Marjo Yliperttula

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Computational prediction of oral drug absorption based on absorption rate constants in humans
    Johanna Linnankoski
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Med Chem 49:3674-81. 2006
  2. doi request reprint High-throughput screening of cell responses to biomaterials
    Marjo Yliperttula
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Eur J Pharm Sci 35:151-60. 2008
  3. doi request reprint Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6
    Anne Soikkeli
    Division of Pharmaceutical Technology, University of Helsinki, Viikinkaari 5E, Helsinki, Finland
    Assay Drug Dev Technol 9:496-502. 2011
  4. doi request reprint A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability
    Leena Stiina Kontturi
    Centre for Drug Research, University of Helsinki, Finland
    J Control Release 152:376-81. 2011
  5. doi request reprint Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid
    Tiina Heikkilä
    Division of Pharmaceutical Technology, University of Helsinki, P O Box 56 Viikinkaari 5E, 00014 University of Helsinki, Finland
    Int J Pharm 405:132-6. 2011
  6. doi request reprint Feasibility evaluation of 3 automated cellular drug screening assays on a robotic workstation
    Anne Soikkeli
    Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland
    J Biomol Screen 15:30-41. 2010
  7. doi request reprint Passive oral drug absorption can be predicted more reliably by experimental than computational models--fact or myth
    Johanna Linnankoski
    Drug Discovery and Development Technology Center, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    Eur J Pharm Sci 34:129-39. 2008
  8. ncbi request reprint Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy
    Jonna Wikström
    Drug Discovery and Development Technology Center, University of Helsinki, P O Box 56, Helsinki 00014, Finland
    Biomaterials 29:869-76. 2008
  9. ncbi request reprint Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release
    Lauri Paasonen
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Bioconjug Chem 18:2131-6. 2007
  10. ncbi request reprint Gold nanoparticles enable selective light-induced contents release from liposomes
    Lauri Paasonen
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    J Control Release 122:86-93. 2007

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Computational prediction of oral drug absorption based on absorption rate constants in humans
    Johanna Linnankoski
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Med Chem 49:3674-81. 2006
    ..Thus, it was shown that, using a combination of only two computational molecular descriptors, it is possible to predict with good accuracy the K(a) value for a new drug candidate...
  2. doi request reprint High-throughput screening of cell responses to biomaterials
    Marjo Yliperttula
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Eur J Pharm Sci 35:151-60. 2008
    ..This is highly important, because predictive pre-clinical methods are needed to improve the high attrition rate of drug candidates during clinical testing...
  3. doi request reprint Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6
    Anne Soikkeli
    Division of Pharmaceutical Technology, University of Helsinki, Viikinkaari 5E, Helsinki, Finland
    Assay Drug Dev Technol 9:496-502. 2011
    ..Further, the results gained with the high-throughput screening assay correlated well with the results obtained, in parallel, with the reference high-performance liquid chromatography method...
  4. doi request reprint A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability
    Leena Stiina Kontturi
    Centre for Drug Research, University of Helsinki, Finland
    J Control Release 152:376-81. 2011
    ..The cells remained viable in alginate-poly-L-lysine-alginate microcapsules and secreted sVEGFR1 for prolonged periods...
  5. doi request reprint Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid
    Tiina Heikkilä
    Division of Pharmaceutical Technology, University of Helsinki, P O Box 56 Viikinkaari 5E, 00014 University of Helsinki, Finland
    Int J Pharm 405:132-6. 2011
    ..The new 96-well plate method is useful for the screening of equilibrium drug solubility during the drug discovery process and it also allows the use of human intestinal fluid in solubility screening...
  6. doi request reprint Feasibility evaluation of 3 automated cellular drug screening assays on a robotic workstation
    Anne Soikkeli
    Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland
    J Biomol Screen 15:30-41. 2010
    ..5, S/B 8.6). Of the assays, the homogeneous Caspase-Glo 3/7 assay benefits the most from automation, but also the heterogeneous SRB assay and Caco-2 permeability experiments gain advantages from automation...
  7. doi request reprint Passive oral drug absorption can be predicted more reliably by experimental than computational models--fact or myth
    Johanna Linnankoski
    Drug Discovery and Development Technology Center, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    Eur J Pharm Sci 34:129-39. 2008
    ....
  8. ncbi request reprint Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy
    Jonna Wikström
    Drug Discovery and Development Technology Center, University of Helsinki, P O Box 56, Helsinki 00014, Finland
    Biomaterials 29:869-76. 2008
    ..ARPE-19 cells show long-term viability and protein secretion within alginate microcapsules cross-linked with Ca(2+) and Ba(2+). This combination may be useful in cell therapy...
  9. ncbi request reprint Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release
    Lauri Paasonen
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Bioconjug Chem 18:2131-6. 2007
    ..This study demonstrates that liposomes surface-modified with HPMA mono/dilactate copolymer are attractive systems for achieving temperature-triggered contents release...
  10. ncbi request reprint Gold nanoparticles enable selective light-induced contents release from liposomes
    Lauri Paasonen
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    J Control Release 122:86-93. 2007
    ..The triggered contents release could also be extended to other applications where local contents release is needed...
  11. pmc Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channels
    Amir Manbachi
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA
    Lab Chip 8:747-54. 2008
    ..Therefore, our studies suggest that microscale shear stresses greatly influence cellular docking, immobilization, and retention in fluidic systems and should be considered for the design of cell-based microdevices...
  12. ncbi request reprint Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studies
    Lauri Paasonen
    University of Kuopio, Department of Pharmaceutics, FIN 70211 Kuopio, Finland
    Int J Pharm 307:188-93. 2006
    ..Liposomal pre-treatment of the stratum corneum augments transfection of viable epidermis...
  13. doi request reprint Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
    Eva M Del Amo
    Centre for Drug Research, University of Helsinki, Helsinki, Finland
    Eur J Pharm Sci 35:161-74. 2008
    ..This review presents the current functional knowledge on LAT1 and LAT2 with emphasis on their potential involvement in pharmacokinetics...