Emily K Forbes

Summary

Publications

  1. pmc Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    J Immunol 187:3738-50. 2011
  2. pmc The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
    Anna L Goodman
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Sci Rep 3:1706. 2013
  3. pmc T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e44943. 2012
  4. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
  5. pmc Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection
    Sumi Biswas
    Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 188:5041-53. 2012
  6. pmc Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors
    Matthew N Davies
    The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom
    PLoS ONE 4:e8084. 2009
  7. pmc Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
    Cell Host Microbe 5:95-105. 2009
  8. pmc The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    Simone C de Cassan
    The Jenner Institute, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:2602-16. 2011
  9. ncbi request reprint CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
  10. pmc Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis
    Elma Z Tchilian
    The Jenner Institute, Oxford University, ORCRB, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom
    Infect Immun 77:622-31. 2009

Collaborators

Detail Information

Publications11

  1. pmc Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    J Immunol 187:3738-50. 2011
    ..These data have important implications for the development of a multistage or multicomponent viral vectored malaria vaccine for use in humans...
  2. pmc The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
    Anna L Goodman
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Sci Rep 3:1706. 2013
    ..An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum...
  3. pmc T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e44943. 2012
    ..The oligomerization domain of C4 bp can thus adjuvant T cell responses induced by AdHu5 vectors against selected antigens and its clinical utility as well as mechanism of action warrant further investigation...
  4. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    ..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
  5. pmc Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection
    Sumi Biswas
    Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 188:5041-53. 2012
    ....
  6. pmc Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors
    Matthew N Davies
    The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom
    PLoS ONE 4:e8084. 2009
    ..An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses...
  7. pmc Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
    Cell Host Microbe 5:95-105. 2009
    ..Multistage immunity against malaria can thus be achieved by using viral vectors recombinant for MSP-1...
  8. pmc The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    Simone C de Cassan
    The Jenner Institute, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:2602-16. 2011
    ....
  9. ncbi request reprint CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
    ..Thus, we identify persistent CD8 T(EM) populations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that has important implications for vaccine design...
  10. pmc Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis
    Elma Z Tchilian
    The Jenner Institute, Oxford University, ORCRB, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom
    Infect Immun 77:622-31. 2009
    ..This emphasizes the need for new biomarkers for the evaluation of TB vaccine efficacy...
  11. pmc In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination
    Jagadeesh Bayry
    The Edward Jenner Institute for Vaccine Research, University of Oxford, Compton, United Kingdom
    Proc Natl Acad Sci U S A 105:10221-6. 2008
    ..The significant adjuvant activity observed provides good evidence supporting our hypothesis that CCR4 is a viable target for rational adjuvant design...