Y Allanore

Summary

Country: France

Publications

  1. pmc Body mass index influences the response to infliximab in ankylosing spondylitis
    Sebastien Ottaviani
    Rheumatology Department, AP HP, Paris Diderot, Sorbonne Paris Cité University, Bichat Claude Bernard Hospital, 46 rue Henri Huchard, Paris, 75018, France
    Arthritis Res Ther 14:R115. 2012
  2. doi request reprint TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients
    Eugénie Koumakis
    Paris Descartes University, Inserm U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France
    Ann Rheum Dis 71:1900-3. 2012
  3. doi request reprint Articular involvement in systemic sclerosis
    Jerome Avouac
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Rheumatology (Oxford) 51:1347-56. 2012
  4. doi request reprint Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies
    Muriel Elhaï
    Rheumatology A Department, Descartes University, Paris, France
    Rheumatology (Oxford) 51:1017-26. 2012
  5. pmc Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis
    Baptiste Coustet
    Universite Paris Descartes, Rhumatologie A, Inserm U1016, Hopital Cochin, APHP, Paris, France
    J Rheumatol 39:997-1003. 2012
  6. doi request reprint Familial autoimmunity in systemic sclerosis -- results of a French-based case-control family study
    Eugénie Koumakis
    Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, France
    J Rheumatol 39:532-8. 2012
  7. doi request reprint Angiogenic biomarkers predict the occurrence of digital ulcers in systemic sclerosis
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, APHP, Sorbonne Paris Cité, Paris, France
    Ann Rheum Dis 71:394-9. 2012
  8. pmc Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy
    Ariane Leboime
    Federation de rhumatologie, Pôle Appareil Locomoteur centre Viggo Petersen, Hopital Lariboisiere, Paris Diderot University, 2 rue Ambroise Pare, Paris 75010, France
    Arthritis Res Ther 11:R164. 2009
  9. pmc Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity
    Vanina Jodon de Villeroché
    INSERM U781, Paris Descartes University, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Arthritis Res Ther 12:R27. 2010
  10. ncbi request reprint Genetic basis for systemic sclerosis
    Yannick Allanore
    Paris Descartes University, School of Medicine, Rheumatology A Department, Cochin Teaching Hospital, AP HP, Paris, France
    Joint Bone Spine 74:577-83. 2007

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. pmc Body mass index influences the response to infliximab in ankylosing spondylitis
    Sebastien Ottaviani
    Rheumatology Department, AP HP, Paris Diderot, Sorbonne Paris Cité University, Bichat Claude Bernard Hospital, 46 rue Henri Huchard, Paris, 75018, France
    Arthritis Res Ther 14:R115. 2012
    ..The aim of this study was to determine whether body mass index (BMI) affects response to infliximab (IFX) in ankylosing spondylitis (AS) patients...
  2. doi request reprint TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients
    Eugénie Koumakis
    Paris Descartes University, Inserm U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France
    Ann Rheum Dis 71:1900-3. 2012
    ..Mutations of transforming growth factor beta (TGFβ) receptor genes strongly contribute to idiopathic and familial PAH...
  3. doi request reprint Articular involvement in systemic sclerosis
    Jerome Avouac
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Rheumatology (Oxford) 51:1347-56. 2012
    ..e. biologics borrowed from RA) may bring new opportunities to treat SSc-related arthritis and even SSc per se. However, the first step will be to study and validate outcome criteria in this insufficiently studied field...
  4. doi request reprint Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies
    Muriel Elhaï
    Rheumatology A Department, Descartes University, Paris, France
    Rheumatology (Oxford) 51:1017-26. 2012
    ..Thus, we set out to determine whether mortality rate in SSc patients has decreased over the past 40 years through a meta-analysis of cohort studies...
  5. pmc Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis
    Baptiste Coustet
    Universite Paris Descartes, Rhumatologie A, Inserm U1016, Hopital Cochin, APHP, Paris, France
    J Rheumatol 39:997-1003. 2012
    ..Our objective was to validate TNFSF4 association with SSc and determine the subset with the higher risk...
  6. doi request reprint Familial autoimmunity in systemic sclerosis -- results of a French-based case-control family study
    Eugénie Koumakis
    Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, France
    J Rheumatol 39:532-8. 2012
    ..To assess the prevalence of autoimmune diseases in first-degree relatives of patients with systemic sclerosis (SSc), and to compare those results with control families in order to identify patterns of autoimmune diseases in relatives...
  7. doi request reprint Angiogenic biomarkers predict the occurrence of digital ulcers in systemic sclerosis
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, APHP, Sorbonne Paris Cité, Paris, France
    Ann Rheum Dis 71:394-9. 2012
    ..To evaluate the possible merit of endothelial markers for the prediction of ischaemic digital ulcers in patients with systemic sclerosis (SSc)...
  8. pmc Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy
    Ariane Leboime
    Federation de rhumatologie, Pôle Appareil Locomoteur centre Viggo Petersen, Hopital Lariboisiere, Paris Diderot University, 2 rue Ambroise Pare, Paris 75010, France
    Arthritis Res Ther 11:R164. 2009
    ..Sinus aspergilloma occurs occasionally in RA patients and can progress to invasive Aspergillus disease. The purpose of this study was to describe symptomatic sinus aspergilloma in RA patients treated with TNFalpha antagonists...
  9. pmc Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity
    Vanina Jodon de Villeroché
    INSERM U781, Paris Descartes University, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Arthritis Res Ther 12:R27. 2010
    ..Contradictory results have been published regarding circulating endothelial progenitor cells (EPCs) in RA. We herein investigated late outgrowth EPC sub-population using recent recommendations in patients with RA and healthy controls...
  10. ncbi request reprint Genetic basis for systemic sclerosis
    Yannick Allanore
    Paris Descartes University, School of Medicine, Rheumatology A Department, Cochin Teaching Hospital, AP HP, Paris, France
    Joint Bone Spine 74:577-83. 2007
    ..Investigations into the genetics of systemic sclerosis may shed light on the complex pathophysiology of this disease, help to identify factors that predict organ involvement, and suggest new treatment strategies...
  11. doi request reprint Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis
    Y Allanore
    Service de Rhumatologie A, Hopital Cochin, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 69:218-21. 2010
    ..To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc)...
  12. ncbi request reprint Treatment of systemic sclerosis
    Yannick Allanore
    Rheumatology A Department, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Paris 5 University, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Joint Bone Spine 73:363-8. 2006
    ..Available results indicate that emphasis should be put on cardiovascular drugs. The development of criteria for disease activity and severity would facilitate future research on the treatment of systemic sclerosis...
  13. ncbi request reprint Genetic background of systemic sclerosis: autoimmune genes take centre stage
    Yannick Allanore
    Universite Paris Descartes, Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
    Rheumatology (Oxford) 49:203-10. 2010
    ..Most likely, these immune-modifying genes could interact and influence both disease phenotype and severity. Less evidence is available yet with regard to genetic markers relating to the vascular and fibrotic aspects of the disease...
  14. ncbi request reprint [Treatment of systemic scleroderma: update]
    Y Allanore
    Service de Rhumatologie A, Universite Paris 5, Faculte de Medecine, Hopital Cochin, Assistance Publique Hopitaux de Paris, 75014 Paris
    Ann Dermatol Venereol 133:286-91. 2006
  15. ncbi request reprint N-terminal pro brain natriuretic peptide: the new cornerstone of cardiovascular assessment in systemic sclerosis
    Y Allanore
    Department of Rheumatology A, Cochin Hospital, Paris Descartes University, Paris, France
    Clin Exp Rheumatol 27:59-63. 2009
    ....
  16. pmc Lack of association between three vascular endothelial growth factor gene polymorphisms and systemic sclerosis: results from a multicenter EUSTAR study of European Caucasian patients
    Y Allanore
    Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 66:257-9. 2007
    ..Systemic sclerosis (SSc) is characterised by disturbed vessel morphology and an overproduction of vascular endothelial growth factor (VEGF). The VEGF gene located on chromosome 6p21.3 has several polymorphisms...
  17. ncbi request reprint [Heart involvement in systemic sclerosis]
    Yannick Allanore
    Universite Rene Descartes, Faculte de Medicine, Service de Rhumatologie A, Hopital Cochin, AP HP, Paris
    Presse Med 35:1938-42. 2006
    ..Treatment for myocardial involvement includes long-term systematic administration of calcium channel blockers and possibly angiotensin-converting enzyme inhibitors, frequently given at high dosage...
  18. ncbi request reprint Hand vascular involvement assessed by magnetic resonance angiography in systemic sclerosis
    Y Allanore
    Rene Descartes University, and Service de Rheumatologie A, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
    Arthritis Rheum 56:2747-54. 2007
    ..Magnetic resonance angiography (MRA) has improved the assessment of vascular lesions of the hand. The aim of this study was to evaluate vascular abnormalities in the hands of patients with SSc, using MRA...
  19. ncbi request reprint New therapeutic strategies in the management of systemic sclerosis
    Yannick Allanore
    Rene Descartes University, Medical Faculty, Department of Rheumatology A, Cochin Hospital, Paris, France
    Expert Opin Pharmacother 8:607-15. 2007
    ..However, recent epidemiological data have revealed a decrease in excess mortality, which may be mostly due to the use of cardiovascular drugs. This article deals with present and possible future therapeutic options...
  20. doi request reprint N-terminal pro-brain natriuretic peptide in systemic sclerosis: a new cornerstone of cardiovascular assessment?
    Y Allanore
    Department of Rheumatology A, Paris Descartes University, Cochin Hospital, APHP, 75014 Paris, France
    Ann Rheum Dis 68:1885-9. 2009
    ..Cardiac involvement, a common and often fatal complication of systemic sclerosis (SSc), is currently detected by standard echocardiography enhanced by tissue Doppler echocardiography (TDE)...
  21. ncbi request reprint High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis
    Y Allanore
    Rene Descartes University, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 58:284-91. 2008
    ..To evaluate predictors of pulmonary arterial hypertension (PAH) in a prospective cohort of patients with systemic sclerosis (SSc)...
  22. ncbi request reprint Systemic sclerosis and cardiac dysfunction: evolving concepts and diagnostic methodologies
    Yannick Allanore
    Departments of Rheumatology A, France bCardiology, Paris Descartes University, Cochin Hospital, AP HP, Paris, France
    Curr Opin Rheumatol 20:697-702. 2008
    ..Clinically evident cardiac involvement is recognized to be a poor prognostic factor; thus preclinical identification is highly encouraged...
  23. ncbi request reprint Primary myocardial involvement in systemic sclerosis: evidence for a microvascular origin
    Y Allanore
    Paris Descartes University, Department of Rheumatology, Cochin Hospital, Paris, France
    Clin Exp Rheumatol 28:S48-53. 2010
    ..Recent quantitative methods such as tissue Doppler echocardiography and magnetic resonance imaging have underlined these results...
  24. ncbi request reprint Is sitaxsentan a good therapeutic option for pulmonary arterial hypertension associated with connective tissue disease?
    Yannick Allanore
    Service de Rhumatologie A, Universite Paris Descartes, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
    Nat Clin Pract Rheumatol 4:238-9. 2008
    ..The effects of sitaxsentan observed in the CTD group were comparable to those seen in the idiopathic PAH group. The authors concluded that treatment with sitaxsentan might be beneficial in patients with PAH associated with CTD...
  25. ncbi request reprint [Genetics and pathophysiology of systemic sclerosis]
    Yannick Allanore
    Rhumatologie A, Hopital Cochin, Universite Paris Descartes, Inserm U1016 et APHP, 27, rue du Faubourg Saint Jacques 75679 Paris cedex 14
    Bull Acad Natl Med 195:55-65; discussion 66-7. 2011
    ..Improvements in diagnostic and prognostic tools are anticipated in the near future, together with more specific immune therapy for these patients, for whom specific treatment is not currently available...
  26. doi request reprint Outcome measures for heart involvement in systemic sclerosis
    Y Allanore
    Department of Rheumatology A, Paris Descartes University, Cochin Hospital, AP HP, Paris, France
    Rheumatology (Oxford) 47:v51-3. 2008
    ..Their predictive value should also be investigated when there is primary heart involvement...
  27. ncbi request reprint Systemic sclerosis: an update in 2008
    Yannick Allanore
    Paris Descartes University, Medical Faculty, Department of Rheumatology A, Cochin Hospital, AP HP and INSERM U781, Necker Hospital, Paris, France
    Joint Bone Spine 75:650-5. 2008
    ..This article deals with current and possible future therapeutic options...
  28. doi request reprint Updating the genetics of systemic sclerosis
    Yannick Allanore
    Universite Paris Descartes, Service de Rhumatologie A, Hopital Cochin, France
    Curr Opin Rheumatol 22:665-70. 2010
    ..In this review, we focus on recent large candidate gene studies that have included replication and very recent genome-wide approaches...
  29. pmc Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    Yannick Allanore
    Universite Paris Descartes, Rhumatologie A, INSERM, U1016, Hopital Cochin, APHP, Paris, France
    PLoS Genet 7:e1002091. 2011
    ..The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis...
  30. doi request reprint Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis
    P Dieude
    Universite Paris 7, and Hôpital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 60:225-33. 2009
    ..The aim of this study was to determine whether the IRF5 rs2004640 single-nucleotide polymorphism is associated with SSc...
  31. doi request reprint BANK1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4
    P Dieude
    Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Arthritis Rheum 60:3447-54. 2009
    ....
  32. doi request reprint STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis
    P Dieude
    Université Paris 7 and Service de Rhumatologie, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 60:2472-9. 2009
    ..The aim of this study was to determine whether the STAT4 rs7574865 single-nucleotide polymorphism is associated with SSc, and whether it interacts with IRF5...
  33. doi request reprint Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population
    P Dieude
    Universite Paris, Hopital Bichat Claude Bernard, APHP, France
    Ann Rheum Dis 69:1958-64. 2010
    ..TNFAIP3 encodes the ubiquitin-modifying enzyme, a key regulator of inflammatory signalling pathways. Convincing associations between TNFAIP3 variants and autoimmune diseases have been reported...
  34. doi request reprint Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population
    J Wipff
    Rene Descartes University, Department of Rheumatology A, Cochin Hospital, Paris
    Scand J Rheumatol 38:291-4. 2009
    ..The aim of this study was to determine whether polymorphisms of the hypoxia-inducible factor 1A gene (HIF1A) affects susceptibility to SSc in a large French European Caucasian population...
  35. ncbi request reprint Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin
    J Wipff
    Department of Rheumatology A, Paris Descartes University, Medical Faculty, Cochin Hospital, Paris, France
    Rheumatology (Oxford) 47:972-5. 2008
    ..The aim of this study was to investigate, in a cross-sectional study, sENG levels together with other serum vascular markers...
  36. doi request reprint Myopathies related to systemic sclerosis: a case-control study of associated clinical and immunological features
    B Ranque
    Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Cochin Hospital, Faculty of Medicine, Paris Descartes University, the Public Assistance Hospitals of Paris AH HP, France
    Scand J Rheumatol 39:498-505. 2010
    ..Little is known about systemic sclerosis (SSc)-related myopathy. We aimed to compare the clinical and immunological features of SSc patients with or without associated myopathy...
  37. doi request reprint Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions
    J Avouac
    Université Paris Descartes and Hôpital Cochin, Assistance Publique Hopitaux de Paris, Paris, and INSERM U781, Hopital Necker, Paris, France
    Arthritis Rheum 58:3550-61. 2008
    ..To assess angiogenesis and explore the expression and regulation of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR-1), and VEGFR-2, the leading mediators of angiogenesis, in SSc patients and controls...
  38. ncbi request reprint [Inducible nitric oxide synthase expression and nitric oxide production by monocytes in systemic sclerosis]
    C J Menkes
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg Saint Jacques 75679 Paris
    Bull Acad Natl Med 185:509-22; discussion 522-3. 2001
    ..Low levels of NO, a vasodilator, may be involved in vasospasm, which is critical in SSc. This may suggest therapeutic implications...
  39. doi request reprint The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis
    P Dieude
    Universite Paris 7, Paris, France
    Arthritis Rheum 58:2183-8. 2008
    ..We then conducted a meta-analysis of the most recent studies of SSc in order to verify the association or lack of association between the PTPN22 1858C>T variant and SSc...
  40. ncbi request reprint N-terminal pro-brain natriuretic peptide as a diagnostic marker of early pulmonary artery hypertension in patients with systemic sclerosis and effects of calcium-channel blockers
    Y Allanore
    Paris V University, Assistance Publique Hopitaux de Paris, Hopital Cochin, Paris, France
    Arthritis Rheum 48:3503-8. 2003
    ....
  41. ncbi request reprint Levels of circulating endothelial progenitor cells in systemic sclerosis
    Y Allanore
    Rheumatology A and Immunology departments, Rene Descartes University, Medical School, Cochin Hospital, Assistance Publique Hopitaux de Paris, France
    Clin Exp Rheumatol 25:60-6. 2007
    ..Our aim was to investigate bone marrow-derived circulating endothelial precursors (EPCs) and activated circulating endothelial cells (CECs) in SSc patients...
  42. doi request reprint Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population
    J Wipff
    Universite Paris Descartes, INSERM U781, Hopital Necker, and Hôpital Cochin, Paris, France
    Arthritis Rheum 62:3093-100. 2010
    ..We undertook this study to determine whether KCNA5 polymorphisms confer susceptibility to SSc and its vascular phenotype, including PAH...
  43. ncbi request reprint Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension
    J Wipff
    Rene Descartes University, Medical Faculty, Rheumatology A Department, Cochin Hospital, AP HP, Paris, France
    Rheumatology (Oxford) 46:622-5. 2007
    ..A 6-base insertion in intron 7 (6bINS) of ENG has been reported to be associated with microvascular disturbance...
  44. pmc Radiological hand involvement in systemic sclerosis
    J Avouac
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 65:1088-92. 2006
    ..The osteoarticular and soft tissue structures of the hand may be involved in systemic sclerosis (SSc), causing functional disability...
  45. pmc Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population
    J Wipff
    Rheumatology A Department, Cochin Hospital, Paris, France
    Ann Rheum Dis 65:1230-2. 2006
    ..38). The PTPN22*620W allele was also not associated with autoantibody patterns. Thus, the PTPN22*R620W polymorphism cannot be regarded as a genetic susceptibility factor for SSc in the French Caucasian population...
  46. pmc Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging
    Y Allanore
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 65:249-52. 2006
    ..Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical...
  47. pmc Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcers
    Y Allanore
    Rheumatology A, Paris V University, Assistance Publique Hopitaux de Paris, France
    Ann Rheum Dis 64:481-3. 2005
    ..Increased expression of CD40L has been reported on activated CD4+ T lymphocytes in systemic sclerosis. CD40L can be expressed in soluble form (sCD40L)...
  48. doi request reprint Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis
    P Dieude
    Universite Paris Diderot, Hopital Bichat Claude Bernard, Paris, France
    Arthritis Rheum 63:1097-105. 2011
    ..The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations...
  49. doi request reprint Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity
    J Avouac
    Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, Paris, France
    Ann Rheum Dis 67:1455-60. 2008
    ..Heterogeneous data have been reported regarding the detection and number of circulating endothelial progenitor cells (EPCs) in systemic sclerosis (SSc)...
  50. ncbi request reprint Serum protein oxidation in patients with rheumatoid arthritis and effects of infliximab therapy
    H Lemarechal
    Department of Biochemistry A, Assistance Publique Hopitaux de Paris, Cochin Hospital, 75014 Paris, France
    Clin Chim Acta 372:147-53. 2006
    ..To examine protein oxidation in rheumatoid arthritis (RA) and evaluate its evolution after infliximab therapy in a subgroup of patients...
  51. doi request reprint Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype
    P Dieude
    Paris Diderot University, AP HP, INSERM U699, Paris, France
    Arthritis Rheum 63:3979-87. 2011
    ..This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype...
  52. ncbi request reprint Primary myocardial involvement in systemic sclerosis
    A Kahan
    Paris 5 René Descartes University, Department of Rheumatology A, Cochin Hospital, AP HP, Paris, France
    Rheumatology (Oxford) 45:iv14-7. 2006
    ..Vasodilators, such as calcium channel blockers and angiotensin converting enzyme inhibitors, improve both myocardial perfusion and function abnormalities...
  53. doi request reprint Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study
    J Avouac
    Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 70:630-3. 2011
    ..To examine the outcomes of hand radiographic x-rays in patients with systemic sclerosis (SSc) and to identify risk factors for the progression of hand radiographic lesions in a prospective cohort...
  54. doi request reprint Angiotensin-converting enzyme gene does not contribute to genetic susceptibility to systemic sclerosis in European Caucasians
    Julien Wipff
    Paris Descartes Université, Rhumatologie A, Hopital Cochin, AP HP, Paris, France
    J Rheumatol 36:337-40. 2009
    ..To determine whether angiotensin-converting enzyme (ACE) polymorphisms including I/D and 2 single-nucleotide polymorphisms (SNP) affect susceptibility to systemic sclerosis (SSc) in a large French Caucasian population...
  55. pmc Evaluation of the effect of nifedipine upon myocardial perfusion and contractility using cardiac magnetic resonance imaging and tissue Doppler echocardiography in systemic sclerosis
    O Vignaux
    Services de Radiologie A, Hopital Cochin, AP HP, Universite Paris V, 75014 Paris, France
    Ann Rheum Dis 64:1268-73. 2005
    ..Previous studies have suggested that dihydropyridine-type calcium channel blockers mitigate both myocardial perfusion and function abnormalities...
  56. ncbi request reprint Prevalence of antiphospholipid antibodies in systemic sclerosis and association with primitive pulmonary arterial hypertension and endothelial injury
    N Assous
    Department of Rheumatology A, Paris 5 University, Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
    Clin Exp Rheumatol 23:199-204. 2005
    ..To investigate the prevalence and clinical significance of antiphospholipid antibodies in patients with systemic sclerosis (SSc)...
  57. doi request reprint Cardiovascular risk in rheumatoid arthritis: effects of anti-TNF drugs
    J Avouac
    Paris Descartes University, Medical Faculty, Department of Rheumatology A, Cochin Hospital, AP HP, Paris, France
    Expert Opin Pharmacother 9:1121-8. 2008
    ....
  58. pmc Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry
    F Tubach
    Universite Paris 7 Denis Diderot, INSERM U738, Assistance Publique Hopitaux de Paris AP HP, Hopital Bichat, Biostatistique et Recherche Clinique, Paris, France
    Arthritis Rheum 60:1884-94. 2009
    ..Our objective was to describe cases of TB associated with anti-TNF mAb therapy, identify risk factors, and estimate the incidence...
  59. ncbi request reprint Systemic sclerosis-associated Sjögren's syndrome and relationship to the limited cutaneous subtype: results of a prospective study of sicca syndrome in 133 consecutive patients
    J Avouac
    Rene Descartes University, Medical Faculty, Hopital Cochin, France
    Arthritis Rheum 54:2243-9. 2006
    ..To determine the prevalence of sicca symptoms and Sjögren's syndrome (SS) in a 2-center prospective series of patients with systemic sclerosis (SSc), using the American-European Consensus Group criteria for SS...
  60. doi request reprint Prognostic factors for lung function in systemic sclerosis: prospective study of 105 cases
    M Gilson
    Dept of Rheumatology A, Paris Descartes University, Cochin Hospital, Paris, France
    Eur Respir J 35:112-7. 2010
    ..Only diffuse SSc was predictive of a decrease in pulmonary function in this early-SSc cohort. This does not support preliminary data suggestive of a causative role of oesophageal involvement...
  61. ncbi request reprint Low levels of nitric oxide (NO) in systemic sclerosis: inducible NO synthase production is decreased in cultured peripheral blood monocyte/macrophage cells
    Y Allanore
    Department of Rheumatology A, Cochin Hospital, , Paris 75014, France
    Rheumatology (Oxford) 40:1089-96. 2001
    ..Low levels of NO, a vasodilator, may be involved in vasospasm, which is critical in SSc. This may have therapeutic implications...
  62. ncbi request reprint Effects of oral treatments on exercise capacity in systemic sclerosis related pulmonary arterial hypertension: a meta-analysis of randomised controlled trials
    J Avouac
    Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, Paris, France
    Ann Rheum Dis 67:808-14. 2008
    ....
  63. doi request reprint Associated autoimmune diseases in systemic sclerosis define a subset of patients with milder disease: results from 2 large cohorts of European Caucasian patients
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France
    J Rheumatol 37:608-14. 2010
    ..To assess the prevalence and potential associations with the systemic sclerosis (SSc) phenotype of additional autoimmune diseases (AID)...
  64. ncbi request reprint Polymorphic markers of the fibrillin-1 gene and systemic sclerosis in European Caucasian patients
    Julien Wipff
    Department of Rheumatology A, Paris Descartes University, Medical Faculty, Cochin Hospital, AP HP, Paris, France
    J Rheumatol 35:643-9. 2008
    ..Significant associations have been found with the fibrillin-1 gene (FBN1) in Choctaw and Japanese populations. We investigated FBN1 polymorphisms in cohorts of European Caucasian patients...
  65. doi request reprint Immunogenetics of systemic sclerosis
    P Dieude
    Universite Paris Diderot, Service de Rhumatologie, Hopital Bichat Claude Bernard, APHP, Paris, France
    Autoimmun Rev 10:282-90. 2011
    ....
  66. doi request reprint A descriptive and prognostic study of systemic sclerosis-associated myopathies
    B Ranque
    Universite Paris Descartes, UPRES EA 4058, Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Hopital Cochin, Assistance Publique des Hopitaux de Paris, Paris, France
    Ann Rheum Dis 68:1474-7. 2009
    ..To describe the clinical characteristics and muscle pathological features of patients with systemic sclerosis (SSc) and myopathy and analyse their impact on muscle outcome...
  67. ncbi request reprint Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: A controlled study of 100 consecutive patients
    Christophe Meune
    Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 58:1803-9. 2008
    ..To assess the prevalence of primary cardiac complications in a large population of patients with systemic sclerosis (SSc), using recently developed echocardiographic techniques...
  68. ncbi request reprint Evaluation of interleukin 13 polymorphisms in systemic sclerosis
    Brigitte Granel
    Laboratoire d Immunologie et de Génétique des Maladies Parasitaires, UMR 399 INSERM, Universite de la Mediterranee, Faculte de Medecine, 13005, Marseille, France
    Immunogenetics 58:693-9. 2006
    ..Our result supports the suggestion that polymorphisms in IL13 are associated to SSc and skin fibrosis process. However, further studies on larger and independent population and functional analyses are needed to confirm these findings...
  69. ncbi request reprint Management of a patient with sarcoid calcaneitis and dactylitis
    Y Allanore
    , Service de Rhumatologie A, H pital Cochin, France
    Joint Bone Spine 68:175-7. 2001
    ..Involvement of the calcaneus is exceedingly rare, and its treatment is not standardized. In our patient, glucocorticoid therapy combined with methotrexate and hydroxychloroquine were effective in controlling the disease...
  70. ncbi request reprint Induction of autoantibodies in refractory rheumatoid arthritis treated by infliximab
    Y Allanore
    Rheumatology A Department, Paris V University, Cochin Hospital, AP HP Paris, France
    Clin Exp Rheumatol 22:756-8. 2004
    ..To investigate autoantibody induction in rheumatoid arthritis (RA) patients treated with infliximab...
  71. ncbi request reprint [Watermelon stomach in systemic sclerosis]
    K Laoubi
    Service de Rhumatologie A, Hopital Cochin, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    J Mal Vasc 35:250-3. 2010
    ..Indeed, specific local treatment must be delivered and is usually efficient despite frequent recurrent events...
  72. ncbi request reprint [Spondylarthropathies and anti-TNFalpha drugs]
    S Pavy
    Service de Rhumatologie A, Universite Paris 5, Hopital Cochin, 27, rue du Faubourg Saint Jacques, AP HP, 75014 Paris, France
    Rev Med Interne 26:717-24. 2005
    ..TNFalpha appears as an important actor in the pathogenesis of spondylarthropathies...
  73. doi request reprint NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis
    P Dieude
    Service de Rhumatologie, Paris Diderot University, INSERM U699, Hopital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France
    Ann Rheum Dis 70:668-74. 2011
    ..NLRP1 provides a scaffold for the assembly of the inflammasome that promotes the processing and maturation of pro-IL-1β. In addition, NLRP1 variants were found to confer susceptibility to autoimmune disorders...
  74. doi request reprint Dermal tissue and cellular expression of fibrillin-1 in diffuse cutaneous systemic sclerosis
    Julien Wipff
    Universite Paris Descartes, Rhumatologie A, Hopital Cochin, AP HP, Paris, France
    Rheumatology (Oxford) 49:657-61. 2010
    ..To assess dermal expression and fibroblast production of fibrillin-1 (FBN-1) in SSc...
  75. doi request reprint Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population
    Julien Wipff
    Universite Paris Descartes, AP HP, Hopital Cochin, France
    J Rheumatol 37:599-602. 2010
    ..Our aim was to determine whether polymorphisms of the MMP2, MMP9, and MMP14 genes confer susceptibility to SSc in a large population...
  76. doi request reprint Heart involvement in systemic sclerosis: evolving concept and diagnostic methodologies
    Christophe Meune
    Service de cardiologie, Hopital Cochin, AP HP, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Arch Cardiovasc Dis 103:46-52. 2010
    ..Biological variables, such as B-type natriuretic peptides, are highly relevant, valuable markers of global heart involvement in systemic sclerosis and should be considered for screening of patients and/or research purposes...
  77. doi request reprint Usefulness of routine electrocardiography for heart disease screening in patients with spondyloarthropathy or rheumatoid arthritis
    Tiphaine Miquel Goulenok
    Services de Rhumatologie A, Hopital Cochin, AP HP, Universite Paris Descartes, 27, rue du faubourg 75679 Paris cedex 14, France
    Joint Bone Spine 77:146-50. 2010
    ..To assess the usefulness of routine electrocardiography for heart disease screening in patients with spondyloarthropathy (SpA) or rheumatoid arthritis (RA)...
  78. doi request reprint Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity
    Philippe Dieude
    Service de Rhumatologie, Hopital Bichat Claude Bernard, APHP, Université Diderot Paris 7, Paris, France
    J Rheumatol 37:987-92. 2010
    ..Our aim was to investigate whether IRF5 haplotypes confer susceptibility to SSc, and to perform genotype haplotype-phenotype correlation analyses...
  79. ncbi request reprint Myocardial contractility is early affected in systemic sclerosis: a tissue Doppler echocardiography study
    Christophe Meune
    Department of Cardiology, Cochin Hospital, AP HP, Rene Descartes University, 27 rue du Fg St Jacques, 75014 Paris, France
    Eur J Echocardiogr 6:351-7. 2005
    ..Our aim was to prospectively investigate LV function in SSc patients, using Tissue Doppler echocardiography (TDE), a modern and accurate method of assessing myocardial function...
  80. ncbi request reprint High risk of clinical cardiovascular events in rheumatoid arthritis: Levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis
    Christophe Meune
    Departement de Cardiologie, Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, 75014 Paris, France
    Arch Cardiovasc Dis 103:253-61. 2010
    ..While there are convergent data suggesting that overall cardiovascular mortality is increased in patients with rheumatoid arthritis, the relative contributions of myocardial infarction and stroke remain unclear...
  81. doi request reprint The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype
    Karen Dawidowicz
    GenHotel EA 3886, University Evry Paris 7 Medical School, Member of the AutoCure European Consortium, Evry Genopole Cedex, France
    Ann Rheum Dis 70:117-21. 2011
    ..Interferon regulatory factors, such as IRF5, coordinate type I IFN expression. Multiple IRF5 variants were suggested as autoimmunity susceptibility factors...
  82. doi request reprint Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study
    Olivier Meyer
    Universite Paris 7 Denis Diderot, UFR de Medecine, APHP Hôpital Bichat, Service de Rhumatologie, Paris, France
    J Rheumatol 37:125-30. 2010
    ..To determine the prevalence of anti-RNA polymerase III autoantibodies in French patients with systemic sclerosis (SSc) and to identify the associated clinical manifestations...
  83. ncbi request reprint Bosentan increases myocardial perfusion and function in systemic sclerosis: a magnetic resonance imaging and Tissue-Doppler echography study
    Yannick Allanore
    Services de Rhumatologie A, Cardiologie, and Radiologie A, Universite Paris Descartes, Faculte de Medecine, Hopital Cochin, Paris, France
    J Rheumatol 33:2464-9. 2006
    ..To evaluate the short-term effects of bosentan on myocardial perfusion and function assessed by cardiac magnetic resonance imaging (MRI) and Tissue-Doppler echography (TDE) respectively in patients with systemic sclerosis (SSc)...
  84. ncbi request reprint [Interactions between fibrillin-1 and tgf-beta: consequences and human pathology]
    Julien Wipff
    INSERM U781, Universite Paris Descartes, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 25:161-7. 2009
    ....
  85. ncbi request reprint Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations
    Julien Wipff
    Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
    J Rheumatol 37:1164-7. 2010
    ..Our objective was to determine whether polymorphisms of SLC6A4 confer susceptibility to SSc and its vascular phenotype...
  86. ncbi request reprint [Management of digital ulcers from systemic scleroderma]
    Camille Frances
    Service de Dermatologie Allergologie, AP HP, Hopital Tenon, F 75020 Paris, France
    Presse Med 37:271-85. 2008
    ..Surgery is useful in the case of substantial retraction or bothersome calcifications. In all cases, calcium channel blockers are continued...
  87. doi request reprint Association of Fcγ receptor IIIA variant with a subset of anti-topoisomerase I-positive patients in systemic sclerosis: a descriptive pilot study
    J Magnant
    Service de Médecine Interne et Vasculaire B, CHRU de Tours, France, Tours, France
    Rheumatol Int 32:2203-7. 2012
    ..SSc patients with anti-topo I appear to be more frequently homozygous for the high-affinity FcγRIIIA-coding allele, suggesting that some autoantibodies may be pathogenic through ADCC...
  88. ncbi request reprint Myocardial dysfunction in rheumatoid arthritis: a controlled tissue-Doppler echocardiography study
    Christophe Meune
    Department of Cardiology, Paris Descartes University, Medical School, Cochin Hospital, Paris, France
    J Rheumatol 34:2005-9. 2007
    ..To determine the sensitivity and accuracy of tissue-Doppler echocardiography (TDE) to assess myocardial contractility. Heart failure is one of the determinants of the excess in mortality in patients with rheumatoid arthritis (RA)...
  89. ncbi request reprint Correlation of serum collagen I carboxyterminal telopeptide concentrations with cutaneous and pulmonary involvement in systemic sclerosis
    Yannick Allanore
    Department of Rheumatology A, Paris V University, France
    J Rheumatol 30:68-73. 2003
    ..Type I collagen (Col I) is the most abundant extracellular matrix protein deposited in cutaneous involvement. We investigated Col I biochemical markers in patients with SSc...
  90. doi request reprint Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group
    J Avouac
    Rheumatology A Department, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 70:476-81. 2011
    ..To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc)...
  91. pmc Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis
    Y Allanore
    Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 63:1276-8. 2004
    ..Cardiovascular diseases, vasospasm, and dysimmunity have been implicated in normal tension glaucoma (NTG)...
  92. ncbi request reprint Sacral inflammatory pseudotumor revealed by paraneoplastic syndrome
    Y Allanore
    Department of Rheumatology, Assistance Publique Hopitaux de Paris, Rene Descartes University, Paris, France
    Rheumatol Int 24:166-8. 2004
    ..All clinical symptoms disappeared within a few days after surgery, which is suggestive of a paraneoplastic syndrome. No relapse has occurred after 4 years...
  93. ncbi request reprint Prevalence of Barrett's esophagus in systemic sclerosis
    J Wipff
    Cochin Hospital, AP HP Paris 5 University, Paris, France
    Arthritis Rheum 52:2882-8. 2005
    ..This study sought to determine the prevalence of BE and esophageal adenocarcinoma in a cohort of SSc patients...
  94. ncbi request reprint [Psoriatic arthritis]
    Y Allanore
    Service de Rhumatologie A, Pr Kahan, Hopital Cochin, AP HP, Universite Paris V, 27, rue du Faubourg Saint Jacques 75014 Paris
    Ann Dermatol Venereol 129:1401-4. 2002
  95. ncbi request reprint Brachial plexopathy associated with systemic sclerosis
    Y Allanore
    Cochin Hospital, Assistance Publique Hopitaux de Paris, Rene Descartes University, France
    Clin Rheumatol 21:401-2. 2002
    ..We report a third case of brachial plexopathy, presumably related to vasculitis, in a patient with systemic sclerosis, which improved after cyclophosphamide therapy...
  96. ncbi request reprint Lack of specificity of the 6-minute walk test as an outcome measure for patients with systemic sclerosis
    Yoland Schoindre
    Universite Paris Descartes, Service de Rhumatologie A, Departement de Cardiologie, and Service Physiologie et Explorations Fonctionnelles, Hopital Cochin, AP HP, 75014 Paris, France
    J Rheumatol 36:1481-5. 2009
    ..However, conflicting results have been reported in systemic sclerosis (SSc). Our objective was to evaluate the relationships of the 6-min walking distance (6MWD) and organ damage in SSc...
  97. ncbi request reprint Lack of association of eNOS (G894T) and p22phox NADPH oxidase subunit (C242T) polymorphisms with systemic sclerosis in a cohort of French Caucasian patients
    Yannick Allanore
    Department of Rheumatology A, Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris V University, 75679 Paris Cedex 14, France
    Clin Chim Acta 350:51-5. 2004
    ..To assess the influence of endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase polymorphisms on the susceptibility of patients to and clinical expression of systemic sclerosis (SSc)...
  98. ncbi request reprint Cardiovascular disease in rheumatoid arthritis: single-center hospital-based cohort study in France
    Noémie Assous
    Rheumatology A Department, School of Medicine, Rene Descartes University, Cochin Teaching Hospital, Paris, France
    Joint Bone Spine 74:66-72. 2007
    ..Rheumatoid arthritis (RA) was independently associated with cardiovascular events in several studies, most of which were conducted in the US...
  99. ncbi request reprint Therapeutic strategy combining intravenous cyclophosphamide followed by oral azathioprine to treat worsening interstitial lung disease associated with systemic sclerosis: a retrospective multicenter open-label study
    Alice Berezne
    Paris Descartes University, Faculty of Medicine, Department of Internal Medicine and Reference Center for Necrotizing Vasculitides and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris France
    J Rheumatol 35:1064-72. 2008
    ..To evaluate the effects and safety of 6-month intravenous cyclophosphamide (CYC) followed by 18-month oral azathioprine (AZA) therapy in patients with systemic sclerosis (SSc) and worsening interstitial lung disease (ILD)...
  100. ncbi request reprint High prevalence of right ventricular systolic dysfunction in early systemic sclerosis
    Christophe Meune
    Department of Cardiology, Cochin Hospital, APHP, Paris V University, Paris, France
    J Rheumatol 31:1941-5. 2004
    ..To assess right ventricular (RV) function in patients with early systemic sclerosis (SSc) and the acute effects of calcium channel blockers on RV ejection fraction (RVEF)...
  101. ncbi request reprint Evaluation of depression and anxiety in patients with systemic sclerosis
    Cécile Legendre
    Rheumatology Department A, Cochin Teaching Hospital, Paris V University, AP HP, 27 rue du Faubourg St Jacques, 75014 Paris, France
    Joint Bone Spine 72:408-11. 2005
    ..To determine the prevalence of depression and anxiety in patients receiving follow-up in France for systemic sclerosis...