T K Fosse
Fosse T, Toutain P, Spadavecchia C, Haga H, Horsberg T, Ranheim B. Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling. J Vet Pharmacol Ther. 2011;34:338-49 pubmed publisher
..7 ?g/mL and an IC(50) for R-ketoprofen of 1.6 ?g/mL. This indicates that R-ketoprofen is a more potent analgesic than S-ketoprofen in piglets. Estimated ED(50) for racemic ketoprofen was 2.5 mg/kg. ..
Fosse T, Horsberg T, Haga H, Hormazabal V, Ranheim B. Enantioselective pharmacokinetics of ketoprofen in piglets: the significance of neonatal age. J Vet Pharmacol Ther. 2011;34:153-9 pubmed publisher
..The clearances of both R- and S-ketoprofen were significantly higher in the 6-day-old piglets compared to when they were 21 days old. Furthermore, the volumes of distribution were larger in the youngest age group. ..