Research Topics
Genomes and Genes
Species | J YlikoskiSummaryAffiliation: University of Helsinki Country: Finland Publications
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Detail Information
Publications
Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise traumaJ Ylikoski
Department of ORL, University of Helsinki, Finland
Hear Res 124:17-26. 1998....- Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell deathJukka Ylikoski
Institute of Biotechnology, University of Helsinki, Finland
Hear Res 166:33-43. 2002..Thus, our results imply that activation of JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia and that attenuation of the lesion can be provided by inhibiting JNK activation... - Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell deathJukka Ylikoski
Institute of Biotechnology, University of Helsinki, Finland
Hear Res 163:71-81. 2002..These results suggest that activation of the JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia, and that attenuation of the lesion can be provided by inhibiting JNK activation... - Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activationU Pirvola
Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland
J Neurosci 20:43-50. 2000..These results suggest that therapeutic intervention in the JNK signaling cascade, possibly by using CEP-1347, may offer opportunities to treat inner ear injuries... 
The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner earJohanna Mantela
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Development 132:2377-88. 2005..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia...- Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: intracochlear GDNF treatment reduces the number of apoptotic cellsA A Aarnisalo
Department of Otolaryngology, University of Helsinki, Finland
ORL J Otorhinolaryngol Relat Spec 62:330-4. 2000..This can be prevented partially by rescuing primary cochlear neurons from degeneration with local GDNF treatment... - Clinically applicable multiplex PCR for four middle ear pathogensP H Hendolin
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
J Clin Microbiol 38:125-32. 2000..001). The LDR was found to be 100% specific. In all, the results demonstrate the feasibility of the rapid (7-h) multiplex PCR method for routine laboratory use... - High incidence of Alloiococcus otitis in otitis media with effusionP H Hendolin
Institute of Biotechnology, University of Helsinki, Finland
Pediatr Infect Dis J 18:860-5. 1999..The etiology of otitis media with effusion (OME) is unclear. Although the majority of effusions show inflammation, culture methods yield positive results for bacteria in only 20 to 30% of cases... - Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactionsUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 273:350-60. 2004..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis... 
Hypertonic saline injections to enhance the radiofrequency thermal ablation effect in the treatment of base of tongue in obstructive sleep apnoea patients: a pilot studyLeif J J Bäck
Department of Otorhinolaryngology Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland
Acta Otolaryngol 129:302-10. 2009..No significant changes in the measured parameters were encountered, although, several of them showed a clear trend. New treatment modalities are needed to keep multilevel RFA treatment as a minimally invasive procedure...- Radiofrequency surgery of the soft palate in the treatment of mild obstructive sleep apnea is not effective as a single-stage procedure: A randomized single-blinded placebo-controlled trialLeif J J Bäck
Department of Otorhinolaryngology, Finland
Laryngoscope 119:1621-7. 2009..Due to its minimally invasive character, it has received attention in the management of mild obstructive sleep apnea syndrome (OSAS)... - The ototoxic interaction of styrene and noiseAntti A Makitie
Department of Otorhinolaryngology, Helsinki University Central Hospital, P O Box 220, 00029 HUCH, Helsinki, Finland
Hear Res 179:9-20. 2003..We conclude that: (1) There is an ototoxic interaction between styrene and noise. (2) Synergism is manifested only if styrene is applied in concentrations above the critical level (between 300 and 600 ppm in this study)... - FGFR1 is required for the development of the auditory sensory epitheliumUlla Pirvola
Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
Neuron 35:671-80. 2002..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium... - Complication rates of radiofrequency surgery in the upper airways: a single institution experienceLeif J J Bäck
Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland
Acta Otolaryngol 129:1469-73. 2009..Radiofrequency (RF) surgery of the upper airways appears to be a safe procedure with an acceptable incidence of minor and moderate complications... - Assessment of submucosal radiofrequency tonsil reduction by magnetic resonance imagingLeif Back
Department of Otorhinolaryngology Head and Neck Surgery, Helsinki University Central Hospital, FIN 00029 HUCH, Helsinki, Finland
J Otolaryngol Head Neck Surg 38:537-44. 2009..The primary objective was to assess the efficacy of submucosal radiofrequency tonsil reduction (SRFTR) in adults by magnetic resonance imaging (MRI). The secondary objective was to evaluate the morbidity of SRFTR... - FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisU Pirvola
Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 20:6125-34. 2000..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear... - p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosisHeidi Laine
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 27:1434-44. 2007.... - Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 inductionMarilin Sulg
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
J Neurochem 112:1513-26. 2010..These data have important clinical implications as they show the importance of p53 in sensory cells that are essential in hearing function... - Hyperbaric oxygen therapy seems to enhance recovery from acute acoustic traumaJ Ylikoski
Helsinki Ear Institute and Department of Otolaryngology, University of Helsinki, Helsinki, Finland
Acta Otolaryngol 128:1110-5. 2008..HBOT can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT)... - Characteristics of acute acoustical trauma in the Finnish Defence ForcesRoderik Mrena
Department of ORL, Helsinki University Central Hospital, HUS, Finland
Int J Audiol 43:177-81. 2004..7% of conscripts had hearing impairment and 94.2% tinnitus. Hearing loss, tinnitus or both were experienced by 45% of conscripts at the last follow-up. Careful planning of training exercises could probably prevent some but not all AATs... - Occupational noise-induced hearing loss reports and tinnitus in FinlandRoderik Mrena
Department of ORL, Helsinki University Central Hospital, Helsinki, Finland
Acta Otolaryngol 127:729-35. 2007..In occupational noise-induced hearing loss (NIHL) reports, many tinnitus sufferers probably remain undetected and untreated at present. Attention should be focused on tinnitus, as well as threshold shifts resulting from NIHL... - Neurotrophic factors during inner ear developmentUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Curr Top Dev Biol 57:207-23. 2003 - Functional and morphological effects of styrene on the auditory system of the ratAntti Mäkitie
Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, PO Box 220, 00029 HUCH, Helsinki, Finland
Arch Toxicol 76:40-7. 2002..We conclude that there appears to be a concentration threshold for styrene ototoxicity in rats (between 300 and 600 ppm)... - High incidence of Alloiococcus otitidis in children with otitis media, despite treatment with antibioticsAtsushi Harimaya
Department of Otolaryngology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
J Clin Microbiol 44:946-9. 2006..Our study suggests that antibiotics such as beta-lactams or erythromycin may not be sufficiently effective to eliminate this organism. Further investigation is expected to reveal the clinical role of the organism in otitis media... - On prediction of hearing recovery after acute acoustic trauma caused by impulse noiseOlli Iltanen
Department of Computer and Information Sciences, 33014 University of Tampere, Finland
Stud Health Technol Inform 90:661-4. 2002..However, more data will be acquired later in order to elaborate the research more widely by using other methods also... - Characteristics of tinnitus induced by acute acoustic trauma: a long-term follow-upRoderik Mrena
Central Hospital of Central Finland, Jyvaskyla, Finland
Audiol Neurootol 7:122-30. 2002..The effects of AAT and possible compensation have been evaluated so far mostly by audiometric findings, but in some cases tinnitus may be an even more serious threat to life satisfaction than mild hearing impairment...