M Oresic

Summary

Affiliation: VTT Biotechnology
Country: Finland

Publications

  1. pmc Detection of molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mouse
    Erno Lindfors
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 4:e7323. 2009
  2. pmc Fatty fish intake decreases lipids related to inflammation and insulin signaling--a lipidomics approach
    Maria Lankinen
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 4:e5258. 2009
  3. pmc Gender-dependent progression of systemic metabolic states in early childhood
    Janne Nikkilä
    Department of Information and Computer Science, Adaptive Informatics Research Centre and Helsinki Institute for Information Technology, Helsinki University of Technology, Espoo, Finland
    Mol Syst Biol 4:197. 2008
  4. pmc High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy
    Laxman Yetukuri
    Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 6:e23589. 2011
  5. pmc Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 6:e15744. 2011
  6. pmc Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS ONE 2:e218. 2007
  7. pmc Metabolic regulation in progression to autoimmune diabetes
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS Comput Biol 7:e1002257. 2011
  8. pmc Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans
    Kirsi H Pietiläinen
    Department of Medicine, Division of Internal Medicine, and Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Biol 9:e1000623. 2011
  9. pmc Integrated model of metabolism and autoimmune response in β-cell death and progression to type 1 diabetes
    Tijana Marinković
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 7:e51909. 2012
  10. pmc Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    Diabetes 62:3268-74. 2013

Detail Information

Publications70

  1. pmc Detection of molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mouse
    Erno Lindfors
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 4:e7323. 2009
    ....
  2. pmc Fatty fish intake decreases lipids related to inflammation and insulin signaling--a lipidomics approach
    Maria Lankinen
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 4:e5258. 2009
    ..The aim of this study was to investigate how fatty fish or lean fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease...
  3. pmc Gender-dependent progression of systemic metabolic states in early childhood
    Janne Nikkilä
    Department of Information and Computer Science, Adaptive Informatics Research Centre and Helsinki Institute for Information Technology, Helsinki University of Technology, Espoo, Finland
    Mol Syst Biol 4:197. 2008
    ..We show that children have different development rates at the level of metabolome and thus the state-based approach may be advantageous when applying metabolome profiling in search of markers for subtle (patho)physiological changes...
  4. pmc High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy
    Laxman Yetukuri
    Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 6:e23589. 2011
    ..In conclusion, a detailed molecular characterization of HDL may provide surrogates for predictors of drug response and thus help identify the patients who might benefit from fenofibrate treatment...
  5. pmc Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 6:e15744. 2011
    ....
  6. pmc Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS ONE 2:e218. 2007
    ..Our results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance...
  7. pmc Metabolic regulation in progression to autoimmune diabetes
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS Comput Biol 7:e1002257. 2011
    ....
  8. pmc Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans
    Kirsi H Pietiläinen
    Department of Medicine, Division of Internal Medicine, and Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Biol 9:e1000623. 2011
    ..Further studies will be needed to determine the cause of this effect...
  9. pmc Integrated model of metabolism and autoimmune response in β-cell death and progression to type 1 diabetes
    Tijana Marinković
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 7:e51909. 2012
    ..The model describes well our observations from clinical and non-clinical studies and allows exploration of how the rate of β-cell loss depends on the amplitude and duration of autoimmune response...
  10. pmc Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    Diabetes 62:3268-74. 2013
    ..94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general. ..
  11. pmc Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, Espoo, 02044 VTT, Finland
    Diabetologia 56:2266-74. 2013
    ....
  12. pmc Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
    Maria Kolak
    Atherosclerosis Research Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Lipids Health Dis 11:115. 2012
    ..The present study characterises enzymes involved in ceramide metabolism in subcutaneous and intra-abdominal adipose tissue...
  13. pmc Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery
    Carsten Denkert
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Genome Med 4:37. 2012
    ..We predict an intensified use of metabolomic screens in clinical and preclinical studies focusing on the onset and progression of tumor development...
  14. pmc Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study
    Jan Budczies
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    BMC Genomics 13:334. 2012
    ..However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far...
  15. pmc Metabolomics in the studies of islet autoimmunity and type 1 diabetes
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FIN 02044 VTT, Finland
    Rev Diabet Stud 9:236-47. 2012
    ..This may have important implications for the understanding of T1D pathophysiology and early disease detection and prevention. ..
  16. pmc Obesity and psychotic disorders: uncovering common mechanisms through metabolomics
    Matej Oresic
    Systems Biology and Bioinformatics, VTT Technical Research Centre of Finland, Espoo, FIN 02044 VTT, Finland
    Dis Model Mech 5:614-20. 2012
    ..Such markers would be applicable as diagnostic tools in a personalized healthcare setting and might also open up novel therapeutic avenues...
  17. pmc Metabolome in progression to Alzheimer's disease
    M Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    Transl Psychiatry 1:e57. 2011
    ..Establishment of pathogenic relevance of predictive biomarkers such as ours may not only facilitate early diagnosis, but may also help identify new therapeutic avenues...
  18. pmc Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Genome Med 1:83. 2009
    ..Given that data acquired at different levels can carry complementary information about early Alzheimer's disease pathology, it is expected that their integration will improve early detection as well as our understanding of the disease...
  19. pmc Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions
    Igor Marin de Mas
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028 Barcelona, Spain
    BMC Syst Biol 5:175. 2011
    ..That is why we accepted a challenge to create a software tool that allows deciphering the compartmentation of metabolites based on the analysis of average isotopic isomer distribution...
  20. pmc Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Genome Med 4:1. 2012
    ..The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission...
  21. pmc Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread
    Isabel Bondia-Pons
    Department of Public Health and Clinical Nutrition, Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio Campus, PO Box 1627, FIN 70211 Kuopio, Finland
    Nutr J 10:116. 2011
    ..The aim of this study was to use the metabolomics approach to identify potential metabolites related to amino acid metabolism involved in this mechanism...
  22. pmc Integrating post-genomic approaches as a strategy to advance our understanding of health and disease
    Jing Tang
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, FIN 02044, Espoo, Finland
    Genome Med 1:35. 2009
    ..While there are many obstacles to overcome, biological models based upon multiple datasets will probably become the basis that drives future biomedical research...
  23. pmc Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis
    Laxman Yetukuri
    VTT Technical Research Centre of Finland, Tietotie 2, FIN 02044, Espoo, Finland
    BMC Syst Biol 1:12. 2007
    ..One of the biggest challenges of lipidomics is elucidation of important pathobiological phenomena from the integration of the large amounts of new data becoming available...
  24. pmc Processing methods for differential analysis of LC/MS profile data
    Mikko Katajamaa
    Turku Centre for Biotechnology, Tykistokatu 6, FIN 20521, Turku, Finland
    BMC Bioinformatics 6:179. 2005
    ..One of the major challenges in this domain remains development of better solutions for processing of LC/MS data...
  25. pmc MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
    Tomáš Pluskal
    G0 Cell Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan
    BMC Bioinformatics 11:395. 2010
    ..An ongoing challenge of these molecular profiling approaches, however, is the development of better data processing methods. Here we introduce a new generation of a popular open-source data processing toolbox, MZmine 2...
  26. pmc Normalization method for metabolomics data using optimal selection of multiple internal standards
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Tietotie 2, FIN 02044 VTT, Espoo, Finland
    BMC Bioinformatics 8:93. 2007
    ..However, chemical diversity of molecular species included in typical metabolic profiling experiments leads to different responses to variations in experimental conditions, making normalization a very demanding task...
  27. ncbi request reprint Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction
    M Oresic
    VTT Technical Research Centre of Finland, FIN 02044 VTT, Espoo, Finland
    Nutr Metab Cardiovasc Dis 19:816-24. 2009
    ..An overview is provided covering recent applications of metabolomics and lipidomics in the context of human physiology, lipid metabolism and nutrition...
  28. doi request reprint Informatics and computational strategies for the study of lipids
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    Biochim Biophys Acta 1811:991-9. 2011
    ..Herein the current state, recent advances and new opportunities in the field of lipid bioinformatics are reviewed...
  29. doi request reprint Systems biology strategy to study lipotoxicity and the metabolic syndrome
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, P O Box 1000, Espoo, FIN 02044 VTT, Finland
    Biochim Biophys Acta 1801:235-9. 2010
    ..The metabolic phenotypes, molecular and genetic networks can be modeled within the context of such integrative framework and the underlying physiology...
  30. ncbi request reprint Metabolomic approaches to phenotype characterization and applications to complex diseases
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FIN 02044 VTT, Finland
    Expert Rev Mol Diagn 6:575-85. 2006
    ..Therefore, metabolomics is a valuable platform for studies of complex diseases and the development of new therapies, both in nonclinical disease model characterization and clinical settings...
  31. pmc Metabolome in schizophrenia and other psychotic disorders: a general population-based study
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, FI 02044 VTT, Espoo, Finland
    Genome Med 3:19. 2011
    ..More detailed molecular information on the metabolic abnormalities may reveal clues about the pathophysiology of these changes, as well as about disease specificity...
  32. doi request reprint Lipidomics: a new window to biomedical frontiers
    Matej Oresic
    VTT Technical Research Centre of Finland, P O Box 1000, Espoo, FI 02044 VTT, Finland
    Trends Biotechnol 26:647-52. 2008
    ..Identification of these allostatic mechanisms and pathological 'scares' might provide a window to unknown pathogenic mechanisms, as well as facilitate identification of early biomarkers of disease...
  33. pmc Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    J Exp Med 205:2975-84. 2008
    ..Recognition of these preautoimmune alterations may aid in studies of disease pathogenesis and may open a time window for novel type 1 diabetes prevention strategies...
  34. doi request reprint Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome
    M Lankinen
    VTT Technical Research Centre of Finland, Espoo, Finland
    Nutr Metab Cardiovasc Dis 20:249-57. 2010
    ..We studied the effect of carbohydrate modification on serum metabolic profiles, including lipids and branched chain amino acids, and dependencies between these and specific gene expression pathways in adipose tissue...
  35. ncbi request reprint Data integration and visualization system for enabling conceptual biology
    Peddinti V Gopalacharyulu
    VTT Biotechnology PO Box 1500, Espoo, FIN 02044 VTT, Finland
    Bioinformatics 21:i177-85. 2005
    ..The problem is not only to enable the study of such data within the context of a biological question but also more fundamentally, how to represent the available knowledge and make it accessible for mining...
  36. ncbi request reprint Capillary electrophoresis with UV detection and mass spectrometry in method development for profiling metabolites of steroid hormone metabolism
    Heli Siren
    Technical Research Centre of Finland, VTT, PO Box 1000, FI 02044 VTT Espoo, Finland
    J Chromatogr B Analyt Technol Biomed Life Sci 871:375-82. 2008
    ..The other steroids could be detected at 500-1000 ng/mL. The identification of cortisone, corticosterone, hydrocortisone, estrogen and testosterone were made in patient urine samples and their concentrations were 1-40 microg/L...
  37. ncbi request reprint Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT
    Bioinformatics 23:i519-28. 2007
    ....
  38. doi request reprint Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data
    Juha R Koikkalainen
    VTT Technical Research Centre of Finland, Tekniikankatu 1, FIN 33101 Tampere, Finland
    Radiology 249:88-96. 2008
    ..To characterize early changes in cardiac anatomy and function for lamin A/C gene (LMNA) mutation carriers by using magnetic resonance (MR) imaging and to develop tools to analyze and visualize the findings...
  39. ncbi request reprint An integrative approach for biological data mining and visualisation
    Peddinti V Gopalacharyulu
    VTT Technical Research Centre of Finland, PO Box 1500, Espoo, Finland
    Int J Data Min Bioinform 2:54-77. 2008
    ....
  40. pmc Connecting genes to metabolites by a systems biology approach
    Kirsi Marja Oksman-Caldentey
    VTT Biotechnology, P O Box 1500, FI 02044, Espoo, Finland
    Proc Natl Acad Sci U S A 101:9949-50. 2004
  41. pmc Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress
    K Ketola
    Medical Biotechnology, VTT Technical Research Centre of Finland, University of Turku, PL 106, FI 20521 Turku, Finland
    Br J Cancer 106:99-106. 2012
    ..We have shown that a sodium ionophore monensin inhibits prostate cancer cell growth. A structurally related compound to monensin, salinomycin, was recently identified as a putative cancer stem cell inhibitor...
  42. ncbi request reprint Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations
    A Kotronen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Diabetologia 52:684-90. 2009
    ....
  43. doi request reprint Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction
    P Ylipaasto
    Intestinal Viruses Unit, National Institute for Health and Welfare THL, Helsinki, Finland
    Diabetologia 55:3273-83. 2012
    ....
  44. doi request reprint Informatics and computational strategies for the study of lipids
    Laxman Yetukuri
    VTT Technical Research Centre of Finland, Tietotie 2, FI 02044 VTT, Espoo, Finland
    Mol Biosyst 4:121-7. 2008
    ..The present report, based on the limited literature, is an update on a young but rapidly emerging field of lipid informatics and related pathway reconstruction strategies...
  45. ncbi request reprint Characterising metabolically healthy obesity in weight-discordant monozygotic twins
    J Naukkarinen
    Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, C424b, PO Box 63, Helsinki, Finland, 00014
    Diabetologia 57:167-76. 2014
    ..Mechanisms maintaining this 'metabolically healthy obesity' (MHO) are as yet unknown. We aimed to study different fat depots and transcriptional pathways in subcutaneous adipose tissue (SAT) as related to the MHO phenomenon...
  46. doi request reprint Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 66:843-9. 2012
    ..The present study was aimed to evaluate the effects of two doses of these lactotripeptides on 24-h ambulatory blood pressure and lipidomics profiles in mildly hypertensive subjects...
  47. pmc Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol
    Laxman Yetukuri
    VTT Technical Research Centre of Finland, Espoo, Finland
    J Lipid Res 51:2341-51. 2010
    ..Our findings have important implications for understanding HDL metabolism and function. For the first time we demonstrate the power of combining molecular profiling of lipoproteins with dynamic modeling of lipoprotein structure...
  48. doi request reprint Bioinformatics and computational methods for lipidomics
    Perttu S Niemelä
    VTT Technical Research Centre of Finland, Tietotie 2, P O Box 1000, FIN 02044 VTT, Espoo, Finland
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2855-62. 2009
    ..In this paper we overview the current state of the lipid bioinformatics field as well as suggest few potential new areas of research...
  49. doi request reprint Application of lipidomics and metabolomics to the study of adipose tissue
    Ismo Mattila
    VTT Technical Research Centre of Finland, Tietotie 2, FI 02044 VTT, Espoo, Finland
    Methods Mol Biol 456:123-30. 2008
    ..Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied...
  50. ncbi request reprint Lipidomics-based safety biomarkers for lipid-lowering treatments
    Reijo Laaksonen
    Science Center, Tampere University Hospital, Zora Biosciences Oy, Espoo, Finland
    Angiology 59:65S-8S. 2008
    ....
  51. ncbi request reprint How to study lipidomes
    Tuulikki Seppanen-Laakso
    VTT Technical Research Centre of Finland, Espoo, Finland
    J Mol Endocrinol 42:185-90. 2009
    ..g., a specific pathway or gene function. Modern lipidomics methods combine the latest mass spectrometry technology and bioinformatics methods with traditional methods such as for sample preparation and lipid extraction...
  52. pmc Multivariate multi-way analysis of multi-source data
    Ilkka Huopaniemi
    Aalto University School of Science and Technology, Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, PO Box 15400, FI 00076 Aalto, Espoo, Finland
    Bioinformatics 26:i391-8. 2010
    ....
  53. doi request reprint Dynamic network topology changes in functional modules predict responses to oxidative stress in yeast
    Peddinti V Gopalacharyulu
    VTT Technical Research Centre of Finland, P O Box 1000, Espoo, FI 02044 VTT, Finland
    Mol Biosyst 5:276-87. 2009
    ..Studies of local network topology dynamics can be used to investigate as well as predict the activity of biological processes and the system's responses to environmental challenges and interventions...
  54. pmc The gut microbiota modulates host energy and lipid metabolism in mice
    Vidya R Velagapudi
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    J Lipid Res 51:1101-12. 2010
    ..Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases...
  55. ncbi request reprint Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs
    Minna T Jänis
    Zora Biosciences Oy, Biologinkuja 1, Espoo, FI 02150, Finland
    Expert Opin Drug Metab Toxicol 4:665-80. 2008
    ....
  56. pmc Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells
    Heiko Rischer
    VTT Technical Research Centre of Finland, Tietotie 2, FIN 02044 VTT, Espoo, Finland
    Proc Natl Acad Sci U S A 103:5614-9. 2006
    ..This study provides the basis for a better understanding of periwinkle secondary metabolism and increases the practical potential of metabolic engineering of this important medicinal plant...
  57. ncbi request reprint Phenotype characterisation using integrated gene transcript, protein and metabolite profiling
    Matej Oresic
    Beyond Genomics Inc, 40 Bear Hill Road, Waltham, MA 02451, USA
    Appl Bioinformatics 3:205-17. 2004
    ..Our results corroborate previous findings and extend predictions for three processes in atherosclerosis: aberrant lipid metabolism, inflammation, and tissue development and maintenance...
  58. ncbi request reprint Pathways to the analysis of microarray data
    R Keira Curtis
    University of Cambridge Department of Clinical Biochemistry, Box 232, Addenbrooke s Hospital, Hills Road, Cambridge, UK, CB2 2QR
    Trends Biotechnol 23:429-35. 2005
    ..Pathway analysis is a promising tool to identify the mechanisms that underlie diseases, adaptive physiological compensatory responses and new avenues for investigation...
  59. ncbi request reprint Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process
    Laura L Elo
    Department of Mathematics, FI 20014 University of Turku, Finland
    Bioinformatics 23:2096-103. 2007
    ..Choosing an appropriate cutoff threshold, above which a gene-gene interaction is considered as relevant, is a critical task in most network-centric applications, especially when two or more networks are being compared...
  60. ncbi request reprint MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data
    Mikko Katajamaa
    Turku Centre for Biotechnology Turku, Finland
    Bioinformatics 22:634-6. 2006
    ....
  61. ncbi request reprint Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
    Maria Kolak
    Atherosclerosis Research Unit, Department of Medicine, King Gustaf V Research Institute, Karolinska Institutet, Stockholm, Sweden
    Diabetes 56:1960-8. 2007
    ..We sought to determine whether adipose tissue is inflamed in individuals with increased liver fat (LFAT) independently of obesity...
  62. pmc Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
    Kaori Minehira
    Gladstone Institute of Cardiovascular Disease, University of California San Francisco, CA 94158, USA
    J Lipid Res 49:2038-44. 2008
    ..Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity...
  63. pmc Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Med 5:e51. 2008
    ..The goal of this study was to investigate this important acquired component and expose obesity-induced changes in biological pathways in an identical genetic background...
  64. pmc Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults
    Riina A Kekkonen
    University of Helsinki, Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki 00014, Finland
    World J Gastroenterol 14:3188-94. 2008
    ....
  65. pmc PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
    Gema Medina-Gomez
    Department of Clinical Biochemistry, Histopathology, University of Cambridge Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Genet 3:e64. 2007
    ....
  66. ncbi request reprint A comparative evaluation of software for the analysis of liquid chromatography-tandem mass spectrometry data from isotope coded affinity tag experiments
    Robert Moulder
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 20521 Turku, Finland
    Proteomics 5:2748-60. 2005
    ..In the quantitative results from the three programs, no statistically significant differences were observed...
  67. pmc Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
    Terhi Karpanen
    Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Helsinki, Finland
    Circ Res 103:1018-26. 2008
    ..These results suggest that VEGF-B regulates lipid metabolism, an unexpected function for an angiogenic growth factor...
  68. ncbi request reprint The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform
    Gema Medina-Gomez
    Department of Clinical Biochemistry, University of Cambridge Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
    Diabetes 54:1706-16. 2005
    ....
  69. ncbi request reprint Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model
    Eugene Davidov
    Beyond Genomics, Inc, Waltham, Massachusetts, USA
    OMICS 8:267-88. 2004
    ....
  70. pmc Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study
    Ursula Schwab
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2630. 2008
    ..The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention...