Serge Adnot

Summary

Country: France

Publications

  1. doi request reprint Serotonin transporter and serotonin receptors
    Serge Adnot
    INSERM U955 and Département de Physiologie, Hopital Henri Mondor, AP HP, 94010, Creteil, France
    Handb Exp Pharmacol 218:365-80. 2013
  2. pmc Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
    Laurent Savale
    INSERM U841, Universite Paris XII, F94010 Creteil, France
    Respir Res 10:6. 2009
  3. doi request reprint Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
    Amal Houssaini
    INSERM U955 Team 8 and Département de Physiologie, Creteil, France
    Am J Respir Cell Mol Biol 48:568-77. 2013
  4. ncbi request reprint Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
  5. doi request reprint Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure
    Thibaud Damy
    Fédération de cardiologie, AP HP, Groupe Henri Mondor Albert Chenevier, Creteil, France
    Eur J Heart Fail 14:1009-19. 2012
  6. doi request reprint Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension
    Nathalie Mouraret
    Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Creteil, France
    Circulation 127:1664-76. 2013
  7. ncbi request reprint Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension
    Laurence Dewachter
    INSERM U651, Faculte de Medecine, 8, rue Général Sarrail, Creteil, France
    Am J Respir Crit Care Med 174:1025-33. 2006
  8. pmc Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice
    William Raoul
    Unité INSERM TGU841 Université Paris XII, Creteil, France
    Respir Res 8:8. 2007
  9. ncbi request reprint Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension
    Olivier Sanchez
    INSERM U841 and Département de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, Creteil, France
    Am J Respir Crit Care Med 176:1041-7. 2007
  10. ncbi request reprint Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension
    Elisabeth Marcos
    INSERM U492, Faculte de Medecine, CHU Henri Mondor, 94010 Creteil, France
    Am J Respir Crit Care Med 168:487-93. 2003

Collaborators

Detail Information

Publications45

  1. doi request reprint Serotonin transporter and serotonin receptors
    Serge Adnot
    INSERM U955 and Département de Physiologie, Hopital Henri Mondor, AP HP, 94010, Creteil, France
    Handb Exp Pharmacol 218:365-80. 2013
    ..However, the 5-HT pathway is still studied only on a preclinical level and the usefulness of drugs interacting with the 5-HT pathway remains to be established in human PAH. ..
  2. pmc Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
    Laurent Savale
    INSERM U841, Universite Paris XII, F94010 Creteil, France
    Respir Res 10:6. 2009
    ..Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 (IL-6)...
  3. doi request reprint Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
    Amal Houssaini
    INSERM U955 Team 8 and Département de Physiologie, Creteil, France
    Am J Respir Cell Mol Biol 48:568-77. 2013
    ..Experimental PH in rats is associated with a sustained proliferative PA-SMC phenotype linked to activation of both mTORC1 and mTORC2 signaling and is suppressed by rapamycin treatment...
  4. ncbi request reprint Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
    ..We investigated the role of pulmonary microvascular endothelial cells (P-ECs) in controlling PA-SMC growth...
  5. doi request reprint Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure
    Thibaud Damy
    Fédération de cardiologie, AP HP, Groupe Henri Mondor Albert Chenevier, Creteil, France
    Eur J Heart Fail 14:1009-19. 2012
    ..Although SDB is frequent during CHF, the relationships between SDB and CHF outcomes are unknown...
  6. doi request reprint Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension
    Nathalie Mouraret
    Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Creteil, France
    Circulation 127:1664-76. 2013
    ..We hypothesized that cell senescence induced by Nutlin-3a exerted therapeutic effects in pulmonary hypertension (PH) by limiting the proliferation of pulmonary artery smooth muscle cells (PA-SMCs)...
  7. ncbi request reprint Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension
    Laurence Dewachter
    INSERM U651, Faculte de Medecine, 8, rue Général Sarrail, Creteil, France
    Am J Respir Crit Care Med 174:1025-33. 2006
    ..Angiopoietins are involved in blood vessel maturation and remodeling...
  8. pmc Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice
    William Raoul
    Unité INSERM TGU841 Université Paris XII, Creteil, France
    Respir Res 8:8. 2007
    ..Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown...
  9. ncbi request reprint Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension
    Olivier Sanchez
    INSERM U841 and Département de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, Creteil, France
    Am J Respir Crit Care Med 176:1041-7. 2007
    ..CC chemokine ligand 2 (CCL2) is synthesized by vascular cells and can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation...
  10. ncbi request reprint Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension
    Elisabeth Marcos
    INSERM U492, Faculte de Medecine, CHU Henri Mondor, 94010 Creteil, France
    Am J Respir Crit Care Med 168:487-93. 2003
    ..These data indicate that 5-HTT plays a key role in hypoxia-induced pulmonary vascular remodeling. The effects of serotonin transporter inhibitors on PH in humans deserve investigation...
  11. ncbi request reprint Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension
    Christophe Guignabert
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circ Res 98:1323-30. 2006
    ..They further support a central role for 5-HTT in the pathogenesis of PH, making 5-HTT a potential therapeutic target...
  12. doi request reprint p21-Dependent Protective Effects of a Carbon Monoxide-Releasing Molecule-3 in Pulmonary Hypertension
    Shariq Abid
    From the INSERM U955, Département de Physiologie S A, A H, N M, E M, V A, F W, G D, J B, R M, S A and Service de Cardiologie J L D R, Hopital Henri Mondor, AP HP, Universite Paris Est Créteil UPEC, Creteil, France
    Arterioscler Thromb Vasc Biol 34:304-12. 2014
    ....
  13. doi request reprint Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice
    Shariq Abid
    INSERM U955 Team 8 and Département de Physiologie, Hopital Henri Mondor, AP HP, Creteil
    Am J Physiol Lung Cell Mol Physiol 303:L500-8. 2012
    ..These results provide proof of concept that inhibiting Tph1 may represent a new therapeutic strategy for human PH...
  14. doi request reprint Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease
    Laurent Savale
    Assistance Publique Hopitaux de Paris, Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Universite Paris 12, 94010 Creteil, France
    Am J Respir Crit Care Med 179:566-71. 2009
    ..Telomere length is considered a marker for biological aging. Chronic obstructive pulmonary disease (COPD) may be associated with premature aging...
  15. pmc Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
    Mohamed Izikki
    INSERM U841, Faculte de Medecine, 8 Avenue du General Sarrail, 94010 Creteil, France
    J Clin Invest 119:512-23. 2009
    ..Thus, endothelial FGF2 is overproduced in IPH and contributes to SMC hyperplasia in IPH, identifying FGF2 as a promising target for new treatments against PH...
  16. ncbi request reprint Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease
    Saadia Eddahibi
    INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, 94010 Creteil, France
    Circulation 108:1839-44. 2003
    ..Because hypoxia and 5-HTT gene polymorphism control 5-HTT expression, we examined 5-HTT gene polymorphism and PH in hypoxemic patients with advanced chronic obstructive pulmonary disease (COPD)...
  17. doi request reprint Effects of polycythemia on systemic endothelial function in chronic hypoxic lung disease
    Laurent Boyer
    Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Assistance Publique Hopitaux de Paris, Université Paris Est Créteil Val de Marne, Creteil, France
    J Appl Physiol (1985) 110:1196-203. 2011
    ..Overall, our results suggest that moderate polycythemia has no adverse effect on vascular function in COPD...
  18. ncbi request reprint Interleukin-6 gene polymorphism confers susceptibility to pulmonary hypertension in chronic obstructive pulmonary disease
    Saadia Eddahibi
    INSERM U492 and Département de Physiologie, Hôpital H Mondor, Creteil, France
    Proc Am Thorac Soc 3:475-476. 2006
  19. doi request reprint Airway responsiveness measured by forced oscillation technique in severely obese patients, before and after bariatric surgery
    Françoise Zerah-Lancner
    Service de Physiologie Explorations Fonctionnelles, Hopital Henri Mondor, AP HP, Creteil, France
    J Asthma 48:818-23. 2011
    ..The influence of obesity on airway responsiveness remains controversial...
  20. ncbi request reprint Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension
    Elisabeth Marcos
    INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, Creteil, France
    Circ Res 94:1263-70. 2004
    ..We conclude that 5-HTT overexpression is a common pathogenic mechanism in various forms of PH...
  21. doi request reprint Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction
    Papa Ahmed Fall
    Urology Department, Henri Mondor Teaching Hospital, Creteil, France
    Eur Urol 56:716-25. 2009
    ....
  22. ncbi request reprint Prognostic significance and normal values of 2D strain to assess right ventricular systolic function in chronic heart failure
    Soulef Guendouz
    Fédération de cardiologie, AP HP, Groupe Henri Mondor Albert Chenevier, Creteil, France
    Circ J 76:127-36. 2012
    ..Normal values and the prognostic significance of right ventricle (RV)-2D strain in chronic heart failure (CHF) patients are unknown...
  23. doi request reprint Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease
    Valerie Amsellem
    Institut National de la Sante et de la Recherche Medicale, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Respir Crit Care Med 184:1358-66. 2011
    ..Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of unknown pathogenesis...
  24. ncbi request reprint Decrease in lung nitric oxide production after peritonitis in mice with sickle cell disease
    Pablo Bartolucci
    Unité INSERM U492 Université Paris XII, Creteil, and Laboratoire de Thérapie Génique Hématopoïétique, Hopital Saint Louis, Paris, France
    Crit Care Med 35:502-9. 2007
    ....
  25. ncbi request reprint Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?
    Saadia Eddahibi
    Department of Physiology, INSERM U492, CHU Henri Mondor, 94010 Creteil, France
    J Lab Clin Med 139:194-201. 2002
    ....
  26. ncbi request reprint Lung overexpression of angiostatin aggravates pulmonary hypertension in chronically hypoxic mice
    Marie Aude Pascaud
    INSERM U492, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Am J Respir Cell Mol Biol 29:449-57. 2003
    ..K3. The results show that inhibition of hypoxia-induced stimulation of lung angiogenic processes aggravates development of hypoxic PH. This suggests that endogenous lung angiogenesis counteracts development of hypoxic PH...
  27. ncbi request reprint [Genetics and physiopathology of primary or secondary pulmonary artery hypertension]
    Serge Adnot
    INSERM U492 Département de Physiologie Explorations Fonctionnelles Hôpital H Mondor AP HP Faculté de Médecine de Créteil, 94010 Creteil, France
    Bull Acad Natl Med 187:1529-42; discussion 1543-5. 2003
    ..This should lead soon to the development of new and more selective therapeutic approaches to pulmonary hypertension...
  28. doi request reprint Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter
    Christophe Guignabert
    INSERM Unity Pulmonary Hypertension Pathophysiology and Innovative Therapies, Centre Chirurgical Marie Lannelongue, 133 avenue de la Resistance, 92350 Le Plessis Robinson, France
    FASEB J 23:4135-47. 2009
    ..Our results support the possibility that DCA may be an interesting agent for investigation in patients with PAH...
  29. ncbi request reprint Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats
    Antoine Vieillard-Baron
    INSERM U492, Faculte de Medecine, 94010 Creteil, France
    Hum Gene Ther 14:861-9. 2003
    ..hTIMP-1-treated rats. These data support a deleterious role for proteases in toxic and inflammatory PH and indicate that MMPs may have opposite effects in different PH models...
  30. pmc Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease
    Hibo Noureddine
    INSERM U955, Hopital Henri Mondor, AP HP, Creteil, France
    Circ Res 109:543-53. 2011
    ..Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases...
  31. doi request reprint The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts
    Maylis Dagouassat
    Faculte de Medecine, Universite Paris Est, UMR U955, Creteil, France
    Am J Respir Crit Care Med 187:703-14. 2013
    ..However, the mechanisms of this phenomenon remain poorly defined...
  32. doi request reprint Lung imaging during acute chest syndrome in sickle cell disease: computed tomography patterns and diagnostic accuracy of bedside chest radiograph
    Armand Mekontso Dessap
    Service de Reanimation Medicale, AP HP, Groupe Henri Mondor Albert Chenevier, Creteil, France
    Thorax 69:144-51. 2014
    ..Our objectives were to describe CT features of ACS and evaluate the reproducibility and diagnostic performance of bedside CR...
  33. pmc Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats
    Guillaume Gary-Bobo
    INSERM U955 and Département de Physiologie Hôpital Henri Mondor, Creteil, France
    Circulation 122:1937-47. 2010
    ....
  34. pmc Lessons learned from cancer may help in the treatment of pulmonary hypertension
    Serge Adnot
    INSERM U651 and Département de Physiologie, Hôpital H Mondor, Assistance Publique des Hopitaux de Paris, Creteil, France
    J Clin Invest 115:1461-3. 2005
    ..These findings raise important issues regarding the role of survivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies...
  35. doi request reprint Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats
    Mohamed Izikki
    Institut National de la Santé et de la Recherche Médicale U841, Institut Mondor de Recherche Biomedicale, Facultéde Médecine, 94010 Creteil, France
    J Pharmacol Exp Ther 330:54-62. 2009
    ..In conclusion, the PDE4 inhibitor roflumilast significantly attenuates pulmonary vascular remodeling and hypertension induced by chronic hypoxia or MCT and reverses established PH after MCT administration...
  36. ncbi request reprint Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in rats
    Vanessa Louzier
    Physiology Department, National Institute for Health and Medical Research INSERM Unit 492, Henri Mondor Teaching Hospital, AP HP, 94010 Creteil, France
    Hum Gene Ther 15:793-804. 2004
    ..V152 died within 3 days. In conclusion, adenovirus-mediated FGF-1 overexpression in the lungs causes epithelial cell proliferation and has beneficial effects in hyperoxic lung injury...
  37. pmc Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury
    Armand Mekontso Dessap
    INSERM, Unité U, Creteil, France
    Am J Respir Cell Mol Biol 46:541-50. 2012
    ..These novel insights should be integrated into the clinical assessment of the risk/benefit of recruitment maneuver strategies...
  38. ncbi request reprint Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension
    Vanessa Louzier
    Departement de Physiologie, Institut National de la Santé et de La Recherche Médicale Unité 492, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 94010 Creteil, France
    Am J Physiol Lung Cell Mol Physiol 284:L926-37. 2003
    ..However, when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability...
  39. ncbi request reprint Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin
    Laurent Belhassen
    Service de Physiologie Explorations Fonctionnelles et Fédération de Cardiologie, CHU Henri Mondor, AP HP, Creteil, France
    J Am Coll Cardiol 41:1198-204. 2003
    ..In this study, we evaluated the effect of S 18886, a specific thromboxane A(2) receptor antagonist, on endothelial function in patients with coronary artery disease (CAD)...
  40. pmc Pulmonary acceleration time to optimize the timing of lung transplant in cystic fibrosis
    Thibaud Damy
    Department of Cardiology, AP HP, Henri Mondor Hospital, Creteil, France
    Pulm Circ 2:75-83. 2012
    ..001) but not in patients with sPAP>35 mmHg. By multivariate analysis, FEV(1)and nocturnal desaturation were the main determinants of reduced PAT. A PAT<101 ms reduction is a promising tool for timing of lung transplantation in CF...
  41. doi request reprint Pulmonary artery thrombosis during acute chest syndrome in sickle cell disease
    Armand Mekontso Dessap
    Service de Reanimation Medicale, Assistance Publique Hopitaux de Paris, Groupe Henri Mondor Albert Chenevier, Creteil, France
    Am J Respir Crit Care Med 184:1022-9. 2011
    ..The pathophysiology of acute chest syndrome (ACS) in patients with sickle cell disease is complex, and pulmonary artery thrombosis (PT) may contribute to this complication...
  42. ncbi request reprint Vascular-wall remodeling of 3 human bypass vessels: organ culture and smooth muscle cell properties
    Armand Mekontso-Dessap
    Institut National de la Sante et de la Recherche Medicale, Faculté de Médecine de Créteil, Creteil, France
    J Thorac Cardiovasc Surg 131:651-8. 2006
    ..The aim of the present study was to compare the vascular-wall remodeling of human internal thoracic artery, radial artery, and saphenous vein bypass conduits...
  43. doi request reprint Left ventricle remodelling is associated with sleep-disordered breathing in non-ischaemic cardiopathy with systolic dysfunction
    Thibaud Damy
    Fédération de cardiologie, AP HP, Groupe Henri Mondor Albert Chenevier, Creteil, France
    J Sleep Res 20:101-9. 2011
    ..LVM Ind was correlated to the AHI (R = 0.27, P = 0.0006) and, using logistic regression, AHI was the unique independent factor of LVH in this population. In non-ischaemic CHF, SDB severity is associated with LV remodelling...
  44. ncbi request reprint Stimulation of angiogenesis by Cyr61 gene: a new therapeutic candidate
    Virginie Fataccioli
    INSERM U492, Hopital Henri Mondor, 94010 Creteil, France
    Hum Gene Ther 13:1461-70. 2002
    ..These findings indicate that Cyr61 could be a promising therapeutic candidate for treating severe peripheral ischemic diseases...
  45. doi request reprint Comparison of four right ventricular systolic echocardiographic parameters to predict adverse outcomes in chronic heart failure
    Thibaud Damy
    Fédération de cardiologie, AP HP, Groupe Henri Mondor Albert Chenevier, 51 Avenue Marechal De Lattre de Tassigny, 94010 Creteil, France
    Eur J Heart Fail 11:818-24. 2009
    ..Our objective was to compare the predictive value of four RV systolic echocardiographic parameters for outcomes in patients with HF...