Joachim W Fluhr

Summary

Publications

  1. doi request reprint Infant epidermal skin physiology: adaptation after birth
    J W Fluhr
    Department of Dermatology, Charite University Clinic, Charite Platz 1, D 10117 Berlin, Germany
    Br J Dermatol 166:483-90. 2012
  2. ncbi request reprint Testing for irritation with a multifactorial approach: comparison of eight non-invasive measuring techniques on five different irritation types
    J W Fluhr
    Department of Dermatology, University of Pavia, IRCCS Policlinico San Mateo, 27100 Pavia, Italy
    Br J Dermatol 145:696-703. 2001
  3. doi request reprint Functional skin adaptation in infancy - almost complete but not fully competent
    Joachim W Fluhr
    Bioskin, Berlin, Germany
    Exp Dermatol 19:483-92. 2010
  4. ncbi request reprint Impact of anatomical location on barrier recovery, surface pH and stratum corneum hydration after acute barrier disruption
    J W Fluhr
    San Gallicano Dermatological Institute, Rome, Italy
    Br J Dermatol 146:770-6. 2002
  5. doi request reprint Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:365-74. 2009
  6. doi request reprint [Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy]
    Joachim W Fluhr
    Bioskin GmbH, Bergmannstr 5, 10961 Berlin und Klinik für Dermatologie und Allergologie, Charite, Berlin, Germany
    J Dtsch Dermatol Ges 8:S24-30. 2010
  7. doi request reprint Kinetics of carotenoid distribution in human skin in vivo after exogenous stress: disinfectant and wIRA-induced carotenoid depletion recovers from outside to inside
    Joachim W Fluhr
    Charité Universitätsmedizin, Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, Berlin, Germany
    J Biomed Opt 16:035002. 2011
  8. ncbi request reprint Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
    J Invest Dermatol 125:1206-14. 2005
  9. ncbi request reprint Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
  10. ncbi request reprint Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, 94121, USA
    J Invest Dermatol 122:320-9. 2004

Detail Information

Publications63

  1. doi request reprint Infant epidermal skin physiology: adaptation after birth
    J W Fluhr
    Department of Dermatology, Charite University Clinic, Charite Platz 1, D 10117 Berlin, Germany
    Br J Dermatol 166:483-90. 2012
    ..This adjustment to the extrauterine dry environment is accomplished in the first year of postnatal life of humans...
  2. ncbi request reprint Testing for irritation with a multifactorial approach: comparison of eight non-invasive measuring techniques on five different irritation types
    J W Fluhr
    Department of Dermatology, University of Pavia, IRCCS Policlinico San Mateo, 27100 Pavia, Italy
    Br J Dermatol 145:696-703. 2001
    ..Non-invasive bioengineering methods are widely used in the assessment of irritant skin reactions...
  3. doi request reprint Functional skin adaptation in infancy - almost complete but not fully competent
    Joachim W Fluhr
    Bioskin, Berlin, Germany
    Exp Dermatol 19:483-92. 2010
    ..This review offers the readership a critical and practical overview of skin physiology in newborns and infants. It emphasizes possible new research fields in neonatal and infantile skin physiology...
  4. ncbi request reprint Impact of anatomical location on barrier recovery, surface pH and stratum corneum hydration after acute barrier disruption
    J W Fluhr
    San Gallicano Dermatological Institute, Rome, Italy
    Br J Dermatol 146:770-6. 2002
    ..It is not known whether distinct anatomical locations will respond with different recovery rates following acute barrier challenges...
  5. doi request reprint Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:365-74. 2009
    ..Hence, PPARalpha activators might be useful to prevent or treat certain common neonatal dermatoses...
  6. doi request reprint [Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy]
    Joachim W Fluhr
    Bioskin GmbH, Bergmannstr 5, 10961 Berlin und Klinik für Dermatologie und Allergologie, Charite, Berlin, Germany
    J Dtsch Dermatol Ges 8:S24-30. 2010
    ..Moreover gram negative folliculitis may develop. Azelaic acid is acting as an antimicrobial and can also reduce comedones. It can also be used in pregnancy and during the lactation period...
  7. doi request reprint Kinetics of carotenoid distribution in human skin in vivo after exogenous stress: disinfectant and wIRA-induced carotenoid depletion recovers from outside to inside
    Joachim W Fluhr
    Charité Universitätsmedizin, Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, Berlin, Germany
    J Biomed Opt 16:035002. 2011
    ..We could show that the Raman microscopic spectroscopy is suited to analyze the carotenoid kinetic of stress effects and recovery...
  8. ncbi request reprint Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
    J Invest Dermatol 125:1206-14. 2005
    ..These results demonstrate that LXR activators stimulate the formation of an acidic SC and improve both permeability barrier homeostasis and SC integrity/cohesion...
  9. ncbi request reprint Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
    ..LXR activators could provide a new class of therapeutic agents for the treatment of cutaneous inflammatory disorders...
  10. ncbi request reprint Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, 94121, USA
    J Invest Dermatol 122:320-9. 2004
    ..Conversely, the impaired acidification of neonatal SC, which has important functional and clinical consequences, can be explained by the relatively low activities of one or both of these mechanisms at birth...
  11. doi request reprint In vivo skin treatment with tissue-tolerable plasma influences skin physiology and antioxidant profile in human stratum corneum
    Joachim W Fluhr
    Universitätsmedizin Charité, Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology, Berlin, Germany
    Exp Dermatol 21:130-4. 2012
    ..Skin physiology parameters were influenced without damaging the skin or skin functions, indicating the safety of TTP under in vivo conditions...
  12. ncbi request reprint Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero
    Matthias Schmuth
    Departments of Medicine Dermatology, University of California San Francisco, California 94121, USA
    J Invest Dermatol 119:1298-303. 2002
    ..The transient and incomplete nature of the developmental delay, however, is consistent with regulation of the late stages of epidermal development by multiple factors...
  13. ncbi request reprint Functional consequences of a neutral pH in neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:140-51. 2004
    ..The delay in acidification of neonatal SC results in abnormalities in permeability barrier homeostasis and SC integrity and are likely due to pH-induced modulations in enzyme activity...
  14. doi request reprint Silver-loaded seaweed-based cellulosic fiber improves epidermal skin physiology in atopic dermatitis: safety assessment, mode of action and controlled, randomized single-blinded exploratory in vivo study
    Joachim W Fluhr
    Department of Dermatology and Allergology, Friedrich Schiller University, Jena, Germany
    Exp Dermatol 19:e9-15. 2010
    ..Previously, we have shown a dose-dependent antibacterial and antifungal activity of silver-loaded seaweed-based cellulosic fibres...
  15. doi request reprint In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods
    Maxim E Darvin
    Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, Charite Universitatsmedizin, Berlin, Germany
    Exp Dermatol 18:1060-3. 2009
    ..Most of the antioxidants cannot be produced by the human organism. Thus, they have to be incorporated by food and beverages...
  16. doi request reprint Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study
    Maxim E Darvin
    Charite Universitatsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Berlin, Germany
    J Dermatol Sci 64:53-8. 2011
    ..The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective network...
  17. ncbi request reprint Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    Matthias Schmuth
    Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
    J Invest Dermatol 122:909-22. 2004
    ..But in contrast to lamellar ichthyosis, the CE scaffold partially normalizes in the outer SC in loricrin keratoderma...
  18. ncbi request reprint Stratum corneum acidification is impaired in moderately aged human and murine skin
    Eung Ho Choi
    Department of Dermatology, University of California San Francisco and Dermatology Service, Veteran s Administration Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:2847-56. 2007
    ..These abnormalities were normalized by exogenously acidifying the SC, suggesting a basis for the well-known acidification therapies that are widely used to treat the pathologic xerosis/eczema seen in moderately aged humans...
  19. doi request reprint Raman spectroscopic analysis of the carotenoid concentration in egg yolks depending on the feeding and housing conditions of the laying hens
    Karoline Hesterberg
    Charite University Hospital Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology CCP, Berlin, Germany
    J Biophotonics 5:33-9. 2012
    ..001). The kinetics of the carotenoid concentration in the egg yolks, depending on fodder, housing and weather conditions, were investigated...
  20. ncbi request reprint Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    Mary Y Sheu
    Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 118:94-101. 2002
    ....
  21. ncbi request reprint Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity
    Sarah L Chamlin
    Department of Dermatology, University of California, San Francisco, USA
    J Am Acad Dermatol 47:198-208. 2002
    ..Yet commonly used emollients and moisturizers do not correct the SC ceramide deficiency, the putative cause of the barrier abnormality...
  22. ncbi request reprint Approaches for optimizing the calibration standard of Tewameter TM 300
    Maria Miteva
    Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Exp Dermatol 15:904-12. 2006
    ..The studied calibration procedure ensures these requirements...
  23. ncbi request reprint Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models
    Joachim W Fluhr
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Germany
    Exp Dermatol 15:483-92. 2006
    ..Together, these results verify the utility of TEWL as a measure of permeability barrier status. Moreover, all tested instruments are reliable tools for the assessment of variations in permeability barrier function...
  24. doi request reprint Topical beta-carotene protects against infra-red-light-induced free radicals
    Maxim E Darvin
    Center of Applied Cutaneous Physiology, Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 20:125-9. 2011
    ..Resonance Raman spectroscopy can be used for the non-invasive measurements of carotenoids, which can be rated as marker substances of redox processes...
  25. doi request reprint Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing
    Monika Kuck
    Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Res Technol 20:1-7. 2014
    ..Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing...
  26. ncbi request reprint The "strip" patch test: results of a multicentre study towards a standardization
    Heinrich Dickel
    Department of Dermatology, Environmental Medicine, and Health Theory, University of Osnabruck, Sedanstr 115, 49090 Osnabrück, Germany
    Arch Dermatol Res 296:212-9. 2004
    ..Penetration of the substances is enhanced by repeated applications of adhesive tape prior to their application to the skin. However, no guidelines exist for standardized performance of the SPT...
  27. doi request reprint Influence of finishing textile materials on the reduction of skin irritations
    Helene Strese
    Charite Universitatsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany
    Skin Res Technol 19:e409-16. 2013
    ..One method to create a pleasant sensation of textile materials on the skin is to coat them with silk proteins. This technologically complex procedure requires both optimization and control...
  28. ncbi request reprint Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice
    Joachim W Fluhr
    Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA
    J Invest Dermatol 120:728-37. 2003
    ..These results show that sebaceous-gland-derived glycerol is a major contributor to stratum corneum hydration...
  29. doi request reprint Efficient Prevention Strategy against the Development of a Palmar-Plantar Erythrodysesthesia during Chemotherapy
    Juergen Lademann
    Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Pharmacol Physiol 27:66-70. 2014
    ..Conclusion: The results of the observation clearly demonstrate that topical application of the ointment is an efficient strategy against the development of PPE during chemotherapy with PLD. ..
  30. ncbi request reprint A new silver-loaded cellulosic fiber with antifungal and antibacterial properties
    Uta Christina Hipler
    Department of Dermatology and Allergology, Friedrich Schiller University of Jena, Jena, Germany
    Curr Probl Dermatol 33:165-78. 2006
    ..aureus and E. coli, must be examined by means of further investigations, especially human in vivo tests considering allergic and toxic effects of the fiber...
  31. ncbi request reprint Primary cutaneous follicle center lymphoma -'crosti lymphoma': what can we learn?
    Mirjana Ziemer
    Department of Dermatology and Allergology, Friedrich Schiller University, Jena, Germany
    Am J Clin Dermatol 9:133-6. 2008
    ..It is also important to recognize that inability to verify monoclonality should not exclude the diagnosis of lymphoma...
  32. doi request reprint Risk assessment of the application of a plasma jet in dermatology
    Juergen Lademann
    Charite Universitatsmedizin Berlin, Center of Experimental and Cutaneous Physiology, Department of Dermatology and Allergology, Chariteplatz 1, Berlin 10117, Germany
    J Biomed Opt 14:054025. 2009
    ..Additionally, thermal damage of the tissue by the plasma can be excluded. The results of the risk assessment stimulate the in vivo application of the investigated plasma jet in the treatment of chronic wounds...
  33. ncbi request reprint Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions
    J W Fluhr
    Department of Dermatology, Klinikum Karlsruhe, Germany
    Dermatology 199:57-60. 1999
    ..To prevent this side effect, natural precursors of RA have been proposed. The aim of the present study was to compare the local tolerance profiles of retinol (ROL), retinaldehyde (RAL) and RA...
  34. ncbi request reprint Functional assessment of a washing emulsion for sensitive skin: mild impairment of stratum corneum hydration, pH, barrier function, lipid content, integrity and cohesion in a controlled washing test
    A Bornkessel
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Skin Res Technol 11:53-60. 2005
    ..The purpose of the study was to assess the effect of an improved washing solution for sensitive skin in a half-site comparison on barrier-related parameters...
  35. doi request reprint Emollients, moisturizers, and keratolytic agents in psoriasis
    Joachim W Fluhr
    Bioskin, Seydelstr 18, D 10117 Berlin, Germany
    Clin Dermatol 26:380-6. 2008
    ..They should be combined with bath oils...
  36. doi request reprint Morphological skin ageing criteria by multiphoton laser scanning tomography: non-invasive in vivo scoring of the dermal fibre network
    Martin Johannes Koehler
    Department of Dermatology and Allergology, Friedrich Schiller University, Jena, Germany
    Exp Dermatol 17:519-23. 2008
    ..Morphological changes in the dermal collagen and elastin fibre network are characteristic for skin ageing and for pathological skin conditions of the dermis...
  37. ncbi request reprint Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements
    Hiroki Tsuruoka
    Dermatology and Medical Metabolism Services, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 277:2916-22. 2002
    ..Second, the increase in SR-BI following barrier disruption suggests that SR-BI expression increases to facilitate cholesterol uptake leading to barrier restoration...
  38. ncbi request reprint Sequential application of cold and sodium lauryl sulphate decreases irritation and barrier disruption in vivo in humans
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University Jena, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 152:702-8. 2005
    ..Few data have been published regarding the irritant potential of sodium lauryl sulphate (SLS) in combination with cold...
  39. ncbi request reprint Fruit acids and sodium hydroxide in the food industry and their combined effect with sodium lauryl sulphate: controlled in vivo tandem irritation study
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 151:1039-48. 2004
    ..Nevertheless, knowledge of the induction of irritant dermatitis, especially by mild irritants at low doses and for a short duration of exposure, is still incomplete...
  40. ncbi request reprint Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 152:1228-34. 2005
    ..These conditions may support the induction of chronic barrier disruption leading subsequently to irritant contact dermatitis (ICD)...
  41. doi request reprint Effect of regular sauna on epidermal barrier function and stratum corneum water-holding capacity in vivo in humans: a controlled study
    D Kowatzki
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Dermatology 217:173-80. 2008
    ..The present data suggest a protective effect of regular sauna on skin physiology, especially surface pH and stratum corneum water-holding capacity...
  42. doi request reprint Skin irritation and sensitization: mechanisms and new approaches for risk assessment. 1. Skin irritation
    J W Fluhr
    Bioskin, Berlin, Germany
    Skin Pharmacol Physiol 21:124-35. 2008
    ..The diverse physiological changes caused by irritating agents require implementation of a multiparametric approach in the evaluation of cutaneous irritancy...
  43. doi request reprint Optical coherence tomography for presurgical margin assessment of non-melanoma skin cancer - a practical approach
    Seyed Arash Alawi
    Department of Dermatology, Venereology and Allergology, Skin Cancer Centre Charité, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 22:547-51. 2013
    ..This study shows that suspected NMSC can effectively be confirmed, and furthermore, resection margin can be minimized under OCT control without reducing the rate of complete removal. ..
  44. ncbi request reprint Generalized pruritic reddish-brown patches in a 7-year-old boy
    Doreen Kowatzki
    Department of Dermatology, Friedrich Schiller University of Jena, Jena, Germany
    Am J Clin Dermatol 8:321-3. 2007
  45. ncbi request reprint Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis
    S M Fuchs
    Department of Dermatology, Friedrich Schiller University Jena, Jena, Germany
    Skin Res Technol 12:223-7. 2006
    ..In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model...
  46. ncbi request reprint Effects of prolonged occlusion on stratum corneum barrier function and water holding capacity
    J W Fluhr
    Department of Dermatology, Stadtisches Klinikum Karlsruhe, Germany
    Skin Pharmacol Appl Skin Physiol 12:193-8. 1999
    ..We aimed to evaluate whether prolonged occlusion can induce stratum corneum barrier damage, alterations in stratum corneum hydration or water-holding capacity (WHC) lasting longer than the occlusion time...
  47. ncbi request reprint Direct comparison of skin physiology in children and adults with bioengineering methods
    J W Fluhr
    Department of Dermatology, Klinikum Karlsruhe, Karlsruhe, Germany
    Pediatr Dermatol 17:436-9. 2000
    ....
  48. doi request reprint Glycerol and the skin: holistic approach to its origin and functions
    J W Fluhr
    Bioskin, Seydelstr 18, 10117 Berlin, Germany
    Br J Dermatol 159:23-34. 2008
    ..g. winter xerosis. This paper provides a review on effects of glycerol on the skin, the mechanisms of its action, and the potential applications of glycerol in dermatology...
  49. doi request reprint Management of anticoagulation during dermatosurgical procedures in Germany - results from a cross-sectional study
    Alexander Nast
    Division of Evidence Based Medicine, Department of Dermatology, Venereology and Allergology, Charite University Medicine Berlin, Germany
    J Dtsch Dermatol Ges 11:52-9. 2013
    ..Treatment with antiplatelet drugs (APD) and vitamin K antagonists (VKA) can be a challenge during the management of dermatosurgical interventions...
  50. doi request reprint In vivo assessment of peripheral vascular function by tcpO₂ and skin blood flow modelling
    Luis Monteiro Rodrigues
    CBIOS Experimental Dermatology Unit, Universidade Lusófona FCTS, Lisbon, Portugal
    Exp Dermatol 21:38-42. 2012
    ....
  51. ncbi request reprint Antifungal and antibacterial properties of a silver-loaded cellulosic fiber
    Uta Christina Hipler
    Department of Dermatology and Allergology, Friedrich Schiller University of Jena, D 07740 Jena, Germany
    J Biomed Mater Res B Appl Biomater 77:156-63. 2006
    ....
  52. ncbi request reprint Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity
    J W Fluhr
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 117:44-51. 2001
    ....
  53. ncbi request reprint Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne
    J W Fluhr
    Department of Dermatology, Karlsruhe Municipal Hospital Complex, Karlsruhe, Germany
    Dermatology 198:273-7. 1999
    ..Literature reports indicate that phospholipid liposomes facilitate the accumulation of active agents in the infundibulum...
  54. ncbi request reprint Differences in corneocyte surface area in pre- and post-menopausal women. Assessment with the noninvasive videomicroscopic imaging of corneocytes method (VIC) under basal conditions
    J W Fluhr
    Department of Dermatology, University of Pavia JRCCS, Policlinico San Matteo, Pavia, Italy
    Skin Pharmacol Appl Skin Physiol 14:10-6. 2001
    ..The detected differences support the hypothesis that sexual hormones have an impact on corneocyte surface area, because sex hormone levels are higher in premenopausal women than in non-hormone-substituted postmenopausal women or men...
  55. ncbi request reprint Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation
    M Breternitz
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Skin Pharmacol Physiol 21:39-45. 2008
    ..The aim of the present study was to evaluate the effect of a single emollient ingredient in AD within the full frame of a phase III drug study...
  56. doi request reprint Standardized tape stripping: a practical and reproducible protocol to uniformly reduce the stratum corneum
    H Dickel
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Skin Pharmacol Physiol 23:259-65. 2010
    ..As a result, our SPT protocol yields a clinically adequate standardization of the SC reduction and the SPT may therefore be recommended for performance in daily clinical routine...
  57. doi request reprint The tape stripping procedure--evaluation of some critical parameters
    J Lademann
    Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 72:317-23. 2009
    ..This is used, e.g., for the determination of the homogeneity of the distribution and the ex vivo determination of a universal sun protection factor (USPF) characterizing the efficacy of sunscreens...
  58. ncbi request reprint The quality of human skin xenografts on SCID mice: a noninvasive bioengineering approach
    U Kappes
    Department of Dermatology and Allergology, Friedrich Schiller University, Erfurter Strasse 35, D 07743 Jena, Germany
    Br J Dermatol 151:971-6. 2004
    ..Therefore, transplantation of human skin on to SCID (severe combined immunodeficiency) mice might offer a promising tool to perform studies in viable human skin without the direct need for human volunteers...
  59. ncbi request reprint Functional assessment of a skin care system in patients on chemotherapy
    J W Fluhr
    Skin Physiology Laboratory, Friedrich Schiller University, Jena, Germany
    Skin Pharmacol Physiol 20:253-9. 2007
    ..The aim of this study was to verify whether a concomitant treatment with an acidic washing and an acidic emollient (both pH 5.5) can significantly improve the quality of the skin in such patients...
  60. ncbi request reprint Acute barrier disruption by adhesive tapes is influenced by pressure, time and anatomical location: integrity and cohesion assessed by sequential tape stripping. A randomized, controlled study
    M Breternitz
    Skin Physiology Laboratory, Department of Dermatology and Allergology, Friedrich Schiller University, Erfurter Strasse 35, 07743 Jena, Germany
    Br J Dermatol 156:231-40. 2007
    ..Although this method is widely used, only scant information about standardization is known. Various protocols are used but are difficult to compare...
  61. ncbi request reprint Additive impairment of the barrier function and irritation by biogenic amines and sodium lauryl sulphate: a controlled in vivo tandem irritation study
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology and Allergology, Friedrich Schiller University, Erfurter Strasse 35, DE 07740 Jena, Germany
    Skin Pharmacol Physiol 18:88-97. 2005
    ..The results are suggestive that in the food-processing industry the simultaneous contact with biogenic amines and harmful detergents like SLS should be minimized...
  62. ncbi request reprint Additive impairment of the barrier function by mechanical irritation, occlusion and sodium lauryl sulphate in vivo
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology and Allergology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 153:125-31. 2005
    ..Prolonged water exposure by occlusion is also common in the workplace. Several studies have revealed the negative effect of the common anionic detergent sodium lauryl sulphate (SLS) on permeability barrier function...
  63. ncbi request reprint The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis
    I Angelova-Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Erfurter Strasse 35, 07740 Jena, Germany
    Br J Dermatol 153:767-73. 2005
    ..The method has been validated for use in infants and children with atopic dermatitis and compared with a referent scoring system...