Research Topics
| Serge AdnotSummaryCountry: France Publications
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Publications
Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary HypertensionNathalie Mouraret
Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, 94010, Creteil, France
Circulation 127:1664-76. 2013..We hypothesized that cell senescence induced by Nutlin-3a exerted therapeutic effects in pulmonary hypertension (PH) by limiting the proliferation of pulmonary artery smooth muscle cells (PA-SMCs)...
Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in miceLaurent Savale
INSERM U841, Universite Paris XII, F94010 Creteil, France
Respir Res 10:6. 2009..Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 (IL-6)...
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertensionElisabeth Marcos
INSERM U492, , CHU Henri Mondor, , France
Am J Respir Crit Care Med 168:487-93. 2003..These data indicate that 5-HTT plays a key role in hypoxia-induced pulmonary vascular remodeling. The effects of serotonin transporter inhibitors on PH in humans deserve investigation...- Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertensionElisabeth Marcos
INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, Creteil, France
Circ Res 94:1263-70. 2004..We conclude that 5-HTT overexpression is a common pathogenic mechanism in various forms of PH... - Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in miceShariq Abid
INSERM U955 Team 8 and Département de Physiologie, Hopital Henri Mondor, AP HP, Creteil
Am J Physiol Lung Cell Mol Physiol 303:L500-8. 2012..These results provide proof of concept that inhibiting Tph1 may represent a new therapeutic strategy for human PH... - Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung diseaseHibo Noureddine
INSERM U955, Hopital Henri Mondor, AP HP, Creteil, France
Circ Res 109:543-53. 2011..Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases... - Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary diseaseValerie Amsellem
Institut National de la Sante et de la Recherche Medicale, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
Am J Respir Crit Care Med 184:1358-66. 2011..Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of unknown pathogenesis... - Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertensionChristophe Guignabert
INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
Circ Res 98:1323-30. 2006..They further support a central role for 5-HTT in the pathogenesis of PH, making 5-HTT a potential therapeutic target... - Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodentsMohamed Izikki
INSERM U841, Faculte de Medecine, 8 Avenue du General Sarrail, 94010 Creteil, France
J Clin Invest 119:512-23. 2009..Thus, endothelial FGF2 is overproduced in IPH and contributes to SMC hyperplasia in IPH, identifying FGF2 as a promising target for new treatments against PH... - Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary diseaseSaadia Eddahibi
INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, 94010 Creteil, France
Circulation 108:1839-44. 2003..Because hypoxia and 5-HTT gene polymorphism control 5-HTT expression, we examined 5-HTT gene polymorphism and PH in hypoxemic patients with advanced chronic obstructive pulmonary disease (COPD)... - Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertensionVanessa Louzier
Departement de Physiologie, Institut National de la Santé et de La Recherche Médicale Unité 492, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 94010 Creteil, France
Am J Physiol Lung Cell Mol Physiol 284:L926-37. 2003..However, when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability... - Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertensionOlivier Sanchez
INSERM U841 and Département de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, Creteil, France
Am J Respir Crit Care Med 176:1041-7. 2007..CC chemokine ligand 2 (CCL2) is synthesized by vascular cells and can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation... - Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporterChristophe Guignabert
INSERM Unity Pulmonary Hypertension Pathophysiology and Innovative Therapies, Centre Chirurgical Marie Lannelongue, 133 avenue de la Resistance, 92350 Le Plessis Robinson, France
FASEB J 23:4135-47. 2009..Our results support the possibility that DCA may be an interesting agent for investigation in patients with PAH... - Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in miceWilliam Raoul
Unité INSERM TGU841 Université Paris XII, Creteil, France
Respir Res 8:8. 2007..Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown... - Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?Saadia Eddahibi
Department of Physiology, INSERM U492, CHU Henri Mondor, 94010 Creteil, France
J Lab Clin Med 139:194-201. 2002.... - Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertensionLaurence Dewachter
INSERM U651, Faculte de Medecine, 8, rue Général Sarrail, Creteil, France
Am J Respir Crit Care Med 174:1025-33. 2006..Angiopoietins are involved in blood vessel maturation and remodeling... - Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasiaSaadia Eddahibi
INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
Circulation 113:1857-64. 2006..We investigated the role of pulmonary microvascular endothelial cells (P-ECs) in controlling PA-SMC growth... - Vascular-wall remodeling of 3 human bypass vessels: organ culture and smooth muscle cell propertiesArmand Mekontso-Dessap
Institut National de la Sante et de la Recherche Medicale, Faculté de Médecine de Créteil, Creteil, France
J Thorac Cardiovasc Surg 131:651-8. 2006..The aim of the present study was to compare the vascular-wall remodeling of human internal thoracic artery, radial artery, and saphenous vein bypass conduits... - Lung overexpression of angiostatin aggravates pulmonary hypertension in chronically hypoxic miceMarie Aude Pascaud
INSERM U492, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
Am J Respir Cell Mol Biol 29:449-57. 2003..K3. The results show that inhibition of hypoxia-induced stimulation of lung angiogenic processes aggravates development of hypoxic PH. This suggests that endogenous lung angiogenesis counteracts development of hypoxic PH... - [Genetics and physiopathology of primary or secondary pulmonary artery hypertension]Serge Adnot
INSERM U492 Département de Physiologie Explorations Fonctionnelles Hôpital H Mondor AP HP Faculté de Médecine de Créteil, 94010 Creteil, France
Bull Acad Natl Med 187:1529-42; discussion 1543-5. 2003..This should lead soon to the development of new and more selective therapeutic approaches to pulmonary hypertension... - Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in ratsAntoine Vieillard-Baron
INSERM U492, Faculte de Medecine, 94010 Creteil, France
Hum Gene Ther 14:861-9. 2003..hTIMP-1-treated rats. These data support a deleterious role for proteases in toxic and inflammatory PH and indicate that MMPs may have opposite effects in different PH models... - Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in ratsGuillaume Gary-Bobo
INSERM U955 and Département de Physiologie Hôpital Henri Mondor, Creteil, France
Circulation 122:1937-47. 2010.... - Effects of polycythemia on systemic endothelial function in chronic hypoxic lung diseaseLaurent Boyer
Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Assistance Publique Hopitaux de Paris, Université Paris Est Créteil Val de Marne, Creteil, France
J Appl Physiol 110:1196-203. 2011..Overall, our results suggest that moderate polycythemia has no adverse effect on vascular function in COPD... - The cyclooxygenase-2-prostaglandin e2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblastsMaylis Dagouassat
1 Faculté de Médecine, Universite Paris Est, UMR U955, Creteil, France
Am J Respir Crit Care Med 187:703-14. 2013..Modulating the described PGE2 signaling pathway could provide a new basis to dampen senescence and senescence-associated inflammation in COPD... - Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in ratsVanessa Louzier
Physiology Department, National Institute for Health and Medical Research (INSERM) Unit 492, Henri Mondor Teaching Hospital, AP-HP, , France
Hum Gene Ther 15:793-804. 2004..V152 died within 3 days. In conclusion, adenovirus-mediated FGF-1 overexpression in the lungs causes epithelial cell proliferation and has beneficial effects in hyperoxic lung injury... - Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in ratsMohamed Izikki
Institut National de la Santé et de la Recherche Médicale U841, Institut Mondor de Recherche Biomedicale, Facultéde Médecine, 94010 Creteil, France
J Pharmacol Exp Ther 330:54-62. 2009..In conclusion, the PDE4 inhibitor roflumilast significantly attenuates pulmonary vascular remodeling and hypertension induced by chronic hypoxia or MCT and reverses established PH after MCT administration... - Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injuryArmand Mekontso Dessap
INSERM, Unité U, Creteil, France
Am J Respir Cell Mol Biol 46:541-50. 2012..These novel insights should be integrated into the clinical assessment of the risk/benefit of recruitment maneuver strategies... - Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary diseaseLaurent Savale
Assistance Publique Hopitaux de Paris, Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Universite Paris 12, 94010 Creteil, France
Am J Respir Crit Care Med 179:566-71. 2009..Telomere length is considered a marker for biological aging. Chronic obstructive pulmonary disease (COPD) may be associated with premature aging... - Decrease in lung nitric oxide production after peritonitis in mice with sickle cell diseasePablo Bartolucci
Unité INSERM U492 Université Paris XII, Creteil, and Laboratoire de Thérapie Génique Hématopoïétique, Hopital Saint Louis, Paris, France
Crit Care Med 35:502-9. 2007.... - Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunctionPapa Ahmed Fall
Urology Department, Henri Mondor Teaching Hospital, Creteil, France
Eur Urol 56:716-25. 2009.... - Lessons learned from cancer may help in the treatment of pulmonary hypertensionSerge Adnot
INSERM U651 and Département de Physiologie, Hôpital H Mondor, Assistance Publique des Hopitaux de Paris, Creteil, France
J Clin Invest 115:1461-3. 2005..These findings raise important issues regarding the role of survivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies... - Stimulation of angiogenesis by Cyr61 gene: a new therapeutic candidateVirginie Fataccioli
INSERM U492, , , France
Hum Gene Ther 13:1461-70. 2002..These findings indicate that Cyr61 could be a promising therapeutic candidate for treating severe peripheral ischemic diseases... - Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirinLaurent Belhassen
Service de Physiologie Explorations Fonctionnelles et Fédération de Cardiologie, CHU Henri Mondor, AP HP, Creteil, France
J Am Coll Cardiol 41:1198-204. 2003..In this study, we evaluated the effect of S 18886, a specific thromboxane A(2) receptor antagonist, on endothelial function in patients with coronary artery disease (CAD)... - Interleukin-6 gene polymorphism confers susceptibility to pulmonary hypertension in chronic obstructive pulmonary diseaseSaadia Eddahibi
, , Creteil, France
Proc Am Thorac Soc 3:475-476. 2006 - Comparison of four right ventricular systolic echocardiographic parameters to predict adverse outcomes in chronic heart failureThibaud Damy
Fédération de cardiologie, AP HP, Groupe Henri Mondor Albert Chenevier, 51 Avenue Marechal De Lattre de Tassigny, 94010 Creteil, France
Eur J Heart Fail 11:818-24. 2009..Our objective was to compare the predictive value of four RV systolic echocardiographic parameters for outcomes in patients with HF...