Tuulia Hyötyläinen

Summary

Affiliation: VTT Biotechnology
Country: Finland

Publications

  1. ncbi Lipidomics in nutrition and food research
    Tuulia Hyötyläinen
    VTT Technical Research Centre of Finland, Espoo, Finland
    Mol Nutr Food Res 57:1306-18. 2013
  2. ncbi Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance
    Tuulia Hyötyläinen
    VTT Technical Research Centre of Finland, Tietotie 2, P O Box 1000, FIN 02044 VTT, Espoo, Finland
    Mol Biosyst 8:2559-65. 2012
  3. ncbi Novel methodologies in metabolic profiling with a focus on molecular diagnostic applications
    Tuulia Hyötyläinen
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Expert Rev Mol Diagn 12:527-38. 2012
  4. pmc Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, Espoo, 02044 VTT, Finland
    Diabetologia 56:2266-74. 2013
  5. ncbi Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
    Mika Hilvo
    Biotechnology for Health and Well being, VTT Technical Research Centre of Finland, VTT, Espoo, Finland
    Int J Cancer 134:1725-33. 2014
  6. ncbi Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry
    Sirkku E Jäntti
    VTT Technical Research Center of Finland, 02044 VTT, Espoo, Finland
    Anal Bioanal Chem 406:7799-815. 2014
  7. pmc Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches
    Anna Marja Aura
    VTT Technical Research Centre of Finland, Espoo, Finland
    Eur J Nutr 52:833-46. 2013
  8. ncbi Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk
    Isabel Bondia-Pons
    VTT Technical Research Centre of Finland, Espoo, Finland Department of Food Science and Physiology, Research Building, University of Navarra, Pamplona, Spain
    Mol Nutr Food Res 58:1873-82. 2014
  9. pmc Metabolome in schizophrenia and other psychotic disorders: a general population-based study
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, FI 02044 VTT, Espoo, Finland
    Genome Med 3:19. 2011
  10. ncbi Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Sirkku E Jäntti
    VTT Technical Research Center of Finland, P O Box 1000, FI 02044 VTT, Finland Faculty of Pharmacy, P O Box 56, FI 00014 University of Helsinki, Finland Electronic address
    Anal Chim Acta 802:56-66. 2013

Collaborators

Detail Information

Publications18

  1. ncbi Lipidomics in nutrition and food research
    Tuulia Hyötyläinen
    VTT Technical Research Centre of Finland, Espoo, Finland
    Mol Nutr Food Res 57:1306-18. 2013
    ..Lipidomics can also be applied to optimize the effects of food processing on the dietary value, and in the evaluation of food-related health effects. ..
  2. ncbi Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance
    Tuulia Hyötyläinen
    VTT Technical Research Centre of Finland, Tietotie 2, P O Box 1000, FIN 02044 VTT, Espoo, Finland
    Mol Biosyst 8:2559-65. 2012
    ..Furthermore, strong lipoprotein-specific associations of metabolites with insulin resistance, as compared to their serum profiles, indicate that lipoproteins may be a rich source of tissue-specific metabolic biomarkers...
  3. ncbi Novel methodologies in metabolic profiling with a focus on molecular diagnostic applications
    Tuulia Hyötyläinen
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Expert Rev Mol Diagn 12:527-38. 2012
    ..This review summarizes the most recent advances and current challenges in metabolomics, with a focus on mass spectrometric methods utilized in biomarker research, highlighted with selected examples...
  4. pmc Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, Espoo, 02044 VTT, Finland
    Diabetologia 56:2266-74. 2013
    ....
  5. ncbi Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
    Mika Hilvo
    Biotechnology for Health and Well being, VTT Technical Research Centre of Finland, VTT, Espoo, Finland
    Int J Cancer 134:1725-33. 2014
    ..The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy. ..
  6. ncbi Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry
    Sirkku E Jäntti
    VTT Technical Research Center of Finland, 02044 VTT, Espoo, Finland
    Anal Bioanal Chem 406:7799-815. 2014
    ..Results showed that 17 targeted BAs were found at ng/g level in human adipose tissue. Our findings give a novel insight of the endogenous role of BAs in adipose tissue and their role as biomarkers (e.g., in metabolic diseases). ..
  7. pmc Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches
    Anna Marja Aura
    VTT Technical Research Centre of Finland, Espoo, Finland
    Eur J Nutr 52:833-46. 2013
    ..Tannins are high molecular weight molecules, proanthocyanidins (PAs), and poorly absorbed in the upper intestine. In this study, gut microbial metabolism of Syrah grape phenolic compounds was investigated...
  8. ncbi Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk
    Isabel Bondia-Pons
    VTT Technical Research Centre of Finland, Espoo, Finland Department of Food Science and Physiology, Research Building, University of Navarra, Pamplona, Spain
    Mol Nutr Food Res 58:1873-82. 2014
    ..The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk...
  9. pmc Metabolome in schizophrenia and other psychotic disorders: a general population-based study
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, FI 02044 VTT, Espoo, Finland
    Genome Med 3:19. 2011
    ..More detailed molecular information on the metabolic abnormalities may reveal clues about the pathophysiology of these changes, as well as about disease specificity...
  10. ncbi Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Sirkku E Jäntti
    VTT Technical Research Center of Finland, P O Box 1000, FI 02044 VTT, Finland Faculty of Pharmacy, P O Box 56, FI 00014 University of Helsinki, Finland Electronic address
    Anal Chim Acta 802:56-66. 2013
    ..The results suggest that steroids and especially steroid glucuronides may provide a valuable diagnostic tool to follow the course of pregnancy. ..
  11. ncbi Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry
    Sandra Castillo
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Anal Chem 83:3058-67. 2011
    ..The methodology has already been successfully used for the analysis of several thousand samples in the field of metabolomics...
  12. pmc Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    Diabetes 62:3268-74. 2013
    ..94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general. ..
  13. ncbi Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry
    Minna Hartonen
    VTT Technical Research Centre of Finland, P O Box 1000, FI 02044 VTT, Finland
    J Chromatogr A 1293:142-9. 2013
    ..The GC×GC-TOFMS allowed detection and identification of several metabolites that have not been previously detected in CSF...
  14. pmc Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Genome Med 4:1. 2012
    ..The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission...
  15. ncbi Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro
    Anna Marja Aura
    VTT Technical Research Centre of Finland, PO Box 1000, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Mol Biosyst 7:437-46. 2011
    ..Our study elucidates a pathway of colonic microbial metabolism of SV as well as demonstrates the applicability of the in vitro colon model and metabolomics to the discovery of novel drug metabolites from drug response profiles...
  16. ncbi Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression
    Mika Hilvo
    Bio and Process Technology, VTT Technical Research Centre of Finland, Espoo, Finland
    Cancer Res 71:3236-45. 2011
    ..Taken together, our results imply that phospholipids may have diagnostic potential as well as that modulation of their metabolism may provide therapeutic opportunities in breast cancer treatment...
  17. ncbi Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues
    Heli Nygren
    VTT Technical Research Centre of Finland, Espoo, Finland
    Methods Mol Biol 708:247-57. 2011
    ..The repeatability of the analysis proved to be good, with relative standard errors for spiked samples being between 4.51 and 10.44%. The throughput of the methodology described here is over 100 samples a day...
  18. ncbi Rapid quantitative analysis of carnitine and acylcarnitines by ultra-high performance-hydrophilic interaction liquid chromatography-tandem mass spectrometry
    Maarit Kivilompolo
    VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, FIN 02044 VTT Espoo, Finland
    J Chromatogr A 1292:189-94. 2013
    ..Limits of detection were 5ng/ml for carnitine and acetylcarnitine and approximately 0.5ng/ml for other acylcarnitines. The method was applied to the analysis of serum and tissue samples...