Laurent Alric

Summary

Country: France

Publications

  1. ncbi request reprint Study of the association between major histocompatibility complex class II genes and the response to interferon alpha in patients with chronic hepatitis C infection
    L Alric
    Service de Médecine Interne Fédération Digestive, Hopital Purpan, Toulouse, France
    Hum Immunol 60:516-23. 1999
  2. ncbi request reprint Treatment of hepatitis C-virus-related glomerulonephritis
    N Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, CHU Rangueil, Toulouse University Hospital, Toulouse, France
    Kidney Int 69:436-9. 2006
  3. ncbi request reprint Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN
    Laurent Alric
    Service de Medecine Interne, Pavillon Dieulafoy, CHU Purpan, Toulouse, France
    Am J Kidney Dis 43:617-23. 2004
  4. ncbi request reprint Pilot study of interferon-alpha-ribavirin-interleukin-2 for treatment of nonresponder patients with severe liver disease infected by hepatitis C virus genotype 1
    L Alric
    Service de Médecine Interne Fédération Digestive, Hopital Purpan, Toulouse, France
    J Viral Hepat 13:139-44. 2006
  5. ncbi request reprint Long-term impact of renal transplantation on liver fibrosis during hepatitis C virus infection
    Laurent Alric
    Service de Medecine Interne, Pavillon Dieulafoy, CHU Purpan, Toulouse, France
    Gastroenterology 123:1494-9. 2002
  6. ncbi request reprint Characterization of overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis according to antimitochondrial antibodies status
    Laurent Alric
    Service de Medecine Interne, Fédération Digestive, Pavillon Dieulafoy, CHU Purpan, Toulouse
    Gastroenterol Clin Biol 31:11-6. 2007
  7. ncbi request reprint [Hepatitis C and pregnancy]
    L Alric
    Service de Medecine Interne, Pavillon Dieulafoy, Hopital Purpan, CHU, Place du Docteur Baylac, 31057 Toulouse, France
    Rev Med Interne 23:283-91. 2002
  8. doi request reprint Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis
    Laurent Alric
    Service de Medecine Interne, Fédération Digestive, CHU Purpan, Toulouse, France
    Transpl Int 22:568-73. 2009
  9. ncbi request reprint Maintenance therapy with gradual reduction of the interferon dose over one year improves histological response in patients with chronic hepatitis C with biochemical response: results of a randomized trial
    L Alric
    Service de Médecine Interne Fédération Digestive, Hĵpital Purpan, Toulouse, France
    J Hepatol 35:272-8. 2001
  10. ncbi request reprint Study of host- and virus-related factors associated with spontaneous hepatitis C virus clearance
    L Alric
    Service de Medecine Interne, Hopital Purpan, Toulouse, France
    Tissue Antigens 56:154-8. 2000

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Study of the association between major histocompatibility complex class II genes and the response to interferon alpha in patients with chronic hepatitis C infection
    L Alric
    Service de Médecine Interne Fédération Digestive, Hopital Purpan, Toulouse, France
    Hum Immunol 60:516-23. 1999
    ..The aim of the study was to determine the influence of HLA class II genes on the response to interferon-alpha (IFN-alpha) in patients with chronic hepatitis C...
  2. ncbi request reprint Treatment of hepatitis C-virus-related glomerulonephritis
    N Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, CHU Rangueil, Toulouse University Hospital, Toulouse, France
    Kidney Int 69:436-9. 2006
    ..During the acute phase, plasmapheresis and steroid pulses can be used. However, future prospective, controlled, and randomized studies are still required to establish evidence-based guidelines to treat HCV-related glomerulopathies...
  3. ncbi request reprint Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN
    Laurent Alric
    Service de Medecine Interne, Pavillon Dieulafoy, CHU Purpan, Toulouse, France
    Am J Kidney Dis 43:617-23. 2004
    ..The influence of hepatitis C virus (HCV) treatment on the course of HCV cryoglobulinemic membranoproliferative glomerulonephritis (MPGN) is controversial...
  4. ncbi request reprint Pilot study of interferon-alpha-ribavirin-interleukin-2 for treatment of nonresponder patients with severe liver disease infected by hepatitis C virus genotype 1
    L Alric
    Service de Médecine Interne Fédération Digestive, Hopital Purpan, Toulouse, France
    J Viral Hepat 13:139-44. 2006
    ..No serious adverse effects were observed. In conclusion, in patients with poor predictive factors of response, the addition of IL-2 to IFN ribavirin combination therapy does not exert a favourable impact on HCV treatment...
  5. ncbi request reprint Long-term impact of renal transplantation on liver fibrosis during hepatitis C virus infection
    Laurent Alric
    Service de Medecine Interne, Pavillon Dieulafoy, CHU Purpan, Toulouse, France
    Gastroenterology 123:1494-9. 2002
    ....
  6. ncbi request reprint Characterization of overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis according to antimitochondrial antibodies status
    Laurent Alric
    Service de Medecine Interne, Fédération Digestive, Pavillon Dieulafoy, CHU Purpan, Toulouse
    Gastroenterol Clin Biol 31:11-6. 2007
    ..The aim of this study was to compare among 102 consecutive patients, 2 subsets of overlap syndrome (OS, N=21) with and without antimitochondrial antibody (AMA) to two groups of patients with typical PBC (N=43) or AIH (N=38)...
  7. ncbi request reprint [Hepatitis C and pregnancy]
    L Alric
    Service de Medecine Interne, Pavillon Dieulafoy, Hopital Purpan, CHU, Place du Docteur Baylac, 31057 Toulouse, France
    Rev Med Interne 23:283-91. 2002
    ..FUTURE PROSPECTS AND PROJECTS: In case of HCV infection, a careful follow-up of both mother and newborns is required. Long-term follow-up of infected infants is needed to assess the consequences of perinatal HCV infection...
  8. doi request reprint Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis
    Laurent Alric
    Service de Medecine Interne, Fédération Digestive, CHU Purpan, Toulouse, France
    Transpl Int 22:568-73. 2009
    ..The FT and LSM are acceptably accurate for diagnosing mild liver fibrosis in kidney-transplant patients with chronic HCV or HBV infections, but their diagnostic value for predicting severe liver disease needs to be confirmed...
  9. ncbi request reprint Maintenance therapy with gradual reduction of the interferon dose over one year improves histological response in patients with chronic hepatitis C with biochemical response: results of a randomized trial
    L Alric
    Service de Médecine Interne Fédération Digestive, Hĵpital Purpan, Toulouse, France
    J Hepatol 35:272-8. 2001
    ..Our aim was to assess whether histological response was improved by continuing interferon-alpha (IFN) treatment in patients with chronic hepatitis C (HCV) with a biochemical response and no viral clearance after a usual IFN treatment...
  10. ncbi request reprint Study of host- and virus-related factors associated with spontaneous hepatitis C virus clearance
    L Alric
    Service de Medecine Interne, Hopital Purpan, Toulouse, France
    Tissue Antigens 56:154-8. 2000
    ..004). In conclusion, spontaneous hepatitis C virus RNA clearance is determined by class II antigens (mainly DQB1*0301) and female sex, while viral genotype plays no role...
  11. doi request reprint Tenofovir therapy in hepatitis B virus-positive solid-organ transplant recipients
    Mathieu Daudé
    Department of Nephrology, Dialysis and Organ Transplantation, Toulouse University Hospital, Toulouse, France
    Transplantation 91:916-20. 2011
    ..The aim of this pilot study was to assess the clinical and biologic response and tolerance to tenofovir therapy in HBV-positive organ transplant recipients...
  12. ncbi request reprint Genetic diversity of HCV genotype 2 strains in south western France
    Fabienne Thomas
    Service de Virologie, Hopital Purpan, CHU Toulouse, Toulouse Cedex, France
    J Med Virol 79:26-34. 2007
    ..56.5 years, P < 0.01). This study shows substantial genetic diversity of HCV-2 subtypes in the south of France and the spread of 2a strains via intravenous drug users...
  13. ncbi request reprint Twenty-four hour kinetics of hepatitis C virus and antiviral effect of alpha-interferon
    Anne Boulestin
    Laboratoire de Virologie EA 2046 IFR30, CHU Purpan, Toulouse, France
    J Med Virol 78:365-71. 2006
    ..Resistant HCV strains could be distinguished from sensitive viruses as early as a few hours after the beginning of the treatment...
  14. ncbi request reprint Evolution of hepatitis C virus quasispecies during therapy with IL2 combinated to alpha interferon and ribavirin
    Anne Boulestin
    Laboratoire de Virologie EA 2046, IFR30, Toulouse, France
    Antivir Ther 10:499-504. 2005
    ..Treatment with IL2 in combination with IFN-alpha and ribavirin had no effect on the selective pressure on HCV quasispecies. IL2 is not the best option to treat hepatitis C...
  15. ncbi request reprint Heterogeneity of hepatitis C virus genotype 4 strains circulating in south-western France
    Florence Nicot
    Service de Virologie, Hopital Purpan, EA2046 IFR30, CHU Toulouse, 31059 Toulouse Cedex, France
    J Gen Virol 86:107-14. 2005
    ..This study of a large cohort of patients shows the great diversity of HCV-4 strains, and that these subtypes have spread differently...
  16. ncbi request reprint Intrahepatic cytokine profile in renal-transplant patients infected by hepatitis C virus
    Nassim Kamar
    Department of Nephrology, Dialysis and Multiorgan Transplantation, CHU Rangueil, Toulouse, France
    J Med Virol 76:482-8. 2005
    ..17, P=0.045). Intrahepatic Th1 cytokine profile seems to be predominant in patients with extensive fibrosis and activity scores, suggesting that it might be responsible for liver injury in renal transplant patients...
  17. ncbi request reprint [The evolution of the hypervariable region-1 of hepatitis C virus may predict liver fibrosis outcome after renal transplantation]
    Nassim Kamar
    Service de Nephrologie, Dialyse et Transplantation, CHU de Toulouse Rangueil, 1, TSA 50032, Toulouse, France
    Nephrol Ther 1:345-54. 2005
    ..The diversification of the HVR-1 of the HCV genome might be used to predict liver fibrosis outcome...
  18. pmc Convenient biological assay for polyethylene glycol-interferons in patients with hepatitis C
    Anne Boulestin
    Laboratoire de Virologie EA 2046 IFR 30, CHU Purpan, Place du Dr Baylac, TSA 40031, 31059 Toulouse Cedex 9, France
    Antimicrob Agents Chemother 48:3610-2. 2004
    ..Human serum and ribavirin did not interfere with the assay. This bioassay was successfully used for assaying PEG-IFN-alpha 2a and PEG-IFN-alpha 2b in serum samples from patients undergoing combination therapy...
  19. doi request reprint Hepatitis E virus and the kidney in solid-organ transplant patients
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Transplantation 93:617-23. 2012
    ..Hepatitis E virus (HEV) infection is an emerging disease in industrialized countries. Few data regarding genotype 3 HEV extrahepatic manifestations exist...
  20. ncbi request reprint Natural history of hepatitis C virus-related liver fibrosis after renal transplantation
    Nassim Kamar
    Department of Nephrology, Dialysis and Multiorgan Transplantation, CHU Rangueil, Toulouse, Paris, France
    Am J Transplant 5:1704-12. 2005
    ..The diversification of the HVR-1 might be used to predict liver fibrosis outcome...
  21. ncbi request reprint Hepatitis E is an autochthonous disease in industrialized countries. Analysis of 23 patients in South-West France over a 13-month period and comparison with hepatitis A
    Jean Marie Peron
    Service d Hepato gastro enterologie, Fédération Digestive Fédération Digestive, CHU Toulouse, Hopital Purpan, Toulouse
    Gastroenterol Clin Biol 30:757-62. 2006
    ..The aim of this study was to describe patients with acute hepatitis E in South West France and compare them with patients with acute hepatitis A...
  22. doi request reprint Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 139:1612-8. 2010
    ..We assessed the antiviral effect of ribavirin monotherapy in patients with chronic HEV infection following kidney transplantation...
  23. doi request reprint Mycophenolic acid 12-hour area under the curve in de novo liver transplant patients given mycophenolate mofetil at fixed versus concentration-controlled doses
    Nassim Kamar
    Department of Nephrology, Dialysis and Multi Organ Transplantation, CHU Rangueil, Toulouse, France
    Ther Drug Monit 31:451-6. 2009
    ..There was a trend toward a lower proportion of patients with MPA AUC0-12h below 30 mg x h/L in the concentration-controlled group. No difference in outcome was found between both groups...
  24. doi request reprint Entecavir therapy for adefovir-resistant hepatitis B virus infection in kidney and liver allograft recipients
    Nassim Kamar
    Nephrology, Dialysis, and Multiorgan Transplant Unit, University Hospital, CHU Rangueil, 31059 Toulouse Cedex 9, France
    Transplantation 86:611-4. 2008
    ..There were no significant changes in renal function or hematological parameters. This study demonstrates that entecavir therapy is safe and efficient in HBV(+) organ-transplant patients...
  25. doi request reprint Influence of the HCV subtype on the virological response to pegylated interferon and ribavirin therapy
    Florence Legrand-Abravanel
    Laboratoire de Virologie, Centre Hospitalier Universitaire, Toulouse, France
    J Med Virol 81:2029-35. 2009
    ..0-2.5; P = 0.04) or subtypes 4a and 4d (OR: 2.03; 95% CI = 1.1-3.8; P = 0.03). In conclusion, among difficult-to-treat genotypes, the subtype 1a is associated with a lower response to anti-HCV therapy than subtypes 1b, 4a, and 4d...
  26. ncbi request reprint Treatment of hepatorenal syndrome as defined by the international ascites club by albumin and furosemide infusion according to the central venous pressure: a prospective pilot study
    Jean Marie Peron
    Service d Hepato gastro enterologie, Fédération Digestive, Hopital Purpan, Toulouse, France
    Am J Gastroenterol 100:2702-7. 2005
    ..7 wks from the time of diagnosis. The aim of the present study was to examine the effects of albumin and furosemide administration tailored to central venous pressure (CVP) on renal function and clinical outcome...
  27. doi request reprint In vitro mitogen-stimulated T-cell from hepatitis C virus-positive liver transplantation candidates, increases T-cell activation markers and T-cell proliferation
    Cindy Canivet
    INSERM U858 I2MR, Equipe 10, CHU Rangueil, Toulouse, France
    Transpl Immunol 19:112-9. 2008
    ....
  28. pmc Performance of two commercial assays for detecting hepatitis E virus RNA in acute or chronic infections
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    J Clin Microbiol 51:1913-6. 2013
    ..Both assays provided good analytical sensitivity and high reproducibility for detecting genotype 3 HEV RNA...
  29. ncbi request reprint Hepatitis E in the south west of France in individuals who have never visited an endemic area
    Jean Michel Mansuy
    Virology Laboratory, Purpan University Hospital, Place du Dr Baylac TSA 40031, 31059, Toulouse, France
    J Med Virol 74:419-24. 2004
    ....
  30. doi request reprint Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis
    Jean Paul Motta
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan CPTP, Toulouse, F 31300, France
    Gastroenterology 140:1272-82. 2011
    ..We investigated the role of Elafin, a serine protease inhibitor expressed by skin and mucosal surfaces in human inflammatory conditions, and the proteases neutrophil elastase (NE) and proteinase-3 (PR-3) in mice with colitis...
  31. doi request reprint Low risk of hepatitis E virus reactivation after haematopoietic stem cell transplantation
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F 31300 France
    J Clin Virol 54:152-5. 2012
    ..HEV infection can evolve to chronic hepatitis in immunocompromised patients. Additionally, HEV reactivation after haematopoietic stem cell transplantation has been reported...
  32. ncbi request reprint Cryoglobulinemia vasculitis
    Patrice Cacoub
    Service de Medecine Interne, hôpital La Pitié Salpêtrière, Paris, France
    Curr Opin Rheumatol 14:29-35. 2002
    ....
  33. ncbi request reprint Genetic heterogeneity of the envelope 2 gene and eradication of hepatitis C virus after a second course of interferon-alpha
    Anne Boulestin
    Laboratoire de Virologie, Hopital Purpan, Toulouse Cedex, France
    J Med Virol 68:221-8. 2002
    ....
  34. doi request reprint Influence of pre-analytical conditions on plasma ribavirin concentrations
    Peggy Gandia
    Laboratoire de Pharmacocinétique et Toxicologie Clinique, Institut Fédératif de Biologie, H6pital Purpan, Toulouse France
    Arzneimittelforschung 60:636-9. 2010
    ..These results suggest that blood samples for ribavirin analysis can be sent at room temperature within a period of 2 h between sampling and centrifugation...
  35. ncbi request reprint High prevalence of anti-hepatitis E virus antibodies in blood donors from South West France
    Jean Michel Mansuy
    Virology Laboratory, Purpan University Hospital, Toulouse Cedex 9, France
    J Med Virol 80:289-93. 2008
    ..As the risk factors for HEV infection in industrialized countries are still unknown, further studies are needed to clarify the epidemiology of HEV infection in the Midi-Pyrénées region...
  36. pmc Immunologically silent autochthonous acute hepatitis E virus infection in France
    Jean Michel Mansuy
    Virology Laboratory, Purpan University Hospital, 31059 Toulouse, France
    J Clin Microbiol 42:912-3. 2004
    ..We report on an autochthonous case in southwestern France in which the diagnosis was based on molecular tools rather than serological testing...
  37. ncbi request reprint "A La Carte" treatment of portal hypertension: Adapting medical therapy to hemodynamic response for the prevention of bleeding
    Christophe Bureau
    Service d Hepato gastro enterologie, Federation Digestive Purpan, CHU Toulouse, France and INSERM, U531, CHU Rangueil, Toulouse, France
    Hepatology 36:1361-6. 2002
    ..In conclusion, hemodynamic response to drug therapy identifies patients who are efficiently protected from variceal bleeding as well as nonresponders in whom an alternative treatment should be considered...
  38. doi request reprint Hepatitis C virus and kidney disease
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France INSERM U1043, IFR BMT, CHU Purpan, Toulouse, France Université Paul Sabatier, Toulouse, France Electronic address
    Clin Res Hepatol Gastroenterol 37:328-33. 2013
    ..The available data also suggest that occult HCV infection does not exist in dialysis and kidney transplant patients. ..
  39. doi request reprint Simplified identification of Lynch syndrome: a prospective, multicenter study
    Delphine Bonnet
    Purpan Hospital, Medical Oncology, Institut Claudius Regaud, Medical Genetics, Cancer Research Centre of Toulouse, INSERM UMR 1037 CNRS ERL 5294 Toulouse 3 University, Markers and Targets for Digestive Cancer Biotherapy, Toulouse, France
    Dig Liver Dis 44:515-22. 2012
    ..Recommended strategies to screen for Lynch syndrome in colorectal cancer are not applied in daily practice and most of Lynch cases remain undiagnosed...
  40. pmc Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals
    Maud Mavigner
    INSERM, UMR1043, Toulouse, France
    J Clin Invest 122:62-9. 2012
    ..Our results thus describe alterations in CD4+ T cell homing to the gut that could prevent efficient mucosal immune reconstitution in HIV-infected individuals despite effective cART...
  41. ncbi request reprint Transient clonal expansion of T-large granular lymphocytes during primary cytomegalovirus infection
    Pierre Delobel
    Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Dr Baylac, TSA 40031, 31059 cedex 9, Toulouse, France
    J Infect 53:e65-7. 2006
    ..This case underlines that clonal expansion of T-LGL could be a reactive phenomenon related to an acute infectious disease and is not specific for lymphoid malignancy...
  42. doi request reprint Predictive factors for posttransplant diabetes mellitus within one-year of liver transplantation
    Loubna Oufroukhi
    Department of Nephrology, Dialysis and Multiorgan Transplant Unit, CHU Rangueil, Toulouse Cedex 9, France
    Transplantation 85:1436-42. 2008
    ....
  43. ncbi request reprint Ureteral stenosis as the sole manifestation of Wegener's granulomatosis
    Nassim Kamar
    Department of Nephrology, CHU Toulouse Purpan, Toulouse, France
    Urology 62:352. 2003
    ..Urologists, nephrologists, and internists should be aware of this atypical presentation of Wegener's granulomatosis. Thorough clinical and biologic assessments are warranted in the initial workup of isolated intrinsic ureteral stenosis...
  44. doi request reprint Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice
    Emilie D'Aldebert
    INSERM Unité 563 Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Gastroenterology 140:275-85. 2011
    ..We investigated whether TRPV4 activation participates in intestinal inflammation and its expression and functions in the gastrointestinal tract...
  45. ncbi request reprint [The farmer's wife will not exceed the limit!]
    L Geffray
    Service de Medecine Interne, Centre Hospitalier Robert Bisson, Lisieux, France
    Rev Med Interne 26:S200-2. 2005
  46. ncbi request reprint Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21(WAF1) down-regulation -- effect of transforming growth factor beta
    Marc Dubourdeau
    Macrophages, médiateurs de l inflammation et interactions cellulaires UPRES EA 2405 INSERM IFR 31, CHU Rangueil, Bat L1, 1 avenue Jean Poulhes, 31403 Toulouse Cedex 04, France
    J Hepatol 37:486-92. 2002
    ..Because core protein has oncogenic properties, we investigated the expression of p21(WAF1) following core expression...