J W Fluhr

Summary

Publications

  1. ncbi In Vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosa
    J W Fluhr
    Hautklinik, Städt Klinikum Karlsruhe, Germany
    Zentralbl Bakteriol 289:53-61. 1999
  2. ncbi Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne
    J W Fluhr
    Department of Dermatology, Karlsruhe Municipal Hospital Complex, Karlsruhe, Germany
    Dermatology 198:273-7. 1999
  3. ncbi Effects of prolonged occlusion on stratum corneum barrier function and water holding capacity
    J W Fluhr
    Department of Dermatology, Stadtisches Klinikum Karlsruhe, Germany
    Skin Pharmacol Appl Skin Physiol 12:193-8. 1999
  4. ncbi Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions
    J W Fluhr
    Department of Dermatology, Klinikum Karlsruhe, Germany
    Dermatology 199:57-60. 1999
  5. ncbi In-vitro and in-vivo efficacy of zinc acetate against propionibacteria alone and in combination with erythromycin
    J W Fluhr
    Dept of Dermatology, Klinikum Karlsruhe, Germany
    Zentralbl Bakteriol 289:445-56. 1999
  6. ncbi Sequential application of cold and sodium lauryl sulphate decreases irritation and barrier disruption in vivo in humans
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University Jena, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 152:702-8. 2005
  7. ncbi Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 152:1228-34. 2005
  8. doi Effect of regular sauna on epidermal barrier function and stratum corneum water-holding capacity in vivo in humans: a controlled study
    D Kowatzki
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Dermatology 217:173-80. 2008
  9. ncbi Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis
    S M Fuchs
    Department of Dermatology, Friedrich Schiller University Jena, Jena, Germany
    Skin Res Technol 12:223-7. 2006
  10. doi In vivo methods for the analysis of the penetration of topically applied substances in and through the skin barrier
    J Lademann
    Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Int J Cosmet Sci 34:551-9. 2012

Collaborators

Detail Information

Publications21

  1. ncbi In Vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosa
    J W Fluhr
    Hautklinik, Städt Klinikum Karlsruhe, Germany
    Zentralbl Bakteriol 289:53-61. 1999
    ..8% of P.acnes and in 0% of the P.granulosum strains. Since sensitivity was seen in 100% of the strains already at a concentration of 16 micrograms/ml, a therapeutic effect may be possible...
  2. ncbi Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne
    J W Fluhr
    Department of Dermatology, Karlsruhe Municipal Hospital Complex, Karlsruhe, Germany
    Dermatology 198:273-7. 1999
    ..Literature reports indicate that phospholipid liposomes facilitate the accumulation of active agents in the infundibulum...
  3. ncbi Effects of prolonged occlusion on stratum corneum barrier function and water holding capacity
    J W Fluhr
    Department of Dermatology, Stadtisches Klinikum Karlsruhe, Germany
    Skin Pharmacol Appl Skin Physiol 12:193-8. 1999
    ..We aimed to evaluate whether prolonged occlusion can induce stratum corneum barrier damage, alterations in stratum corneum hydration or water-holding capacity (WHC) lasting longer than the occlusion time...
  4. ncbi Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions
    J W Fluhr
    Department of Dermatology, Klinikum Karlsruhe, Germany
    Dermatology 199:57-60. 1999
    ..To prevent this side effect, natural precursors of RA have been proposed. The aim of the present study was to compare the local tolerance profiles of retinol (ROL), retinaldehyde (RAL) and RA...
  5. ncbi In-vitro and in-vivo efficacy of zinc acetate against propionibacteria alone and in combination with erythromycin
    J W Fluhr
    Dept of Dermatology, Klinikum Karlsruhe, Germany
    Zentralbl Bakteriol 289:445-56. 1999
    ..The in vivo antibacterial efficacy on 32 acne patients supports the hypothesis that the antibacterial effect of ZA/E in short-term treatment can be mostly attributed to ZA...
  6. ncbi Sequential application of cold and sodium lauryl sulphate decreases irritation and barrier disruption in vivo in humans
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University Jena, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 152:702-8. 2005
    ..Few data have been published regarding the irritant potential of sodium lauryl sulphate (SLS) in combination with cold...
  7. ncbi Air flow at different temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 152:1228-34. 2005
    ..These conditions may support the induction of chronic barrier disruption leading subsequently to irritant contact dermatitis (ICD)...
  8. doi Effect of regular sauna on epidermal barrier function and stratum corneum water-holding capacity in vivo in humans: a controlled study
    D Kowatzki
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Dermatology 217:173-80. 2008
    ..The present data suggest a protective effect of regular sauna on skin physiology, especially surface pH and stratum corneum water-holding capacity...
  9. ncbi Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis
    S M Fuchs
    Department of Dermatology, Friedrich Schiller University Jena, Jena, Germany
    Skin Res Technol 12:223-7. 2006
    ..In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model...
  10. doi In vivo methods for the analysis of the penetration of topically applied substances in and through the skin barrier
    J Lademann
    Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Int J Cosmet Sci 34:551-9. 2012
    ..The advantages and disadvantages of these methods will be discussed in this article...
  11. ncbi Direct comparison of skin physiology in children and adults with bioengineering methods
    J W Fluhr
    Department of Dermatology, Klinikum Karlsruhe, Karlsruhe, Germany
    Pediatr Dermatol 17:436-9. 2000
    ....
  12. ncbi Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation
    M Breternitz
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Skin Pharmacol Physiol 21:39-45. 2008
    ..The aim of the present study was to evaluate the effect of a single emollient ingredient in AD within the full frame of a phase III drug study...
  13. doi Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles
    J Lademann
    Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 80:615-20. 2012
    ..Also, the hair follicles are a long-term reservoir for topically applied substances. This is of clinical importance, where a long-lasting therapeutic effect beyond the application time is required...
  14. ncbi Functional assessment of a washing emulsion for sensitive skin: mild impairment of stratum corneum hydration, pH, barrier function, lipid content, integrity and cohesion in a controlled washing test
    A Bornkessel
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Skin Res Technol 11:53-60. 2005
    ..The purpose of the study was to assess the effect of an improved washing solution for sensitive skin in a half-site comparison on barrier-related parameters...
  15. doi Infant epidermal skin physiology: adaptation after birth
    J W Fluhr
    Department of Dermatology, Charite University Clinic, Charite Platz 1, D 10117 Berlin, Germany
    Br J Dermatol 166:483-90. 2012
    ..This adjustment to the extrauterine dry environment is accomplished in the first year of postnatal life of humans...
  16. ncbi Efficacy and safety testing. The clinical perspective
    J W Fluhr
    Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Curr Probl Dermatol 34:33-46. 2007
    ..The nature of the plausible biological or even toxic reactions that might occur and the types of tests designed to determine the safety of the topical formulations in men are described in this chapter...
  17. doi Standardized tape stripping: a practical and reproducible protocol to uniformly reduce the stratum corneum
    H Dickel
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Skin Pharmacol Physiol 23:259-65. 2010
    ..As a result, our SPT protocol yields a clinically adequate standardization of the SC reduction and the SPT may therefore be recommended for performance in daily clinical routine...
  18. doi The tape stripping procedure--evaluation of some critical parameters
    J Lademann
    Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 72:317-23. 2009
    ..This is used, e.g., for the determination of the homogeneity of the distribution and the ex vivo determination of a universal sun protection factor (USPF) characterizing the efficacy of sunscreens...
  19. ncbi Fruit acids and sodium hydroxide in the food industry and their combined effect with sodium lauryl sulphate: controlled in vivo tandem irritation study
    J W Fluhr
    Skin Physiology Laboratory, Department of Dermatology, Friedrich Schiller University, Erfurter Str 35, 07740 Jena, Germany
    Br J Dermatol 151:1039-48. 2004
    ..Nevertheless, knowledge of the induction of irritant dermatitis, especially by mild irritants at low doses and for a short duration of exposure, is still incomplete...
  20. ncbi Microtubules regulate expression of ICAM-1 in epidermoid cells (KB cells)
    M Kaatz
    Department of Dermatology, University of Jena, Jena, Germany
    Skin Pharmacol Physiol 19:322-8. 2006
    ..In addition, they did not change the ICAM-1 mRNA half-life. These studies indicate a control function of the microtubule network on the expression of ICAM-1...
  21. doi Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin
    R Voegeli
    DSM Nutritional Products Ltd, Basel, Switzerland
    Int J Cosmet Sci 33:560-5. 2011
    ..However, the mass levels of KLK7 and KLK11 together with plasmin were greatly elevated compared with the extracts from the non-lesional and the healthy skin and correlated with the corresponding enzymatic activities...