Research Topics
| C AdrieSummaryCountry: France Publications
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Detail Information
Publications
Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathwayChristophe Adrie
Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
J Am Coll Cardiol 46:21-8. 2005..We investigated coagulation abnormalities in out-of-hospital cardiac arrest (OHCA) patients, with special attention to the protein C anticoagulant pathway...- Predicting survival with good neurological recovery at hospital admission after successful resuscitation of out-of-hospital cardiac arrest: the OHCA scoreChristophe Adrie
Intensive Care Unit, Delafontaine Hospital, 2, rue du Dr Delafontaine, Saint Denis, France
Eur Heart J 27:2840-5. 2006..The aim of this study was to develop a simple tool for predicting survival with good neurological function in the overall population of patients with successfully resuscitated cardiac arrest... - Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndromeChristophe Adrie
Medical ICU, Cochin Hospital, Paris, France
Circulation 106:562-8. 2002..We investigated the immunoinflammatory profile of patients successfully resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion syndrome... - An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrestChristophe Adrie
Intensive Care Unit, Delafontaine Hospital, 2 rue du Dr Delafontaine, Saint Denis, France
Intensive Care Med 34:132-7. 2008..To identify predictors of brain death after successful resuscitation of out-of-hospital cardiac arrest (OHCA), with the goal of improving the detection of brain death, and to evaluate outcomes of solid organs harvested from these patients... - Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsisC Adrie
Laboratory of Respiratory Physiology and Medical Intensive Care Unit, APHP, Cochin Port Royal Hospital, Paris, France
Am J Respir Crit Care Med 164:389-95. 2001..Keywords: mitochondria; apoptosis; sepsis; heat-shock protein 70; proto-oncogene protein c-Bcl-2.. - Exhaled and nasal nitric oxide as a marker of pneumonia in ventilated patientsC Adrie
Medical Intensive Care Unit, and Respiratory Physiology Department, Cochin Port Royal Hospital, University of Paris V, Paris, France
Am J Respir Crit Care Med 163:1143-9. 2001..Furthermore, because these differences in airway NO levels were not paralleled in blood nitrite concentrations, we conclude that pneumonia per se is not associated with systemic NO production... 
Study of prone positioning to reduce ventilator-associated pneumonia in hypoxaemic patientsR Mounier
Assistance Publique Hopitaux de Paris, Louis Mourier Hospital, Medical ICU, Colombes, France
Eur Respir J 35:795-804. 2010..In ICU patients with hypoxaemic acute respiratory failure, PP had no effect on the risk of VAP. PP delayed mortality without decreasing 28-day mortality. PP >1 day might decrease mortality, particularly in the sickest patients...- Predictors of short-term mortality in critically ill patients with solid malignanciesE Azoulay
Medical Intensive Care Unit, Saint Louis Teaching Hospital and University Paris 7, France
Intensive Care Med 26:1817-23. 2000.... - Reprogramming of circulatory cells in sepsis and SIRSJ M Cavaillon
UP Cytokines and Inflammation, Institut Pasteur, Paris, France
J Endotoxin Res 11:311-20. 2005..e. isolated monocytes versus peripheral blood mononuclear cells versus whole blood assays), and the nature of the analyzed cytokines (e.g. IL-1beta versus IL-1ra; TNF versus IL-10) have a profound influence on the outcome of the response... - High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized studyIvan Laurent
Medical ICU, Cochin Teaching Hospital, Rene Descartes University, Paris, France
J Am Coll Cardiol 46:432-7. 2005..21 (95% CI, 0.05 to 0.85) in the HF group. CONCLUSIONS: The HF may improve the overall prognosis after resuscitation from OHCA. Combination of HF with mild HT is feasible and should be evaluated in larger trials... - Immune status and apoptosis activation during brain deathChristophe Adrie
Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
Shock 33:353-62. 2010..Both abnormalities may play a role in organ dysfunction associated with brain death. However, the level of systemic inflammation or the presence of circulating endotoxin was not associated with lower graft survival... - Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: a propensity analysisChristophe Clec'h
Intensive Care Unit, Avicenne Teaching Hospital, 125 route de Stalingrad, 93000 Bobigny, France
Crit Care Med 35:132-8. 2007..To examine the association between the performance of a tracheostomy and intensive care unit and postintensive care unit mortality, controlling for treatment selection bias and confounding variables... - Postresuscitation disease after cardiac arrest: a sepsis-like syndrome?Christophe Adrie
Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
Curr Opin Crit Care 10:208-12. 2004..The mechanisms underlying this postresuscitation disease probably involve a whole-body ischemia and reperfusion syndrome that triggers a systemic inflammatory response... - Decisions to forgo life-sustaining therapy in ICU patients independently predict hospital deathElie Azoulay
Saint Louis Teaching Hospital, Medical ICU Department, 1 avenue Claude Vellefaux, 75010, Paris, France
Intensive Care Med 29:1895-901. 2003..The objectives of this study were to describe the factors and mortality associated with DFLSTs and to evaluate the potential independent impact of DFLSTs on hospital mortality... - Calibration and discrimination by daily Logistic Organ Dysfunction scoring comparatively with daily Sequential Organ Failure Assessment scoring for predicting hospital mortality in critically ill patientsJean Francois Timsit
Service de Reanimation Polyvalente, Hopital St Joseph, Paris, France
Crit Care Med 30:2003-13. 2002..The objective of this study was to evaluate how accurately daily LOD scoring predicts mortality comparatively with daily Sequential Organ Failure Assessment (SOFA) scoring... - Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patientsMinou Adib-Conquy
Cytokines and Inflammation Unit, Institut Pasteur, Paris, France
Crit Care Med 34:2377-85. 2006..In this study, we addressed the specificity of this hyporeactivity and investigated some of the possible associated mechanistic events... - Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU staysDelphine Moreau
Medical ICU, Saint Louis Teaching Hospital, 1 Ave Claude Vellefaux, 75010 Paris, France
Chest 131:1735-41. 2007..Thrombocytopenia is common in ICU patients. The objective of this study was to evaluate possible links between declining platelet counts early in the ICU stay and survival... - Cortisol levels and adrenal reserve after successful cardiac arrest resuscitationGuillaume Hekimian
Intensive Care Unit and Biochemistry Department, Delafontaine Hospital, Saint Denis, France
Shock 22:116-9. 2004..Thresholds for cortisol levels at baseline and after corticotropin need to be determined in this clinical setting... - Association between hypernatraemia acquired in the ICU and mortality: a cohort studyMichael Darmon
Medical Intensive Care Unit, Saint Louis University Hospital, APHP, 1 avenue Claude Vellefaux, Paris, France
Nephrol Dial Transplant 25:2510-5. 2010..The aim of this study is to describe the prevalence and outcomes of intensive care unit (ICU)-acquired hypernatraemia (IAH)... - Effectiveness of platelet transfusions after plasma exchange in adult thrombotic thrombocytopenic purpura: a report of two casesP Coppo
Service d immuno hématologie, Hôpital Saint Louis et Université, Paris, France
Am J Hematol 68:198-201. 2001..Am. J. Hematol. 68:198-201, 2001. Published 2001 Wiley-Liss, Inc... - Human immunodeficiency virus-associated thrombotic microangiopathies: clinical characteristics and outcome according to ADAMTS13 activityS Malak
Service d Hématologie et de Thérapie Cellulaire, AP HP, Hôpital Saint Antoine and UPMC Université Paris 06, Paris, France
Scand J Immunol 68:337-44. 2008..04). In conclusion, HIV-associated TMA with severe ADAMTS13 deficiency have less AIDS-related complications and a higher CD4(+) T cell count. TMA prognosis is better and comparable to this of idiopathic forms... 
Model for predicting short-term mortality of severe sepsisChristophe Adrie
Medical Surgical Intensive Care Unit, Delafontaine Hospital, 93205 Saint Denis, France
Crit Care 13:R72. 2009..To establish a prognostic model for predicting 14-day mortality in ICU patients with severe sepsis overall and according to place of infection acquisition and to sepsis episode number...- Half the family members of intensive care unit patients do not want to share in the decision-making process: a study in 78 French intensive care unitsElie Azoulay
Intensive Care Unit of the Saint-Louis Teaching Hospital and University of Paris 7, , Paris, France
Crit Care Med 32:1832-8. 2004..Staff members must strive to identify practical and psychological obstacles that may limit their ability to promote autonomy. Finally, they must develop interventions and attitudes capable of empowering families... - Impact of adverse events on outcomes in intensive care unit patientsMaite Garrouste Orgeas
Medical Surgical ICU, Saint Joseph Hospital Network, Paris, France
Crit Care Med 36:2041-7. 2008..To examine the association between predefined adverse events (AE) (including nosocomial infections) and intensive care unit (ICU) mortality, controlling for multiple adverse events in the same patient and confounding variables... - Influence of gender on the outcome of severe sepsis: a reappraisalChristophe Adrie
Medical Surgical ICU, Hopital Delafontaine, 2, rue du Dr Delafontaine, 93205 Sant Denis, France
Chest 132:1786-93. 2007..The influence of gender on survival of patients with severe sepsis is unclear. Earlier studies suggested better survival in women, possibly related to the sex-steroid profile... - Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infectionMinou Adib-Conquy
Cytokines and Inflammation Unit, Institute Pasteur, Paris, France
Shock 28:406-10. 2007..In conclusion, sTREM-1 and PCT are not specific for infection and can increase markedly in acute inflammation without infection... - Ability of family members to predict patient's consent to critical care researchMagali Ciroldi
Medical Intensive Care Unit, AP HP, Saint Louis Teaching Hospital, Paris 7 University, Paris, France
Intensive Care Med 33:807-13. 2007..The accuracy with which surrogates consent to research on behalf of patients has not been evaluated in the intensive care unit (ICU)... - Junior versus senior physicians for informing families of intensive care unit patientsDelphine Moreau
, , Paris, France
Am J Respir Crit Care Med 169:512-7. 2004..9 vs. 34.4%, p = 0.004). Specialty residents, if given opportunities for acquiring experience, can become proficient in communicating with families and share this task with senior physicians... - Opinions about surrogate designation: a population survey in FranceElie Azoulay
The French Famirea Study Group, Intensive Care Unit of the Saint-Louis Teaching Hospital, University Paris 7, , Paris, France
Crit Care Med 31:1711-4. 2003..Primary care physicians should inform their patients about the benefits of discussing illness-related issues among friends and family... - Epidemiology and economic evaluation of severe sepsis in France: age, severity, infection site, and place of acquisition (community, hospital, or intensive care unit) as determinants of workload and costChristophe Adrie
Medical-Surgical ICU, Delafontaine Hospital, Saint Denis, France
J Crit Care 20:46-58. 2005..CONCLUSIONS: The wide variations in cost and workload invite efforts to identify patient subgroups most likely to benefit from high-cost treatments and from prevention, particularly targeting severe nosocomial infections... - Infectious diseases as a trigger in thrombotic microangiopathies in intensive care unit (ICU) patients?Paul Coppo
Department of Critical Care Medicine, Hôpital Saint Louis and University of Paris VII, 1 rue Claude Vellefaux, 75010, Paris, France
Intensive Care Med 29:564-9. 2003..We conducted a descriptive, retrospective study including all TMA adult patients admitted to our ICU, with a particular interest in infectious episodes as a trigger of TMA... - Practices in non-neutropenic ICU patients with Candida-positive airway specimensElie Azoulay
Intensive Care Unit, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France
Intensive Care Med 30:1384-9. 2004..Design : Closed-item questionnaire with a clinical vignette... - Cytokine cascade in sepsisJean Marc Cavaillon
UP Cytokine and Inflammation, Institut Pasteur, Paris, France
Scand J Infect Dis 35:535-44. 2003..Although TNF contributes towards favouring the production of many other cytokines within a complex cascade, there are numerous examples to illustrate that its presence is not a prerequisite for these productions... - Does catheter-associated urinary tract infection increase mortality in critically ill patients?Christophe Clec'h
Medical Surgical Intensive Care Unit, Avicenne Teaching Hospital, Bobigny, France
Infect Control Hosp Epidemiol 28:1367-73. 2007..To produce an accurate estimate of the association between catheter-associated urinary tract infection (UTI) and intensive care unit (ICU) and hospital mortality, controlling for major confounding factors... - Impact of a family information leaflet on effectiveness of information provided to family members of intensive care unit patients: a multicenter, prospective, randomized, controlled trialElie Azoulay
Intensive Care Department, Saint Louis Teaching Hospital, Paris 7 University, France
Am J Respir Crit Care Med 165:438-42. 2002..01). These results indicate that ICU caregivers should consider using an FIL to improve the effectiveness of the information they impart to families... - Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections: a reappraisalMaite Garrouste-Orgeas
Medical Surgical Intensive Care Unit, Saint Joseph Hospital, Paris, France corrected
Clin Infect Dis 42:1118-26. 2006..We investigated whether ICU-acquired BSI increased mortality (by > or = 10%) after adjustment for severity of infection at ICU admission and during the pre-BSI stay... - Limitations of computed tomographic angiography in the diagnosis of brain deathChristophe Quesnel
Universite Pierre and Marie Curie, Hopital Tenon, Assistance Publique Hopitaux de Paris, Service d Anesthesie Reanimation, 4 rue de la Chine, 75970 Paris Cedex 20, France
Intensive Care Med 33:2129-35. 2007..To evaluate the accuracy of cerebral computed tomographic angiography (CT-a) for the diagnosis of brain death (BD)... - High-dose plasma infusion versus plasma exchange as early treatment of thrombotic thrombocytopenic purpura/hemolytic-uremic syndromePaul Coppo
Laboratoire Hématopoïèse et Cellules souches, Institut Gustave Roussy, Villejuif, France
Medicine (Baltimore) 82:27-38. 2003..However, the large volumes of plasma required to reach complete remission may result in fluid overload, which may necessitate subsequent therapeutic plasma exchange...