Anthony B Firulli
Vandusen N, Casanovas J, Vincentz J, Firulli B, Osterwalder M, Lopez Rios J, et al
. Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium. Cell Rep. 2014;9:2071-83 pubmed publisher
..Thus, Hand2 functions as a crucial downstream transcriptional effector of endocardial Notch signaling during both cardiogenesis and coronary vasculogenesis. ..
Vandusen N, Vincentz J, Firulli B, Howard M, Rubart M, Firulli A. Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Dev Biol. 2014;388:149-58 pubmed publisher
..In conjunction with the aforementioned gene expression analyses, these results strongly suggest that the observed postnatal lethality occurs due to a catecholamine deficiency and subsequent heart failure. ..
Vincentz J, Casasnovas J, Barnes R, Que J, Clouthier D, Wang J, et al
. Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. Proc Natl Acad Sci U S A. 2016;113:7563-8 pubmed publisher
..These findings provide insights into how multiple signaling pathways direct transcriptional outcomes that pattern the developing jaw. ..
Firulli B, Milliar H, Toolan K, Harkin J, Fuchs R, Robling A, et al
. Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis. Development. 2017;144:2480-2489 pubmed publisher
..A reduction of Hand2 and Shh gene dosage improves the integrity of anterior limb structures, validating the importance of the Twist-family bHLH dimer pool in limb morphogenesis. ..