M C Alessi

Summary

Country: France

Publications

  1. ncbi Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity
    M C Alessi
    Laboratoire d Hématologie Faculté de Médecine Timone, Centre Hospitalier Universitaire Timone, Marseille, France
    Diabetes 49:1374-80. 2000
  2. ncbi Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity
    I Juhan-Vague
    Laboratory of Hematology, Faculty of Medicine, CHU Timone, Marseille, France
    Ann Med 32:78-84. 2000
  3. ncbi Fat cell function and fibrinolysis
    M C Alessi
    Laboratory of Hematology, Faculty of Medicine, CHU Timone, Marseille, France
    Horm Metab Res 32:504-8. 2000
  4. ncbi Hypofibrinolysis in the insulin resistance syndrome: implication in cardiovascular diseases
    A Mavri
    Laboratory of Hematology, CHU Timone, Marseille, France
    J Intern Med 255:448-56. 2004
  5. ncbi Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study
    P E Morange
    INSERM, U626, Universite de la Mediterranee, Marseille, France
    Arterioscler Thromb Vasc Biol 27:2250-7. 2007
  6. ncbi Thrombin-activatable fibrinolysis inhibitor antigen levels and cardiovascular risk factors
    I Juhan-Vague
    Laboratory of Hematology, Centre de Détection et de Prévention de l Athérosclérose, CHU Timone, Marseille, France
    Arterioscler Thromb Vasc Biol 20:2156-61. 2000
  7. ncbi Relations between hemostatic variables, insulin resistance and inflammation
    Pierre E Morange
    Hematology Laboratory CHU Timone Insern U626, Faculty of Medicine, Marseille, France
    Hematol J 5:S15-9. 2004
  8. ncbi Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
    I Juhan-Vague
    Laboratory of Hematology, CHU Timone, Inserm EPI 99 36, Marseille, France
    J Thromb Haemost 1:1575-9. 2003
  9. doi Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha
    M Canault
    INSERM, U626, Marseille, F 13385, France
    J Pathol 214:574-83. 2008
  10. ncbi Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort
    P E Morange
    Hematology Laboratory, Faculty of Medicine, INSERM U626, CHU Timone, Marseille, France
    Br J Haematol 128:91-9. 2005

Collaborators

Detail Information

Publications17

  1. ncbi Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity
    M C Alessi
    Laboratoire d Hématologie Faculté de Médecine Timone, Centre Hospitalier Universitaire Timone, Marseille, France
    Diabetes 49:1374-80. 2000
    ..This increased PAI-1 expression could be the result of tissue cytokine disturbances, such as elevated TGF-beta1 expression...
  2. ncbi Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity
    I Juhan-Vague
    Laboratory of Hematology, Faculty of Medicine, CHU Timone, Marseille, France
    Ann Med 32:78-84. 2000
    ..The role of PAI-1 in the development of adipose tissue metabolism is important to consider as PAI-1 -/- mice submitted to a high-fat diet showed changes in cell composition of adipose tissue and in plasma insulin and triglyceride levels...
  3. ncbi Fat cell function and fibrinolysis
    M C Alessi
    Laboratory of Hematology, Faculty of Medicine, CHU Timone, Marseille, France
    Horm Metab Res 32:504-8. 2000
    ..Moreover alteration of adipose tissue cellular composition induced by the modulation of PAI-1 expression opens a novel field of interest...
  4. ncbi Hypofibrinolysis in the insulin resistance syndrome: implication in cardiovascular diseases
    A Mavri
    Laboratory of Hematology, CHU Timone, Marseille, France
    J Intern Med 255:448-56. 2004
    ..Modifying PAI-1 expression by PAI-1 inhibitors may open a new field of research and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes...
  5. ncbi Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study
    P E Morange
    INSERM, U626, Universite de la Mediterranee, Marseille, France
    Arterioscler Thromb Vasc Biol 27:2250-7. 2007
    ....
  6. ncbi Thrombin-activatable fibrinolysis inhibitor antigen levels and cardiovascular risk factors
    I Juhan-Vague
    Laboratory of Hematology, Centre de Détection et de Prévention de l Athérosclérose, CHU Timone, Marseille, France
    Arterioscler Thromb Vasc Biol 20:2156-61. 2000
    ..Because of the large interindividual variability of TAFI levels in plasma, genetic control may be involved...
  7. ncbi Relations between hemostatic variables, insulin resistance and inflammation
    Pierre E Morange
    Hematology Laboratory CHU Timone Insern U626, Faculty of Medicine, Marseille, France
    Hematol J 5:S15-9. 2004
  8. ncbi Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
    I Juhan-Vague
    Laboratory of Hematology, CHU Timone, Inserm EPI 99 36, Marseille, France
    J Thromb Haemost 1:1575-9. 2003
    ..Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes...
  9. doi Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha
    M Canault
    INSERM, U626, Marseille, F 13385, France
    J Pathol 214:574-83. 2008
    ..TNF-dependent progression of atherosclerosis is probably linked to the differential production of pro-inflammatory mediators whether tmTNF is preponderant or essentially cleaved...
  10. ncbi Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort
    P E Morange
    Hematology Laboratory, Faculty of Medicine, INSERM U626, CHU Timone, Marseille, France
    Br J Haematol 128:91-9. 2005
    ..The D2080N polymorphism of the LRP gene weakly contributed to the variability of FVIII:C levels in this healthy population...
  11. ncbi High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome
    T Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    J Thromb Haemost 4:542-9. 2006
    ..Low response to antiplatelet therapy may be a risk factor for the development of ischemic complications in patients with non-ST segment elevation acute coronary syndrome (NSTE ACS) undergoing coronary stenting...
  12. ncbi Chronic plasminogen activator inhibitor-1 (PAI-1) overexpression dampens CD25+ lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung
    M Poggi
    Faculte de Medecine, Aix Marseille Universite, Marseille, France
    J Thromb Haemost 5:2467-75. 2007
    ..Beside fibrin deposits, increased tissue PAI-1 expression may contribute to the poor outcome of endotoxemia through other mechanisms...
  13. ncbi Antibodies to phosphatidylethanolamine as the only antiphospholipid antibodies found in patients with unexplained thromboses
    M Sanmarco
    Fédération Autoimmunité Thrombose, Laboratoire d Immunologie, H pital de la Conception, CHU, Marseille, France
    Thromb Haemost 85:800-5. 2001
    ..Thus, aPE investigation appears to be of interest in UT and their persistent presence could define a biological variant of APS...
  14. ncbi Prognostic value of plasma tissue factor and tissue factor pathway inhibitor for cardiovascular death in patients with coronary artery disease: the AtheroGene study
    P E Morange
    INSERM, U626, Marseille, and Université de la Méditerranée, Marseille, France
    J Thromb Haemost 5:475-82. 2007
    ..Tissue factor (TF) and its specific inhibitor, tissue factor pathway inhibitor (TFPI), are important contributors to the initiation of the coagulation process...
  15. ncbi Weak and non-independent association between plasma TAFI antigen levels and the insulin resistance syndrome
    H Aubert
    Laboratoire d Hematologie, INSERM EPI99 36, CHU Timone and Center d Investigation Clinique de Marseille AP HM, INSERM, Marseille, France
    J Thromb Haemost 1:791-7. 2003
    ..Increased plasma TAFI antigen levels in obesity might reflect a specific pathway of regulation at the liver level...
  16. doi In vivo assessment of murine elastase-induced abdominal aortic aneurysm with high resolution magnetic resonance imaging
    M A Bartoli
    Aix Marseille Universite, CNRS, CRMBM UMR, Marseille, France
    Eur J Vasc Endovasc Surg 44:475-81. 2012
    ..This MRI study at 11.75 T aimed at evaluating the reliability of longitudinal in vivo aortic diameter and wall thickness measurements in this particular model...
  17. doi Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat
    B Gaborit
    Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Marseille, France
    Int J Obes (Lond) 36:422-30. 2012
    ..To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function...