Jing Zou

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. doi request reprint Mitochondria toxin-induced acute cochlear cell death indicates cellular activity-correlated energy consumption
    Jing Zou
    Department of Otolaryngology Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
    Eur Arch Otorhinolaryngol 270:2403-15. 2013
  2. doi request reprint Size-dependent passage of liposome nanocarriers with preserved posttransport integrity across the middle-inner ear barriers in rats
    Jing Zou
    Department of Otolaryngology, University of Tampere Medical School, Tampere, Finland
    Otol Neurotol 33:666-73. 2012
  3. doi request reprint Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    Otol Neurotol 31:637-41. 2010
  4. pmc Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    J Nanobiotechnology 8:32. 2010
  5. doi request reprint MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear
    Jing Zou
    Department of Otolaryngology, University of Tampere, FM1, 3rd Floor, Biokatu 6, 33520 Tampere, Finland
    Nanomedicine (Lond) 5:739-54. 2010
  6. doi request reprint Differential passage of gadolinium through the mouse inner ear barriers evaluated with 4.7T MRI
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, FM1, 3rd Floor, Biokatu 6, 33520 Tampere, Finland
    Hear Res 259:36-43. 2010
  7. doi request reprint Dynamic enhancement of the rat inner ear after ultra-small-volume administration of Gd-DOTA to the medial wall of the middle ear cavity
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    ORL J Otorhinolaryngol Relat Spec 73:275-81. 2011
  8. doi request reprint Biocompatibility of different biopolymers after being implanted into the rat cochlea
    Jing Zou
    Department of Otolaryngology, Medical School, University of Tampere, Tampere, Finland
    Otol Neurotol 29:714-9. 2008
  9. doi request reprint Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation
    Jing Zou
    Department of Otolaryngology, University of Tampere, School of Medicine, 33520 Tampere, Finland
    J Biomed Mater Res B Appl Biomater 87:10-8. 2008
  10. ncbi request reprint Communication between the perilymphatic scalae and spiral ligament visualized by in vivo MRI
    Jing Zou
    Department of Otolaryngology, Tampere University Hospital, Tampere, Finland
    Audiol Neurootol 10:145-52. 2005

Collaborators

Detail Information

Publications35

  1. doi request reprint Mitochondria toxin-induced acute cochlear cell death indicates cellular activity-correlated energy consumption
    Jing Zou
    Department of Otolaryngology Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
    Eur Arch Otorhinolaryngol 270:2403-15. 2013
    ..These results may be relevant to the mechanisms of injury in sudden onset sensorineural hearing loss and hazardous substance exposure-induced hearing loss. ..
  2. doi request reprint Size-dependent passage of liposome nanocarriers with preserved posttransport integrity across the middle-inner ear barriers in rats
    Jing Zou
    Department of Otolaryngology, University of Tampere Medical School, Tampere, Finland
    Otol Neurotol 33:666-73. 2012
    ..The goal of this study was to evaluate the impact of liposome nanocarrier size on the efficacy of its transport across the middle-inner ear barriers...
  3. doi request reprint Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    Otol Neurotol 31:637-41. 2010
    ..To investigate the inner ear uptake of the contrast agent gadolinium administered intratympanically through transtympanic injection or using a gelatin sponge placed on the round window...
  4. pmc Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    J Nanobiotechnology 8:32. 2010
    ..abstract:..
  5. doi request reprint MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear
    Jing Zou
    Department of Otolaryngology, University of Tampere, FM1, 3rd Floor, Biokatu 6, 33520 Tampere, Finland
    Nanomedicine (Lond) 5:739-54. 2010
    ..The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear...
  6. doi request reprint Differential passage of gadolinium through the mouse inner ear barriers evaluated with 4.7T MRI
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, FM1, 3rd Floor, Biokatu 6, 33520 Tampere, Finland
    Hear Res 259:36-43. 2010
    ..The perilymph volume demonstrated by Gd-DOTA uptake was statistically significantly larger in the IV group (1.72mm(3)) than in the IT group (1.28mm(3)) (p<0.05)...
  7. doi request reprint Dynamic enhancement of the rat inner ear after ultra-small-volume administration of Gd-DOTA to the medial wall of the middle ear cavity
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    ORL J Otorhinolaryngol Relat Spec 73:275-81. 2011
    ..To investigate minimally invasive administration of contrast agent to the middle ear and the enhancement efficacy on the inner ear compartments...
  8. doi request reprint Biocompatibility of different biopolymers after being implanted into the rat cochlea
    Jing Zou
    Department of Otolaryngology, Medical School, University of Tampere, Tampere, Finland
    Otol Neurotol 29:714-9. 2008
    ..To assess the biocompatibility of different biopolymers with cochlea implant...
  9. doi request reprint Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation
    Jing Zou
    Department of Otolaryngology, University of Tampere, School of Medicine, 33520 Tampere, Finland
    J Biomed Mater Res B Appl Biomater 87:10-8. 2008
    ..Nuclear localization was detected in the spiral ganglion, though infrequently. These results suggest that LNCs are potential vectors for drug delivery into the spiral ganglion cells, nerve fibers, hair cells, and spiral ligament...
  10. ncbi request reprint Communication between the perilymphatic scalae and spiral ligament visualized by in vivo MRI
    Jing Zou
    Department of Otolaryngology, Tampere University Hospital, Tampere, Finland
    Audiol Neurootol 10:145-52. 2005
    ..After 12 h the apex did still not show any uptake. Gd-DTPA-BMA is transported from the RW to the semicircular canal, the scala tympani and scala vestibuli without passing the helicotrema...
  11. ncbi request reprint In vivo observation of dynamic perilymph formation using 4.7 T MRI with gadolinium as a tracer
    Jing Zou
    Department of Otolaryngology, Tampere University Hospital, Tampere, Finland
    Acta Otolaryngol 123:910-5. 2003
    ..To investigate the pharmacokinetics of gadolinium in the perilymphatic fluid spaces of the cochlea in vivo using high-resolution MRI to obtain information concerning perilymph formation...
  12. ncbi request reprint Vibration induced hearing loss in guinea pig cochlea: expression of TNF-alpha and VEGF
    Jing Zou
    Department of Otolaryngology, Tampere University Hospital, Finland
    Hear Res 202:13-20. 2005
    ..Also VEGF and VEGF R2 are up-regulated. These responses may be linked to both the damage and repair process of the cochlea...
  13. pmc Nuclear entry of hyperbranched polylysine nanoparticles into cochlear cells
    Weikai Zhang
    Department of Otolaryngology, University of Tampere, Medical School, Finland
    Int J Nanomedicine 6:535-46. 2011
    ..This study aimed to investigate the potential nuclear entry of hyperbranched polylysine nanoparticles (HPNPs) for gene delivery to cochlear targets...
  14. pmc Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
    Ya Zhang
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    Int J Nanomedicine 7:1015-22. 2012
    ..Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection...
  15. doi request reprint Visualization of intracellular trafficking of Math1 protein in different cell types with a newly-constructed nonviral gene delivery plasmid
    Weikai Zhang
    Department of Otolaryngology, University of Tampere, Tampere, Finland
    J Gene Med 13:134-44. 2011
    ..The present study aimed to construct the pCDNA6.2/C-EmGFP-Math1 plasmid and evaluate its transfection efficiency and intracellular trafficking of Math1 protein corresponding to transcription regulation function...
  16. doi request reprint Inner ear biocompatibility of lipid nanocapsules after round window membrane application
    Ya Zhang
    Department of Otolaryngology, University of Tampere, Medical School, FM1, 3rd Floor, Biokatu 6, 33520 Tampere, Finland
    Int J Pharm 404:211-9. 2011
    ..LNCs are potential vectors for the delivery of drugs to the inner ear...
  17. doi request reprint Nanoparticle-based delivery for the treatment of inner ear disorders
    Ilmari Pyykko
    Department of Otolaryngology, University of Tampere Medical School, Tampere, Finland
    Curr Opin Otolaryngol Head Neck Surg 19:388-96. 2011
    ....
  18. doi request reprint Vestibular dysfunction in vitamin D receptor mutant mice
    Anna Minasyan
    Department of Anatomy, Medical School, University of Tampere, Finland
    J Steroid Biochem Mol Biol 114:161-6. 2009
    ..These data suggest that VDR deficiency in mice is associated with decreased balance function, and may be relevant to poorer balance/posture control in humans with low levels of vitamin D...
  19. doi request reprint Prestin binding peptides as ligands for targeted polymersome mediated drug delivery to outer hair cells in the inner ear
    Elena V Surovtseva
    Department of Otolaryngology, University of Tampere, Tampere, Finland
    Int J Pharm 424:121-7. 2012
    ..PEG6K-b-PCL19K polymersomes covalently labelled with these peptides demonstrated effective targeting to outer hair cells in a rat cochlear explant study...
  20. doi request reprint Comparison of the distribution pattern of PEG-b-PCL polymersomes delivered into the rat inner ear via different methods
    Ya Zhang
    Department of Otolaryngology, University of Tampere, Medical School and University Hospital of Tampere, Finland
    Acta Otolaryngol 131:1249-56. 2011
    ..Cochleostomy is the most efficient approach in delivering PEG-b-PCL polymersomes (PMs) to the inner ear. PMs can be delivered to the vestibule by transtympanic injection or cochleostomy...
  21. doi request reprint Transport augmentation through the blood-inner ear barriers of guinea pigs treated with 3-nitropropionic acid and patients with acute hearing loss, visualized with 3.0 T MRI
    Jing Zou
    Department of Otolaryngology Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People s Republic of China
    Otol Neurotol 32:204-12. 2011
    ..To visualize the permeability changes in the blood-inner ear barriers of guinea pigs with acute mitochondria dysfunction and in patients with acute hearing loss using contrast agent-enhanced MRI...
  22. ncbi request reprint Oval window transport of Gd-dOTA from rat middle ear to vestibulum and scala vestibuli visualized by in vivo magnetic resonance imaging
    Jing Zou
    Department of Otolaryngology, University of Tampere Medical School, 33520 Tampere, Finland
    Ann Otol Rhinol Laryngol 121:119-28. 2012
    ..We tested our hypothesis that the oval window (OW) potentially functions as a route to carry substances from the middle ear to the vestibulum and then the scala vestibuli through the annular ligament across the stapediovestibular joint...
  23. doi request reprint Magnetic resonance imaging of the inner ear in Meniere's disease
    Ilmari Pyykko
    Department of Otolaryngology, University of Tampere, Teiskontie 35, 33520, Tampere, Finland
    Otolaryngol Clin North Am 43:1059-80. 2010
    ..In almost all patients with probable or suspected Ménière's disease, EH was verified. Specific algorithms with a 12-pole coil using fluid attenuation inversion recovery sequences are recommended for initial imaging in humans...
  24. doi request reprint Premature aging in vitamin D receptor mutant mice
    Tiina Keisala
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    J Steroid Biochem Mol Biol 115:91-7. 2009
    ....
  25. ncbi request reprint Vibration-induced hearing loss: mechanical and physiological aspects
    Paivi Sutinen
    Department of Otolaryngology, Tampere University Hospital, Tampere, Finland
    Otol Neurotol 28:171-7. 2007
    ..The sensorineural hearing loss (HL) after middle ear surgery has been explained by the noise generated by drilling, without considering the vibration generated by the burr...
  26. doi request reprint Improving the visualization of fluorescently tagged nanoparticles and fluorophore-labeled molecular probes by treatment with CuSO(4) to quench autofluorescence in the rat inner ear
    Ya Zhang
    Department of Otolaryngology, University of Tampere, Tampere, Finland
    Hear Res 269:1-11. 2010
    ..01 M ammonium acetate buffer) for 70-90 min, while the fluorescent tag in the nanoparticle was absolutely preserved and the labeling fluorescence signals of the molecular probes were mostly retained...
  27. doi request reprint Progressive hearing loss in mice with a mutated vitamin D receptor gene
    Jing Zou
    Department of Otolaryngology, School of Medicine, University of Tampere, Tampere, Finland
    Audiol Neurootol 13:219-30. 2008
    ..Hormonal forms of vitamin D regulate transcription by binding with the high-affinity vitamin D receptor (VDR)...
  28. ncbi request reprint Comparison of the protective efficacy of neurotrophins and antioxidants for vibration-induced trauma
    Jing Zou
    Department of Otolaryngology, Tampere University Hospital, Teiskontie 35, FI 33521 Tampere, Finland
    ORL J Otorhinolaryngol Relat Spec 65:155-61. 2003
    ..The aim of this study was to characterize the effects of pretreatment with N-acetylcysteine (NAC) or the neurotrophic factors, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), on VHL in an animal model...
  29. doi request reprint Mitochondrial dysfunction disrupts trafficking of Kir4.1 in spiral ganglion satellite cells
    Jing Zou
    Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Neurosci Res 87:141-9. 2009
    ..Kir4.1 failed to reach the perineural cytoplasm of the satellite cells after 3-NP treatment. The results of this study suggest that mitochondrial dysfunction disrupts trafficking of Kir4.1 in spiral ganglion satellite cells...
  30. ncbi request reprint Compensative shuttling of merlin to phosphorylation on serine 518 in vestibular schwannoma
    Jingrong Lü
    Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Laryngoscope 118:169-74. 2008
    ..Therefore, we sought to detect the expression of endogenous merlin and its subcellular distribution using cyclin D1 as a cell cycle marker in VS...
  31. pmc Low-frequency sound pressure and transtympanic endoscopy of the middle ear in assessment of "spontaneous" perilymphatic fistula
    Ilmari Pyykko
    Department of Otolaryngology, University Hospital of Tampere, University of Tampere, Teiskontie 35, 33521 Tampere, Finland
    ISRN Otolaryngol 2012:137623. 2012
    ..No permanent tympanic membrane perforation occurred. It is unlikely that disease entity of "spontaneous PLF" exists. Tympanoscopy should be regarded as the first choice when a PLF is suspected...
  32. ncbi request reprint In vivo visualization of endolymphatic hydrops in guinea pigs: magnetic resonance imaging evaluation at 4.7 tesla
    Jing Zou
    Department of Otolaryngology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
    Ann Otol Rhinol Laryngol 112:1059-65. 2003
    ..Damage to the inner ear barrier or possible rupture of membranes can be shown with the assistance of Gd-DTPA-BMA...
  33. ncbi request reprint 3D MRI of the in vivo vestibulo-cochlea labyrinth during Gd-DTPA-BMA uptake
    S Allen Counter
    Neurology Department, Harvard Medical School, Massachusetts General Hospital, Harvard University Biological Laboratories, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuroreport 14:1707-12. 2003
    ..The findings demonstrate that Gd-enhanced 3D MRI of the perilymphatic space may be used to examine the morphology, kinetics and intravenous substance delivery in the in vivo mammalian vestibulo-cochlea labyrinth...
  34. pmc Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI
    Xin Yu
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Neuroimage 39:223-30. 2008
    ..This represents a significant advance in the development of MEMRI for quantitative and unbiased analysis of brain function in the deep brain nuclei of mice...
  35. ncbi request reprint In vivo visualization of endolymphatic hydrops in guinea pigs: magnetic resonance imaging evaluation at 4.7 tesla
    Jing Zou
    Ann Otol Rhinol Laryngol 114:738. 2005