P Amarenco

Summary

Country: France

Publications

  1. ncbi request reprint Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
    Stroke 35:2902-9. 2004
  2. ncbi request reprint High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
  3. doi request reprint Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France Diderot University, Paris, France
    Lancet Neurol 8:802-9. 2009
  4. doi request reprint Coronary artery disease and risk of major vascular events after cerebral infarction
    Pierre Amarenco
    INSERM U 698, Paris, France
    Stroke 44:1505-11. 2013
  5. doi request reprint High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke
    Bertrand Lapergue
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 44:699-707. 2013
  6. doi request reprint Patients with transient ischemic attack with ABCD2 <4 can have similar 90-day stroke risk as patients with transient ischemic attack with ABCD2 ≥4
    Pierre Amarenco
    INSERM U 698 and the Department of Neurology and Stroke Center, Paris Diderot University, Bichat University Hospital, Paris, France
    Stroke 43:863-5. 2012
  7. doi request reprint Prevalence of coronary atherosclerosis in patients with cerebral infarction
    Pierre Amarenco
    INSERM U 698 and Paris Diderot University, Paris, France
    Stroke 42:22-9. 2011
  8. ncbi request reprint Lipid lowering and recurrent stroke: a definitive answer?
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Int J Stroke 2:111-3. 2007
  9. ncbi request reprint The dynamics of statins: from event prevention to neuroprotection
    Pierre Amarenco
    Department of Neurology, Stroke Centre, Denis Diderot University and Medical School, Bichat Hospital, Paris, France
    Stroke 37:294-6. 2006
  10. doi request reprint Telemedicine for improving emergent management of acute cerebrovascular syndromes
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris VII, Paris, France
    Int J Stroke 2:47-50. 2007

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
    Stroke 35:2902-9. 2004
    ..Statin trials have now included >90,000 patients. We have determined the effect of statins and LDL-C reduction on stroke prevention...
  2. ncbi request reprint High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
    ..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
  3. doi request reprint Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France Diderot University, Paris, France
    Lancet Neurol 8:802-9. 2009
    ..The aim of this study was to ascertain the effect of a combined IV-endovascular approach (intra-arterial alteplase and, if required, additional thrombectomy) in patients with stroke due to arterial occlusion...
  4. doi request reprint Coronary artery disease and risk of major vascular events after cerebral infarction
    Pierre Amarenco
    INSERM U 698, Paris, France
    Stroke 44:1505-11. 2013
    ..The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown...
  5. doi request reprint High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke
    Bertrand Lapergue
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 44:699-707. 2013
    ..We hypothesized that HDL vasculoprotective actions on the blood-brain barrier (BBB) may decrease hemorrhagic transformation-associated with tissue plasminogen activator (tPA) administration in acute stroke...
  6. doi request reprint Patients with transient ischemic attack with ABCD2 <4 can have similar 90-day stroke risk as patients with transient ischemic attack with ABCD2 ≥4
    Pierre Amarenco
    INSERM U 698 and the Department of Neurology and Stroke Center, Paris Diderot University, Bichat University Hospital, Paris, France
    Stroke 43:863-5. 2012
    ..It is unclear whether patients with transient ischemic attack with an ABCD(2) score <4 can be safely evaluated within the following week as recommended by some national guidelines rather than in emergency...
  7. doi request reprint Prevalence of coronary atherosclerosis in patients with cerebral infarction
    Pierre Amarenco
    INSERM U 698 and Paris Diderot University, Paris, France
    Stroke 42:22-9. 2011
    ....
  8. ncbi request reprint Lipid lowering and recurrent stroke: a definitive answer?
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Int J Stroke 2:111-3. 2007
  9. ncbi request reprint The dynamics of statins: from event prevention to neuroprotection
    Pierre Amarenco
    Department of Neurology, Stroke Centre, Denis Diderot University and Medical School, Bichat Hospital, Paris, France
    Stroke 37:294-6. 2006
  10. doi request reprint Telemedicine for improving emergent management of acute cerebrovascular syndromes
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris VII, Paris, France
    Int J Stroke 2:47-50. 2007
  11. doi request reprint Does ABCD2 score below 4 allow more time to evaluate patients with a transient ischemic attack?
    Pierre Amarenco
    Department of Neurology and Stroke Center, Paris, France
    Stroke 40:3091-5. 2009
    ....
  12. doi request reprint Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial
    Pierre Amarenco
    INSERM U 698, Denis Diderot University Paris VII, Department of Neurology, Bichat University Hospital, Paris, France
    Stroke 40:2486-92. 2009
    ....
  13. doi request reprint Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention
    Pierre Amarenco
    INSERM U 698 clinical research in atherothrombosis and Paris Diderot University, Paris, France
    Lancet Neurol 8:453-63. 2009
    ..8 mmol/L (70 mg/dL), the effects of triglyceride-lowering therapy alone or in combination with statins, and the effects of treatments to raise HDL cholesterol concentrations...
  14. doi request reprint New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke
    P Amarenco
    Department of Neurology and Stroke Center, INSERM U 698 and Paris Diderot University, Bichat University Hospital, Paris, France
    Cerebrovasc Dis 27:502-8. 2009
    ..g. for genetic analysis purpose), while clinical trials can focus on 1 or several of these 4 phenotypes (e.g. focus on patients A1-A2-A3)...
  15. doi request reprint Classification of stroke subtypes
    P Amarenco
    Department of Neurology and Stroke Center, INSERM U 698 and Paris Diderot University, Bichat University Hospital, Paris, France
    Cerebrovasc Dis 27:493-501. 2009
    ..Parallel classifications (i.e. surrogate markers) may serve as within-study abnormalities to support research findings...
  16. doi request reprint Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypes
    Pierre Amarenco
    INSERM U 698 and Denis Diderot University, Paris, France
    Stroke 40:1405-9. 2009
    ..We tested the hypothesis that the benefit of treatment varies according to index event stroke subtype...
  17. doi request reprint Baseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
    Pierre Amarenco
    INSERM U 698 and Denis Diderot University, Paris, France
    Atherosclerosis 204:515-20. 2009
    ....
  18. doi request reprint Stroke is a coronary heart disease risk equivalent: implications for future clinical trials in secondary stroke prevention
    Pierre Amarenco
    INSERM U 698 and Denis Diderot University Paris VII, France
    Eur Heart J 29:1605-7. 2008
  19. doi request reprint EXPRESS transient ischemic attack study: speed the process!
    Pierre Amarenco
    INSERM U 698 and Denis Diderot University Paris VII, France
    Stroke 39:2400-1. 2008
  20. ncbi request reprint Predictors for malignant middle cerebral artery infarctions: a postmortem analysis
    A Jaramillo
    APHP, Department of Neuropathology Raymond Escourolle, Salpetriere Hospital, Pierre and Marie Curie University, Paris, France
    Neurology 66:815-20. 2006
    ..Early detection of malignant infarction of the middle cerebral artery (MI-MCA) is important because of possible treatment by hemicraniectomy...
  21. ncbi request reprint Blood lipids in brain infarction subtypes
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat Hospital, Denis Diderot University, INSERM U 360, Paris, France
    Cerebrovasc Dis 22:101-8. 2006
    ..Little is known about the relationship between hypercholesterolaemia and specific aetiological subtypes of brain infarction (BI)...
  22. ncbi request reprint Aortic arch atheroma and the risk of stroke
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France
    Curr Atheroscler Rep 8:343-6. 2006
    ..In this category of patients new potential causes, such as aortic arch atheroma in the elderly, have been investigated in the past two decades...
  23. ncbi request reprint The paradox of cholesterol and stroke
    Pierre Amarenco
    INSERM U 698, and Université Paris 7 Denis Diderot, Paris, France
    Lancet 370:1803-4. 2007
  24. ncbi request reprint Atorvastatin in prevention of stroke and transient ischaemic attack
    Pierre Amarenco
    Bichat University Hospital, Department of Neurology and Stroke Centre, 46 rue Henri Huchard, 75018 Paris, France
    Expert Opin Pharmacother 8:2789-97. 2007
    ..Statins are effective in reducing both first-ever and recurrent stroke, and this effect seems driven by the extent of LDL-C lowering...
  25. doi request reprint Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with
    M G Bousser
    Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:509-18. 2009
    ....
  26. ncbi request reprint Mitral valve strands and the risk of ischemic stroke in elderly patients. The French Study of Aortic Plaques in Stroke (FAPS) Investigators
    A Cohen
    Service de cardiologie, Hopital Saint Antoine, Universite Pierre et Marie Curie, Paris, France
    Stroke 28:1574-8. 1997
    ..Their nature and their potential for embolization are largely unknown. The objective was to estimate the risk of brain infarction in patients with mitral valve strands...
  27. ncbi request reprint Chlamydia pneumoniae seropositivity in aetiological subtypes of brain infarction and carotid atherosclerosis: a case control study
    S Alamowitch
    Stroke Unit, Department of Neurology, Tenon University Hospital, AP HP, 4 rue de la Chine, Paris, France
    J Neurol Neurosurg Psychiatry 79:147-51. 2008
    ..We investigated Chlamydia pneumoniae infection in a large cohort of patients with BI according to aetiological subtypes and carotid atherosclerosis...
  28. ncbi request reprint Statins for stroke prevention: disappointment and hope
    Pierre Amarenco
    Department of Neurology and Stroke Center, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
    Circulation 109:III44-9. 2004
    ..Treatment strategies based on global cardiovascular risk may be most effective. Additional studies in patients representative of the typical stroke population are needed...
  29. ncbi request reprint Intracranial arterial dolichoectasia is associated with enlarged descending thoracic aorta
    F Pico
    Department of Neurology, Mignot Versailles Hospital, Versailles, France
    Neurology 63:2016-21. 2004
    ..The pathophysiology is unknown; some data suggest that IADE is not merely a complication of atherosclerosis, but a distinct arteriopathy characterized by loss of elastic tissue in the media...
  30. doi request reprint Prevalence of subdiaphragmatic visceral infarction in cardioembolic stroke
    T Slaoui
    Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France
    Neurology 74:1030-2. 2010
    ..Coexistence of subdiaphragmatic visceral infarction (SDVI; e.g., renal, splenic, hepatic, bowel infarction) may be a suggestion of a common source of embolism. One large autopsy study found SDVI in 21.5% of patients with fatal stroke...
  31. ncbi request reprint Aortic plaque morphology and vascular events: a follow-up study in patients with ischemic stroke. FAPS Investigators. French Study of Aortic Plaques in Stroke
    A Cohen
    Service de cardiologie, Saint Antoine University and Medical School, Paris, France
    Circulation 96:3838-41. 1997
    ..The purpose of this study was to evaluate the impact, if any, of plaque morphology (ulceration, hypoechoic plaques or calcification) on the risk of subsequent vascular events...
  32. doi request reprint Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease
    Philippa C Lavallee
    Department of Neurology, Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Stroke 40:1721-8. 2009
    ..We sought to determine whether high-dose atorvastatin increases CVR compared with placebo in patients with severe small vessel disease...
  33. doi request reprint Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial
    Marie Germaine Bousser
    Hopital Lariboisiere, INSERM U, Paris Diderot University, France
    Lancet 377:2013-22. 2011
    ..We compared the selective thromboxane-prostaglandin receptor antagonist terutroban with aspirin in the prevention of cerebral and cardiovascular ischaemic events in patients with a recent non-cardioembolic cerebral ischaemic event...
  34. ncbi request reprint Genetic susceptibility and ischaemic stroke
    A Elbaz
    INSERM Unité 360, Hopital de la Salpetriere, Paris, France
    Curr Opin Neurol 12:47-55. 1999
    ..This may have therapeutic and preventive implications...
  35. ncbi request reprint Carotid intima-media thickness, plaques, and Framingham risk score as independent determinants of stroke risk
    Pierre Jean Touboul
    Department of Neurology and Stroke Center, Bichat University Hospital and Medical School, Paris, France
    Stroke 36:1741-5. 2005
    ..The purpose of this study was to correlate Framingham risk score (FRS) with CCA-IMT and CPs and evaluate their respective contribution to stroke risk...
  36. ncbi request reprint Common carotid artery intima-media thickness and brain infarction : the Etude du Profil Génétique de l'Infarctus Cérébral (GENIC) case-control study. The GENIC Investigators
    P J Touboul
    Department of Neurology, Lariboisiere Hospital, Paris, France
    Circulation 102:313-8. 2000
    ..73; 95% confidence interval, 1.45 to 2.07). CONCLUSIONS-An increased CCA-IMT was associated with BI, both overall and in the main subtypes. An increased IMT may help select patients at high risk for BI...
  37. doi request reprint Prevalence of nephroangiosclerosis in patients with fatal stroke
    H Abboud
    Assistance Publique Hopitaux de Paris, Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Neurology 72:899-904. 2009
    ..Glomerular filtration rate and decline in renal function can be improved by global cardiovascular prevention. However, the prevalence of nephroangiosclerosis in patients with stroke is unknown...
  38. doi request reprint Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial
    Jean Louis Mas
    Hôpitaux Sainte Anne, Universite Paris Descartes, Paris, France
    Lancet Neurol 7:885-92. 2008
    ..We now report the results up to 4 years...
  39. doi request reprint The Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack (PERFORM) study: baseline characteristics of the population
    M G Bousser
    Department of Neurology, Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:608-13. 2009
    ..Here we describe the baseline characteristics of the population...
  40. ncbi request reprint Determinants of outcome and safety of intravenous rt-PA therapy in the very old: a clinical registry study and systematic review
    Elena Meseguer
    Department of Neurology and Stroke Centre, Bichat University Hospital, 46, rue Henri Huchard, 75018 Paris, France
    Age Ageing 37:107-11. 2008
  41. ncbi request reprint Recurrent stroke and vascular events in elderly patients with anticardiolipin antibodies: a prospective study
    O Heinzlef
    Department of Neurology, Vasculaire Saint Antoine Hospital, Paris, France
    J Neurol 248:373-9. 2001
    ..In contrast to young patients, elderly patients with 10 or more GPL units aCL and negative for anti-beta2 glycoprotein I do not seem to have a higher risk of vascular events...
  42. doi request reprint Glucose level and brain infarction: a prospective case-control study and prospective study
    M Mazighi
    INSERM U 698 and Denis Diderot University, Paris VII, France
    Int J Stroke 4:346-51. 2009
    ..Additional data are needed to resolve this uncertainty and identify patients at higher risk if any...
  43. doi request reprint Anatomical and technical factors associated with stroke or death during carotid angioplasty and stenting: results from the endarterectomy versus angioplasty in patients with symptomatic severe carotid stenosis (EVA-3S) trial and systematic review
    Olivier Naggara
    Universite Paris Descartes, Inserm UMR 894, Department of Neurology, Hopital Sainte Anne, 75014 Paris, France
    Stroke 42:380-8. 2011
    ....
  44. doi request reprint Effect of early cerebral magnetic resonance imaging on clinical decisions in infective endocarditis: a prospective study
    Xavier Duval
    Paris 7 University Medical School, AP HP Bichat University Hospital, and INSERM CIC 007, Paris, France
    Ann Intern Med 152:497-504, W175. 2010
    ..Neurologic complications of endocarditis can influence diagnosis, therapeutic plans, and prognosis...
  45. doi request reprint Country-based reference values and impact of cardiovascular risk factors on carotid intima-media thickness in a French population: the 'Paroi Artérielle et Risque Cardio-Vasculaire' (PARC) Study
    Pierre Jean Touboul
    INSERM U 698, Paris, France
    Cerebrovasc Dis 27:361-7. 2009
    ..To define reference values for mean common carotid artery intima-media thickness (CCAIMT(mean)) from subjects without conventional cardiovascular risk factors...
  46. ncbi request reprint Flow-mediated vasodilatation of carotid and brachial arteries in healthy subjects and in lacunar stroke patients
    Philippa C Lavallee
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Paris, France
    Ultrasound Med Biol 32:1165-9. 2006
    ..CCA vasodilatation induced by CO(2) inhalation and NTG administration can be measured. The strong negative correlation between CCA- and BA-FMVD suggests that there could be different mechanisms of vasodilatation...
  47. doi request reprint Outcomes of mechanical endovascular therapy for acute ischemic stroke: a clinical registry study and systematic review
    Aymeric Rouchaud
    Department of Neurology and Stroke Centre, Bichat University Hospital, INSERM U 698 and Paris Diderot University, 46, rue Henri Huchard, 75018 Paris, France
    Stroke 42:1289-94. 2011
    ..However, the benefit and safety of MET remain to be determined. The aim of this study was to give reliable estimates of efficacy and safety outcomes of MET...
  48. doi request reprint Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
    Eric Bruckert
    Department of Endocrinology, Pitie Salpetriere University Hospital, Pierre and Marie Curie University, 83 bd de l hopital, 75651, Paris, France
    Atherosclerosis 210:353-61. 2010
    ....
  49. ncbi request reprint [Transient ischemic attacks]
    Philippa Lavallée
    Service de Neurologie et Centre d Accueil et de Traitement de l Attaque Cérébrale, Hopital Bichat, Paris
    Presse Med 36:134-41. 2007
    ..Treatment by platelet aggregation inhibitors (aspirin 160-300 mg) should begin immediately and be adjusted according to test results...
  50. ncbi request reprint Intracranial arterial dolichoectasia and its relation with atherosclerosis and stroke subtype
    Fernando Pico
    Department of Neurology, Versailles Hospital, France
    Neurology 61:1736-42. 2003
    ..To investigate the relationship between intracranial arterial dolichoectasia (IADE) and vascular risk factors, atherosclerosis of the carotid arteries as measured by ultrasound scan, and stroke subtypes...
  51. ncbi request reprint Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness--the ECTIM, AXA, EVA and GENIC Studies
    Odette Poirier
    INSERM U525, Epidemiologic and Molecular Genetics of Cardiovascular Diseases, Paris, France
    Eur J Hum Genet 12:213-9. 2004
    ..70 (0.09) vs 0.67 (0.13), P=0.02). No significant association of the 92Q allele was found with BI in the GENIC Study. Overall, these results may suggest that carriers of the 92Q allele may be at increased risk of atherosclerosis...
  52. doi request reprint Fibrates effect on cardiovascular risk is greater in patients with high triglyceride levels or atherogenic dyslipidemia profile: a systematic review and meta-analysis
    Eric Bruckert
    Department of Endocrinology, Pitie Salpetriere University Hospital, Pierre and Marie Curie University, 83 Boulevard de l hopital, 75651 Paris, France
    J Cardiovasc Pharmacol 57:267-72. 2011
    ..0001), respectively, but only by 6% (95% CI, 22% to 13%, P = 0.13) in nonatherogenic dyslipidemia patients. Targeting patients with high triglyceride levels or atherogenic dyslipidemia with fibrates may help reduce residual vascular risk...
  53. doi request reprint Coronary heart disease risk in patients with stroke or transient ischemic attack and no known coronary heart disease: findings from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
    Pierre Amarenco
    Department of Neurology and Stroke Centre, INSERM U 698 and Denis Diderot University Paris VII, Bichat Claude Bernard University Hospital, 46 rue Henri Huchard, 75018 Paris, France
    Stroke 41:426-30. 2010
    ..We evaluated the risk of developing clinically recognized CHD in SPARCL patients...
  54. ncbi request reprint Stroke prevention, blood cholesterol and statins
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
    Acta Neurol Taiwan 14:96-112. 2005
    ....
  55. doi request reprint Reperfusion therapy in acute cerebrovascular syndrome
    Mikael Mazighi
    Neurology and Stroke Departments, Paris 7 Denis Diderot University, Unité INSERM 698 Recherche Clinique en Athérothrombose, Groupe Hospitalier Bichat Claude Bernard, Paris, France
    Curr Opin Neurol 24:59-62. 2011
    ..However, arterial recanalization may be achieved without favorable clinical outcome, raising the question of the target population to be treated. We outline key issues that underline acute revascularization therapies...
  56. doi request reprint Carotid endarterectomy in the acute phase of crescendo cerebral transient ischemic attacks is safe and effective
    Guy Leseche
    Department of Vascular and Thoracic Surgery, Bichat Claude Bernard University Hospital, Denis Diderot University, and Medical School Paris VII, Assistance Publique Hopitaux de Paris, Paris, France
    J Vasc Surg 53:637-42. 2011
    ..To document the 30- and 90-day outcomes in patients with severe internal carotid artery stenosis who underwent carotid endarterectomy in the acute phase of crescendo cerebral transient ischemic attacks (CcTIAs)...
  57. ncbi request reprint Association studies between haemochromatosis gene mutations and the risk of cardiovascular diseases
    G Hetet
    INSERM U409 and Association Claude Bernard, Paris, France, Salpetriere Hospital, Paris, France
    Eur J Clin Invest 31:382-8. 2001
    ..Positive association studies have been recently published between cardiovascular diseases and heterozygosity for the major mutation C282Y in the haemochromatosis gene HFE...
  58. ncbi request reprint Cost of a recurrent vs. cost of first-ever stroke over an 18-month period
    J F Spieler
    Centre of Health Economic and Administration Research CHEAR, Institut National de la Santé et de la Recherche Médicale INSERM U 537, Paris, France
    Eur J Neurol 10:621-4. 2003
    ..This study suggests that the costs of recurrent BI are roughly similar to the costs of first-ever BI, which may be helpful when studying the cost-effectiveness of secondary stroke prevention trials...
  59. ncbi request reprint Hypercholesterolemia, lipid-lowering agents, and the risk for brain infarction
    P Amarenco
    Department of Neurology Bichat Hospital, Rene Descartes University and Stroke Unit, Paris, France
    Neurology 57:S35-44. 2001
    ..However, for the remaining patients with ischemic stroke, there is no proven therapeutic approach, and several large randomized, placebo-controlled trials are under way or planned for this indication...
  60. ncbi request reprint Stroke prevention, blood cholesterol, and statins
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat Claude Bernard University Hospital and Medical School, Denis Diderot University Paris VII, France
    Lancet Neurol 3:271-8. 2004
    ..Treatment strategies on the basis of global cardiovascular risk may be most effective. Additional studies in patients representative of the typical stroke population are needed...
  61. ncbi request reprint Ischemia-modified albumin in acute stroke
    Halim Abboud
    Department of Neurology and Stroke Center, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Cerebrovasc Dis 23:216-20. 2007
    ..Ischemia-modified albumin (IMA)is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels...
  62. ncbi request reprint Correlation between the Framingham risk score and intima media thickness: the Paroi Artérielle et Risque Cardio-vasculaire (PARC) study
    Pierre Jean Touboul
    Department of Neurology and Stroke Center, Bichat Claude Bernard University Hospital and Medical School, Denis Diderot University Paris VII, Paris, France
    Atherosclerosis 192:363-9. 2007
    ....
  63. ncbi request reprint Statin therapy and stroke prevention: what was known, what is new and what is next?
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat Hospital, Denis Diderot University and Medical School, Paris, France
    Curr Opin Lipidol 18:622-5. 2007
    ..Randomized trials have shown that statins may reduce the risk of primary stroke. There is no evidence however that statins can reduce recurrent stroke incidence...
  64. ncbi request reprint High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: a systematic review
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Denis Diderot University and Medical School, Bichat University Hospital, 46 rue Henri Huchard, 75018 Paris, France
    Atherosclerosis 196:489-96. 2008
    ..Epidemiological studies have found no relationship between total cholesterol and stroke risk, but little attention has been paid to high-density lipoprotein-cholesterol (HDL-C)...
  65. ncbi request reprint In vivo middle cerebral artery plaque imaging by high-resolution MRI
    I F Klein
    Department of Radiology, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Neurology 67:327-9. 2006
    ..At the level of stenosis, an MCA plaque was clearly delineated and significantly measured vs nonatherosclerotic MCA segments, showing that HR-MRI is an accurate direct imaging method...
  66. pmc Multiple microembolic borderzone brain infarctions and endomyocardial fibrosis in idiopathic hypereosinophilic syndrome and in Schistosoma mansoni infestation
    M Sarazin
    Department of Psychogeriatrics, Bretonneau Hospital, Paris, France
    J Neurol Neurosurg Psychiatry 75:305-7. 2004
    ....
  67. doi request reprint Cerebral microbleeds are frequent in infective endocarditis: a case-control study
    Isabelle Klein
    Department of Radiology, Bichat University Hospital, 75018 Paris, France
    Stroke 40:3461-5. 2009
    ..CMBs have been reported in isolated cases of infective endocarditis (IE), but their frequency and the association of CMBs with IE have not yet been studied...
  68. ncbi request reprint Frequency of migraine attacks following stroke starts to decrease before PFO closure
    B Lapergue
    Department of Neurology and Stroke Center, Bichat University Hospital, Denis Diderot University and Medical School, 46 rue Henri Huchard, 75018 Paris, France
    Neurology 67:1099-100. 2006
  69. pmc Patent foramen ovale and the risk of stroke: smoking gun guilty by association?
    P Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France
    Heart 91:441-3. 2005
  70. ncbi request reprint Intracranial arterial dolichoectasia and small-vessel disease in stroke patients
    Fernando Pico
    Department of Neurology, Versailles Mignot Hospital, Versailles, France
    Ann Neurol 57:472-9. 2005
    ..IADE in stroke patients was independently associated with parenchymal manifestations of small-vessel disease. These conditions may have in common underlying pathophysiological processes...
  71. ncbi request reprint Adverse associations between CX3CR1 polymorphisms and risk of cardiovascular or cerebrovascular disease
    Elise Lavergne
    Laboratoire d Immunologie Cellulaire, INSERM U543, Hopital Pitie Salpetriere, Paris, France
    Arterioscler Thromb Vasc Biol 25:847-53. 2005
    ..We investigated the role of monocyte-recruiting chemokines in cerebrovascular diseases among the subjects of the GENIC case-control study of brain infarction (BI)...
  72. ncbi request reprint Polypill strategy vs. prevention clinics for stroke prevention
    Pierre Amarenco
    Department of Neurology and Stroke Center, Bichat Hospital, Denis Diderot University and Medical School, Paris, France
    Cerebrovasc Dis 21:35-40. 2006
    ....
  73. doi request reprint Prevalence of embolic signals in acute coronary syndromes
    Elena Meseguer
    INSERM U 698 and Paris Diderot University, Bichat Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Stroke 41:261-6. 2010
    ..The purpose of this study was to assess the prevalence of embolic signals (ES) in acute coronary syndromes (ACS) and their association with stroke...
  74. ncbi request reprint Should the MATCH results be extrapolated to all stroke patients and affect ongoing trials evaluating clopidogrel plus aspirin?
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, 46 rue Henri Huchard, Paris, France 75018
    Stroke 35:2606-8. 2004
  75. ncbi request reprint Insular involvement in brain infarction increases risk for cardiac arrhythmia and death
    Halim Abboud
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Ann Neurol 59:691-9. 2006
    ..Brain injuries may induce cardiac dysrhythmias and sudden cardiac death...
  76. ncbi request reprint Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients
    David Brenner
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Stroke 37:1691-6. 2006
    ..Evidence exists that carotid IMT is heritable, and genetic studies can provide clues in the pathogenesis of atherosclerosis...
  77. doi request reprint Yield of systematic transcranial Doppler in patients with transient ischemic attack
    Elena Meseguer
    INSERM U698 and Denis Diderot University and Medical School, Paris, France
    Ann Neurol 68:9-17. 2010
    ..Our aim was to determine whether the use of transcranial Doppler (TCD) examination on arrival at the TIA clinic yields additional information that facilitates the identification of patients at high risk of stroke recurrence...
  78. ncbi request reprint Update on imaging aortic atherosclerosis
    Pierre Amarenco
    Department of Neurology, Denis Diderot University, Department of Neurology and Stroke Centre, Bichat Hospital, Paris, France
    Adv Neurol 92:75-89. 2003
  79. ncbi request reprint Association between influenza vaccination and reduced risk of brain infarction
    Philippa Lavallée
    Department of Neurology and the Formation de Recherche en Neurologie Vasculaire Association Claude Bernard, Lariboisiere Hospital, Denis Diderot University, Paris, France corrected
    Stroke 33:513-8. 2002
    ..Because infections subsequent to influenza may play a role in promoting the complications of atherosclerotic disease and may also induce hypercoagulation, we hypothesized that influenza vaccination may protect against brain infarction...
  80. doi request reprint Atherothrombosis and the role of antiplatelet therapy
    Ph G Steg
    INSERM U 698, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Paris, France
    J Thromb Haemost 9:325-32. 2011
    ....
  81. ncbi request reprint A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects
    Philippa C Lavallee
    Department of Neurology and Stroke Centre, Bichat Claude Bernard University Hospital, Denis Diderot University and Medical School Paris VII, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet Neurol 6:953-60. 2007
    ..We evaluated the effects of rapid assessment of patients with TIA on clinical decision making, length of hospital stay, and subsequent stroke rates...
  82. ncbi request reprint Predictive values of lacunar transient ischemic attacks
    Dominique Herve
    Department of Neurology and Stroke Center, Bichat University Hospital and Medical School, Denis Diderot University, Paris, France
    Stroke 35:1430-5. 2004
    ....
  83. ncbi request reprint Soluble thrombomodulin and brain infarction: case-control and prospective study
    Jean Marc Olivot
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, Paris, France
    Stroke 35:1946-51. 2004
    ....
  84. doi request reprint Prehospital stroke care: potential, pitfalls, and future
    Mikael Mazighi
    INSERM U 698, Clinical Research in Atherothrombosis and Denis Diderot University, France
    Curr Opin Neurol 23:31-5. 2010
    ..New strategies are being developed and evaluated to increase the number of tissue-type plasminogen activator-treated patients...
  85. doi request reprint Is moderate atherosclerotic stenosis in the middle cerebral artery a cause of or a coincidental finding in ischemic stroke?
    Isabelle F Klein
    INSERM U 698 and Denis Diderot University, Paris, France
    Cerebrovasc Dis 29:140-5. 2010
    ..The objective of this study was to investigate the cause of middle cerebral artery (MCA) atherosclerotic disease in patients with fatal stroke...
  86. doi request reprint Protective effect of high-density lipoprotein-based therapy in a model of embolic stroke
    Bertrand Lapergue
    INSERM U 698, Paris, France
    Stroke 41:1536-42. 2010
    ..Using a rat model, we tested the hypothesis that HDL exerts direct vasculo-/neuroprotective effects when administered during the acute phase of embolic stroke...
  87. doi request reprint Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review
    Elena Meseguer
    INSERM U 698 and Paris Diderot University, Paris, France
    Stroke 40:2104-10. 2009
    ..We evaluated gender differences in the efficacy and safety outcomes of intravenous rtPA using a clinical registry and systematic review...
  88. doi request reprint Underlying pathology of stroke of unknown cause (cryptogenic stroke)
    Pierre Amarenco
    INSERM U 698 and Paris Diderot University, Paris, France
    Cerebrovasc Dis 27:97-103. 2009
    ..g. arterial dissection, mobile intracardiac/luminal thrombus disappeared at the time of examination). In the next years, new diagnostic tools may hopefully determine which of these pathologies are or are not causally related to stroke...
  89. ncbi request reprint Association of small-vessel disease with dilatative arteriopathy of the brain: neuropathologic evidence
    Fernando Pico
    Department of Neuropathology Raymond Escourolle, AP HP Pitié Salpêtrière Hospital, Pierre et Marie Curie University, Paris, France
    Stroke 38:1197-202. 2007
    ..We used a large brain-autopsy collection to investigate the relation between IADE and pathologically assessed cerebral SVD...
  90. ncbi request reprint High blood pressure in early acute stroke: a sign of a poor outcome?
    Halim Abboud
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Paris, France
    J Hypertens 24:381-6. 2006
    ..To evaluate the prognostic value of admission blood pressure in patients with acute ischemic stroke by determining whether it contributes to clinical outcome and vascular death...
  91. ncbi request reprint Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, 46, rue Henri Huchard, 75018, Paris, France
    Stroke 38:3198-204. 2007
    ..In this exploratory analysis, our aim was to evaluate the benefit and risks associated with achieving a >or=50% low-density lipoprotein cholesterol (LDL-C) reduction from baseline...
  92. ncbi request reprint Effect of statins in stroke prevention
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Curr Opin Lipidol 16:614-8. 2005
    ..This paper reviews recent studies into the outcomes of clinical trials in which statin therapy has been used in the prevention and treatment of strokes...
  93. ncbi request reprint Renin-angiotensin-aldosterone system in brain infarction and vascular death
    David Brenner
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University, Paris, France
    Ann Neurol 58:131-8. 2005
    ..These results suggest that renin-angiotensin-aldosterone system activity and genes contribute to cerebrovascular disease and poststroke vascular death in white patients...
  94. ncbi request reprint Prevalence and determinants of subdiaphragmatic visceral infarction in patients with fatal stroke
    Halim Abboud
    Assistance Publique Hopitaux de Paris, Paris, France
    Stroke 38:1442-6. 2007
    ..We therefore investigated the prevalence of SDVI in subjects who died from stroke. We also evaluated the yield of SDVI diagnosis for stroke subtyping...
  95. ncbi request reprint Reversible leukoencephalopathy in cerebral amyloid angiopathy presenting as subacute dementia
    M Sarazin
    Service de Neurologie, Hopital Bichat, Paris, France
    Eur J Neurol 9:353-8. 2002
    ..We suggest that hypertensive encephalopathy may worsen or reveal cerebral amyloid angiopathy...
  96. doi request reprint Atherogenic dyslipidemia in patients with transient ischemic attack
    Gaia Sirimarco
    INSERM U 698 and Paris Diderot University, Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France
    Stroke 42:2131-7. 2011
    ..There is mounting evidence that atherogenic dyslipidemia (ie, low high-density lipoprotein cholesterol combined with high triglyceride concentrations) is an independent predictor of high cardiovascular risk and possibly of stroke...
  97. ncbi request reprint Blood pressure and lipid lowering in the prevention of stroke: a note to neurologists
    Pierre Amarenco
    Department of Neurology and Stroke Center, Bichat University Hospital and Medical School, 46 rue Henri Huchard, F 75018 Paris, France
    Cerebrovasc Dis 16:33-8. 2003
    ..It follows that rigorous identification and targeting of high- risk or stroke-prone individuals for blood pressure and lipid-lowering interventions should be of practical importance to all physicians involved in the management of stroke...
  98. ncbi request reprint Stroke research priorities for the next decade--A representative view of the European scientific community
    Stephen Meairs
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Theodor Kutzer Ufer, DE 68135 Mannheim Germany
    Cerebrovasc Dis 22:75-82. 2006
  99. ncbi request reprint Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome
    Aline Hoy
    INSERM Unite 525 equipe 4, Centre de Medecine Preventive, 2 Avenue du Doyen Jacques Parisot, 54501 Vandoeuvre Les Nancy, Nancy, France
    Atherosclerosis 167:223-30. 2003
    ..02). In conclusion, MPO polymorphisms were associated with the extent of brain damage and the functional outcome rather than with the risk of developing a BI...
  100. ncbi request reprint Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease
    Eric J Topol
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 108:399-406. 2003
    ....
  101. doi request reprint Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gregory W Albers
    Stanford University Medical Center, Stanford Stroke Center, 701 Welch Road, Palo Alto, CA 94304 1705, USA
    Chest 133:630S-669S. 2008
    ..5; range, 2.0 to 3.0) [Grade 1A]. In patients with venous sinus thrombosis, we recommend unfractionated heparin (Grade 1B) or low-molecular-weight heparin (Grade 1B) over no anticoagulant therapy during the acute phase...