Riitta Korpela

Summary

Affiliation: Valio Ltd
Country: Finland

Publications

  1. ncbi Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects
    U Sairanen
    Valio Ltd R and D, Helsinki, Finland
    Eur J Clin Nutr 61:1423-8. 2007
  2. ncbi Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols
    R Korpela
    Foundation for Nutrition Research, Helsinki, Finland
    Eur J Clin Nutr 60:633-42. 2006
  3. pmc Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 64:424-31. 2010
  4. pmc Effects of a fibre-enriched milk drink on insulin and glucose levels in healthy subjects
    Netta Lummela
    Valio Ltd, Research Center, PO Box 30, 00039 Valio, Finland
    Nutr J 8:45. 2009
  5. doi Colonic methane production modifies gastrointestinal toxicity associated with adjuvant 5-fluorouracil chemotherapy for colorectal cancer
    Reetta Holma
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Clin Gastroenterol 47:45-51. 2013
  6. doi High intestinal IgA associates with reduced risk of IgE-associated allergic diseases
    Kaarina Kukkonen
    The Skin and Allergy Hospital, Department of Pediatric Allergology, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 21:67-73. 2010
  7. doi Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese
    Maija Saxelin
    Valio Ltd, Research and Development, P O Box 30, FI 00039 Valio, Helsinki, Finland
    Int J Food Microbiol 144:293-300. 2010
  8. doi Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort
    Mikael Kuitunen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 123:335-41. 2009
  9. doi Human bocavirus in the nasopharynx of otitis-prone children
    Liisa Lehtoranta
    Institute of Biomedicine, Department of Pharmacology, University of Helsinki, PO Box 63, 00014 University of Helsinki, Finland
    Int J Pediatr Otorhinolaryngol 76:206-11. 2012
  10. doi In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own
    Laura Piirainen
    Nutraceuticals Group, Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Ann Nutr Metab 52:204-8. 2008

Detail Information

Publications93

  1. ncbi Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects
    U Sairanen
    Valio Ltd R and D, Helsinki, Finland
    Eur J Clin Nutr 61:1423-8. 2007
    ..Constipation is a common problem in the elderly. Dietary fibre is recommended for its treatment. The aim was to examine whether yoghurt containing galacto-oligosaccharides (GOS), prunes and linseed relieve constipation in elderly subjects...
  2. ncbi Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols
    R Korpela
    Foundation for Nutrition Research, Helsinki, Finland
    Eur J Clin Nutr 60:633-42. 2006
    ....
  3. pmc Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects
    T Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 64:424-31. 2010
    ..Our aim was to evaluate whether the milk-based drink containing Ile-Pro-Pro and Val-Pro-Pro influence arterial stiffness, measured as augmentation index (AIx), and endothelial function in man...
  4. pmc Effects of a fibre-enriched milk drink on insulin and glucose levels in healthy subjects
    Netta Lummela
    Valio Ltd, Research Center, PO Box 30, 00039 Valio, Finland
    Nutr J 8:45. 2009
    ..However, the effects of lactose-free products on insulin and glucose metabolism have not been studied...
  5. doi Colonic methane production modifies gastrointestinal toxicity associated with adjuvant 5-fluorouracil chemotherapy for colorectal cancer
    Reetta Holma
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Clin Gastroenterol 47:45-51. 2013
    ..To investigate the association of colonic methane, formed by methanogenic achaea, and pH with gastrointestinal symptoms during colorectal cancer chemotherapy...
  6. doi High intestinal IgA associates with reduced risk of IgE-associated allergic diseases
    Kaarina Kukkonen
    The Skin and Allergy Hospital, Department of Pediatric Allergology, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 21:67-73. 2010
    ..085) and significantly increased faecal alpha1-AT (p = 0.001). High intestinal IgA in early life associates with minimal intestinal inflammation and indicates reduced risk for IgE-associated allergic diseases...
  7. doi Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese
    Maija Saxelin
    Valio Ltd, Research and Development, P O Box 30, FI 00039 Valio, Helsinki, Finland
    Int J Food Microbiol 144:293-300. 2010
    ....
  8. doi Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort
    Mikael Kuitunen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 123:335-41. 2009
    ..Allergic children have a different fecal microflora, with less lactobacilli and bifidobacteria. Beneficial effects regarding the development of allergy have been suggested to come through probiotic supplementation...
  9. doi Human bocavirus in the nasopharynx of otitis-prone children
    Liisa Lehtoranta
    Institute of Biomedicine, Department of Pharmacology, University of Helsinki, PO Box 63, 00014 University of Helsinki, Finland
    Int J Pediatr Otorhinolaryngol 76:206-11. 2012
    ....
  10. doi In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own
    Laura Piirainen
    Nutraceuticals Group, Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Ann Nutr Metab 52:204-8. 2008
    ..Ingestion of LGG combined with 2 g of GOS increased the bifidobacteria more than LGG on its own and thus GOS clearly has a prebiotic effect in children. The children tolerated well a daily intake of 2 g of GOS...
  11. doi High blood pressure-lowering and vasoprotective effects of milk products in experimental hypertension
    Pauliina I Ehlers
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Br J Nutr 106:1353-63. 2011
    ..86; P = 0.047). In conclusion, long-term treatment with fermented milk enriched with tripeptides and plant sterols decreases SBP, improves endothelial dysfunction and affects signalling pathways related to inflammatory responses in SHR...
  12. doi Skeletal muscle gene expression profile is modified by dietary protein source and calcium during energy restriction
    Eveliina Tauriainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Nutrigenet Nutrigenomics 4:49-62. 2011
    ..The potential of whey protein and calcium to modify skeletal muscle gene expression during energy restriction (ER) was investigated in a model of diet-induced obesity...
  13. ncbi Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement
    Tiina Jauhiainen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Am J Hypertens 18:1600-5. 2005
    ....
  14. pmc Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults
    Riina A Kekkonen
    University of Helsinki, Institute of Biomedicine, Pharmacology, PO Box 63, 00014 Helsinki, Finland
    World J Gastroenterol 14:2029-36. 2008
    ..To evaluate the effects of three potentially anti-inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses...
  15. ncbi Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial
    Kaarina Kukkonen
    Skin and Allergy Hospital, University of Helsinki, Finland
    J Allergy Clin Immunol 119:192-8. 2007
    ..The increase in allergic diseases is attributed to a relative lack of microbial stimulation of the infantile gut immune system. Probiotics, live health-promoting microbes, might offer such stimulation...
  16. ncbi Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol
    Leena Seppo
    Valio Ltd, Helsinki, Finland
    Eur J Nutr 46:111-7. 2007
    ..Oil-based matrices enriched with plant stanol esters lower serum LDL cholesterol. The effects of low-fat milk products have been less thoroughly examined...
  17. ncbi Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study
    Laura Paajanen
    Foundation for Nutrition Research, Helsinki, Finland
    Am J Clin Nutr 82:1327-35. 2005
    ..Gastrointestinal hypersensitivity to cow milk (CM) may be more common among school-aged children and young adults than previously thought...
  18. doi Factors associated with acute respiratory illness in day care children
    Katja Hatakka
    Valio R and D, Helsinki, Finland
    Scand J Infect Dis 42:704-11. 2010
    ..Parental and environmental factors had a significant impact on recurrent ARI and AOM episodes in children attending DCCs. These risk factors should be considered in future studies intending to reduce DCC infections...
  19. pmc Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome
    Kajsa Kajander
    Institute of Biomedicine, Pharmacology, University of Helsinki, PO Box 63, FI 00014, Helsinki, Finland
    World J Gastroenterol 15:6068-74. 2009
    ..To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls...
  20. ncbi Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome
    Mirva Viljanen
    Skin and Allergy Hospital, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland
    J Allergy Clin Immunol 115:1254-9. 2005
    ..The immunomodulating mechanisms of Lactobacillus GG (LGG) and other probiotics are poorly understood...
  21. ncbi The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women
    Mirkka Narva
    Institute of Biomedicine, Pharmacology, Helsinki University, Helsinki, Finland
    Eur J Nutr 43:61-8. 2004
    ..helveticus) has been shown to lower blood pressure and to increase bone mineral content in spontaneously hypertensive rats. The effect of L.helveticus may be due to better calcium availability...
  22. ncbi Intestinal cytokine mRNA expression in delayed-type cow's milk allergy
    Laura Paajanen
    Foundation for Nutrition Research, Helsinki, Finland
    J Pediatr Gastroenterol Nutr 43:470-6. 2006
    ....
  23. pmc Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction
    Taru K Pilvi
    University of Helsinki, Helsinki FI 00390, Finland
    World J Gastroenterol 14:4462-72. 2008
    ..We also investigated whether the effect of energy restriction can be further enhanced by modification of dietary protein source and calcium...
  24. doi Ile-Pro-Pro and Val-Pro-Pro tripeptide-containing milk product has acute blood pressure lowering effects in mildly hypertensive subjects
    Anu M Turpeinen
    Valio Ltd, R and D, Helsinki, Finland
    Clin Exp Hypertens 33:388-96. 2011
    ..placebo (p = 0.01). The results indicate that a single dose of a fermented milk product containing Ile-Pro-Pro and Val-Pro-Pro and plant sterols acutely lowers brachial SBP and DBP in mildly hypertensive subjects...
  25. doi The use of the probiotic Lactobacillus rhamnosus GG and viral findings in the nasopharynx of children attending day care
    Minna Kumpu
    Valio Ltd, Helsinki, Finland
    J Med Virol 85:1632-8. 2013
    ....
  26. ncbi Can primary hypolactasia manifest itself after the age of 20 years? A two-decade follow-up study
    Leena Seppo
    Valio Ltd, Helsinki, Finland
    Scand J Gastroenterol 43:1082-7. 2008
    ..The purpose of this study was to investigate whether primary hypolactasia can appear after the age of 20 among the Finnish population and to investigate the outcome of different diagnostic methods of lactose maldigestion...
  27. ncbi Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats
    Mirkka Narva
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Ann Nutr Metab 48:228-34. 2004
    ..Lactobacillus helveticus-fermented milk has been shown to increase calcium absorption compared to ordinary sour milk. In the present study the possible effect of L. helveticus-fermented milk on bone was studied in growing rats...
  28. doi A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids
    Lotta K Stenman
    Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, University of Helsinki, Helsinki, Finland
    Am J Physiol Gastrointest Liver Physiol 304:G227-34. 2013
    ..6 mM concentration. LPS had no significant effect on barrier function at 0.5-4.5 μg/ml concentrations. We suggest a novel mechanism for barrier dysfunction on a high-fat diet involving the effect of hydrophobic luminal bile acids...
  29. ncbi Effects of bioactive peptide, valyl-prolyl-proline (VPP), and lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats
    Mirkka Narva
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Ann Nutr Metab 51:65-74. 2007
    ..helveticus), has been shown to increase bone formation in vitro. The aim of the study was to determine whether VPP and L. helveticus fermented milk prevent bone loss in ovariectomized (OVX) rats...
  30. doi Breakfast high in whey protein or carbohydrates improves coping with workload in healthy subjects
    Nora Sihvola
    Institute of Biomedicine, Medical Nutrition Physiology, Pharmacology, University of Helsinki, PO Box 63, Helsinki FIN 00014, Finland
    Br J Nutr 110:1712-21. 2013
    ..We conclude that a breakfast drink high in whey protein or carbohydrates may improve coping with mental tasks in healthy subjects...
  31. ncbi Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats
    Marika Sipola
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
    Life Sci 71:1245-53. 2002
    ..The beneficial effect of alpha-lactorphin was directed towards endothelial function, whereas beta-lactorphin also enhanced endothelium-independent relaxation...
  32. ncbi Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp shermanii JS administered in capsules is ineffective in lowering serum lipids
    Katja Hatakka
    Department of Applied Chemistry and Microbiology, Nutrition, Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Am Coll Nutr 27:441-7. 2008
    ....
  33. doi Plant sterols and casein-derived tripeptides attenuate blood pressure increase in spontaneously hypertensive rats
    Pauliina I Ehlers
    Institute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, Finland
    Nutr Res 32:292-300. 2012
    ..Plant sterols do not provide any beneficial effects on endothelial function in hypertensive rats; however, treatment with both PS and tripeptides showed mild anti-inflammatory effects...
  34. doi Genetically obese mice do not show increased gut permeability or faecal bile acid hydrophobicity
    Lotta K Stenman
    Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, University of Helsinki, PO Box 63, FI 00014 Helsinki, Finland
    Br J Nutr 110:1157-64. 2013
    ..In conclusion, genetic obesity did not impair gut barrier function in mice on a regular chow diet, nor was faecal bile acid hydrophobicity affected...
  35. doi Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice
    Taru K Pilvi
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Br J Nutr 102:337-41. 2009
    ..It can be concluded that a high-Ca diet with ALA significantly improves the outcome of weight loss and subsequent weight regain during the feeding of a high-fat diet in C57BL/6J mice, in comparison with WPI...
  36. doi Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study
    Reetta Holma
    Institute of Biomedicine, Pharmacology, PO Box 63, FIN 00014 University of Helsinki, Finland
    Br J Nutr 111:301-9. 2014
    ..Men with a low serum enterolactone concentration harbour less colonic bacteria, especially those belonging to the Lactobacillus-Enterococcus group. A synbiotic mixture does not increase serum enterolactone concentration. ..
  37. pmc Effect of dietary calcium and dairy proteins on the adipose tissue gene expression profile in diet-induced obesity
    Taru K Pilvi
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Nutrigenet Nutrigenomics 1:240-51. 2008
    ..We have shown that a high-calcium diet with whey protein attenuates weight gain and now we describe the effects of this diet on adipose tissue gene expression...
  38. ncbi Effects of Lactobacillus helveticus fermented milk on bone cells in vitro
    Mirkka Narva
    University of Helsinki, Institute of Biomedicine, Pharmacology, Finland
    Life Sci 75:1727-34. 2004
    ..The effect may be due to the ACE-inhibitory IPP and VPP peptides, which showed a similar effect to that of the L. helveticus fermented milk whey...
  39. pmc Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults
    Riina A Kekkonen
    University of Helsinki, Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki 00014, Finland
    World J Gastroenterol 14:3188-94. 2008
    ....
  40. ncbi Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants
    Mirva Viljanen
    The Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 16:65-71. 2005
    ..014), and TNF-alpha was lower for LGG than for placebo, but non-significantly (p=0.111). In conclusion, 4-wk treatment with LGG may alleviate intestinal inflammation in infants with AEDS and CMA...
  41. doi Recovery of probiotic Lactobacillus rhamnosus GG in tonsil tissue after oral administration: randomised, placebo-controlled, double-blind clinical trial
    Minna Kumpu
    Valio Limited, PO Box 10, FI 00039 Valio, Helsinki, Finland
    Br J Nutr 109:2240-6. 2013
    ..Further clinical trials are warranted to evaluate whether probiotic adherence in the tonsil tissue could have a role in respiratory symptom prevalence...
  42. doi Casein-derived tripeptide Ile-Pro-Pro improves angiotensin-(1-7)- and bradykinin-induced rat mesenteric artery relaxation
    Pauliina I Ehlers
    Institute of Biomedicine, Pharmacology, University of Helsinki, PO Box 63, 00014 University of Helsinki, Finland
    Life Sci 88:206-11. 2011
    ..The present study was aimed to further evaluate the renin-angiotensin system (RAS)-related vascular effects of Ile-Pro-Pro in vitro using rat mesenteric arteries...
  43. doi Higher fecal bile acid hydrophobicity is associated with exacerbation of dextran sodium sulfate colitis in mice
    Lotta K Stenman
    Institute of Biomedicine, Pharmacology, Medical Nutrition Physiology, and
    J Nutr 143:1691-7. 2013
    ..43; P = 0.028) and fecal deoxycholic acid concentration (Spearman's ρ = 0.39; P = 0.048). These results suggest that luminal bile acid modification, induced by altered dietary fat composition, may alter susceptibility to DSS colitis. ..
  44. ncbi A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects
    Leena Seppo
    Valio, Ltd, Research Center, Helsinki, Finland
    Am J Clin Nutr 77:326-30. 2003
    ..By inhibiting these processes, ACE inhibitors have antihypertensive effects. Peptides derived from milk proteins can have ACE-inhibiting properties and may thus be used as antihypertensive components...
  45. doi Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro
    Risto Lehtinen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Arzneimittelforschung 60:182-5. 2010
    ..No inhibition of chymase and cathepsin G was observed by the tripeptides. The findings support the hypothesis that Ile-Pro-Pro, Val-Pro-Pro and Leu-Pro-Pro act favourably on blood pressure mainly by selective inhibition of ACE1...
  46. ncbi Genistein treatment reduces arterial contractions by inhibiting tyrosine kinases in ovariectomized hypertensive rats
    Riikka Nevala
    Biomedicum, Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
    Eur J Pharmacol 452:87-96. 2002
    ..The mechanism for attenuated contractility in the renal arteries after the 2-day low-dose genistein treatment is independent of the estrogenic effect of genistein, but is due to the tyrosine kinase inhibitory property of genistein...
  47. doi Allergy in day care children: prevalence and environmental risk factors
    Katja Hatakka
    Valio R and D, Helsinki, Finland
    Acta Paediatr 98:817-22. 2009
    ..To investigate the prevalence of atopic disease among Finnish day care children and the relationship between atopy and environmental factors...
  48. pmc Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages
    Minja Miettinen
    Valio R and D, Helsinki, Finland
    Gut Microbes 3:510-22. 2012
    ..Our results indicate that nonpathogenic bacteria are able to activate the inflammasome. In addition, our results suggest that L. rhamnosus may prime the antiviral potential of human macrophages...
  49. pmc Even low-grade inflammation impacts on small intestinal function
    Katri Peuhkuri
    Institute of Biomedicine, University of Helsinki, Pharmacology, PO Box 63, FI 00014 Helsinki, Finland
    World J Gastroenterol 16:1057-62. 2010
    ..Moreover, nutritional strategies to support functional restitution are needed...
  50. doi Early human enterovirus infections in healthy Swedish children participating in the PRODIA pilot study
    Marja Leena Simonen-Tikka
    Intestinal Viruses Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland
    J Med Virol 84:923-30. 2012
    ..Also it was shown that serotypes belonging to HEV-A species can be detected by means of viral culturing...
  51. ncbi Milk peptides and blood pressure
    Tiina Jauhiainen
    Valio Ltd, Research Center, Helsinki, Finland
    J Nutr 137:825S-9S. 2007
    ..The future challenge is to identify the antihypertensive components in milk and their mechanisms of action and thus to find more possibilities for using these constituents and products as a dietary treatment of hypertension...
  52. doi Effect of Lactobacillus rhamnosus GG on rBet v1 and rMal d1 specific IgA in the saliva of patients with birch pollen allergy
    Laura Piirainen
    National Public Health Institute, Laboratory for Immunobiology, Helsinki, Finland
    Ann Allergy Asthma Immunol 100:338-42. 2008
    ..Lactobacillus rhamnosus GG (LGG) has demonstrated promising results in the treatment and prevention of atopic eczema...
  53. pmc Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats
    Hanna Ventola
    Institute of Biomedicine, Pharmacology, University of Helsinki, FI 00014 Helsinki, Finland
    World J Gastroenterol 18:5925-31. 2012
    ..To study the effects of live and dead Lactobacillus rhamnosus GG (GG) on rotavirus infection in a neonatal rat model...
  54. ncbi A follow-up study of nutrient intake, nutritional status, and growth in infants with cow milk allergy fed either a soy formula or an extensively hydrolyzed whey formula
    Leena Seppo
    Foundation for Nutrition Research, Helsinki, Finland
    Am J Clin Nutr 82:140-5. 2005
    ..Infants with cow milk allergy (CMA) are reported to have reduced growth and special nutritional needs...
  55. pmc High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids
    Lotta K Stenman
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki 00280, Finland
    World J Gastroenterol 18:923-9. 2012
    ..To investigate whether high-fat-feeding is associated with increased intestinal permeability via alterations in bile acid metabolism...
  56. pmc Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-gamma production
    Riina A Kekkonen
    University of Helsinki, Institute of Biomedicine, Pharmacology, Helsinki 00014, Finland
    World J Gastroenterol 14:1192-203. 2008
    ....
  57. ncbi High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice
    Taru K Pilvi
    Foundation for Nutrition Research, PO Box 30, FIN 00390 Helsinki, Finland
    Br J Nutr 98:900-7. 2007
    ..9 (SEM 0.9) % in the high-Ca whey v. 1.4 (SEM 0.2) % in the low-Ca casein group; P < 0.05), which may partly explain the effect on body weight...
  58. ncbi The effect of probiotic fermented milk and inulin on the functions and microecology of the intestine
    Ulla Sairanen
    Valio Ltd RandD, Helsinki, Finland
    J Dairy Res 74:367-73. 2007
    ..001). In conclusion, the probiotic fermented milk product had a positive effect by increasing the number of lactobacilli and bifidobacteria in the colon. Inulin did not alter this effect but it increased gastrointestinal symptoms...
  59. ncbi Caseinphosphopeptides in milk and fermented milk do not affect calcium metabolism acutely in postmenopausal women
    Mirkka Narva
    Valio Research Centre, Pharmacology, University of Helsinki, Helsinki, Finland
    J Am Coll Nutr 22:88-93. 2003
    ..Caseinphosphopeptides (CPPs) are formed in food processing or during digestion in the gastrointestinal tract. CPPs prevent the formation of insoluble calcium salts; thus, the hypothesis is that CPPs increase the absorption of calcium...
  60. ncbi Effect of long-term intake of milk products on blood pressure in hypertensive rats
    Marika Sipola
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    J Dairy Res 69:103-11. 2002
    ..This difference could be explained by larger intake of ACE inhibitory tripeptides in the group receiving fermented milk A as compared with fermented milk B...
  61. pmc Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes
    Anna Lyra
    Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 10:110. 2010
    ..rhamnosus Lc705, Propionibacterium freudenreichii ssp. shermanii JS and Bifidobacterium breve Bb99. The intervention has previously been shown to successfully alleviate gastrointestinal symptoms of IBS...
  62. ncbi Increased IFN-gamma secretion from duodenal biopsy samples in delayed-type cow's milk allergy
    Laura Paajanen
    Foundation for Nutrition Research, PO Box 30, FIN 00039 Valio, Helsinki, Finland
    Pediatr Allergy Immunol 16:439-44. 2005
    ..059). In conclusion, the children with delayed CMA showed up-regulation of IFN-gamma. Interestingly, TGF-beta secretion was up-regulated in those children with delayed CMA who avoided CM suggesting recovery of regulation mechanisms...
  63. doi Colonic methanogenesis in vivo and in vitro and fecal pH after resection of colorectal cancer and in healthy intact colon
    Reetta Holma
    Institute of Biomedicine, University of Helsinki, P O Box 63, FIN 00014, Helsinki, Finland
    Int J Colorectal Dis 27:171-8. 2012
    ..We compared colonic methanogenesis in vivo and in vitro as well as fecal pH in healthy subjects and in patients with resected colorectal cancer thus without the possible confounding effects of the tumor...
  64. ncbi Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study
    Katja Hatakka
    Valio Ltd, R and D, FIN 00039 Helsinki, Finland
    Clin Nutr 26:314-21. 2007
    ..To examine whether probiotics would reduce the occurrence or duration of acute otitis media (AOM), or the nasopharyngeal carriage of otitis pathogens in otitis-prone children...
  65. ncbi Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland
    Liisa Lehtoranta
    Centre for Military Medicine, Research and Development Department, Finnish Defense Forces, FI 00301 Helsinki, Finland Institute of Biomedicine, Pharmacology, University of Helsinki, FI 00014 Helsinki, Finland Electronic address
    J Clin Virol 60:276-81. 2014
    ..Probiotics have reduced viral infections in children attending day care. Limited data are available on the effects of probiotics on the nasopharyngeal presence of respiratory viruses...
  66. ncbi Effect of accurate diagnostic criteria on incidence of acute otitis media in otitis-prone children
    Karin Blomgren
    Helsinki University Hospital, Department of Otorhinolaryngology, Helsinki, Finland
    Scand J Infect Dis 36:6-9. 2004
    ..AOM is frequently over-diagnosed. Use of proper diagnostic criteria, the pneumatic otoscope, and tympanometry can help correct diagnosis, and thereby reduce incidence of AOM...
  67. ncbi The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners
    Riina A Kekkonen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Int J Sport Nutr Exerc Metab 17:352-63. 2007
    ..2.3 d, respectively, during the 2 wk after the marathon (P = 0.046). LGG had no effect on the incidence of respiratory infections or GI-symptom episodes in marathon runners, but it seemed to shorten the duration of GI-symptom episodes...
  68. pmc Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein
    Matti Kankainen
    Institute of Biotechnology, University of Helsinki, P O Box 56, FIN 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 106:17193-8. 2009
    ..The presence of mucus-binding pili on the surface of a nonpathogenic Gram-positive bacterial strain reveals a previously undescribed mechanism for the interaction of selected probiotic lactobacilli with host tissues...
  69. ncbi Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis--a pilot study
    K Hatakka
    Rheumatism Foundation Hospital, Heinola
    Scand J Rheumatol 32:211-5. 2003
    ..To study the effects of Lactobacillus rhamnosus GG (LGG) on rheumatoid arthritis (RA)...
  70. pmc Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial
    K Hatakka
    Valio Research and Development, PO Box 30, FIN-00039 Valio, Helsinki, Finland
    BMJ 322:1327. 2001
    ..CONCLUSIONS: Lactobacillus GG may reduce respiratory infections and their severity among children in day care. The effects of the probiotic Lactobacillus GG were modest but consistently in the same direction...
  71. ncbi Effects of low-fat hard cheese enriched with plant stanol esters on serum lipids and apolipoprotein B in mildly hypercholesterolaemic subjects
    T Jauhiainen
    Valio Ltd, Helsinki, Finland
    Eur J Clin Nutr 60:1253-7. 2006
    ..To investigate the cholesterol-lowering effects of a low-fat cheese enriched with plant stanol esters in mildly hypercholesterolaemic subjects, as part of their normal diet...
  72. ncbi Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial
    M Viljanen
    The Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
    Allergy 60:494-500. 2005
    ..Probiotic bacteria are suggested to reduce symptoms of the atopic eczema/dermatitis syndrome (AEDS) in food-allergic infants. We aimed to investigate whether probiotic bacteria have any beneficial effect on AEDS...
  73. ncbi Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors
    A J Ahola
    Division of Nutrition, University of Helsinki, Helsinki, Finland
    Arch Oral Biol 47:799-804. 2002
    ..37, 95% CI 0.08-1.75, P=0.21) and salivary yeasts (OR=0.40, 0.09-1.71, P=0.22)...
  74. ncbi Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy--a placebo-controlled, double-blind randomized pilot study
    E Myllyluoma
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Aliment Pharmacol Ther 21:1263-72. 2005
    ..H. pylori is the major cause of chronic gastritis, and a risk factor for peptic ulcer and gastric cancer...
  75. ncbi A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention
    K Kajander
    Valio Ltd, Research Centre, Helsinki, Finland
    Aliment Pharmacol Ther 22:387-94. 2005
    ..Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear...
  76. ncbi Probiotics reduce the prevalence of oral candida in the elderly--a randomized controlled trial
    K Hatakka
    Valio Ltd, R and D, PO Box 30, FIN 00039 Helsinki, Finland
    J Dent Res 86:125-30. 2007
    ..25, 95%CI 0.10-0.65, p = 0.004), and the risk of hyposalivation by 56% (OR = 0.44, 95%CI 0.19-1.01, p = 0.05). Thus, probiotic bacteria can be effective in controlling oral Candida and hyposalivation in the elderly...
  77. ncbi Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia
    R Volpe
    Institute of Systematic Medical Theraphy, University of Rome 'La Sapienza, Rome, Italy
    Br J Nutr 86:233-9. 2001
    ..To conclude, a low-fat yoghurt-based drink moderately enriched with plant sterols may lower total cholesterol and LDL-cholesterol effectively in patients with primary moderate hypercholesterolaemia...
  78. doi Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation
    E Marschan
    The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Clin Exp Allergy 38:611-8. 2008
    ..Probiotics are widely studied both in the treatment and prevention of allergic diseases, but their mode of action is poorly known...
  79. pmc Effects of multispecies probiotic combination on helicobacter pylori infection in vitro
    E Myllyluoma
    Department of Pharmacology, Institute of Biomedicine, P O Box 63, University of Helsinki BIOMEDICUM Helsinki, Helsinki FIN 00014, Finland
    Clin Vaccine Immunol 15:1472-82. 2008
    ..Our results stress that the therapeutic response can be optimized if probiotic strains are characterized before they are used in combination...
  80. ncbi Effects of anti-Helicobacter pylori treatment and probiotic supplementation on intestinal microbiota
    E Myllyluoma
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland Foundation for Nutrition Research, Helsinki, Finland
    Int J Antimicrob Agents 29:66-72. 2007
    ..The recommended treatment for H. pylori infection induces long-term disturbances in the intestinal microbiota. The probiotic combination appeared to result in only minor changes in the microbiota...
  81. ncbi The expression of COX2 protein induced by Lactobacillus rhamnosus GG, endotoxin and lipoteichoic acid in T84 epithelial cells
    R Korhonen
    The Immunopharmacological Research Group, University of Tampere, Medical School and Tampere University Hospital, Tampere, Finland
    Lett Appl Microbiol 39:19-24. 2004
    ..rhamnosus GG) possess immunomodulatory effects in the host. In the present study, the effect of L. rhamnosus GG on cyclooxygenase 2 (COX2) expression and its pharmacological control was investigated in human T84 colon epithelial cells...
  82. ncbi Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Hum Hypertens 18:795-802. 2004
    ..0+/-8.3 mmHg between the two test products was not significant either (P=0.4431). In conclusion, the ingestion of sour milk fermented by L. helveticus bacteria and that containing ACE inhibitory tripeptides seems to lower BP modestly...
  83. ncbi Galacto-oligosaccharides stimulate the growth of bifidobacteria but fail to attenuate inflammation in experimental colitis in rats
    R Holma
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    Scand J Gastroenterol 37:1042-7. 2002
    ....
  84. ncbi Induction of nitric oxide synthesis by probiotic Lactobacillus rhamnosus GG in J774 macrophages and human T84 intestinal epithelial cells
    R Korhonen
    The Immunopharmacological Research Group, Medical School, University of Tampere, Finland
    Inflammation 25:223-32. 2001
    ..Induction of iNOS and low-level synthesis of NO may be involved in the protective actions of LGG in the gastrointestinal tract...
  85. pmc Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study
    P Osterlund
    Department of Oncology, Helsinki University Central Hospital, PO Box 180, 00029 HUS Helsinki, Finland
    Br J Cancer 97:1028-34. 2007
    ..We conclude that Lactobacillus GG supplementation is well tolerated and may reduce the frequency of severe diarrhoea and abdominal discomfort related to 5-FU-based chemotherapy...
  86. ncbi A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation
    S M Hongisto
    Valio Ltd, R and D, Helsinki, Finland
    Eur J Clin Nutr 60:319-24. 2006
    ....
  87. ncbi Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial
    N Vendt
    Department of Pediatrics, University of Tartu, Tartu, Estonia
    J Hum Nutr Diet 19:51-8. 2006
    ..The aim of this study was to evaluate the influence of Lactobacillus rhamnosus GG (LGG)-enriched formula on growth and faecal microflora during the first 6 months of life in normal healthy infants...
  88. ncbi Probiotic intervention decreases serum gastrin-17 in Helicobacter pylori infection
    E Myllyluoma
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Dig Liver Dis 39:516-23. 2007
    ..Previously we showed that a probiotic combination with L. rhamnosus GG was beneficial as an adjuvant therapy during H. pylori eradication...
  89. ncbi Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children
    R Korpela
    Department of Anaesthesia and Intensive Care, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Acta Anaesthesiol Scand 51:726-30. 2007
    ..The primary outcome was the requirement of rescue analgesic for post-operative pain and the secondary outcome was post-operative nausea and vomiting (PONV)...
  90. ncbi Removing lactose from milk does not delay bowel function or harden stool consistency in lactose-tolerant women
    S Seppanen
    Department of Applied Chemistry and Microbiology, Nutrition, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 62:727-32. 2008
    ..We also examined how well the participants' subjective evaluation of the stool consistency according to the Bristol Stool Form Scale correlated with values obtained by dry matter analysis and penetrometry...
  91. ncbi Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome
    K Kajander
    Institute of Biomedicine, Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Aliment Pharmacol Ther 26:463-73. 2007
    ..A multispecies probiotic has shown beneficial effects in irritable bowel syndrome. In addition, certain other probiotics have demonstrated advantageous effects, but the mechanisms behind this are poorly understood...
  92. ncbi Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota
    K Kajander
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Aliment Pharmacol Ther 27:48-57. 2008
    ..Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial...
  93. ncbi Effects of Lactobacillus rhamnosus GG and Lactobacillus reuteri R2LC on acetic acid-induced colitis in rats
    R Holma
    Institute of Biomedicine, Dept. of Pharmacology and Toxicology, P.O. Box 63, FIN-00014, University of Helsinki, Finland
    Scand J Gastroenterol 36:630-5. 2001
    ..These results suggest that it is not the total amount of Lactobacillus but the particular species or strain of Lactobacillus that is important in attenuating experimental colitis...