Jyrki Lotjonen

Summary

Affiliation: VTT Biotechnology
Country: Finland

Publications

  1. pmc Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease
    Robin Wolz
    Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom
    PLoS ONE 6:e25446. 2011
  2. pmc Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy
    Miia Holmström
    Department of Radiology, University of Helsinki and HUS Radiology Medical Imaging Center P, O, Box 340, FI 00029 HUS, Finland
    J Cardiovasc Magn Reson 13:30. 2011
  3. pmc Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease
    Jyrki Lotjonen
    Knowledge Intensive Services, VTT Technical Research Centre of Finland, Tampere, Finland
    Neuroimage 56:185-96. 2011
  4. doi request reprint Fast and robust multi-atlas segmentation of brain magnetic resonance images
    Jyrki Mp Lötjönen
    Knowledge Intensive Services, VTT Technical Research Centre of Finland, PO Box 1300 street address Tekniikankatu 1, FIN 33101 Tampere, Finland
    Neuroimage 49:2352-65. 2010
  5. ncbi request reprint Automatic sleep-wake and nap analysis with a new wrist worn online activity monitoring device vivago WristCare
    Jyrki Lotjonen
    VTT Information Technology, Tampere, Finland
    Sleep 26:86-90. 2003
  6. doi request reprint Evaluation of cardiac biventricular segmentation from multiaxis MRI data: a multicenter study
    Jyrki M P Lötjönen
    VTT Technical Research Centre of Finland, Tampere, Finland
    J Magn Reson Imaging 28:626-36. 2008
  7. ncbi request reprint Correction of motion artifacts from cardiac cine magnetic resonance images
    Jyrki Lotjonen
    VTT Information Technology, P O Box 1206, FIN 33101 Tampere, Finland
    Acad Radiol 12:1273-84. 2005
  8. ncbi request reprint Construction of patient-specific surface models from MR images: application to bioelectromagnetism
    Jyrki Lotjonen
    VTT Information Technology, P O Box 1206, FIN 33101 Tampere, Finland
    Comput Methods Programs Biomed 72:167-78. 2003
  9. ncbi request reprint Statistical shape model of atria, ventricles and epicardium from short- and long-axis MR images
    J Lotjonen
    VTT Information Technology, P O Box 1206, Sinitaival 6, FIN 33101 Tampere, Finland
    Med Image Anal 8:371-86. 2004
  10. doi request reprint A disease state fingerprint for evaluation of Alzheimer's disease
    Jussi Mattila
    VTT Technical Research Centre of Finland, Tampere, Finland
    J Alzheimers Dis 27:163-76. 2011

Detail Information

Publications30

  1. pmc Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease
    Robin Wolz
    Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom
    PLoS ONE 6:e25446. 2011
    ..The most stable and reliable classification was achieved when combining all available features...
  2. pmc Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy
    Miia Holmström
    Department of Radiology, University of Helsinki and HUS Radiology Medical Imaging Center P, O, Box 340, FI 00029 HUS, Finland
    J Cardiovasc Magn Reson 13:30. 2011
    ..We also investigated the connection between myocardial fibrosis and conduction abnormalities...
  3. pmc Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease
    Jyrki Lotjonen
    Knowledge Intensive Services, VTT Technical Research Centre of Finland, Tampere, Finland
    Neuroimage 56:185-96. 2011
    ..The computation time of the method is about 2 minutes on a standard laptop computer. The results show a clear potential for applying the method in clinical practice...
  4. doi request reprint Fast and robust multi-atlas segmentation of brain magnetic resonance images
    Jyrki Mp Lötjönen
    Knowledge Intensive Services, VTT Technical Research Centre of Finland, PO Box 1300 street address Tekniikankatu 1, FIN 33101 Tampere, Finland
    Neuroimage 49:2352-65. 2010
    ..The correlation coefficient for hippocampal volumes was 0.95 with the ADNI data. The computation time using a standard multicore PC computer was about 3-4 min. Our results compare favourably with other recently published results...
  5. ncbi request reprint Automatic sleep-wake and nap analysis with a new wrist worn online activity monitoring device vivago WristCare
    Jyrki Lotjonen
    VTT Information Technology, Tampere, Finland
    Sleep 26:86-90. 2003
    ..This study evaluates the ability of the device to discriminate sleep/wake patterns during nighttime and during napping...
  6. doi request reprint Evaluation of cardiac biventricular segmentation from multiaxis MRI data: a multicenter study
    Jyrki M P Lötjönen
    VTT Technical Research Centre of Finland, Tampere, Finland
    J Magn Reson Imaging 28:626-36. 2008
    ..To validate a volumetric biventricular segmentation solution for multiaxis cardiac magnetic resonance (CMR) images...
  7. ncbi request reprint Correction of motion artifacts from cardiac cine magnetic resonance images
    Jyrki Lotjonen
    VTT Information Technology, P O Box 1206, FIN 33101 Tampere, Finland
    Acad Radiol 12:1273-84. 2005
    ..An image registration method was developed to automatically correct motion artifacts, mostly from breathing, from cardiac cine magnetic resonance (MR) images...
  8. ncbi request reprint Construction of patient-specific surface models from MR images: application to bioelectromagnetism
    Jyrki Lotjonen
    VTT Information Technology, P O Box 1206, FIN 33101 Tampere, Finland
    Comput Methods Programs Biomed 72:167-78. 2003
    ..The application area demonstrated in this work is bioelectromagnetism but the program can be used as well in other engineering problems. The tool has been successfully applied in numerous cases, both for the thorax and the head...
  9. ncbi request reprint Statistical shape model of atria, ventricles and epicardium from short- and long-axis MR images
    J Lotjonen
    VTT Information Technology, P O Box 1206, Sinitaival 6, FIN 33101 Tampere, Finland
    Med Image Anal 8:371-86. 2004
    ..The statistical atlas was built from 25 healthy subjects. The shape model was evaluated by applying it to image segmentation. The probabilistic atlas was found to be superior to the other shape models (P < 0.001) in this study...
  10. doi request reprint A disease state fingerprint for evaluation of Alzheimer's disease
    Jussi Mattila
    VTT Technical Research Centre of Finland, Tampere, Finland
    J Alzheimers Dis 27:163-76. 2011
    ..The results suggest that the DSF establishes an effective decision support and data visualization framework for improving AD diagnostics, allowing clinicians to rapidly analyze large quantities of diverse patient data...
  11. pmc Multi-template tensor-based morphometry: application to analysis of Alzheimer's disease
    Juha Koikkalainen
    VTT Technical Research Centre of Finland, Tampere, Finland
    Neuroimage 56:1134-44. 2011
    ..The statistical group-level difference maps produced using multi-template TBM were smoother, formed larger continuous regions, and had larger t-values than the maps obtained with single-template TBM...
  12. doi request reprint Optimizing the diagnosis of early Alzheimer's disease in mild cognitive impairment subjects
    Jussi Mattila
    VTT Technical Research Centre of Finland, Tampere, Finland
    J Alzheimers Dis 32:969-79. 2012
    ..5%, 95% confidence interval: 48.6-54.2%) of MCI subjects who progressed to AD can be classified with a high accuracy of 87.7%, possibly enough to support earlier diagnostic decisions...
  13. ncbi request reprint Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation
    Juha Koikkalainen
    VTT, P O B 1300, FIN 33101 Tampere, Finland
    Med Image Comput Comput Assist Interv 11:543-50. 2008
    ..The methods were evaluated using data from four functional brain areas from 56 healthy subjects. The accuracy of the estimates of the locations of the functional brain regions was about nine millimeters...
  14. ncbi request reprint Measurement of hippocampal atrophy using 4D graph-cut segmentation: application to ADNI
    Robin Wolz
    Department of Computing, Imperial College London, London, UK
    Neuroimage 52:109-18. 2010
    ..Power analysis shows that 67 and 206 subjects are needed for the AD and MCI groups respectively to detect a 25% change in volume loss with 80% power and 5% significance...
  15. pmc Improved classification of Alzheimer's disease data via removal of nuisance variability
    Juha Koikkalainen
    VTT Technical Research Centre of Finland, Tampere, Finland
    PLoS ONE 7:e31112. 2012
    ..In conclusion, the study shows that the excess variability caused by nuisance features should be removed from the data to improve the classification accuracy, and therefore, the reliability of diagnosis making...
  16. doi request reprint Nonlinear dimensionality reduction combining MR imaging with non-imaging information
    Robin Wolz
    Medical Image Analysis Group, Department of Computing, Imperial College London, 180 Queen s Gate, London SW7 2AZ, UK
    Med Image Anal 16:819-30. 2012
    ..Our classification results compare favorably to what has been reported in a recent meta-analysis using established neuroimaging methods on the same database...
  17. doi request reprint Design and application of a generic clinical decision support system for multiscale data
    Jussi Mattila
    VTT Technical Research Centre of Finland, Tampere, Finland
    IEEE Trans Biomed Eng 59:234-40. 2012
    ..The system is evaluated by applying it to several medical datasets and demonstrated by implementing a novel clinical decision support tool for early prediction of Alzheimer's disease...
  18. doi request reprint Methods of artificial enlargement of the training set for statistical shape models
    Juha Koikkalainen
    VTT Technical Research Centre of Finland, FIN 33101 Tampere, Finland
    IEEE Trans Med Imaging 27:1643-54. 2008
    ..The active shape model segmentation gave better segmentation accuracy than the one based on the simulated annealing optimization of the model weights...
  19. ncbi request reprint A MATLAB toolbox for classification and visualization of heterogenous multi-scale human data using the Disease State Fingerprint method
    Luc Cluitmans
    VTT Technical Research Centre of Finland, Tampere, Finland
    Stud Health Technol Inform 189:77-82. 2013
    ..With this implementation, a powerful and flexible tool is made available to the biomedical research community...
  20. ncbi request reprint Quantitative evaluation of disease progression in a longitudinal mild cognitive impairment cohort
    Hilkka Runtti
    VTT Technical Research Centre of Finland, Tampere, Finland
    J Alzheimers Dis 39:49-61. 2014
    ..6% for the intercepts. In conclusion, this study demonstrated that quantifying longitudinal patient data using the DSI method provides valid information for follow-up of disease progression and support for decision making. ..
  21. pmc Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis
    Ville Härmä
    Medical Biotechnology Knowledge Centre, VTT Technical Research Centre of Finland, Turku, Finland Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 9:e96426. 2014
    ..Our approach supports the growing needs for user-friendly, straightforward solutions that facilitate large-scale, cell-based 3D assays in basic research, drug discovery, and target validation. ..
  22. doi request reprint Heterogeneous biological network visualization system: case study in context of medical image data
    Erno Lindfors
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, Finland
    Adv Exp Med Biol 736:95-118. 2012
    ..The flexibility of megNet assures that the tool can be applied in diverse applications, from target discovery in medical applications to metabolic engineering in industrial biotechnology...
  23. ncbi request reprint Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information
    Anu Juslin
    Institute of Signal Processing, Tampere University of Technology, Tampere, Finland
    J Nucl Cardiol 14:82-91. 2007
    ....
  24. doi request reprint Automatic extraction of mandibular bone geometry for anatomy-based synthetization of radiographs
    Kari Antila
    Laboratory of Mathematics in Imaging, Brigham and Women s Hospital, Harvard Medical School, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:490-3. 2008
    ..57+/-0.16 mm mean distance from hand drawn reference. The estimation of tooth orientations was accurate with error of 0.65+/-8.0 degrees. An example of these results used in synthetizing panoramic radiographs is presented...
  25. ncbi request reprint Shape variability of the human striatum--Effects of age and gender
    Juha Koikkalainen
    Laboratory of Biomedical Engineering, Helsinki University of Technology, PO Box 2200, FIN 02015 HUT, Finland
    Neuroimage 34:85-93. 2007
    ..This method will be particularly useful for investigating neuropsychiatric disorders that are associated with subtle morphological alterations of the brain, such as schizophrenia...
  26. ncbi request reprint Circadian activity rhythm in demented and non-demented nursing-home residents measured by telemetric actigraphy
    Paula Paavilainen
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    J Sleep Res 14:61-8. 2005
    ....
  27. pmc Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy
    Marko Sysi-Aho
    VTT Technical Research Centre of Finland, Espoo, Finland
    PLoS ONE 6:e15744. 2011
    ....
  28. doi request reprint Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease
    Mark van Gils
    VTT Technical Research Centre of Finland, Tampere, Finland
    Conf Proc IEEE Eng Med Biol Soc 2010:2886-9. 2010
    ..Optimal feature combinations are to be used in a Clinical Decision Support System that is to be used in clinical AD diagnosis practice...
  29. pmc Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Genome Med 1:83. 2009
    ..Given that data acquired at different levels can carry complementary information about early Alzheimer's disease pathology, it is expected that their integration will improve early detection as well as our understanding of the disease...
  30. pmc A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses
    Ville Härmä
    Medical Biotechnology Knowledge Centre, VTT Technical Research Centre of Finland, Turku, Finland
    PLoS ONE 5:e10431. 2010
    ....