Rene Adam

Summary

Country: France

Publications

  1. doi request reprint Is perioperative chemotherapy useful for solitary, metachronous, colorectal liver metastases?
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Univ Paris Sud, UMR S 776, Villejuif, France
    Ann Surg 252:774-87. 2010
  2. ncbi request reprint Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases
    Dennis A Wicherts
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg 248:994-1005. 2008
  3. pmc Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy?
    Rene Adam
    Centre Hépato Biliare, Hospital Paul Brousse, Assistance Publique, Hospitaux de Paris Université Paris Sud Villejuif, France
    Ann Surg 238:508-18; discussion 518-9. 2003
  4. pmc Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, 14 Av PV Couturier, 94800 Villejuif, France
    Ann Surg 240:1052-61; discussion 1061-4. 2004
  5. ncbi request reprint Developing strategies for liver metastases from colorectal cancer
    Rene Adam
    Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, University Paris Sud 11, 14 avenue Paul Vaillant Couturier, 94800 Villejuif, Paris, France
    Semin Oncol 34:S7-11. 2007
  6. pmc Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival
    Rene Adam
    Centre Hépato Biliaire and Inserm E0354 Cancer Chronotherapeutics, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris Université Paris, Sud Villejuif, France
    Ann Surg 240:644-57; discussion 657-8. 2004
  7. ncbi request reprint A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignancies
    Rene Adam
    Department of Hepatobiliary Surgery and Liver Transplantation, Centre Hepato Biliaire, Hopital Paul Brousse, Universite Paris Sud, Villejuif, France
    Arch Surg 137:1332-9; discussion 1340. 2002
  8. ncbi request reprint Hepatic resection after down-staging of unresectable hepatic colorectal metastases
    Rene Adam
    Department of Surgery, Centre Hepato Biliaire, Hopital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94804 Villejuif, France
    Surg Oncol Clin N Am 12:211-20, xii. 2003
  9. ncbi request reprint Hepatic colorectal metastases: methods of improving resectability
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif, Universite Paris Sud, 14, av P V Couturier, 94800 Villejuif, France
    Surg Clin North Am 84:659-71. 2004
  10. ncbi request reprint Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry
    Rene Adam
    European Liver Transplant Registry, Villejuif, France
    Liver Transpl 9:1231-43. 2003

Detail Information

Publications107 found, 100 shown here

  1. doi request reprint Is perioperative chemotherapy useful for solitary, metachronous, colorectal liver metastases?
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Univ Paris Sud, UMR S 776, Villejuif, France
    Ann Surg 252:774-87. 2010
    ..The aim of our study was to address the still pending question of whether perioperative chemotherapy is really beneficial in patients developing solitary metastases at a distance from surgery of the primary...
  2. ncbi request reprint Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases
    Dennis A Wicherts
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg 248:994-1005. 2008
    ..To assess feasibility, risks, and long-term outcome of 2-stage hepatectomy as a means to improve resectability of colorectal liver metastases (CLM)...
  3. pmc Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy?
    Rene Adam
    Centre Hépato Biliare, Hospital Paul Brousse, Assistance Publique, Hospitaux de Paris Université Paris Sud Villejuif, France
    Ann Surg 238:508-18; discussion 518-9. 2003
    ..To assess the viability of a strategy of primary resection with secondary liver transplantation (LT) for hepatocellular carcinoma (HCC) on cirrhosis...
  4. pmc Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, 14 Av PV Couturier, 94800 Villejuif, France
    Ann Surg 240:1052-61; discussion 1061-4. 2004
    ..To evaluate the influence of the response to preoperative chemotherapy, especially tumor progression, on the outcome following resection of multiple colorectal liver metastases (CRM)...
  5. ncbi request reprint Developing strategies for liver metastases from colorectal cancer
    Rene Adam
    Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, University Paris Sud 11, 14 avenue Paul Vaillant Couturier, 94800 Villejuif, Paris, France
    Semin Oncol 34:S7-11. 2007
    ..This brief report describes data supporting the expanding application of hepatectomy for patients with colorectal liver metastases...
  6. pmc Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival
    Rene Adam
    Centre Hépato Biliaire and Inserm E0354 Cancer Chronotherapeutics, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris Université Paris, Sud Villejuif, France
    Ann Surg 240:644-57; discussion 657-8. 2004
    ....
  7. ncbi request reprint A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignancies
    Rene Adam
    Department of Hepatobiliary Surgery and Liver Transplantation, Centre Hepato Biliaire, Hopital Paul Brousse, Universite Paris Sud, Villejuif, France
    Arch Surg 137:1332-9; discussion 1340. 2002
    ..The complication and success rates in patients treated with either percutaneous cryosurgery (PCS) or percutaneous radiofrequency (PRF) for unresectable hepatic malignancies are similar...
  8. ncbi request reprint Hepatic resection after down-staging of unresectable hepatic colorectal metastases
    Rene Adam
    Department of Surgery, Centre Hepato Biliaire, Hopital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94804 Villejuif, France
    Surg Oncol Clin N Am 12:211-20, xii. 2003
    ..This article reviews the literature and major areas of progress in treatments for unresectable colorectal cancer...
  9. ncbi request reprint Hepatic colorectal metastases: methods of improving resectability
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif, Universite Paris Sud, 14, av P V Couturier, 94800 Villejuif, France
    Surg Clin North Am 84:659-71. 2004
    ..To achieve this objective, a close collaboration between oncologists, radiologists, and surgeons is mandatory, with routine re-evaluation of patients for an adequate timing of each treatment...
  10. ncbi request reprint Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry
    Rene Adam
    European Liver Transplant Registry, Villejuif, France
    Liver Transpl 9:1231-43. 2003
    ..As with split LT or domino LT, LRLT aims to provide more patients to be transplanted. Special attention is paid to reducing the risk for the donor, which is now estimated to be 0.5% mortality and 21% postoperative morbidity...
  11. pmc Liver resection for colorectal metastases: the third hepatectomy
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, 14 Av PV Couturier, 94800 Villejuif, France
    Ann Surg 238:871-83; discussion 883-4. 2003
    ..To determine the risk, the benefit, and the main factors of prognosis of third liver resections for recurrent colorectal metastases...
  12. ncbi request reprint Liver transplantation in Europe: is there a room for improvement?
    Rene Adam
    Hepatobiliary Center, Paul Brousse Hospital, 12 avenue Paul Vaillant Couturier, 94804 Villejuif Cedex, France
    J Hepatol 42:33-40. 2005
  13. ncbi request reprint Evolution of liver transplantation for hepatocellular carcinoma
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Universite Paris Sud, 12 14, avenue Paul Vaillant Couturier, 94804 Villejuif Cedex, France
    J Hepatol 39:888-95. 2003
  14. ncbi request reprint Normalised intrinsic mortality risk in liver transplantation: European Liver Transplant Registry study
    R Adam
    ELTR Coordinating Centre, Paul Brousse Hospital, Villejuif, France
    Lancet 356:621-7. 2000
    ..We investigated the intrinsic mortality risk in the absence of known mortality risk factors...
  15. ncbi request reprint Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal
    R Adam
    Centre Hepato Biliaire, Service de Cancérologie Hopital Paul Brousse, Villejuif, France
    Ann Surg Oncol 8:347-53. 2001
    ..Our experience with neoadjuvant chemotherapy followed by resection and five years survival analysis of the patients treated is presented...
  16. pmc Two-stage hepatectomy: A planned strategy to treat irresectable liver tumors
    R Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif, and Université Paris Sud, France
    Ann Surg 232:777-85. 2000
    ..To assess feasibility, risks, and patient outcomes in the treatment of colorectal metastases with two-stage hepatectomy...
  17. ncbi request reprint [Chemotherapy and surgery in the treatment of liver metastasis of colorectal cancer: a sacred union...]
    R Adam
    Centre Hepatobiliaire, Hopital Paul Brousse, Villejuif, France
    Ann Chir 128:2-4. 2003
  18. ncbi request reprint [Induction chemotherapy and surgery of colorectal liver metastases]
    Rene Adam
    Centre Hepatobiliaire, Hopital Paul Brousse, Universite de Paris Sud, 12, avenue Paul Vaillant Couturier, 94804 Villejuif Cedex
    Bull Cancer 93:S45-9. 2006
    ..The objective of this article is to describe this multidisciplinary approach of liver metastases and to report the results of these new strategies...
  19. pmc Tumor marker evolution: comparison with imaging for assessment of response to chemotherapy in patients with colorectal liver metastases
    Robbert J de Haas
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg Oncol 17:1010-23. 2010
    ....
  20. ncbi request reprint Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases
    Thomas Aloia
    Department of Hepatobiliary Surgery and Liver Transplantation, Paul Brousse Hospital, Villejuif, France
    J Clin Oncol 24:4983-90. 2006
    ..Preoperative chemotherapy for colorectal liver metastases (CLM) can produce histologic changes in the nontumor-bearing liver (NTBL) that may impact on surgical outcomes...
  21. pmc Regenerative nodular hyperplasia of the liver related to chemotherapy: impact on outcome of liver surgery for colorectal metastases
    Dennis A Wicherts
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg Oncol 18:659-69. 2011
    ..The goal was to evaluate its incidence and impact on the outcome of patients resected for colorectal liver metastases (CLM)...
  22. doi request reprint Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, 14 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Cancer Chemother Pharmacol 67:339-48. 2011
    ..We hypothesized that EGFR blockade with cetuximab would enhance the activity of chronotherapy as a result of improved circadian coordination...
  23. ncbi request reprint Ischemic preconditioning for major liver resection under vascular exclusion of the liver preserving the caval flow: a randomized prospective study
    Daniel Azoulay
    Centre Hépato Biliare, Hopital Paul Brousse, Villejuif, Universite Paris Sud, and IFR 89 9, Paris, France
    J Am Coll Surg 202:203-11. 2006
    ..The primary goal of this study was to determine whether IP protects the human liver against ischemia-reperfusion injury after hepatectomy under continuous vascular exclusion with preservation of the caval flow...
  24. ncbi request reprint Chronomodulated irinotecan, oxaliplatin, and leucovorin-modulated 5-Fluorouracil as ambulatory salvage therapy in patients with irinotecan- and oxaliplatin-resistant metastatic colorectal cancer
    Dany Gholam
    INSERM U776 Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif, France
    Oncologist 11:1072-80. 2006
    ..Patients and..
  25. ncbi request reprint Survival and recurrence of hepatitis C after liver transplantation in patients coinfected with human immunodeficiency virus and hepatitis C virus
    Jean Charles Duclos-Vallée
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Hepatology 47:407-17. 2008
    ..03; risk ratio, 1.08; 95% confidence interval, 1.01, 1.15). Using the Kaplan-Meier method, the progression to fibrosis >or= F2 was significantly higher in the coinfected group (P < 0.0001)...
  26. doi request reprint Fungal infections after liver transplantation: outcomes and risk factors revisited in the MELD era
    Faouzi Saliba
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Clin Transplant 27:E454-61. 2013
    ..1-fold or 3.1-fold increase in relative risk of invasive fungal infection. In conclusion, liver transplant patients with a MELD score ≥ 20, and particularly patients with a score ≥ 30, are candidates for antifungal prophylaxis...
  27. doi request reprint Is hepatic resection justified after chemotherapy in patients with colorectal liver metastases and lymph node involvement?
    Rene Adam
    Assistance Publique Hôpitaux de Paris Hôpital Paul Brousse, Centre Hepato Biliaire, 12 avenue Paul Vaillant Couturier, F 94804 Villejuif, France
    J Clin Oncol 26:3672-80. 2008
    ..The objective of this study was to evaluate the ability of a multidisciplinary approach, including preoperative chemotherapy and hepatectomy, to improve patient outcomes...
  28. pmc Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft's preservation and function: the ying and the yang
    Daniel Azoulay
    Centre Hepato Biliaire, Département de Chirurgie Hépato Biliaire, Hopital Paul Brousse, Villejuif, France
    Ann Surg 242:133-9. 2005
    ..Although extensively studied in animal models, ischemic preconditioning has not yet been studied in clinical transplantation...
  29. pmc Decision for retransplantation of the liver: an experience- and cost-based analysis
    Daniel Azoulay
    Hepatobiliary Center, Hospital Paul Brousse, Assitance Publique Hôpitaux de Paris and Université Paris Sud, Villejuif, France
    Ann Surg 236:713-21; discussion 721. 2002
    ..To determine the patient factors affecting patient outcome of first liver retransplantation at a single center to help in the decision process for retransplantation...
  30. doi request reprint Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or reality?
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, 12 avenue Paul Vaillant Couturier, F 94804 Villejuif, France
    J Clin Oncol 26:1635-41. 2008
    ..The objective of this study was to determine predictive factors of CPR as well as its impact on survival...
  31. pmc Is liver resection justified for patients with hepatic metastases from breast cancer?
    Rene Adam
    Centre Hepato Biliaire, Paul Brousse Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Sud, 11 Villejuif, France
    Ann Surg 244:897-907; discussion 907-8. 2006
    ..The purpose of this study was to examine our experience with hepatic resection (HR) in a relatively unselected group of patients with breast cancer liver metastases (BCLM)...
  32. doi request reprint Impact of expanding criteria for resectability of colorectal metastases on short- and long-term outcomes after hepatic resection
    Robbert J de Haas
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Ann Surg 253:1069-79. 2011
    ..An expansion of resectability criteria of colorectal liver metastases (CLM) is justified provided "acceptable" short-term and long-term outcomes. The aim of the present study was to ascertain this paradigm in an era of modern liver surgery...
  33. doi request reprint Caval inflow to the graft for liver transplantation in patients with diffuse portal vein thrombosis: a 12-year experience
    Prashant Bhangui
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif Cedex, France
    Ann Surg 254:1008-16. 2011
    ..To analyze the short- and long-term results of cavoportal anastomosis (CPA) and renoportal anastomosis (RPA) in 20 consecutive liver transplantation (LT) candidates with diffuse portal vein thrombosis (PVT)...
  34. doi request reprint Concomitant extrahepatic disease in patients with colorectal liver metastases: when is there a place for surgery?
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, 12 avenue Paul Vaillant Couturier, Villejuif, France
    Ann Surg 253:349-59. 2011
    ....
  35. ncbi request reprint Donor age influences 10-year liver graft histology independently of hepatitis C virus infection
    Kinan Rifai
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif Assistance Publique Hôpitaux de Paris, Universite Paris Sud, 12 14 avenue Paul Vaillant Couturier, 94800 Villejuif, France
    J Hepatol 41:446-53. 2004
    ..Factors influencing the long-term histological outcome of liver graft are not known. We conducted a prospective study based on a 10-year liver biopsy in order to identify the main factors influencing long-term graft histology...
  36. doi request reprint R1 resection by necessity for colorectal liver metastases: is it still a contraindication to surgery?
    Robbert J de Haas
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Ann Surg 248:626-37. 2008
    ..To compare long-term outcome of R0 (negative margins) and R1 (positive margins) liver resections for colorectal liver metastases (CLM) treated by an aggressive approach combining chemotherapy and repeat surgery...
  37. pmc In situ hypothermic perfusion of the liver versus standard total vascular exclusion for complex liver resection
    Daniel Azoulay
    Centre Hepato Biliaire, Département de Chirurgie Hépato Biliaire, IFR 89 9, Hopital Paul Brousse, Villejuif, France
    Ann Surg 241:277-85. 2005
    ..The safe duration of TVE is still debated. Promising results have been reported following TVE associated with hypothermic perfusion of the liver with durations of up to several hours. The 2 techniques have not been compared so far...
  38. doi request reprint Successful long-term outcome of ABO-incompatible liver transplantation using antigen-specific immunoadsorption columns
    Faouzi Saliba
    Hepatobiliary Center, Paul Brousse Hospital, Villejuif, France
    Ther Apher Dial 14:116-23. 2010
    ..Two patients are alive at 1.5 and 3 years follow-up with a normally functioning graft. The third patient died with a functioning graft, one month after the transplantation, from septic complications...
  39. doi request reprint Long-term outcomes after hepatic resection for colorectal metastases in young patients
    Robbert J de Haas
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Cancer 116:647-58. 2010
    ..The aim of the current study was to evaluate long-term outcomes in patients < or = 40 years old, and to compare them with patients >40 years old...
  40. doi request reprint Patients with initially unresectable colorectal liver metastases: is there a possibility of cure?
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hépato Biliaire and Department of Medical Oncology, Villejuif, France
    J Clin Oncol 27:1829-35. 2009
    ..The aim of this study was to evaluate long-term outcome after combining downsizing chemotherapy and rescue surgery and to define prognostic factors of cure...
  41. doi request reprint Influence of larger graft weight to recipient weight on the post-liver transplantation course
    Eric Levesque
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Clin Transplant 27:239-47. 2013
    ..Using large grafts for recipient size did not impair liver function and did not modify graft and patient outcomes at one yr. However, a GWRW >2.5% appeared to be a determining factor for respiratory morbidity following LT...
  42. ncbi request reprint Beneficial effect of pentoxifylline on microvesicular steatotic livers submitted to a prolonged cold ischemia
    Isabelle Arnault
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif, France
    Transplantation 76:77-83. 2003
    ..We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepatic microcirculation...
  43. ncbi request reprint Hepatic resection after rescue cetuximab treatment for colorectal liver metastases previously refractory to conventional systemic therapy
    Rene Adam
    Centre Hépato Biliaire and the Department of Medical Oncology, Assistance Publique Hopitaux de Paris, France
    J Clin Oncol 25:4593-602. 2007
    ..This study was performed to determine the post-cetuximab resectability rate and to examine postoperative outcomes for these heavily pretreated patients...
  44. doi request reprint Resection or transplantation for early hepatocellular carcinoma in a cirrhotic liver: does size define the best oncological strategy?
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Ann Surg 256:883-91. 2012
    ..Resection and liver transplantation (LT) are the only curative options for hepatocellular carcinoma in cirrhotic patients (HCC-cirr)...
  45. doi request reprint Liver transplantation for hepatocellular carcinoma: the impact of human immunodeficiency virus infection
    Eric Vibert
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Hepatology 53:475-82. 2011
    ..08). RFS rates at 1 and 3 years were 69% and 69% in HIV+ patients and 89% and 84% in HIV- patients, respectively (P = 0.09). In univariate analysis, HIV status did not emerge as a prognostic factor for OS or RFS...
  46. doi request reprint Plasma disappearance rate of indocyanine green: a tool to evaluate early graft outcome after liver transplantation
    Eric Levesque
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Liver Transpl 15:1358-64. 2009
    ..8 to 10.3 +/- 2.5%/minute; P < 0.002). In conclusion, after LT, PDR-ICG (a noninvasive technique), measured regularly during the first 5 postoperative days, is a safe technique that can predict early postoperative complications...
  47. doi request reprint Intention-to-treat analysis of liver transplantation for hepatocellular carcinoma: living versus deceased donor transplantation
    Prashant Bhangui
    Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Villejuif, France
    Hepatology 53:1570-9. 2011
    ..On an intention-to-treat basis, the overall survival (OS) in the two groups was comparable. Patients beyond the Milan and UCSF criteria showed a trend toward worse outcomes with LDLT compared with DDLT (P = 0.06)...
  48. doi request reprint Actual incidence and long-term consequences of posthepatectomy liver failure after hepatectomy for colorectal liver metastases
    Eric Vibert
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France INSERM, Unite 785, Villejuif, France Université Paris Sud, Villejuif, France Electronic address
    Surgery 155:94-105. 2014
    ..This study evaluated its actual incidence and its effects on short- and long-term overall survival (OS) in a specialized center...
  49. ncbi request reprint Combined effects of fasting and alanine on liver function recovery after cold ischemia
    Isabelle Arnault
    Centre Hepato Biliaire, Hopital Paul Brousse, 14 av P V Couturier, 94800 Villejuif, France
    Transpl Int 15:89-95. 2002
    ..In a clinical setting, the infusion of alanine to the recipient at reperfusion may be a convenient way to compensate for donor undernutrition, especially after a long stay in an intensive care unit...
  50. ncbi request reprint [Auxiliary partial orthotopic liver transplantation using small grafts. A way to avoid small-for-size syndrome?]
    Olivier Scatton
    Centre Hepato Biliaire, Hopital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94800 Villejuif Cedex, France
    Gastroenterol Clin Biol 29:76-9. 2005
    ..With a follow-up of 5 years, the patient is in good condition. This original technique could be a solution to increase the number of transplantations using small grafts, especially left grafts, provided by splits or living donors...
  51. doi request reprint Posthepatectomy portal vein pressure predicts liver failure and mortality after major liver resection on noncirrhotic liver
    Marc Antoine Allard
    AP HP, Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France Université Paris Sud, Villejuif, France INSERM, Unite 785, Villejuif, France INSERM, Unité 776, Villejuif, France
    Ann Surg 258:822-9; discussion 829-30. 2013
    ..To evaluate the predictive value of portal vein pressure (PVP) after major liver resection for posthepatectomy liver failure (PLF) and 90-day mortality in patients without cirrhosis...
  52. pmc Combined liver resection and reconstruction of the supra-renal vena cava: the Paul Brousse experience
    Daniel Azoulay
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif, France
    Ann Surg 244:80-8. 2006
    ....
  53. doi request reprint Treatment of failed Roux-en-Y hepaticojejunostomy after post-cholecystectomy bile ducts injuries
    Amine Benkabbou
    AH HP, Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Surgery 153:95-102. 2013
    ..The aim of this study was to report our experience with a multidisciplinary approach to failed RYHJ after post-cholecystectomy BDI...
  54. ncbi request reprint Oxaliplatin plus irinotecan and FU-FOL combination and pharmacokinetic analysis in advanced colorectal cancer patients
    Marian A Gil-Delgado
    SOMPS, Salpetriere Hospital, Paris, France
    Am J Clin Oncol 27:294-8. 2004
    ..It would appear that the dose and schedule defined by this trial could be proposed as front-line therapy for advanced colorectal carcinoma to establish rapid disease control and to permit patients to proceed to surgery...
  55. doi request reprint Resection of colorectal liver metastases with extrahepatic disease
    Robbert J de Haas
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Paris, France
    Dig Surg 25:461-6. 2008
    ..Long-term survival in these patients with advanced disease could be achieved if they are managed by experienced multidisciplinary teams...
  56. ncbi request reprint Liver transplantation for primary and metastatic liver cancers
    Emir Hoti
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Transpl Int 21:1107-17. 2008
    ..Conversely, the value of transplantation for colorectal liver metastases (currently a contraindication) requires further evaluation by well-designed trials...
  57. ncbi request reprint Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis
    Mohamed Bouchahda
    Chronotherapy Unit and Department of Medical Oncology, Assistance Publique Hopitaux de Paris, Villejuif, France
    Cancer Chemother Pharmacol 66:605-9. 2010
    ..We report the first case of multiple KRAS mutations acquired during the metastatic phase of CRC, and retrospectively reviewed all patients with CRC, in whom KRAS was analyzed in at least two tumor samples from distinct lesions...
  58. pmc Therapeutic strategies in symptomatic portal biliopathy
    Eric Vibert
    Centre Hepato Biliaire, Hôpital Paul Brousse AP HP, Universite Paris Sud, Villejuif, France
    Ann Surg 246:97-104. 2007
    ..Because of the high hemorrhage risk associated with biliary surgery in patients with PC, the optimal therapeutic strategy is controversial...
  59. doi request reprint Portal stenting for hepatocellular carcinoma extending into the portal vein in cirrhotic patients
    Eric Vibert
    AP HP, Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    J Surg Oncol 107:696-701. 2013
    ..To prevent the malignant progression from a portal branch to the main portal trunk, we have placed noncovered metallic stents extending from the portal trunk to the contralateral tumor free portal pedicle...
  60. doi request reprint Evolution of neoadjuvant therapy for extended hepatic metastases--have we reached our (non-resectable) limit?
    Rene Adam
    AP HP Hospital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    J Surg Oncol 102:922-31. 2010
    ..Bringing them together into an integrated framework has expanded the number of patients that can be treated with curative intent. This review focuses on recent oncosurgical changes, their impact, and future directions...
  61. ncbi request reprint [Chemotherapy of liver metastasis from colorectal cancer]
    Henri Bismuth
    Centre Hepato Biliaire, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 12 avenue P V Couturier, 94800 Villejuif
    Bull Acad Natl Med 191:1647-60; discussion 1660. 2007
    ..New medical treatments, including monoclonal antibodies against tumoral growth factors (cetuximab) and vascular growth factors (bevacizumab), are also proving useful for tumor shrinkage prior to surgical resection...
  62. ncbi request reprint Medical community preferences concerning adult living related donor liver transplantation
    Denis Castaing
    Centre Hepato Biliaire, Hopital Paul Brousse, UPRES 1596, Universite Paris Sud, Villejuif
    Gastroenterol Clin Biol 30:183-7. 2006
    ..To assess acceptance and acceptable estimated mortality levels for right lobe adult-to-adult living related liver transplantation for the medical and allied professions...
  63. doi request reprint Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer
    Mohamed Bouchahda
    Chronotherapy Unit, Medical Oncology Department, Hepatobiliary Center, Public Assistance Hospital of Paris, Paul Brousse Hospital, Villejuif, France
    Cancer 115:4990-9. 2009
    ..In this article, the authors report their experience with chronomodulated HAI chemotherapy as rescue therapy in heavily pretreated patients who had metastatic colorectal cancer...
  64. ncbi request reprint Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation
    Vincent Karam
    Centre Hepatobiliaire, UPRES 1596, Assistance Publique Hopitaux de Paris, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Liver Transpl 9:703-11. 2003
    ..The results of transplant recipients were generally close to those of the general population. Although it is not a true return to normal status, it approaches it...
  65. doi request reprint Oncologic results of laparoscopic versus open hepatectomy for colorectal liver metastases in two specialized centers
    Denis Castaing
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif F 94804, France
    Ann Surg 250:849-55. 2009
    ..Compare oncologic results of laparoscopic versus open hepatectomy for resection of colorectal metastases to the liver...
  66. ncbi request reprint [Increased long-term permeability of transjugular intrahepatic portosystemic shunt (TIPS) in 218 cirrhotic patients, with strict monitoring]
    Denis Castaing
    Centre Hepato Biliaire, Hopital Paul Brousse, AP HP, Universite Paris Sud, Paris, Villejuif 94
    Presse Med 33:1239-46. 2004
    ..To measure the impact of strict monitoring on long term permeability of TIPS...
  67. doi request reprint MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer
    Bernard Paule
    Centre Hepatobiliaire, Department of Pharmacy Pharmacology, Paul Brousse University Hospital, AP HP, 12 14, avenue Paul Vaillant Couturier, Villejuif, France
    Med Oncol 27:1066-72. 2010
    ..Among patients resistant to irinotecan, it is still possible to use the association of cetuximab plus irinotecan to obtain a complete resection of hepatic metastases that is necessary to improve their survival...
  68. pmc Importance of conserving middle hepatic vein distal branches for homogeneous regeneration of the left liver after right hepatectomy
    Francois Faitot
    Hepatobiliary Centre Unit 785, INSERM, University of Paris South, Villejuif, France
    HPB (Oxford) 14:746-53. 2012
    ..This study examined left liver regeneration after right hepatectomy and the impact of hepatic venous drainage on the regeneration of the paramedian sector (Couinaud's segment IV)...
  69. ncbi request reprint Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas
    Bernard Paule
    Hepato Biliary Center, Assistance Publique Hopitaux de Paris, Hopital Paul Brousse, Faculté de Médecine Paris Sud 11, Villejuif, France
    Oncology 72:105-10. 2007
    ..To assess the efficacy and safety of cetuximab in the palliative treatment of patients with intrahepatic cholangiocarcinomas (CCA) unresponsive to first-line gemcitabine-oxaliplatin (GEMOX) pretreatment...
  70. ncbi request reprint Liver transplantation: the current situation
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Semin Liver Dis 29:3-18. 2009
    ..This article discusses the utility of the mentioned techniques along with other strategies (e.g., Model for End-Stage Liver Disease [MELD] score), as well as the evolution of indications, contraindications, and postoperative care...
  71. doi request reprint Results of percutaneous manoeuvres in biliary disease: the Paul Brousse experience
    Denis Castaing
    AP HP, Hopital Paul Brousse, Centre Hepato Biliaire, 12, avenue Paul Vaillant Couturier, 94804, Villejuif Cedex, France
    Surg Endosc 25:1858-65. 2011
    ..Percutaneous manoeuvres are alternatives to the endoscopic approach in the management of complex biliary disease...
  72. doi request reprint [Oncosurgical strategies for metastatic liver cancer]
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, Francia
    Cir Esp 89:10-9. 2011
    ..In this review, we have described the current oncosurgical strategies employed in patients with resectable and non resectable CRLM, their benefits, and future treatment strategies...
  73. ncbi request reprint Quality control of the European Liver Transplant Registry: results of audit visits to the contributing centers
    Vincent Karam
    Centre Hepatobiliaire, Hopital Paul Brousse, Villejuif, France vincent
    Transplantation 75:2167-73. 2003
    ..The number of registries is increasing, but few of them perform reliability audits by comparing the data contained in the database with data contained in hospital charts...
  74. ncbi request reprint Two-stage hepatectomy approach for initially unresectable colorectal hepatic metastases
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, 12 avenue Paul Vaillant Couturier, 94804 Villejuif, France
    Surg Oncol Clin N Am 16:525-36, viii. 2007
    ..This article describes strategic surgical approaches to multinodular metastatic disease and provides decision guidelines for two-stage hepatectomies...
  75. ncbi request reprint [Liver transplantation with cavoportal or renoportal anastomosis: a solution in cases of diffuse portal thrombosis]
    Daniel Azoulay
    Centre Hepato Biliaire, UPRES 1596, IFR 89 9, Hopital Paul Brousse, Villejuif Université Paris Sud, Paris, France
    Gastroenterol Clin Biol 26:325-30. 2002
    ..Long term results of these procedures are reported here...
  76. doi request reprint Progression of alphafetoprotein before liver transplantation for hepatocellular carcinoma in cirrhotic patients: a critical factor
    E Vibert
    AP HP, Hopital Paul Brousse, Centre Hepato Biliaire, INSERM, Unite 785, Universite Paris Sud, Villejuif, France
    Am J Transplant 10:129-37. 2010
    ..In conclusion, increasing AFP>15 microg/L/month while waiting for LT is the most relevant preoperative prognostic factor for low OS/DFS. AFP progression could be a pathological preoperative marker of tumor aggressiveness...
  77. ncbi request reprint [Liver transplantation for intrahepatic Rendu-Osler-Weber's disease: the Paul Brousse hospital experience]
    Daniel Azoulay
    Département de Chirurgie Hépato Biliaire, Hopital Paul Brousse, Universite Paris Sud, UPRES 1596, IFR 89 9, Villejuif, France
    Gastroenterol Clin Biol 26:828-34. 2002
    ..Nine centers have reported 15 cases of liver transplantation for Rendu-Osler-Weber's disease with liver involvement. Six cases are reported to analyse the specific technical and hemodynamical aspects...
  78. ncbi request reprint [Adult to adult living-related liver transplantation. The Paul-Brousse Hospital preliminary experience]
    D Azoulay
    Centre Hepato Biliaire, Hopital Paul Brousse, UPRES 1596, IFR 89 9, Universite Paris Sud, Villejuif, France
    Gastroenterol Clin Biol 25:773-80. 2001
    ..Follow-up ranged from 41 to 157 days (median: 117 days)...
  79. pmc Split-liver transplantation for two adult recipients: feasibility and long-term outcomes
    D Azoulay
    Centre Hepatobiliaire, UPRES 1596, Assistance Publique Hopitaux de Paris, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Ann Surg 233:565-74. 2001
    ..To identify the outcomes and risks of split-liver transplantation (SLT) for two adult recipients to determine the feasibility of more widespread use of this procedure to increase the graft pool for adults...
  80. ncbi request reprint [Severe visual loss due to retinal artery occlusion associated with Susac's syndrome: a case report]
    B Bodaghi
    Service d Ophtalmologie, CHU Pitie Salpetriere, Paris
    Rev Neurol (Paris) 161:1221-4. 2005
    ..Susac's syndrome consists of the clinical triad of cerebral microangiopathy, branch retinal artery occlusions, and hearing loss. The pathogenesis of the disease remains unknown. The severity of retinal vasculopathy remains variable...
  81. pmc Auxiliary partial orthotopic versus standard orthotopic whole liver transplantation for acute liver failure: a reappraisal from a single center by a case-control study
    D Azoulay
    Hepatobiliary Surgery and Liver Transplant Unit, UPRES 1596, IFR 89 9, Hopital Paul Brousse, Universite Paris Sud, 94804 Villejuif, France
    Ann Surg 234:723-31. 2001
    ..To reappraise the results of auxiliary partial orthotopic liver transplantation (APOLT) compared with those of standard whole-liver transplantation (OLT) in terms of postoperative death and complications, including neurologic sequelae...
  82. ncbi request reprint Hepatocellular carcinoma with lymphoid stroma: a tumour with good prognosis after liver transplantation
    J F Emile
    Service d Anatomopathologie, Centre Hepatobiliaire, Hôpital Paul Brousse and UPRES 1596 Virus Hépatotropes et Cancer, Universite Paris Sud, France
    Histopathology 37:523-9. 2000
    ..We determined the frequency, characteristics and prognosis of hepatocellular carcinomas with lymphoid stroma...
  83. ncbi request reprint Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    S Giacchetti
    International Organization of Cancer Chronotherapy, Centre de Chronothérapie, Hopital Paul Brousse, Villejuif, France
    J Clin Oncol 18:136-47. 2000
    ..To study how adding oxaliplatin (l-OHP) to chronomodulated fluorouracil (5-FU)-leucovorin (LV) affected the objective response rate, as first-line treatment of metastatic colorectal cancer...
  84. ncbi request reprint [Training of residents in surgery: need for contractual agreement]
    D Castaing
    Centre Hepato Biliaire, Hopital Paul Brousse, Villejuif
    J Chir (Paris) 139:46-9. 2002
  85. ncbi request reprint [Multistage liver resections in colorectal liver metastases. The Paul Brousse concept]
    D Azoulay
    Centre Hepato Biliaire, Hopital Paul Brousse, France
    Chirurg 72:765-9. 2001
    ..The aim of this paper is to report the strategies we use in our center to achieve curative resection in these three schematic situations despite initial contraindications...
  86. ncbi request reprint [New surgical strategies for liver metastasis of colorectal cancer: report of 3 cases]
    G Pascal
    Centre Hepatobiliaire, Hopital Paul Brousse, Villejuif, France
    Ann Chir 128:5-8. 2003
  87. ncbi request reprint Liver transplantation for hepatocellular carcinoma
    H Bismuth
    Centre Hepatobiliaire, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Semin Liver Dis 19:311-22. 1999
    ..Resection may be indicated if the waiting time is likely to be long...
  88. ncbi request reprint Bringing unresectable liver disease to resection with curative intent
    D A Wicherts
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif F 94804, France
    Eur J Surg Oncol 33:S42-51. 2007
    ..Overall, surgery should be performed as soon as liver metastases become resectable. Collaboration between oncologists and surgeons is essential to optimize individual therapeutic strategies...
  89. ncbi request reprint Chemotherapy and surgery: new perspectives on the treatment of unresectable liver metastases
    R Adam
    , Hopital Paul Brousse, Villejuif, Paris, France
    Ann Oncol 14:ii13-6. 2003
    ..The poor prognosis of patients with non-resectable hepatic metastases might now be improved by the combination of chemotherapy and surgery...
  90. ncbi request reprint [Percutaneous destruction of hepatic tumors]
    E Savier
    Service de chirurgie digestive et de transplantation hépatique, Groupe Hospitalier Pitie Salpetriere, Paris
    J Chir (Paris) 140:100-3. 2003
  91. pmc Hepatic resection for noncolorectal nonendocrine liver metastases: analysis of 1,452 patients and development of a prognostic model
    Rene Adam
    Paul Brousse Hospital, Villejuif, France
    Ann Surg 244:524-35. 2006
    ..To determine the utility of hepatic resection (HR) in the treatment of patients with noncolorectal nonendocrine liver metastases (NCNELM)...
  92. ncbi request reprint Strategies to treat primary unresectable colorectal liver metastases
    Eric Vibert
    Centre Hepato Biliaire, Hopîtal Paul Brousse Hospital, Assistance Publique Hopitaux de Paris, Universite de Paris Sud, Villejuif, France
    Semin Oncol 32:33-9. 2005
    ..The development of new chemotherapy protocols that offer the potential for curative surgery with optimum timing within the natural history of this metastatic disease is a shared therapeutic challenge...
  93. ncbi request reprint Hepatitis C virus viral recurrence and liver mitochondrial damage after liver transplantation in HIV-HCV co-infected patients
    Jean Charles Duclos-Vallée
    Centre Hépato Biliaire Hôpital Paul Brousse, Assistance Publique Hopitaux de Paris, 94804 Villejuif, France
    J Hepatol 42:341-9. 2005
    ..We report the Paul Brousse Hospital experience of transplantation for end stage cirrhosis in HIV-HCV co-infected patients...
  94. doi request reprint Impact of portal vein embolization on long-term survival of patients with primarily unresectable colorectal liver metastases
    D A Wicherts
    Centre Hepato Biliaire, Assistance Publique Hopitaux de Paris, Hopital Paul Brousse, Villejuif, France
    Br J Surg 97:240-50. 2010
    ..Portal vein embolization (PVE) increases the resectability of initially unresectable colorectal liver metastases (CLM). This study evaluated long-term survival in patients with CLM who underwent hepatectomy following PVE...
  95. ncbi request reprint [Alcoholic liver cirrhosis. Treatment of hepatocellular carcinoma]
    L A Veilhan
    , , Villejuif
    Presse Med 30:1170-7. 2001
    ..The management of patients with HCC with or without cirrhosis may combine several treatment modalities and needs a multi-disciplinary approach...
  96. ncbi request reprint [Resection of liver metastasis of colorectal origin following chemotherapy with irinotecan]
    R Adam
    Centre Hepatobiliaire, Hopital Paul Brousse, 94800 Villejuif, France
    Ann Chir 129:2-4. 2004
  97. ncbi request reprint Colorectal cancer with synchronous liver metastases
    R Adam
    Centre Hepato Biliaire, Paul Brousse Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Sud 11, Villejuif, Paris, France
    Br J Surg 94:129-31. 2007
  98. doi request reprint Comparison of simultaneous or delayed liver surgery for limited synchronous colorectal metastases
    R J de Haas
    Hepato Biliary Centre, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, France
    Br J Surg 97:1279-89. 2010
    ..The aim of this study was to compare simultaneous colorectal and hepatic resection with a delayed strategy in patients who had a limited hepatectomy (fewer than three segments)...
  99. ncbi request reprint Regional treatment of metastasis: surgery of colorectal liver metastases
    R Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Université Paris Sud and INSERM E 0354 Chronothérapie des Cancers, Villejuif, France
    Ann Oncol 15:iv103-6. 2004
  100. doi request reprint Long-term outcome in patients with adrenal metastases following resection of colorectal liver metastases
    R J de Haas
    Assistance Publique Hopitaux de Paris, Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Br J Surg 96:935-40. 2009
    ..The aim of this study was to determine the influence of AMs on long-term outcome and the role of adrenalectomy in patients with CLMs...
  101. ncbi request reprint Prospective phase II trial of iriontecan, 5-fluorouracil, and leucovorin in combination as salvage therapy for advanced colorectal cancer
    M A Gil-Delgado
    Department of Medical Oncology, , Paris, France
    Am J Clin Oncol 24:101-5. 2001
    ..Efficacy in this poor prognosis group of patients is very encouraging, and the schedule is well tolerated by even previously treated patients...