Serge H Ahmed

Summary

Country: France

Publications

  1. ncbi request reprint Dissociation of psychomotor sensitization from compulsive cocaine consumption
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, Bordeaux, France
    Neuropsychopharmacology 31:563-71. 2006
  2. ncbi request reprint Imbalance between drug and non-drug reward availability: a major risk factor for addiction
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, 33076 Bordeaux, France
    Eur J Pharmacol 526:9-20. 2005
  3. ncbi request reprint Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, 33076, Bordeaux, France
    Psychopharmacology (Berl) 180:473-90. 2005
  4. ncbi request reprint Neuroscience. Addiction as compulsive reward prediction
    Serge H Ahmed
    CNRS UMR 5541, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Science 306:1901-2. 2004
  5. pmc Extended heroin access increases heroin choices over a potent nondrug alternative
    Magalie Lenoir
    Universite de Bordeaux, Institut des Maladies Neurodégénératives, rue Leo Saignat, Bordeaux, France
    Neuropsychopharmacology 38:1209-20. 2013
  6. ncbi request reprint Supply of a nondrug substitute reduces escalated heroin consumption
    Magalie Lenoir
    University Victor Segalen Bordeaux2, CNRS UMR 5227, 146 rue Leo Saignat, Bordeaux, France
    Neuropsychopharmacology 33:2272-82. 2008
  7. doi request reprint A choice-based screening method for compulsive drug users in rats
    Magalie Lenoir
    Universite de Bordeaux, CNRS, Institut des Maladies Neurodégénératives, Bordeaux, France
    Curr Protoc Neurosci . 2013
  8. pmc Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats
    Leandro F Vendruscolo
    CNRS UMR5227, Universite de Bordeaux, Bordeaux, France
    PLoS ONE 5:e9296. 2010
  9. pmc Intense sweetness surpasses cocaine reward
    Magalie Lenoir
    University Bordeaux 2, Universite Bordeaux 1, CNRS, UMR 5227, Bordeaux, France
    PLoS ONE 2:e698. 2007
  10. pmc Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction
    Lauriane Cantin
    Unité Mixte de Recherche 5227, Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS ONE 5:e11592. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Dissociation of psychomotor sensitization from compulsive cocaine consumption
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, Bordeaux, France
    Neuropsychopharmacology 31:563-71. 2006
    ....
  2. ncbi request reprint Imbalance between drug and non-drug reward availability: a major risk factor for addiction
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, 33076 Bordeaux, France
    Eur J Pharmacol 526:9-20. 2005
    ....
  3. ncbi request reprint Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, 33076, Bordeaux, France
    Psychopharmacology (Berl) 180:473-90. 2005
    ..The transition from initial drug use to drug addiction has been proposed to result from an allostatic decrease in reward function driven by an overactivation of brain antireward processes...
  4. ncbi request reprint Neuroscience. Addiction as compulsive reward prediction
    Serge H Ahmed
    CNRS UMR 5541, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Science 306:1901-2. 2004
  5. pmc Extended heroin access increases heroin choices over a potent nondrug alternative
    Magalie Lenoir
    Universite de Bordeaux, Institut des Maladies Neurodégénératives, rue Leo Saignat, Bordeaux, France
    Neuropsychopharmacology 38:1209-20. 2013
    ..This higher addiction liability may contribute to explain why more drug users become addicted to heroin than to cocaine in epidemiological studies...
  6. ncbi request reprint Supply of a nondrug substitute reduces escalated heroin consumption
    Magalie Lenoir
    University Victor Segalen Bordeaux2, CNRS UMR 5227, 146 rue Leo Saignat, Bordeaux, France
    Neuropsychopharmacology 33:2272-82. 2008
    ..Escalated drug use may therefore persist, not so much because of a relative devaluation of nondrug substitutes, but because of a loss or reduction of their availability...
  7. doi request reprint A choice-based screening method for compulsive drug users in rats
    Magalie Lenoir
    Universite de Bordeaux, CNRS, Institut des Maladies Neurodégénératives, Bordeaux, France
    Curr Protoc Neurosci . 2013
    ..This choice-based screening method for compulsive drug users is easy to implement, has several important applications, and compares well with other methods in the field...
  8. pmc Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats
    Leandro F Vendruscolo
    CNRS UMR5227, Universite de Bordeaux, Bordeaux, France
    PLoS ONE 5:e9296. 2010
    ..This study examined in rats the effects of unlimited access to sucrose during adolescence on the motivation for natural and pharmacological rewards in adulthood...
  9. pmc Intense sweetness surpasses cocaine reward
    Magalie Lenoir
    University Bordeaux 2, Universite Bordeaux 1, CNRS, UMR 5227, Bordeaux, France
    PLoS ONE 2:e698. 2007
    ..Though there are many biological commonalities between sweetened diets and drugs of abuse, the addictive potential of the former relative to the latter is currently unknown...
  10. pmc Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction
    Lauriane Cantin
    Unité Mixte de Recherche 5227, Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS ONE 5:e11592. 2010
    ..Surprisingly, recent experiments in rats--by far the most frequently used animal model in this field--suggest that the value of cocaine is lower than previously thought...
  11. ncbi request reprint A critical transition in cocaine self-administration: behavioral and neurobiological implications
    Amandine Zittel-Lazarini
    Laboratoire de Neuropsychobiologie, University Victor Segalen Bordeaux 2, CNRS UMR 5227, 146 rue Leo Saignat, 33076, Bordeaux, France
    Psychopharmacology (Berl) 192:337-46. 2007
    ..This hypothesis predicts that the dose-injection function of each subject individually should be a decreasing function, with no initial, gradual ascending limb...
  12. doi request reprint Risk-prone individuals prefer the wrong options on a rat version of the Iowa Gambling Task
    Marion Rivalan
    CNRS UMR 5227, Universite Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    Biol Psychiatry 66:743-9. 2009
    ..The cognitive processes underlying these deficits are poorly understood, in part due to a lack of suitable animal models assessing complex decision making with good construct validity...
  13. ncbi request reprint Heroin-induced reinstatement is specific to compulsive heroin use and dissociable from heroin reward and sensitization
    Magalie Lenoir
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, Bordeaux, France
    Neuropsychopharmacology 32:616-24. 2007
    ..This study reproduces and extends previous research on compulsive cocaine use by showing that heroin-induced reinstatement is also specific to compulsive drug use and dissociable from heroin-induced reward and psychomotor sensitization...
  14. doi request reprint Levodopa gains psychostimulant-like properties after nigral dopaminergic loss
    Michel Engeln
    Institute of Neurodegenerative Diseases, UMR 5293, F 33000 Bordeaux, France, University of Bordeaux, Bordeaux, France Institute of Neurodegenerative Diseases, UMR 5293, F 33000 Bordeaux, France, National Center for Scientific Research, Bordeaux, France
    Ann Neurol 74:140-4. 2013
    ..These 2 effects may combine to explain the addictive use of levodopa after loss of midbrain dopamine neurons in some PD patients...
  15. doi request reprint Discriminative inhibitory control of cocaine seeking involves the prelimbic prefrontal cortex
    Claudia Mihindou
    Université de Bordeaux and the Centre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, Bordeaux, France
    Biol Psychiatry 73:271-9. 2013
    ..Here, we report similar findings in a rat model of inhibitory control of cocaine seeking...
  16. doi request reprint Sugar addiction: pushing the drug-sugar analogy to the limit
    Serge H Ahmed
    Universite de Bordeaux, Bordeaux, France
    Curr Opin Clin Nutr Metab Care 16:434-9. 2013
    ..To review research that tests the validity of the analogy between addictive drugs, like cocaine, and hyperpalatable foods, notably those high in added sugar (i.e., sucrose)...
  17. pmc Preclinical validation of a novel cocaine exposure therapy for relapse prevention
    Claudia Mihindou
    Institut des Maladies Neurodégénératives, Universite de Bordeaux, Bordeaux, France
    Biol Psychiatry 70:593-8. 2011
    ..Here we sought to prevent this effect by extinguishing the conditioned interoceptive cues of cocaine that are thought to be acquired during repeated cocaine use...
  18. ncbi request reprint Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
    Nat Neurosci 5:625-6. 2002
    ....
  19. ncbi request reprint Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie Desadaptations, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Psychopharmacology (Berl) 172:450-4. 2004
    ..The present study tested the hypothesis that escalating use of cocaine is associated with chronic alterations in dopamine neurotransmission...
  20. doi request reprint Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction
    Serge H Ahmed
    Universite Bordeaux 2, CNRS, Mouvement Adaptation Cognition, UMR 5227, France
    Neurosci Biobehav Rev 35:172-84. 2010
    ..Other competing interpretations of the same pattern of results are also discussed at the end of this review...
  21. ncbi request reprint The simulation of addiction: pharmacological and neurocomputational models of drug self-administration
    Serge H Ahmed
    Universite Victor Segalen Bordeaux, CNRS UMR 5227, Bordeaux, France
    Drug Alcohol Depend 90:304-11. 2007
    ....
  22. ncbi request reprint Mesolimbic dopamine drives the diurnal variation in opiate-induced feeding
    M Flavia Barbano
    Laboratoire de Neuropsychobiologie des Desadaptations, Centre National de la Recherche Scientifique, UMR 5541, Université Victor Segalen Bordeaux 2 146, rue Leo Saignat, BP 31, 33076 Bordeaux Cedex, France
    Pharmacol Biochem Behav 81:569-74. 2005
    ..This finding suggests that mesolimbic dopamine transmission contributes to the neural mechanisms that normally drive the circadian timing of opioid-dependent feeding...
  23. ncbi request reprint Escalation of cocaine intake and incubation of cocaine seeking are correlated with dissociable neuronal processes in different accumbens subregions
    Karine Guillem
    Universite de Bordeaux, Institut des Maladies Neurodégénératives, Unité Mixte de Recherche 5293, Bordeaux, France Centre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, Unité Mixte de Recherche 5293, Bordeaux, France Electronic address
    Biol Psychiatry 76:31-9. 2014
    ..Whether these two prominent features of cocaine addiction are related to each other and are mediated by similar or different neuronal processes is currently unknown...
  24. pmc Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction
    Serge H Ahmed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92103, USA
    Proc Natl Acad Sci U S A 102:11533-8. 2005
    ..Results also support the value of using multiple analysis strategies to identify the most robust changes in gene expression and to compensate for the biases that affect each strategy...
  25. ncbi request reprint Neurobiological mechanisms in the transition from drug use to drug dependence
    George F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 27:739-49. 2004
    ....
  26. ncbi request reprint Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests
    Gerald Zernig
    Experimental Psychiatry Unit, Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Pharmacology 80:65-119. 2007
    ..The review concludes by making suggestions on how to improve the current behavioral experimental approaches...
  27. ncbi request reprint The transition from controlled to compulsive drug use is associated with a loss of sensitization
    Osnat Ben-Shahar
    Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
    Brain Res 995:46-54. 2004
    ..These data suggest that the transition to escalating patterns of drug use is associated with neuroadaptive changes that counteract those initially associated with controlled stable patterns of drug use...
  28. ncbi request reprint Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels
    Serge H Ahmed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 86:102-13. 2003
    ..These findings show that changes in cocaine efficacy or pharmacokinetics do not play a critical role in cocaine intake escalation...