- Inflammation and immunity in radiation damage to the gut mucosaAgnès François
Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, 31 Avenue de la Division Leclerc, 92262 Fontenay aux Roses, France
Biomed Res Int 2013:123241. 2013..This paper will focus on what has been observed in the normal gut and what remains to be done concerning the immunoinflammatory response following localized radiation exposure...
- [Radiotherapy: what therapeutic orientations against the digestive aftereffects?]Agnès François
Institut de Radioprotection et de Surete Nucleaire, 31, avenue de la Division Leclerc, 92260 Fontenay aux Roses, France
Med Sci (Paris) 25:267-72. 2009..Effective strategies are multiple on preclinical models, but numerous efforts have to be made to achieve the complicated goal of protection of normal tissues from the side effects of radiation therapy...
- PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injuryRym Abderrahmani
Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay aux Roses, France
PLoS ONE 7:e35740. 2012..This study demonstrates that PAI-1 plays a key role in radiation-induced EC death in the intestine and suggests that this contributes strongly to the progression of radiation-induced intestinal injury...
- Effects of pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 in radiation-induced intestinal injuryRym Abderrahmani
Institute for Radiological Protection and Nuclear Safety, Laboratory of Radiopathology, Fontenay aux Roses, France
Int J Radiat Oncol Biol Phys 74:942-8. 2009..To investigate effects of plasminogen activator inhibitor 1 (PAI-1) genetic deficiency and pharmacological PAI-1 inhibition with PAI-039 in a mouse model of radiation-induced enteropathy...