Rene Adam

..To assess feasibility, risks, and long-term outcome of 2-stage hepatectomy as a means to improve resectability of colorectal liver metastases (CLM)...

..The aim of our study was to address the still pending question of whether perioperative chemotherapy is really beneficial in patients developing solitary metastases at a distance from surgery of the primary...

..To assess the viability of a strategy of primary resection with secondary liver transplantation (LT) for hepatocellular carcinoma (HCC) on cirrhosis...

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..To achieve this objective, a close collaboration between oncologists, radiologists, and surgeons is mandatory, with routine re-evaluation of patients for an adequate timing of each treatment...

..The complication and success rates in patients treated with either percutaneous cryosurgery (PCS) or percutaneous radiofrequency (PRF) for unresectable hepatic malignancies are similar...

..This article reviews the literature and major areas of progress in treatments for unresectable colorectal cancer...

..As with split LT or domino LT, LRLT aims to provide more patients to be transplanted. Special attention is paid to reducing the risk for the donor, which is now estimated to be 0.5% mortality and 21% postoperative morbidity...

..To determine the risk, the benefit, and the main factors of prognosis of third liver resections for recurrent colorectal metastases...

..To evaluate the influence of the response to preoperative chemotherapy, especially tumor progression, on the outcome following resection of multiple colorectal liver metastases (CRM)...

..This brief report describes data supporting the expanding application of hepatectomy for patients with colorectal liver metastases...

..Our experience with neoadjuvant chemotherapy followed by resection and five years survival analysis of the patients treated is presented...

..We investigated the intrinsic mortality risk in the absence of known mortality risk factors...

..To assess feasibility, risks, and patient outcomes in the treatment of colorectal metastases with two-stage hepatectomy...

..The objective of this article is to describe this multidisciplinary approach of liver metastases and to report the results of these new strategies...

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..The goal was to evaluate its incidence and impact on the outcome of patients resected for colorectal liver metastases (CLM)...

..We hypothesized that EGFR blockade with cetuximab would enhance the activity of chronotherapy as a result of improved circadian coordination...

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..Although extensively studied in animal models, ischemic preconditioning has not yet been studied in clinical transplantation...

..To determine the patient factors affecting patient outcome of first liver retransplantation at a single center to help in the decision process for retransplantation...

..The objective of this study was to evaluate the ability of a multidisciplinary approach, including preoperative chemotherapy and hepatectomy, to improve patient outcomes...

..The objective of this study was to determine predictive factors of CPR as well as its impact on survival...

..The aim of the present study was to ascertain this paradigm in an era of modern liver surgery...

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..To analyze the short- and long-term results of cavoportal anastomosis (CPA) and renoportal anastomosis (RPA) in 20 consecutive liver transplantation (LT) candidates with diffuse portal vein thrombosis (PVT)...

..The aim of this study was to evaluate long-term outcome after combining downsizing chemotherapy and rescue surgery and to define prognostic factors of cure...

..This study was performed to determine the post-cetuximab resectability rate and to examine postoperative outcomes for these heavily pretreated patients...

..The safe duration of TVE is still debated. Promising results have been reported following TVE associated with hypothermic perfusion of the liver with durations of up to several hours. The 2 techniques have not been compared so far...

..The purpose of this study was to examine our experience with hepatic resection (HR) in a relatively unselected group of patients with breast cancer liver metastases (BCLM)...

..Two patients are alive at 1.5 and 3 years follow-up with a normally functioning graft. The third patient died with a functioning graft, one month after the transplantation, from septic complications...

..To compare long-term outcome of R0 (negative margins) and R1 (positive margins) liver resections for colorectal liver metastases (CLM) treated by an aggressive approach combining chemotherapy and repeat surgery...

..The aim of the current study was to evaluate long-term outcomes in patients < or = 40 years old, and to compare them with patients >40 years old...

..With a follow-up of 5 years, the patient is in good condition. This original technique could be a solution to increase the number of transplantations using small grafts, especially left grafts, provided by splits or living donors...

..Shorter waiting time preventing dropouts is an additional advantage with LDLT. LDLT for HCC patients beyond validated criteria should be proposed with caution...

..8 to 10.3 +/- 2.5%/minute; P < 0.002). In conclusion, after LT, PDR-ICG (a noninvasive technique), measured regularly during the first 5 postoperative days, is a safe technique that can predict early postoperative complications...

..CONCLUSION: Because of a higher dropout rate among HIV+ patients, HIV infection impaired the results of LT for HCC on an intent-to-treat basis but had no significant impact on OS and RFS after LT...

..We report the first case of multiple KRAS mutations acquired during the metastatic phase of CRC, and retrospectively reviewed all patients with CRC, in whom KRAS was analyzed in at least two tumor samples from distinct lesions...

..Conversely, the value of transplantation for colorectal liver metastases (currently a contraindication) requires further evaluation by well-designed trials...

..Because of the high hemorrhage risk associated with biliary surgery in patients with PC, the optimal therapeutic strategy is controversial...

..It would appear that the dose and schedule defined by this trial could be proposed as front-line therapy for advanced colorectal carcinoma to establish rapid disease control and to permit patients to proceed to surgery...

..Long-term survival in these patients with advanced disease could be achieved if they are managed by experienced multidisciplinary teams...

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..Compare oncologic results of laparoscopic versus open hepatectomy for resection of colorectal metastases to the liver...

..In this article, the authors report their experience with chronomodulated HAI chemotherapy as rescue therapy in heavily pretreated patients who had metastatic colorectal cancer...

..Bringing them together into an integrated framework has expanded the number of patients that can be treated with curative intent. This review focuses on recent oncosurgical changes, their impact, and future directions...

..New medical treatments, including monoclonal antibodies against tumoral growth factors (cetuximab) and vascular growth factors (bevacizumab), are also proving useful for tumor shrinkage prior to surgical resection...

..To assess acceptance and acceptable estimated mortality levels for right lobe adult-to-adult living related liver transplantation for the medical and allied professions...

..To measure the impact of strict monitoring on long term permeability of TIPS...

..The results of transplant recipients were generally close to those of the general population. Although it is not a true return to normal status, it approaches it...

..Among patients resistant to irinotecan, it is still possible to use the association of cetuximab plus irinotecan to obtain a complete resection of hepatic metastases that is necessary to improve their survival...

..Resection and liver transplantation (LT) are the only curative options for hepatocellular carcinoma in cirrhotic patients (HCC-cirr)...

..Percutaneous manoeuvres are alternatives to the endoscopic approach in the management of complex biliary disease...

..To assess the efficacy and safety of cetuximab in the palliative treatment of patients with intrahepatic cholangiocarcinomas (CCA) unresponsive to first-line gemcitabine-oxaliplatin (GEMOX) pretreatment...

..This article discusses the utility of the mentioned techniques along with other strategies (e.g., Model for End-Stage Liver Disease [MELD] score), as well as the evolution of indications, contraindications, and postoperative care...

..This article describes strategic surgical approaches to multinodular metastatic disease and provides decision guidelines for two-stage hepatectomies...

..The number of registries is increasing, but few of them perform reliability audits by comparing the data contained in the database with data contained in hospital charts...

..In this review, we have described the current oncosurgical strategies employed in patients with resectable and non resectable CRLM, their benefits, and future treatment strategies...

..Long term results of these procedures are reported here...

..In conclusion, increasing AFP>15 microg/L/month while waiting for LT is the most relevant preoperative prognostic factor for low OS/DFS. AFP progression could be a pathological preoperative marker of tumor aggressiveness...

..Nine centers have reported 15 cases of liver transplantation for Rendu-Osler-Weber's disease with liver involvement. Six cases are reported to analyse the specific technical and hemodynamical aspects...

..To study how adding oxaliplatin (l-OHP) to chronomodulated fluorouracil (5-FU)-leucovorin (LV) affected the objective response rate, as first-line treatment of metastatic colorectal cancer...

..To reappraise the results of auxiliary partial orthotopic liver transplantation (APOLT) compared with those of standard whole-liver transplantation (OLT) in terms of postoperative death and complications, including neurologic sequelae...

..Follow-up ranged from 41 to 157 days (median: 117 days)...

..The poor prognosis of patients with non-resectable hepatic metastases might now be improved by the combination of chemotherapy and surgery...

..The aim of this paper is to report the strategies we use in our center to achieve curative resection in these three schematic situations despite initial contraindications...

..Resection may be indicated if the waiting time is likely to be long...

..We determined the frequency, characteristics and prognosis of hepatocellular carcinomas with lymphoid stroma...

..To identify the outcomes and risks of split-liver transplantation (SLT) for two adult recipients to determine the feasibility of more widespread use of this procedure to increase the graft pool for adults...

..Susac's syndrome consists of the clinical triad of cerebral microangiopathy, branch retinal artery occlusions, and hearing loss. The pathogenesis of the disease remains unknown. The severity of retinal vasculopathy remains variable...

..Overall, surgery should be performed as soon as liver metastases become resectable. Collaboration between oncologists and surgeons is essential to optimize individual therapeutic strategies...

..This study examined left liver regeneration after right hepatectomy and the impact of hepatic venous drainage on the regeneration of the paramedian sector (Couinaud's segment IV)...

..The development of new chemotherapy protocols that offer the potential for curative surgery with optimum timing within the natural history of this metastatic disease is a shared therapeutic challenge...

..To determine the utility of hepatic resection (HR) in the treatment of patients with noncolorectal nonendocrine liver metastases (NCNELM)...

..We report the Paul Brousse Hospital experience of transplantation for end stage cirrhosis in HIV-HCV co-infected patients...

..The management of patients with HCC with or without cirrhosis may combine several treatment modalities and needs a multi-disciplinary approach...

..The aim of this study was to compare simultaneous colorectal and hepatic resection with a delayed strategy in patients who had a limited hepatectomy (fewer than three segments)...

..Portal vein embolization (PVE) increases the resectability of initially unresectable colorectal liver metastases (CLM). This study evaluated long-term survival in patients with CLM who underwent hepatectomy following PVE...

..Efficacy in this poor prognosis group of patients is very encouraging, and the schedule is well tolerated by even previously treated patients...

..The aim of this study was to determine the influence of AMs on long-term outcome and the role of adrenalectomy in patients with CLMs...

..To describe our initial experience and to evaluate the outcomes of patients treated with 23-gauge transconjunctival sutureless vitrectomy for a variety of vitreoretinal conditions...

..The objectives of this expert conference were to review the different options, the available prognostic or predictive factors to optimally guide the treatment...

..Evidence of efficacy was seen at all dose levels examined and justifies further exploration of this combination in a less heavily pretreated patient population...

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..Little is known of the outcome of isolated metastases to the liver for which resection is potentially curative...