Affiliation: University of Helsinki
- Computational prediction of oral drug absorption based on absorption rate constants in humansJohanna Linnankoski
Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
J Med Chem 49:3674-81. 2006..Thus, it was shown that, using a combination of only two computational molecular descriptors, it is possible to predict with good accuracy the K(a) value for a new drug candidate...
- High-throughput screening of cell responses to biomaterialsMarjo Yliperttula
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Eur J Pharm Sci 35:151-60. 2008..This is highly important, because predictive pre-clinical methods are needed to improve the high attrition rate of drug candidates during clinical testing...
- Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6Anne Soikkeli
Division of Pharmaceutical Technology, University of Helsinki, Viikinkaari 5E, Helsinki, Finland
Assay Drug Dev Technol 9:496-502. 2011..Further, the results gained with the high-throughput screening assay correlated well with the results obtained, in parallel, with the reference high-performance liquid chromatography method...
- A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viabilityLeena Stiina Kontturi
Centre for Drug Research, University of Helsinki, Finland
J Control Release 152:376-81. 2011..The cells remained viable in alginate-poly-L-lysine-alginate microcapsules and secreted sVEGFR1 for prolonged periods...
- Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluidTiina Heikkilä
Division of Pharmaceutical Technology, University of Helsinki, P O Box 56 Viikinkaari 5E, 00014 University of Helsinki, Finland
Int J Pharm 405:132-6. 2011..The new 96-well plate method is useful for the screening of equilibrium drug solubility during the drug discovery process and it also allows the use of human intestinal fluid in solubility screening...
- Feasibility evaluation of 3 automated cellular drug screening assays on a robotic workstationAnne Soikkeli
Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland
J Biomol Screen 15:30-41. 2010..5, S/B 8.6). Of the assays, the homogeneous Caspase-Glo 3/7 assay benefits the most from automation, but also the heterogeneous SRB assay and Caco-2 permeability experiments gain advantages from automation...
- Passive oral drug absorption can be predicted more reliably by experimental than computational models--fact or mythJohanna Linnankoski
Drug Discovery and Development Technology Center, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
Eur J Pharm Sci 34:129-39. 2008....
- Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapyJonna Wikström
Drug Discovery and Development Technology Center, University of Helsinki, P O Box 56, Helsinki 00014, Finland
Biomaterials 29:869-76. 2008..ARPE-19 cells show long-term viability and protein secretion within alginate microcapsules cross-linked with Ca(2+) and Ba(2+). This combination may be useful in cell therapy...
- Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents releaseLauri Paasonen
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
Bioconjug Chem 18:2131-6. 2007..This study demonstrates that liposomes surface-modified with HPMA mono/dilactate copolymer are attractive systems for achieving temperature-triggered contents release...
- Gold nanoparticles enable selective light-induced contents release from liposomesLauri Paasonen
Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
J Control Release 122:86-93. 2007..The triggered contents release could also be extended to other applications where local contents release is needed...
- Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channelsAmir Manbachi
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA
Lab Chip 8:747-54. 2008..Therefore, our studies suggest that microscale shear stresses greatly influence cellular docking, immobilization, and retention in fluidic systems and should be considered for the design of cell-based microdevices...
- Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studiesLauri Paasonen
University of Kuopio, Department of Pharmaceutics, FIN 70211 Kuopio, Finland
Int J Pharm 307:188-93. 2006..Liposomal pre-treatment of the stratum corneum augments transfection of viable epidermis...
- Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2Eva M Del Amo
Centre for Drug Research, University of Helsinki, Helsinki, Finland
Eur J Pharm Sci 35:161-74. 2008..This review presents the current functional knowledge on LAT1 and LAT2 with emphasis on their potential involvement in pharmacokinetics...