Gerard Ailhaud

Summary

Country: France

Publications

  1. pmc Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse
    Anne Marie Rodriguez
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 Centre National de la Recherche Scientifique, 06108 Nice Cedex 2, France
    J Exp Med 201:1397-405. 2005
  2. pmc Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis
    Marcel Scheideler
    Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    BMC Genomics 9:340. 2008
  3. ncbi request reprint Angiotensinogen, angiotensin II and adipose tissue development
    G Ailhaud
    Laboratoire Biologie du Développement du Tissu Adipeux, Centre de Biochimie UMR 6543 CNRS, UNSA, Nice, France
    Int J Obes Relat Metab Disord 24:S33-5. 2000
  4. doi request reprint An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?
    Gerard Ailhaud
    ISDBC, Universite de Nice Sophia Antipolis, CNRS, 28 Avenue Valrose, Nice 06100, France
    Br J Nutr 100:461-70. 2008
  5. ncbi request reprint Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome
    Gerard Ailhaud
    ISDBC, Centre de Biochimie, UMR 6543 CNRS, laboratoire developpement du tissu adipeux, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    C R Biol 329:570-7; discussion 653-5. 2006
  6. ncbi request reprint Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity
    Gerard Ailhaud
    ISDBC, Centre de Biochimie UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Prog Lipid Res 45:203-36. 2006
  7. ncbi request reprint [Development of adipose tissue and dietary lipids: from basic science to medicine]
    G Ailhaud
    Institut de Recherches Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie UMR 6543 CNRS, UNSA, Faculte des Sciences, Nice, France
    Ann Endocrinol (Paris) 66:2S7-10. 2005
  8. ncbi request reprint Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion
    G Ailhaud
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie, Faculte des Sciences, Parc Valrose, Nice, France
    Obes Rev 5:21-6. 2004
  9. ncbi request reprint Angiotensinogen, adipocyte differentiation and fat mass enlargement
    Gerard Ailhaud
    Institute of Signaling, Developmental Biology and Cancer Research, Centre de Biochimie UMR 6543 CNRS, Laboratory Biology of Adipose Tissue Development, Faculte des Sciences, Parc Valrose, Nice, France
    Curr Opin Clin Nutr Metab Care 5:385-9. 2002
  10. ncbi request reprint Adipose tissue as an endocrine organ
    G Ailhaud
    Laboratoire de Biologie du Développement du Tissu Adipeux, Centre de Biochimie, UNSA, Faculte des Sciences, Nice, France
    Int J Obes Relat Metab Disord 24:S1-3. 2000

Collaborators

Detail Information

Publications50

  1. pmc Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse
    Anne Marie Rodriguez
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 Centre National de la Recherche Scientifique, 06108 Nice Cedex 2, France
    J Exp Med 201:1397-405. 2005
    ....
  2. pmc Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis
    Marcel Scheideler
    Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    BMC Genomics 9:340. 2008
    ....
  3. ncbi request reprint Angiotensinogen, angiotensin II and adipose tissue development
    G Ailhaud
    Laboratoire Biologie du Développement du Tissu Adipeux, Centre de Biochimie UMR 6543 CNRS, UNSA, Nice, France
    Int J Obes Relat Metab Disord 24:S33-5. 2000
    ..Altogether the data are consistent with an autocrine/paracrine mechanism implicating AGT, angII and prostacyclin in adipose tissue development...
  4. doi request reprint An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?
    Gerard Ailhaud
    ISDBC, Universite de Nice Sophia Antipolis, CNRS, 28 Avenue Valrose, Nice 06100, France
    Br J Nutr 100:461-70. 2008
    ..More research is needed to address whether disequilibration of dietary PUFA intake contributes to the risk of obesity in humans...
  5. ncbi request reprint Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome
    Gerard Ailhaud
    ISDBC, Centre de Biochimie, UMR 6543 CNRS, laboratoire developpement du tissu adipeux, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    C R Biol 329:570-7; discussion 653-5. 2006
    ..Associated to the effect of secretory products from macrophages (cytokines), a disturbance in the balance between these various secreted factors leads to the development of a metabolic syndrome...
  6. ncbi request reprint Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity
    Gerard Ailhaud
    ISDBC, Centre de Biochimie UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Prog Lipid Res 45:203-36. 2006
    ..If prevention of obesity is a key issue for future generations, agricultural and food industry policies should be thoroughly reevaluated...
  7. ncbi request reprint [Development of adipose tissue and dietary lipids: from basic science to medicine]
    G Ailhaud
    Institut de Recherches Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie UMR 6543 CNRS, UNSA, Faculte des Sciences, Nice, France
    Ann Endocrinol (Paris) 66:2S7-10. 2005
    ..The main findings of his studies are summarised in this review...
  8. ncbi request reprint Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion
    G Ailhaud
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie, Faculte des Sciences, Parc Valrose, Nice, France
    Obes Rev 5:21-6. 2004
    ..It is proposed that unnoticed changes in fatty acid composition of ingested fats over the last decades have been important determinants in the increasing prevalence of childhood overweight and obesity...
  9. ncbi request reprint Angiotensinogen, adipocyte differentiation and fat mass enlargement
    Gerard Ailhaud
    Institute of Signaling, Developmental Biology and Cancer Research, Centre de Biochimie UMR 6543 CNRS, Laboratory Biology of Adipose Tissue Development, Faculte des Sciences, Parc Valrose, Nice, France
    Curr Opin Clin Nutr Metab Care 5:385-9. 2002
    ..Moreover, the functional importance of angiotensin II receptor subtypes in preadipocytes and adipocytes still remains a controversial subject...
  10. ncbi request reprint Adipose tissue as an endocrine organ
    G Ailhaud
    Laboratoire de Biologie du Développement du Tissu Adipeux, Centre de Biochimie, UNSA, Faculte des Sciences, Nice, France
    Int J Obes Relat Metab Disord 24:S1-3. 2000
    ..In addition to the role of adipose tissue as an endocrine organ, the results emphasize the autocrine/paracrine mechanisms which are postulated to play a role in adipose tissue development and enlargement...
  11. ncbi request reprint Cross talk between adipocytes and their precursors: relationships with adipose tissue development and blood pressure
    G Ailhaud
    Laboratoire de Biologie du Développement du Tissu Adipeux, Centre de Biochimie, IFR 349, Nice, France
    Ann N Y Acad Sci 892:127-33. 1999
    ..Hormonal regulation of AT production from adipose tissue is also discussed...
  12. ncbi request reprint Cell surface receptors, nuclear receptors and ligands that regulate adipose tissue development
    G Ailhaud
    Laboratoire de Biologie du Développement du Tissu Adipeux, Centre de Biochimie UMR 6543 CNRS, UNSA, Faculte des Sciences, Nice, France
    Clin Chim Acta 286:181-90. 1999
    ..Altogether, these studies have provided a molecular link between high-fat diets and excess of adipose tissue development through hyperplasia and hypertrophy...
  13. doi request reprint Omega-6 fatty acids and excessive adipose tissue development
    G Ailhaud
    ISDBC, CNRS UMR 6543, Centre de Biochimie, Nice, France
    World Rev Nutr Diet 98:51-61. 2008
  14. ncbi request reprint [Does obesity protect against diabetes? A new controversy]
    G Ailhaud
    Laboratoire Biologie du Développement du Tissu Adipeux CNRS UMR 6543, Faculte des Sciences, Nice
    Ann Endocrinol (Paris) 62:S43-54. 2001
    ....
  15. ncbi request reprint Transdifferentiation of preadipose cells into smooth muscle-like cells: role of aortic carboxypeptidase-like protein
    Anissa Abderrahim-Ferkoune
    Developmental Biology and Cancer Research UMR 6543 CNRS, Institute of Signaling, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Exp Cell Res 293:219-28. 2004
    ....
  16. ncbi request reprint Adipocyte differentiation of multipotent cells established from human adipose tissue
    Anne Marie Rodriguez
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 CNRS, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Biochem Biophys Res Commun 315:255-63. 2004
    ..Thus, for the first time, human adipose cells with normal karyotype and indefinite life span have been established. They represent a novel and valuable tool for studies of fat tissue development and metabolism...
  17. doi request reprint Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells
    Chiara Chiellini
    IBDC, Universite de Nice Sophia Antipolis, CNRS, 28 Avenue Valrose, 06108 Nice Cedex 2, France
    Biochem Biophys Res Commun 374:64-8. 2008
    ..Thus STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance...
  18. ncbi request reprint Differential effect of HIV protease inhibitors on adipogenesis: intracellular ritonavir is not sufficient to inhibit differentiation
    Cecile Vernochet
    Institute of Signalling, Development Biology and Cancer Research, Biochemistry Centre, UMR 6543 CNRS, Faculty of Science, Nice, France
    AIDS 17:2177-80. 2003
    ..We assessed the effect of six different PIs on the differentiation of cells from four clonal lines. We also studied the capacity of ritonavir to accumulate both into drug-sensitive and drug-resistant cultured adipocytes...
  19. doi request reprint The influence of auranofin, a clinically established antiarthritic gold drug, on bone metabolism: analysis of its effects on human multipotent adipose-derived stem cells, taken as a model
    Chiara Chiellini
    ISBDC, Universite de Nice Sophia Antipolis, CNRS, 28 Avenue de Valrose, F 06100 Nice
    Chem Biodivers 5:1513-20. 2008
    ..In contrast, auranofin turned out to greatly affect glutathione peroxidase 3 activity. The possible medical implications of these findings are discussed...
  20. doi request reprint Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis
    Christian Elabd
    ISBDC, Universite de Nice Sophia Antipolis, CNRS, Nice, France
    Stem Cells 26:2399-407. 2008
    ..Taken together, these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease...
  21. pmc A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations
    Florence Massiera
    Universite de Nice Sophia Antipolis, CNRS, IBDC, UMR 6543, 06107 Nice, France
    J Lipid Res 51:2352-61. 2010
    ....
  22. ncbi request reprint Prostacyclin IP receptor up-regulates the early expression of C/EBPbeta and C/EBPdelta in preadipose cells
    J Aubert
    Centre de Biochimie IFR 349 and UMR 6543 CNRS, UNSA, Faculte des Sciences, Parc Valrose, 06108, Nice, France
    Mol Cell Endocrinol 160:149-56. 2000
    ....
  23. pmc Activin a plays a critical role in proliferation and differentiation of human adipose progenitors
    Laure Emmanuelle Zaragosi
    UMR6543 Centre National de la Recherche Scientifique, Institute of Developmental Biology and Cancer, University of Nice Sophia Antipolis, Nice, France
    Diabetes 59:2513-21. 2010
    ..However, factors controlling self-renewal of human adipose progenitors are largely unknown. We investigated the expression profile and the role of activin A in this process...
  24. ncbi request reprint Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
    Florence Massiera
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie UMR6543CNRS, UNSA, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Lipid Res 44:271-9. 2003
    ..These results raise the issue of the high content of linoleic acid of i) ingested lipids during pregnancy and lactation, and ii) formula milk and infant foods in relation to the epidemic of childhood obesity...
  25. ncbi request reprint Human adipose tissue-derived multipotent stem cells differentiate in vitro and in vivo into osteocyte-like cells
    Christian Elabd
    ISBDC, Universite de Nice Sophia Antipolis, CNRS, 28 Avenue de Valrose, 06100 Nice, France
    Biochem Biophys Res Commun 361:342-8. 2007
    ..Thus hMADS cells represent a valuable tool for pharmacological and biological studies of osteoblast differentiation in vitro and bone development in vivo...
  26. doi request reprint Oxytocin and bone remodelling: relationships with neuropituitary hormones, bone status and body composition
    Veronique Breuil
    Service de Rhumatologie, CHU de Nice, Hopital l Archet 1, Nice, France
    Joint Bone Spine 78:611-5. 2011
    ..Herein, we evaluated the relationships between oxytocin and other hormonal factors known to regulate bone remodeling and body composition in postmenopausal osteoporotic women, compared to healthy controls...
  27. pmc Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation
    Chiara Chiellini
    ISBDC, Universite de Nice Sophia Antipolis, CNRS 28 avenue de Valrose, 06100 Nice, France
    BMC Mol Biol 9:26. 2008
    ..As secreted proteins could regulate the balance between both lineages, we aimed at characterizing the secretome of human multipotent adipose-derived stem cell (hMADS) at an early step of commitment to adipocytes and osteoblasts...
  28. ncbi request reprint PPARgamma-dependent and PPARgamma-independent effects on the development of adipose cells from embryonic stem cells
    C Vernochet
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre du Biochimie, 06108 Nice Cedex 2, France
    FEBS Lett 510:94-8. 2002
    ..Taken together, these results favor a critical PPARgamma-independent phase culminating in preadipocyte formation that precedes a PPARgamma-dependent phase in the development of adipose cells from pluripotent stem cells...
  29. doi request reprint Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes
    Christian Elabd
    IBDC, Universite de Nice Sophia Antipolis, CNRS, 06 107 Nice Cedex 2, France
    Stem Cells 27:2753-60. 2009
    ..Thus, hMADS cells represent an invaluable cell model to screen for drugs stimulating the formation and/or the uncoupling capacity of human brown adipocytes that could help to dissipate excess caloric intake of individuals...
  30. ncbi request reprint Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade
    J Aubert
    Centre de Biochimie IFR349 and UMR6543 CNRS Université de Nice Sophia Antipolis, Faculte des Sciences, Parc Valrose, 06108 Nice, France
    J Biol Chem 274:24965-72. 1999
    ....
  31. ncbi request reprint Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors
    E Z Amri
    Centre de Biochimie, UMR 134 CNRS, Faculte des Sciences, Nice, France
    J Biol Chem 270:2367-71. 1995
    ..Transcriptional induction of these genes exhibited inducer specificity identical to that described in preadipocytes. In summary, the data indicate that FAAR is likely a mediator of fatty acid transcriptional effects in preadipocytes...
  32. ncbi request reprint Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Développement et Cander, UMR6543 Centre National de la Recerche Scientifique, Centre de Biochimie, Faculte des Sciences, Université Nice Sophia Antiplis, Nice, France
    Stem Cells 24:2412-9. 2006
    ..Together, our data clearly identify the key function of FGF2 in the maintenance of self-renewal of adipose tissue-derived stem cells...
  33. ncbi request reprint The crucial role of dietary n-6 polyunsaturated fatty acids in excessive adipose tissue development: relationship to childhood obesity
    Florence Massiera
    ISDBC, Centre de Biochimie UMR 6543 CNRS, Faculte des Sciences, Nice, France
    Nestle Nutr Workshop Ser Pediatr Program 57:235-42; discussion 243-5. 2006
  34. pmc Regulation by fatty acids of angiotensinogen gene expression in preadipose cells
    I Safonova
    Centre de Biochimie du CNRS UMR 6543, Universite de Nice Sophia Antipolis, France
    Biochem J 322:235-9. 1997
    ..Thus the AT gene appears to be a fatty acid-responsive gene; this regulation provides a potential link between the flux of fatty acids and the potential of adipose tissue to produce AT and possibly A-II...
  35. ncbi request reprint Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes
    N Belmonte
    Institute of Signaling, Development Biology and Cancer Research, UMR 6543 Centre Nationale de la Recherche Scientifique, Centre de Biochimie 06108 Nice Cedex 2, France
    Mol Endocrinol 15:2037-49. 2001
    ..Our findings suggest that ERK activation is required for CREB transcriptional activity, possibly by recruitment of a coactivator...
  36. ncbi request reprint Nucleofection is a valuable transfection method for transient and stable transgene expression in adipose tissue-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Developpement et Cancer, CNRS UMR6543, Centre de Biochimie, Faculte des Sciences, université Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    Stem Cells 25:790-7. 2007
    ..Taken together, our data demonstrate that nucleofection allows both transient and stable gene expression in adipose tissue-derived stem cells, without impairing their differentiation potential...
  37. ncbi request reprint Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines
    Cecile Vernochet
    Institut Signalisation, Biologie du Developpement et Cancer, UMR 6543 CNRS, Centre de Biochimie, 06108 Nice, France
    J Biol Chem 280:2238-43. 2005
    ....
  38. ncbi request reprint Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells
    Anissa Abderrahim-Ferkoune
    Institute of Signaling, Developmental Biology and Cancer Research, Centre de Biochimie, UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Lipid Res 44:994-1000. 2003
    ..In conclusion, PTX3 appears as a TNFalpha-induced protein that provides a new link between chronic low-level inflammatory state and obesity...
  39. ncbi request reprint Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation
    Olivier Bezy
    Institute of Signaling, Developmental Biology, and Cancer Research, Centre de Biochimie, UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Biol Chem 280:11432-8. 2005
    ..Thus, DIPA is a novel partner of C/EBP beta that down-regulates early events of adipogenesis...
  40. ncbi request reprint Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation
    P Saint-Marc
    Institut de Recherches Signalisation, Biologie du Developpement et Cancer, Laboratoire Biologie du Développement du Tissu Adipeux, Centre de Biochimie, 06108 Nice, France
    Endocrinology 142:487-92. 2001
    ..It is proposed that AngII enhances the formation of GPDH-expressing cells from preadipocytes in response to prostacyclin released from adipocytes...
  41. ncbi request reprint Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells
    J Aubert
    Centre de Biochimie du CNRS UMR 134, Universite de Nice Sophia Antipolis, Faculte des Sciences, Nice, France
    FEBS Lett 397:117-21. 1996
    ..This regulation is likely mediated by some member(s) of the peroxisome proliferator-activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation...
  42. ncbi request reprint Differentiation of embryonic stem cells into adipocytes in vitro
    C Dani
    Centre de Biochimie UMR 6543 CNRS, Universite de Nice Sophia Antipolis, Faculte des Sciences, Parc Valrose, Nice, France
    J Cell Sci 110:1279-85. 1997
    ....
  43. ncbi request reprint Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
    F Massiera
    CNRS UMR 6543, Institute of Signaling, Development and Cancer, Nice, France
    FASEB J 15:2727-9. 2001
    ..These animal models demonstrate that AGT produced by adipose tissue plays a role in both local adipose tissue development and in the endocrine system, which supports a role of adipose AGT in hypertensive obese patients...
  44. ncbi request reprint Expression of ob gene in adipose cells. Regulation by insulin
    P Leroy
    Centre de Biochimie UMR 134 CNRS, Universite de Nice Sophia Antipolis, Faculte des Sciences, Nice, France
    J Biol Chem 271:2365-8. 1996
    ..The level of secreted Ob protein is also regulated by insulin. These results indicate that the ob gene is expressed in mature fat cells only and support the possibility that insulin is an important regulator of ob gene expression...
  45. ncbi request reprint Autocrine/paracrine effectors of adipogenesis
    G Ailhaud
    Laboratoire Biologie du Développement du Tissu Adipeux, Centre de Biochimie UMR 6543 CNRS, UNSA, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Ann Endocrinol (Paris) 63:83-5. 2002
  46. ncbi request reprint The human adipose tissue is a source of multipotent stem cells
    A M Rodriguez
    Faculte des Sciences, Centre de Biochimie, Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Biochimie 87:125-8. 2005
    ..Finally, potential applications of stem cells isolated from adipose tissue in medicine will be discussed...
  47. ncbi request reprint Compactin enhances osteogenesis in murine embryonic stem cells
    B W Phillips
    Centre de Biochimie (UMR 6543 CNRS, , , Parc Valrose, Nice, 06108, France
    Biochem Biophys Res Commun 284:478-84. 2001
    ..These results establish ES-cell derived osteogenesis as an effective model system to study the molecular mechanisms by which the statin compactin promotes osteoblastic differentiation and bone nodule formation...
  48. ncbi request reprint Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity
    F Massiera
    Centre National de la Recherche Scientifique 6543, Centre de Biochimie, Nice 06108, France
    Endocrinology 142:5220-5. 2001
    ..Thus, AGT appears to be involved in the regulation of fat mass through a combination of decreased lipogenesis and increased locomotor activity that may be centrally mediated...
  49. ncbi request reprint Differential expression of adenosine A1 and A2 receptors in preadipocytes and adipocytes
    G Vassaux
    Centre de Biochimie CNRS UMR 134, Faculte des Sciences, Universite de Nice Sophia Antipolis, France
    Biochem Biophys Res Commun 193:1123-30. 1993
    ..These findings emphasize the role that adenosine might play as a bimodal regulatory extracellular signal in adipose tissue development...
  50. pmc Cloning of alpha 2 chain of type VI collagen and expression during mouse development
    A Ibrahimi
    Centre de Biochimie UMR 134 CNRS, Universite de Nice Sophia Antipolis, Faculte des Sciences, Parc Valrose, Nice, France
    Biochem J 289:141-7. 1993
    ..These results indicate that A2COL6 gene expression is a marker of the preadipose state, but may also be a marker of other differentiation programmes such as that of muscle...