Florence Abravanel

Summary

Country: France

Publications

  1. doi request reprint Performance of anti-HEV assays for diagnosing acute hepatitis E in immunocompromised patients
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France CHU Toulouse, Hopital Purpan, Laboratoire de Virologie, National Reference Center for Hepatitis E, F 31300, France Electronic address
    J Clin Virol 58:624-8. 2013
  2. doi request reprint Hepatitis E virus
    F Abravanel
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, 31300 Toulouse, France
    Med Mal Infect 43:263-70. 2013
  3. pmc Performance of two commercial assays for detecting hepatitis E virus RNA in acute or chronic infections
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    J Clin Microbiol 51:1913-6. 2013
  4. pmc HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    PLoS ONE 7:e50289. 2012
  5. doi request reprint Low risk of hepatitis E virus reactivation after haematopoietic stem cell transplantation
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F 31300 France
    J Clin Virol 54:152-5. 2012
  6. ncbi request reprint Influence of the HCV subtype on the virological response to pegylated interferon and ribavirin therapy
    Florence Legrand-Abravanel
    Laboratoire de Virologie, Centre Hospitalier Universitaire, Toulouse, France
    J Med Virol 81:2029-35. 2009
  7. doi request reprint New NS5B polymerase inhibitors for hepatitis C
    Florence Legrand-Abravanel
    CHU Toulouse, Hopital Purpan, Laboratoire de Virologie, Institut Fédératif de Biologie de Purpan, France
    Expert Opin Investig Drugs 19:963-75. 2010
  8. pmc Hepatitis E virus infection without reactivation in solid-organ transplant recipients, France
    Florence Legrand-Abravanel
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Emerg Infect Dis 17:30-7. 2011
  9. ncbi request reprint Hepatitis E virus reinfections in solid-organ-transplant recipients can evolve into chronic infections
    Florence Abravanel
    Centre de Physiopathologie de Toulouse Purpan, INSERM U1043 National Reference Center for Hepatitis E, Laboratoire de Virologie, Institut Fédératif de Biologie, Hopital Purpan
    J Infect Dis 209:1900-6. 2014
  10. doi request reprint Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 139:1612-8. 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint Performance of anti-HEV assays for diagnosing acute hepatitis E in immunocompromised patients
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France CHU Toulouse, Hopital Purpan, Laboratoire de Virologie, National Reference Center for Hepatitis E, F 31300, France Electronic address
    J Clin Virol 58:624-8. 2013
    ..In contrast, molecular detection of HEV RNA appears essential to exclude an HEV infection in patients who are negative for anti-HEV IgM and to assess the evolution of hepatitis E 3 months thereafter. ..
  2. doi request reprint Hepatitis E virus
    F Abravanel
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, 31300 Toulouse, France
    Med Mal Infect 43:263-70. 2013
    ..Ribavirin is currently the reference treatment for HEV infections in immunocompromised patients. Several vaccines have proved safe and effective in clinical trials, but none have been approved for use in Europe yet. ..
  3. pmc Performance of two commercial assays for detecting hepatitis E virus RNA in acute or chronic infections
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    J Clin Microbiol 51:1913-6. 2013
    ..Both assays provided good analytical sensitivity and high reproducibility for detecting genotype 3 HEV RNA...
  4. pmc HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    PLoS ONE 7:e50289. 2012
    ..We investigated the influence of HIV tropism on liver fibrosis and the concentration of HCV RNA in HIV-HCV co-infected patients...
  5. doi request reprint Low risk of hepatitis E virus reactivation after haematopoietic stem cell transplantation
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F 31300 France
    J Clin Virol 54:152-5. 2012
    ..HEV infection can evolve to chronic hepatitis in immunocompromised patients. Additionally, HEV reactivation after haematopoietic stem cell transplantation has been reported...
  6. ncbi request reprint Influence of the HCV subtype on the virological response to pegylated interferon and ribavirin therapy
    Florence Legrand-Abravanel
    Laboratoire de Virologie, Centre Hospitalier Universitaire, Toulouse, France
    J Med Virol 81:2029-35. 2009
    ..0-2.5; P = 0.04) or subtypes 4a and 4d (OR: 2.03; 95% CI = 1.1-3.8; P = 0.03). In conclusion, among difficult-to-treat genotypes, the subtype 1a is associated with a lower response to anti-HCV therapy than subtypes 1b, 4a, and 4d...
  7. doi request reprint New NS5B polymerase inhibitors for hepatitis C
    Florence Legrand-Abravanel
    CHU Toulouse, Hopital Purpan, Laboratoire de Virologie, Institut Fédératif de Biologie de Purpan, France
    Expert Opin Investig Drugs 19:963-75. 2010
    ..Specific targeted antiviral therapies represent a promising approach to eradicate the infection...
  8. pmc Hepatitis E virus infection without reactivation in solid-organ transplant recipients, France
    Florence Legrand-Abravanel
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Emerg Infect Dis 17:30-7. 2011
    ..Effective prophylactic measures that include those for potential zoonotic infections should reduce the risk for HEV transmission in this population...
  9. ncbi request reprint Hepatitis E virus reinfections in solid-organ-transplant recipients can evolve into chronic infections
    Florence Abravanel
    Centre de Physiopathologie de Toulouse Purpan, INSERM U1043 National Reference Center for Hepatitis E, Laboratoire de Virologie, Institut Fédératif de Biologie, Hopital Purpan
    J Infect Dis 209:1900-6. 2014
    ..Hepatitis E virus (HEV) infections are a major cause of acute hepatitis in developing and industrialized countries. Little is known about anti-HEV immunity in solid-organ recipients...
  10. doi request reprint Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 139:1612-8. 2010
    ..We assessed the antiviral effect of ribavirin monotherapy in patients with chronic HEV infection following kidney transplantation...
  11. doi request reprint Risk of zoonotic transmission of HEV from rabbits
    Sebastien Lhomme
    INSERM, UMR 1043, F 31300 Toulouse, France Laboratoire de Virologie, CHU Purpan, 330 avenue de Grande Bretagne, F 31300 Toulouse, France
    J Clin Virol 58:357-62. 2013
    ..Rabbit HEV can replicate efficiently in human cell lines. Collectively, these data support the possibility of zoonotic transmission of HEV from rabbits. ..
  12. doi request reprint Influence of polyproline region and macro domain genetic heterogeneity on HEV persistence in immunocompromised patients
    Sebastien Lhomme
    Centre de Physiopathologie de Toulouse Purpan, INSERM, U1043, Toulouse
    J Infect Dis 209:300-3. 2014
    ..Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence. ..
  13. doi request reprint Pegylated interferon-alpha for treating chronic hepatitis E virus infection after liver transplantation
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, Centre Hospitalier Universitaire, Toulouse, France
    Clin Infect Dis 50:e30-3. 2010
    ..A virological response was sustained for 6 and 5 months in 2 patients after Peg-IFN-alpha-2a therapy was completed. A relapse was observed in the third patient...
  14. pmc Hepatitis E virus quasispecies and the outcome of acute hepatitis E in solid-organ transplant patients
    Sebastien Lhomme
    INSERM, UMR1043, Toulouse, France
    J Virol 86:10006-14. 2012
    ..Slow quasispecies diversification during the first year was associated with rapidly developing liver fibrosis...
  15. pmc Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France
    Jacques Izopet
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Emerg Infect Dis 18:1274-81. 2012
    ..These findings indicate that the host range of HEV in Europe is expanding and that zoonotic transmission of HEV from rabbits is possible...
  16. pmc Genotype 3 diversity and quantification of hepatitis E virus RNA
    Florence Abravanel
    INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse
    J Clin Microbiol 50:897-902. 2012
    ..The bias between the 2 RT-PCR assays was significantly greater for genotype 3c than for genotype 3f (P = 0.007). We therefore recommend the use of an RT-PCR protocol based on ORF3 to quantify HEV RNA of genotype 3 strains...
  17. doi request reprint Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis
    Laurent Alric
    Service de Medecine Interne, Fédération Digestive, CHU Purpan, Toulouse, France
    Transpl Int 22:568-73. 2009
    ..The FT and LSM are acceptably accurate for diagnosing mild liver fibrosis in kidney-transplant patients with chronic HCV or HBV infections, but their diagnostic value for predicting severe liver disease needs to be confirmed...
  18. doi request reprint Influence of immunosuppressive therapy on the natural history of genotype 3 hepatitis-E virus infection after organ transplantation
    Nassim Kamar
    Department of Nephrology, Dialysis and Multi Organ Transplantation, CHU Rangueil, Toulouse, France
    Transplantation 89:353-60. 2010
    ..Hepatitis-E virus (HEV) infection can be responsible for chronic hepatitis in solid-organ transplant patients...
  19. ncbi request reprint Hepatitis E virus and chronic hepatitis in organ-transplant recipients
    Nassim Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France
    N Engl J Med 358:811-7. 2008
    ..The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed...
  20. ncbi request reprint Hepatitis E in the south west of France in individuals who have never visited an endemic area
    Jean Michel Mansuy
    Virology Laboratory, Purpan University Hospital, Place du Dr Baylac TSA 40031, 31059, Toulouse, France
    J Med Virol 74:419-24. 2004
    ....
  21. pmc Hepatitis E virus infection
    Nassim Kamar
    Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France
    Clin Microbiol Rev 27:116-38. 2014
    ..In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries...