Karl von Smitten

Summary

Country: Finland

Publications

  1. ncbi request reprint Surgical management of breast cancer in the future
    K von Smitten
    Fourth Department of Surgery, Helsinki University Central Hospital, Finland
    Acta Oncol 39:437-9. 2000
  2. doi request reprint Margin status after breast-conserving treatment of breast cancer: how much free margin is enough?
    Karl von Smitten
    Department of GI and General Surgery, Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Oncol 98:585-7. 2008
  3. doi request reprint Concordance between HER-2 and steroid hormone receptor expression between primary breast cancer, sentinel node metastases, and isolated tumor cells
    Leena Strien
    Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
    Pathol Res Pract 206:253-8. 2010
  4. ncbi request reprint VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast cancer
    Vincent van Iterson
    Breast Surgery Unit, Department of Oncology, Helsinki University Hospital, Helsinki, Finland
    Am J Clin Pathol 128:759-66. 2007
  5. ncbi request reprint Accuracy of axillary staging using sentinel node biopsy or diagnostic axillary lymph node dissection--a case-control study
    Marjut Leidenius
    Breast Surgery Unit, Maria Hospital, Lapinlahdenkatu, Helsinki, Finland
    APMIS 112:264-70. 2004
  6. ncbi request reprint Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer
    Mikael Railo
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Tumour Biol 28:45-51. 2007
  7. ncbi request reprint Predictive factors for the status of non-sentinel nodes in breast cancer patients with tumor positive sentinel nodes
    Vincent van Iterson
    Breast Surgery Unit, Maria Hospital, Helsinki, Finland
    Breast Cancer Res Treat 82:39-45. 2003
  8. doi request reprint NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
    Rainer Fagerholm
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, FI 00029 Helsinki, Finland
    Nat Genet 40:844-53. 2008
  9. doi request reprint Metastasis to sentinel lymph nodes in breast cancer is associated with maturation arrest of dendritic cells and poor co-localization of dendritic cells and CD8+ T cells
    Aaron Scott Mansfield
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    Virchows Arch 459:391-8. 2011
  10. ncbi request reprint BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition
    Pia Vahteristo
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Hum Genet 14:167-72. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Surgical management of breast cancer in the future
    K von Smitten
    Fourth Department of Surgery, Helsinki University Central Hospital, Finland
    Acta Oncol 39:437-9. 2000
    ..The real surgical challenges during the next decade will be immediate breast reconstruction and oncoplastic breast-conserving procedures. Therefore breast surgery will increasingly be performed by plastic surgeons...
  2. doi request reprint Margin status after breast-conserving treatment of breast cancer: how much free margin is enough?
    Karl von Smitten
    Department of GI and General Surgery, Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Oncol 98:585-7. 2008
    ..In ductal cancer in situ the free margin should be at least 5 mm, preferably 10 mm. Oncoplastic surgery is beneficial for reaching adequate margins...
  3. doi request reprint Concordance between HER-2 and steroid hormone receptor expression between primary breast cancer, sentinel node metastases, and isolated tumor cells
    Leena Strien
    Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
    Pathol Res Pract 206:253-8. 2010
    ..The concordance in HER-2, ER, and PR was high between the PT and their SN metastases. However, the concordance may be remarkably lower when analyzed simultaneously for all three predictive factors...
  4. ncbi request reprint VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast cancer
    Vincent van Iterson
    Breast Surgery Unit, Department of Oncology, Helsinki University Hospital, Helsinki, Finland
    Am J Clin Pathol 128:759-66. 2007
    ....
  5. ncbi request reprint Accuracy of axillary staging using sentinel node biopsy or diagnostic axillary lymph node dissection--a case-control study
    Marjut Leidenius
    Breast Surgery Unit, Maria Hospital, Lapinlahdenkatu, Helsinki, Finland
    APMIS 112:264-70. 2004
    ..03. SNB seems to be as accurate a method for axillary staging as ALND. However, SNB generated no upstaging effect in IDC, only in other histological tumour types...
  6. ncbi request reprint Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer
    Mikael Railo
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Tumour Biol 28:45-51. 2007
    ..The aim of the present study was to evaluate a series of biomarkers with regard to long-term prognostic value in patients with T1 (< or =2 cm) node-negative breast cancer...
  7. ncbi request reprint Predictive factors for the status of non-sentinel nodes in breast cancer patients with tumor positive sentinel nodes
    Vincent van Iterson
    Breast Surgery Unit, Maria Hospital, Helsinki, Finland
    Breast Cancer Res Treat 82:39-45. 2003
    ..Because the clinical relevance of micrometastases in lymph nodes is still unclear it is not advisable to omit axillary lymph node dissection even in these patients...
  8. doi request reprint NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
    Rainer Fagerholm
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, FI 00029 Helsinki, Finland
    Nat Genet 40:844-53. 2008
    ....
  9. doi request reprint Metastasis to sentinel lymph nodes in breast cancer is associated with maturation arrest of dendritic cells and poor co-localization of dendritic cells and CD8+ T cells
    Aaron Scott Mansfield
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    Virchows Arch 459:391-8. 2011
    ..These findings extend our understanding of regional immunosuppression and suggest that most regional immunosuppressive changes are associated with nodal metastasis in breast cancer...
  10. ncbi request reprint BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition
    Pia Vahteristo
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Hum Genet 14:167-72. 2006
    ..These results suggest that the contribution of the BARD1 germline variants to breast cancer predisposition is very limited, and that neither Cys557Ser nor Val507Met have an effect on familial breast cancer susceptibility...
  11. ncbi request reprint Radio-guided occult lesion localization in patients undergoing breast-conserving surgery and sentinel node biopsy
    Riitta Rönkä
    Breast Surgery Unit, Maria Hospital, Helsinki University Hospital, Helsinki, Finland
    Am J Surg 187:491-6. 2004
    ..The objective of the study was to evaluate the feasibility of radio-guided occult lesion localization (ROLL) in breast-conserving surgery for nonpalpable breast cancer...
  12. doi request reprint Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer
    Katja Hukkinen
    Department of Radiology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Oncol 47:1037-45. 2008
    ..The frequent need for additional biopsies raised the total expenses of FNAC over those of CNB. Multiple biopsies may also delay cancer surgery. It is therefore recommended to use CNB as the initial needle biopsy method...
  13. ncbi request reprint Motion restriction and axillary web syndrome after sentinel node biopsy and axillary clearance in breast cancer
    Marjut Leidenius
    Breast Surgery Unit, Maria Hospital, Helsinki University Hospital, Lapinlahdenkatu 16, FIN 00180 Helsinki, Finland
    Am J Surg 185:127-30. 2003
    ..AWS is a self-limiting cause of early postoperative morbidity after axillary surgery. Limited range of motion associated with palpable cords of tissue in the axilla are typical for AWS...
  14. ncbi request reprint Predicting invasion in patients with DCIS in the preoperative percutaneous biopsy
    Junnu Leikola
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    Acta Oncol 46:798-802. 2007
    ..0686. In conclusion, the visibility of the lesion in US may predict detecting invasion in the surgical specimen in patients with DCIS in the preoperative biopsy...
  15. ncbi request reprint Breast cancer patients with p53 Pro72 homozygous genotype have a poorer survival
    Johanna Tommiska
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Clin Cancer Res 11:5098-103. 2005
    ..The p53 R72P polymorphism has been suggested to play a role in many cancers, including breast cancer. Our aim was to evaluate association of R72P with breast cancer risk as well as histopathologic features of the breast tumors and survival...
  16. doi request reprint Comparison of in vitro breast cancer visibility in analyser-based computed tomography with histopathology, mammography, computed tomography and magnetic resonance imaging
    Jani Keyriläinen
    Department of Physics, HUCH Cancer Center, Helsinki University Central Hospital, Helsinki, Finland
    J Synchrotron Radiat 18:689-96. 2011
    ....
  17. ncbi request reprint Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer
    Tuuli Ranki
    Cancer Gene Therapy Group, Molecular Cancer Biology Program, University of Helsinki, Helsinki, Finland
    Int J Cancer 121:165-74. 2007
    ..These results facilitate clinical translation of oncolytic adenoviruses for the treatment of hormone refractory metastatic breast cancer...
  18. ncbi request reprint Amplification of erbB2 and erbB2 expression are superior to estrogen receptor status as risk factors for distant recurrence in pT1N0M0 breast cancer: a nationwide population-based study
    Heikki Joensuu
    Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 180, FIN 00029 Helsinki, Finland
    Clin Cancer Res 9:923-30. 2003
    ..To assess the relative importance of 10 prognostic factors in pT1N0M0 breast cancer (< or =2 cm in diameter, node negative)...