSERM, U888, Montpellier F 34093, France
    Psychoneuroendocrinology 34:287-98. 2009
    ..Few studies have considered the influence of life-time estrogen exposure which may have an independent effect on cognition and/or modulate treatment response...
  35. doi A prospective study of hormonal treatment and anxiety disorders in community-dwelling elderly women (the Esprit Study)
    Jacqueline Scali
    INSERM, U888, Montpellier, F 34093 France
    J Affect Disord 115:274-9. 2009
    ..The impact of hormone therapy use on late-life anxiety disorder in elderly women has not been evaluated...
  36. doi 5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population
    Tom Power
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neurobiol Aging 31:886-7. 2010
    ..In the only analysis known to the authors to be carried out in an exclusively elderly, European population, this null finding remained consistent after restriction of analysis to prevalent or incident cases...
  37. pmc Lifetime hormonal factors may predict late-life depression in women
    Joanne Ryan
    INSERM, U888, Montpellier, F 34093 France
    Int Psychogeriatr 20:1203-18. 2008
    ..Fluctuating hormone levels are known to influence a woman's mood and well-being. This study aimed to determine whether lifetime hormonal markers are associated with late-life depression symptoms among elderly community-dwelling women...
  38. doi Risk profiles for mild cognitive impairment and progression to dementia are gender specific
    S Artero
    INSERM U888, Nervous System Pathologies Epidemiological and Clinical Research, La Colombière Hospital, 34093 Montpellier Cedex 5, France
    J Neurol Neurosurg Psychiatry 79:979-84. 2008
    ..To examine risk factors for mild cognitive impairment (MCI) and progression to dementia in a prospective community-based study of subjects aged 65 years and over...
  39. doi Lipid levels and cardiovascular risk in elderly women: a general population study of the effects of hormonal treatment and lipid-lowering agents
    A M Dupuy
    INSERM U888, Montpellier, France
    Climacteric 11:74-83. 2008
    ..To evaluate plasma lipid levels in elderly women in the general population as a function of use of lipid-lowering agents (LLA) and hormone therapy (HT)...
  40. doi Late-life depression and mortality: influence of gender and antidepressant use
    Joanne Ryan
    Institut National de la Santé et de la Recherche Médicale Inserm U888, University of Montpellier, France
    Br J Psychiatry 192:12-8. 2008
    ..Depression may increase the risk of mortality among certain subgroups of older people, but the part played by antidepressants in this association has not been thoroughly explored...
  41. pmc Hormonal treatment, mild cognitive impairment and Alzheimer's disease
    Joanne Ryan
    INSERM, U888, Montpellier, F 34093 France
    Int Psychogeriatr 20:47-56. 2008
    ....
  42. ncbi Abnormal reactions to environmental stress in elderly persons with anxiety disorders: evidence from a population study of diurnal cortisol changes
    Isabelle Chaudieu
    INSERM, U888, Montpellier, F 34093 France
    J Affect Disord 106:307-13. 2008
    ..Cortisol secretion in elderly persons with anxiety disorders exposed to common stressful situations has not been evaluated...
  43. ncbi [Hormonal replacement therapy and Alzheimer's disease. All quiet on the western front?]
    Marie Laure Ancelin
    Inserm E 361, Hôpital La Colombière, Montpellier
    Psychol Neuropsychiatr Vieil 1:251-7. 2003
    ..g. estradiol [transdermal] + progesterone). On the basis of the data of the literature, there is currently no reason to propose HRT for the prevention of Alzheimer's disease...
  44. doi Sex differences in the associations between lipid levels and incident dementia
    Marie Laure Ancelin
    INSERM, U1061, Montpellier, France Univ Montpellier 1, U1061, Montpellier, France
    J Alzheimers Dis 34:519-28. 2013
    ..Low HDL-cholesterol and high TG levels may be risk factors of dementia in elderly men whereas low TG is associated with decreased incident AD in women. This data suggests a complex sex-specific etiology of vascular dementia and AD...
  45. doi Steroid and nonsteroidal anti-inflammatory drugs, cognitive decline, and dementia
    Marie Laure Ancelin
    INSERM, U1061, Montpellier, France
    Neurobiol Aging 33:2082-90. 2012
    ..Long-term use of inhaled corticosteroids may constitute a form of reversible cognitive disorder in elderly women. Physicians should check this possibility before assuming neurodegenerative changes...
  46. pmc Lipid lowering agents, cognitive decline, and dementia: the three-city study
    Marie Laure Ancelin
    INSERM, U1061, Montpellier, France
    J Alzheimers Dis 30:629-37. 2012
    ....