In Vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosaJ W Fluhr
Hautklinik, Städt Klinikum Karlsruhe, Germany
Zentralbl Bakteriol 289:53-61. 1999
..8% of P.acnes and in 0% of the P.granulosum strains. Since sensitivity was seen in 100% of the strains already at a concentration of 16 micrograms/ml, a therapeutic effect may be possible...
- Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne
J W Fluhr
Department of Dermatology, Karlsruhe Municipal Hospital Complex, Karlsruhe, Germany
Dermatology 198:273-7. 1999
..Literature reports indicate that phospholipid liposomes facilitate the accumulation of active agents in the infundibulum...
- Effects of prolonged occlusion on stratum corneum barrier function and water holding capacity
J W Fluhr
Department of Dermatology, Stadtisches Klinikum Karlsruhe, Germany
Skin Pharmacol Appl Skin Physiol 12:193-8. 1999
..We aimed to evaluate whether prolonged occlusion can induce stratum corneum barrier damage, alterations in stratum corneum hydration or water-holding capacity (WHC) lasting longer than the occlusion time...
- Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions
J W Fluhr
Department of Dermatology, Klinikum Karlsruhe, Germany
Dermatology 199:57-60. 1999
..To prevent this side effect, natural precursors of RA have been proposed. The aim of the present study was to compare the local tolerance profiles of retinol (ROL), retinaldehyde (RAL) and RA...
- In-vitro and in-vivo efficacy of zinc acetate against propionibacteria alone and in combination with erythromycin
J W Fluhr
Dept of Dermatology, Klinikum Karlsruhe, Germany
Zentralbl Bakteriol 289:445-56. 1999
..The in vivo antibacterial efficacy on 32 acne patients supports the hypothesis that the antibacterial effect of ZA/E in short-term treatment can be mostly attributed to ZA...
- Sequential application of cold and sodium lauryl sulphate decreases irritation and barrier disruption in vivo in humans
J W Fluhr
Skin Physiology Laboratory, Department of Dermatology, Friedrich-Schiller-University Jena, Erfurter Str. 35, 07740 Jena, Germany
Br J Dermatol 152:702-8. 2005
..CONCLUSIONS: We conclude that the application of cold may have a protective effect on the development of ICD, at least in our short-term model...
- Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo
J W Fluhr
Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
Br J Dermatol 152:1228-34. 2005
..These conditions may support the induction of chronic barrier disruption leading subsequently to irritant contact dermatitis (ICD)...
Effect of regular sauna on epidermal barrier function and stratum corneum water-holding capacity in vivo in humans: a controlled studyD Kowatzki
Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
Dermatology 217:173-80. 2008
..The present data suggest a protective effect of regular sauna on skin physiology, especially surface pH and stratum corneum water-holding capacity...
- Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis
S M Fuchs
Department of Dermatology, Friedrich-Schiller-University Jena, Jena, Germany
Skin Res Technol 12:223-7. 2006
..This effect can be explained by its influence on pro-inflammatory enzymes, namely phospholipase A2...
- Direct comparison of skin physiology in children and adults with bioengineering methods
J W Fluhr
Department of Dermatology, Klinikum Karlsruhe, Karlsruhe, Germany
Pediatr Dermatol 17:436-9. 2000
....
- In vivo methods for the analysis of the penetration of topically applied substances in and through the skin barrier
J Lademann
Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
Int J Cosmet Sci 34:551-9. 2012
..The advantages and disadvantages of these methods will be discussed in this article...
- Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation
M Breternitz
Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
Skin Pharmacol Physiol 21:39-45. 2008
..The aim of the present study was to evaluate the effect of a single emollient ingredient in AD within the full frame of a phase III drug study...
- Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles
J Lademann
Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur J Pharm Biopharm 80:615-20. 2012
..Also, the hair follicles are a long-term reservoir for topically applied substances. This is of clinical importance, where a long-lasting therapeutic effect beyond the application time is required...
- Functional assessment of a washing emulsion for sensitive skin: mild impairment of stratum corneum hydration, pH, barrier function, lipid content, integrity and cohesion in a controlled washing test
A Bornkessel
Skin Physiology Laboratory, Department of Dermatology, Friedrich-Schiller-University, Jena, Germany
Skin Res Technol 11:53-60. 2005
....
- Infant epidermal skin physiology: adaptation after birth
J W Fluhr
Department of Dermatology, Charite University Clinic, Charite Platz 1, D 10117 Berlin, Germany
Br J Dermatol 166:483-90. 2012
..This adjustment to the extrauterine dry environment is accomplished in the first year of postnatal life of humans...
- Standardized tape stripping: a practical and reproducible protocol to uniformly reduce the stratum corneum
H Dickel
Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
Skin Pharmacol Physiol 23:259-65. 2010
..As a result, our SPT protocol yields a clinically adequate standardization of the SC reduction and the SPT may therefore be recommended for performance in daily clinical routine...
- Efficacy and safety testing. The clinical perspective
J W Fluhr
Department of Dermatology, Friedrich Schiller University, Jena, Germany
Curr Probl Dermatol 34:33-46. 2007
..The nature of the plausible biological or even toxic reactions that might occur and the types of tests designed to determine the safety of the topical formulations in men are described in this chapter...
- The tape stripping procedure--evaluation of some critical parameters
J Lademann
Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur J Pharm Biopharm 72:317-23. 2009
..This is used, e.g., for the determination of the homogeneity of the distribution and the ex vivo determination of a universal sun protection factor (USPF) characterizing the efficacy of sunscreens...
- Fruit acids and sodium hydroxide in the food industry and their combined effect with sodium lauryl sulphate: controlled in vivo tandem irritation study
J W Fluhr
Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
Br J Dermatol 151:1039-48. 2004
..Nevertheless, knowledge of the induction of irritant dermatitis, especially by mild irritants at low doses and for a short duration of exposure, is still incomplete...
- Microtubules regulate expression of ICAM-1 in epidermoid cells (KB cells)
M Kaatz
Department of Dermatology, University of Jena, Jena, Germany
Skin Pharmacol Physiol 19:322-8. 2006
..In addition, they did not change the ICAM-1 mRNA half-life. These studies indicate a control function of the microtubule network on the expression of ICAM-1...
- Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin
R Voegeli
DSM Nutritional Products Ltd, Basel, Switzerland
Int J Cosmet Sci 33:560-5. 2011
..However, the mass levels of KLK7 and KLK11 together with plasmin were greatly elevated compared with the extracts from the non-lesional and the healthy skin and correlated with the corresponding enzymatic activities...
