Hannele Yki-Jarvinen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Curr Opin Clin Nutr Metab Care 13:709-14. 2010
  2. ncbi request reprint The fatty liver and insulin resistance
    H Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki Finland
    Curr Mol Med 5:287-95. 2005
  3. pmc Effects of adding linagliptin to basal insulin regimen for inadequately controlled type 2 diabetes: a ≥52-week randomized, double-blind study
    Hannele Yki-Jarvinen
    Corresponding author Hannele Yki Järvinen
    Diabetes Care 36:3875-81. 2013
  4. pmc Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
    Maria Kolak
    Atherosclerosis Research Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Lipids Health Dis 11:115. 2012
  5. ncbi request reprint Insulin therapy in type 2 diabetes: role of the long-acting insulin glargine analogue
    H Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Eur J Clin Invest 34:410-6. 2004
  6. doi request reprint Liver fat in the pathogenesis of insulin resistance and type 2 diabetes
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Dig Dis 28:203-9. 2010
  7. ncbi request reprint Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups
    Hannele Yki-Jarvinen
    University of Helsinki, Helsinki, Finland
    Diabetes Care 30:1364-9. 2007
  8. ncbi request reprint Thiazolidinediones
    Hannele Yki-Jarvinen
    Division of Diabetes, Department of Medicine, University of Helsinki, Finland
    N Engl J Med 351:1106-18. 2004
  9. ncbi request reprint Insulin resistance, arterial stiffness and wave reflection
    Hannele Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Adv Cardiol 44:252-60. 2007
  10. ncbi request reprint Fat in the liver and insulin resistance
    Hannele Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Ann Med 37:347-56. 2005

Detail Information

Publications89

  1. doi request reprint Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Curr Opin Clin Nutr Metab Care 13:709-14. 2010
    ..NAFLD predicts, independent of obesity, the metabolic syndrome and type 2 diabetes and can progress to cirrhosis. This review focuses on studies in humans addressing effects of dietary changes in NAFLD...
  2. ncbi request reprint The fatty liver and insulin resistance
    H Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki Finland
    Curr Mol Med 5:287-95. 2005
    ..The fatty liver thus may help to explain why some but not all obese individuals are insulin resistant and why even lean individuals may be insulin resistant, and thereby at risk of developing type 2 diabetes and cardiovascular disease...
  3. pmc Effects of adding linagliptin to basal insulin regimen for inadequately controlled type 2 diabetes: a ≥52-week randomized, double-blind study
    Hannele Yki-Jarvinen
    Corresponding author Hannele Yki Järvinen
    Diabetes Care 36:3875-81. 2013
    ..To evaluate the efficacy and long-term safety of linagliptin added to basal insulins in type 2 diabetes inadequately controlled on basal insulin with or without oral agents...
  4. pmc Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
    Maria Kolak
    Atherosclerosis Research Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Lipids Health Dis 11:115. 2012
    ..The present study characterises enzymes involved in ceramide metabolism in subcutaneous and intra-abdominal adipose tissue...
  5. ncbi request reprint Insulin therapy in type 2 diabetes: role of the long-acting insulin glargine analogue
    H Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Eur J Clin Invest 34:410-6. 2004
    ..These data support use of insulin glargine instead of NPH insulin for basal insulin replacement in patients with type 2 diabetes...
  6. doi request reprint Liver fat in the pathogenesis of insulin resistance and type 2 diabetes
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Dig Dis 28:203-9. 2010
    ..In subjects who cannot sustain hyperinsulinemia to maintain glucose concentrations in the nondiabetic range, overt hyperglycemia, i.e. type 2 diabetes, develops...
  7. ncbi request reprint Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups
    Hannele Yki-Jarvinen
    University of Helsinki, Helsinki, Finland
    Diabetes Care 30:1364-9. 2007
    ..Insulin is often postponed for years because initiation is time-consuming. We sought to compare initiation of insulin individually and in groups with respect to change in A1C and several other parameters in type 2 diabetic patients...
  8. ncbi request reprint Thiazolidinediones
    Hannele Yki-Jarvinen
    Division of Diabetes, Department of Medicine, University of Helsinki, Finland
    N Engl J Med 351:1106-18. 2004
  9. ncbi request reprint Insulin resistance, arterial stiffness and wave reflection
    Hannele Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Adv Cardiol 44:252-60. 2007
    ..In insulin-resistant subjects, this effect of insulin is blunted implying that insulin resistance involves also large arteries. This may provide one mechanism linking insulin resistance and cardiovascular disease...
  10. ncbi request reprint Fat in the liver and insulin resistance
    Hannele Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Ann Med 37:347-56. 2005
    ..The fatty liver may help to explain why some but not all obese individuals are insulin resistant and why even lean individuals may be insulin resistant, and thereby at risk of developing type 2 diabetes and cardiovascular disease...
  11. ncbi request reprint Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study
    H Yki-Jarvinen
    Department of Medicine, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    Diabetologia 49:442-51. 2006
    ..The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia...
  12. doi request reprint Thiazolidinediones and the liver in humans
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Curr Opin Lipidol 20:477-83. 2009
    ..To review recent advances in the understanding of the mechanism of action of thiazolidinediones (TZDs) in humans...
  13. ncbi request reprint Combination therapy with insulin and oral agents: optimizing glycemic control in patients with type 2 diabetes mellitus
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Finland
    Diabetes Metab Res Rev 18:S77-81. 2002
    ....
  14. ncbi request reprint Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes
    Mirja Tiikkainen
    Division of Diabetes, Department of Oncology, University of Helsinki, FIN 00029 HUCH, Helsinki, Finland
    Obes Res 10:859-67. 2002
    ..We determined whether fat accumulation in the liver is associated with features of insulin resistance independent of obesity...
  15. ncbi request reprint Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy
    Hannele Yki-Jarvinen
    Department of Medicine, Helsinki University Central Hospital, PO Box 348, FIN 00029 HUS, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 23:688-94. 2003
    ..We determined whether (1). plasma PAI-1 antigen concentrations are related to liver fat content (LFAT) independently of the size of other fat depots and (2) rosiglitazone decreases PAI-1 and LFAT in these patients...
  16. ncbi request reprint Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy
    Jussi Sutinen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    J Clin Endocrinol Metab 88:1907-10. 2003
    ..These data suggest that the decreased production of adiponectin in lipoatrophic adipose tissue may contribute to hepatic insulin resistance in these patients...
  17. ncbi request reprint Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins
    Kirsi Hannele Pietiläinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Am J Physiol Endocrinol Metab 288:E768-74. 2005
    ..55, P = 0.015) but not liver (r = -0.20, P = 0.20) fat. We conclude that acquired obesity is associated with increases in intra-abdominal and liver fat and insulin resistance, independent of genetic factors...
  18. doi request reprint Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease
    Jenni Hyysalo
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Finland
    J Gastroenterol Hepatol 27:951-6. 2012
    ..Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort...
  19. doi request reprint Obesity-related derangements of coagulation and fibrinolysis: a study of obesity-discordant monozygotic twin pairs
    Sanna M Kaye
    Obesity Research Unit, Department of Medicine, Division of Internal Medicine and Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Obesity (Silver Spring) 20:88-94. 2012
    ..This study confirms the mechanisms of simultaneous activities of intrinsic coagulation factors and impaired fibrinolysis predisposing obese subjects to thrombosis...
  20. ncbi request reprint Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content
    Mirja Tiikkainen
    Department of Medicine, Division of Diabetes, University of Helsinki, FIN 00029 HUCH, Helsinki, Finland
    Diabetes 52:701-7. 2003
    ..These data suggest that LFAT is regulated by factors other than intra-abdominal and subcutaneous fat. Therefore, LFAT does not appear to simply reflect the size of endogenous fat stores...
  21. ncbi request reprint Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study
    Jussi Sutinen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Antivir Ther 8:199-207. 2003
    ..Rosiglitazone unexpectedly caused significant increases in serum triglyceride and cholesterol concentrations, which must be carefully monitored if glitazones are used in these patients...
  22. ncbi request reprint Effects of acquired obesity on endothelial function in monozygotic twins
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry Helsinki University Central Hospital, Helsinki, Finland
    Obesity (Silver Spring) 14:826-37. 2006
    ....
  23. ncbi request reprint Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    Mirja Tiikkainen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Diabetes 53:2169-76. 2004
    ..The decrease in liver fat by rosiglitazone is associated with an increase in serum adiponectin concentrations. Both agents increase hepatic insulin sensitivity, but only rosiglitazone increases peripheral glucose uptake...
  24. ncbi request reprint Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes
    Robert Bergholm
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetes Care 26:1667-72. 2003
    ..i.d., n = 23) and placebo (n = 24) on in vivo endothelial function in a high-risk group of obese (BMI 32.1 +/- 0.4 kg/m(2)) premenopausal nondiabetic women with a history of gestational diabetes...
  25. ncbi request reprint Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy
    Jussi Sutinen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Finland
    AIDS 16:2183-93. 2002
    ..To determine liver fat content in patients with highly active antiretroviral therapy (HAART)-associated lipodystrophy...
  26. ncbi request reprint Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
    Ksenia Sevastianova
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    Am J Clin Nutr 96:727-34. 2012
    ..Cross-sectional studies have identified a high intake of simple sugars as an important dietary factor predicting nonalcoholic fatty liver disease (NAFLD)...
  27. doi request reprint Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity
    Jenni Hyysalo
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Diabetes 63:312-22. 2014
    ..Obese NAFLD' is associated with multiple changes in TAGs, which can be attributed to obesity/insulin resistance rather than increased liver fat content per se. ..
  28. ncbi request reprint Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes
    Leena Juurinen
    Department of Medicine, Helsinki University of Technology, Finland
    Am J Physiol Endocrinol Metab 292:E829-35. 2007
    ..Conclusions: insulin therapy improves hepatic insulin sensitivity and slightly but significantly reduces liver fat content, independent of serum adiponectin...
  29. ncbi request reprint Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects
    Anna Kotronen
    Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetes Care 31:165-9. 2008
    ....
  30. pmc Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Med 5:e51. 2008
    ..The goal of this study was to investigate this important acquired component and expose obesity-induced changes in biological pathways in an identical genetic background...
  31. doi request reprint Comparison of the relative contributions of intra-abdominal and liver fat to components of the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 19:23-8. 2011
    ....
  32. doi request reprint Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype
    Elina M Petäjä
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    Obesity (Silver Spring) 21:1174-9. 2013
    ....
  33. ncbi request reprint Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses
    Leena Juurinen
    Department of Medicine, Division of Diabetes, University of Helsinki, PO Box 700, Room C418B, FIN 00029 HUCH Helsinki, Finland
    J Clin Endocrinol Metab 93:118-24. 2008
    ..Peroxisome proliferator-activated receptor (PPAR)-gamma agonists reduce liver fat. We therefore hypothesized that type 2 diabetic patients using exceptionally high doses of insulin might respond well to addition of a PPARgamma agonist...
  34. ncbi request reprint Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women
    Mirja Tiikkainen
    Division of Diabetes, Department of Medicine, University of Helsinki, Finland
    Am J Clin Nutr 79:22-30. 2004
    ..Dietary fat has been reported to influence insulin sensitivity...
  35. ncbi request reprint 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes
    Satu Vehkavaara
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 24:325-30. 2004
    ..To determine long-term effects of insulin glargine on vascular function in patients with type 2 diabetes...
  36. ncbi request reprint Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 700, Room C418B, FIN 00029 HUCH, Helsinki, Finland
    Diabetes 56:2759-65. 2007
    ..The objective of this study is to quantitate expression of genes possibly contributing to insulin resistance and fat deposition in the human liver...
  37. doi request reprint Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans
    Ksenia Sevastianova
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    Am J Clin Nutr 94:104-11. 2011
    ..The I148M mutation impedes triglyceride hydrolysis in vitro, and its carriers have an increased risk of developing severe liver disease...
  38. ncbi request reprint Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis
    Robert Bergholm
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:1637-41. 2002
    ..We determined whether endothelial dysfunction characterizes patients with newly diagnosed RA (n=10) compared with normal subjects (control group, n=33) and whether it is reversible with 6 months of anti-inflammatory therapy...
  39. ncbi request reprint Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy
    Jussi Sutinen
    Division of Diabetes, Department of Medicine, Helsinki University Central Hospital, PO Box 348, FIN 00029 HUS, Helsinki, Finland
    Am J Physiol Endocrinol Metab 286:E941-9. 2004
    ..Increased expression of adiponectin might have mediated most of the favorable insulin-sensitizing effects of rosiglitazone in these patients...
  40. ncbi request reprint Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    Anneli Seppälä-Lindroos
    Department of Medicine, Division of Diabetes, University of Helsinki, FIN 00029 HUCH, Helsinki, Finland
    J Clin Endocrinol Metab 87:3023-8. 2002
    ..min; P = NS). Fat accumulation in the liver is, independent of body mass index and intraabdominal and overall obesity, characterized by several features of insulin resistance in normal weight and moderately overweight subjects...
  41. ncbi request reprint Effect of liver fat on insulin clearance
    Anna Kotronen
    Dept of Medicine, Division of Diabetes, Univ of Helsinki, P O Box 700, Rm C418B, FIN 00029 HUCH, Helsinki, Finland
    Am J Physiol Endocrinol Metab 293:E1709-15. 2007
    ..40, P = 0.0002). We conclude that increased liver fat is associated with both impaired insulin clearance and hepatic insulin resistance. Hepatic insulin sensitivity associates with liver fat content, independent of insulin clearance...
  42. ncbi request reprint Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 24:320-4. 2004
    ..In the present study, we compared effects of glargine and regular human insulin on blood flow responses to endothelium-dependent and endothelium-independent vasoactive agents in vivo in normal subjects...
  43. doi request reprint Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Gastroenterology 135:122-30. 2008
    ..We also examined whether insulin suppression of serum free fatty acid (FFA) correlates with liver fat...
  44. ncbi request reprint Postprandial lipemia associates with liver fat content
    Niina Matikainen
    Department of Medicine, University of Helsinki, P O Box 700, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:3052-9. 2007
    ..Postprandial lipemia and low adiponectin represent novel risk factors for vascular disease. This study aimed to determine whether liver fat content and adiponectin are predictors of postprandial triglyceride (TG)-rich lipoproteins (TRL)...
  45. doi request reprint Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
    Piia Simonen
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    J Hepatol 54:153-9. 2011
    ..However, the metabolism of cholesterol in NAFLD remains unexplored. We investigated how fatty liver influences cholesterol metabolism in 242 non-diabetic subjects...
  46. doi request reprint Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Liver Int 31:176-83. 2011
    ....
  47. ncbi request reprint Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial
    Jussi Sutinen
    Division of Diabetes, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Antivir Ther 12:97-105. 2007
    ..In vitro, uridine abrogates thymidine analogue-induced toxicity in adipocytes...
  48. pmc Physical inactivity and obesity: a vicious circle
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Obesity (Silver Spring) 16:409-14. 2008
    ..Physical activity (PA) begins to decline in adolescence with a concomitant increase in weight. We hypothesized that a vicious circle may arise between decreasing PA and weight gain from adolescence to early adulthood...
  49. ncbi request reprint Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling
    Ksenia Sevastianova
    Department of Medicine, Division of Diabetes, University of Helsinki, PO Box 340, Helsinki 00029 HUCH, Finland
    Radiology 256:466-73. 2010
    ....
  50. ncbi request reprint Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity
    Jukka Westerbacka
    Department of Medicine, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:167-72. 2002
    ..These platelet-inhibitory actions of insulin are blunted or absent in obese subjects and could provide 1 mechanism linking insulin resistance to atherothrombotic disease...
  51. ncbi request reprint Liver fat in the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, The Finnish Twin Cohort Study, University of Helsinki, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:3490-7. 2007
    ..The amount of liver fat in subjects with and without the metabolic syndrome has not been determined. It is unknown which clinically available markers best reflect liver fat content...
  52. doi request reprint Insulin regulation of MCP-1 in human adipose tissue of obese and lean women
    Jukka Westerbacka
    University of Helsinki, Department of Medicine, Division of Diabetes, Biomedicum, FIN 00029 HUCH, Helsinki, Finland
    Am J Physiol Endocrinol Metab 294:E841-5. 2008
    ..MIP-1alpha was undetectable in serum. Insulin regulation of CCL2 differs between insulin-sensitive and -resistant subjects in a direction that could exacerbate adipose tissue inflammation...
  53. doi request reprint Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Gastroenterology 139:1961-1971.e1. 2010
    ..There are no data on splanchnic free fatty acid (FFA), glycerol, ketone body, endocannabinoid, and lipid fluxes in vivo in subjects with NAFLD...
  54. doi request reprint Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum
    Anna Kotronen
    Department of Medicine, Division of Diabetes, Helsinki, Finland
    Obesity (Silver Spring) 18:937-44. 2010
    ..89, P = 0.012) and Delta6 (18:3[n-6]/18:2, r = 1.0, P < 0.001) desaturase activities. We conclude that the human liver contains higher concentrations of ceramides and saturated free fatty acids than either SCfat or IAfat...
  55. ncbi request reprint Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy
    Ksenia Sevastianova
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Antivir Ther 10:925-35. 2005
    ..011) were identified as independent factors predicting AgI(HR). Prolonged antiretroviral treatment, thus, delineates as a risk factor for systemic arterial stiffness and the associated cardiovascular mortality...
  56. ncbi request reprint Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 700, Room C425B, FIN 00029 HUCH, Helsinki, Finland
    J Clin Endocrinol Metab 93:4867-72. 2008
    ..Here we examined how serum IGFBP-1 concentrations are related to directly measured hepatic insulin sensitivity and liver fat content in humans...
  57. ncbi request reprint Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity
    Kirsi H Pietiläinen
    The Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Finland
    Twin Res 7:421-9. 2004
    ..Young adulthood represents a critical period of gaining weight irrespective of genetic background in this twin sample...
  58. doi request reprint Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Gastroenterology 137:865-72. 2009
    ....
  59. ncbi request reprint Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men
    Kirsti Hallsten
    Turku PET Centre and Department of Medicine, University of Helsinki, Finland Department of Medicine, University of Turku, Finland
    Obes Res 11:257-65. 2003
    ..g., skeletal muscle. In the present study, we determined whether insulin resistance in obesity is associated with an impaired ability of exercise to stimulate muscle blood flow, oxygen delivery, or glucose uptake...
  60. pmc Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects
    Jarkko Soronen
    FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Finland
    BMC Med Genomics 5:9. 2012
    ..To get insight into molecular mechanisms underlying insulin resistance, we compared acute in vivo effects of insulin on adipose tissue transcriptional profiles between obese insulin-resistant and lean insulin-sensitive women...
  61. pmc Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
    Linda Mustelin
    Department of Laboratory Medicine, Division of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Physiol Endocrinol Metab 295:E148-54. 2008
    ..8 +/- 0.5 vs. 3.3 +/- 0.6, P < 0.01). This implies that acquired poor physical fitness is associated with defective expression of the oxidative pathway components in adipose tissue mitochondria...
  62. ncbi request reprint Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy
    Jussi Sutinen
    Department of Medicine, Helsinki University Central Hospital, PO Box 348, FIN 00029 HUS, Helsinki, Finland
    Am J Physiol Endocrinol Metab 292:E687-92. 2007
    ..These results imply that HAART-associated lipodystrophy is associated with increased REE and lipid oxidation and with increased caloric and fat intake...
  63. pmc Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes
    Jussi Naukkarinen
    FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Finland
    PLoS Genet 6:e1000976. 2010
    ..This study presents a new approach to utilizing gene expression studies for informing choice of candidate genes for complex human phenotypes, such as obesity...
  64. doi request reprint Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
    Anna Kotronen
    Division of Diabetes, Department of Medicine, University of Helsinki, FIN 00029 Helsinki, Finland
    Eur J Endocrinol 160:593-602. 2009
    ..We investigated whether polymorphisms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver fat content...
  65. ncbi request reprint Skeletal muscle mitochondrial DNA content and aerobic metabolism in patients with antiretroviral therapy-associated lipoatrophy
    Jussi Sutinen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, PO Box 348, FIN 00029 HUS, Helsinki, Finland
    J Antimicrob Chemother 65:1497-504. 2010
    ..To assess whether mitochondrial dysfunction in skeletal muscle characterizes antiretroviral therapy (ART)-associated lipoatrophy (LA)...
  66. ncbi request reprint Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes
    Marjo Tamminen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland
    Diabetes Care 25:2314-9. 2002
    ..To determine whether large arteries are resistant to insulin...
  67. ncbi request reprint Dietary fat content modifies liver fat in overweight nondiabetic subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, Obesity Research Unit, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    J Clin Endocrinol Metab 90:2804-9. 2005
    ..The reason for interindividual variation in liver fat content is unknown. Cross-sectional data suggest that dietary fat content may influence liver fat, but this possibility has not been directly tested in humans...
  68. ncbi request reprint Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, 00029 Helsinki, Finland
    J Clin Endocrinol Metab 88:4924-31. 2003
    ....
  69. ncbi request reprint Endothelial dysfunction in human diabetes
    Sari Mäkimattila
    University of Helsinki, Department of Medicine, Division of Diabetes, P O Box 340, Helsinki, 00029 HUCH, Finland
    Curr Diab Rep 2:26-36. 2002
    ....
  70. ncbi request reprint Nonglycemic effects of insulin
    Hannele Yki-Jarvinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Clin Cornerstone . 2003
    ..Insulin therapy in patients with type 2 diabetes can lead to improved glycemic control, insulin sensitivity, lipid profile, and endothelial function and may impact the incidence and severity of cardiovascular disease...
  71. doi request reprint Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy
    Ksenia Sevastianova
    Minerva Institute for Medical Research, Helsinki, Finland
    Am J Physiol Endocrinol Metab 295:E85-91. 2008
    ..CD68, ITGAM, CCL2, and CCL3 expression is significantly associated with accumulation of liver fat...
  72. doi request reprint Gene expression in human NAFLD
    Dario Greco
    Institute of Biotechnology, University of Helsinki, Finland
    Am J Physiol Gastrointest Liver Physiol 294:G1281-7. 2008
    ..The data show that multiple changes in gene expression characterize simple steatosis...
  73. doi request reprint PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis
    Julia Perttilä
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    Am J Physiol Endocrinol Metab 302:E1063-9. 2012
    ..These data do not exclude an effect of PNPLA3 I148M on hepatocyte lipogenesis but show that the mutant increases the stability of triglycerides...
  74. pmc Ectopic fat accumulation: an important cause of insulin resistance in humans
    Hannele Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, PO Box 340, FIN 00029 HUCH, Helsinki, Finland
    J R Soc Med 95:39-45. 2002
  75. ncbi request reprint Glycodelin responses to hyperinsulinaemic clamp vary according to basal serum glycodelin concentration
    Markku Seppala
    Department of Clinical Chemistry, Division of Diabetes, Helsinki University Central Hospital and University of Helsinki, Finland
    Clin Endocrinol (Oxf) 62:611-5. 2005
    ..This finding led to the hypothesis that insulin might decrease serum glycodelin concentration...
  76. pmc OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype
    You Zhou
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    PLoS ONE 7:e45352. 2012
    ..These data identify the patterns of ORP expression in human adipose depots and SGBS adipocytes, and provide the first evidence for a functional impact of ORPs on the adipocyte phenotype...
  77. pmc Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans
    Kirsi H Pietiläinen
    Department of Medicine, Division of Internal Medicine, and Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Biol 9:e1000623. 2011
    ..Further studies will be needed to determine the cause of this effect...
  78. pmc Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy
    Ksenia Sevastianova
    Minerva Institute for Medical Research, Helsinki, Finland
    Diabetes 60:1894-900. 2011
    ..It is unknown how preserved dorsocervical fat differs from abdominal subcutaneous fat in HIV-1-infected cART-treated patients with (cART+LD+) and without (cART+LD-) lipodystrophy...
  79. ncbi request reprint Fatty liver: a novel component of the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 28:27-38. 2008
    ..Intervention studies have shown that liver fat can be decreased by weight loss, PPARgamma agonists, and insulin therapy...
  80. doi request reprint Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins
    Janne Makkonen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    J Hepatol 50:1035-42. 2009
    ....
  81. doi request reprint Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus
    Anne Hiukka
    Department of Medicine, University of Helsinki, Helsinki University Central Hospital and Biomedicum, Helsinki, Finland
    J Am Coll Cardiol 52:2190-7. 2008
    ..The aim of this substudy was to ascertain whether long-term treatment with fenofibrate reduces surrogate measures of atherosclerosis, biomarkers of inflammation, and endothelial activation in patients with type 2 diabetes...
  82. pmc Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS ONE 2:e218. 2007
    ..Our results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance...
  83. ncbi request reprint Insulin resistance and endothelial dysfunction
    Hannele Yki-Jarvinen
    Division of Diabetes, Department of Medicine, University of Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland
    Best Pract Res Clin Endocrinol Metab 17:411-30. 2003
    ..Therapies which reverse insulin resistance-such as exercise, insulin and inhibitors of the renin-angiotensin-aldosterone (RAA) axis-also reverse endothelial dysfunction, which may thus be an inherent feature of insulin resistance...
  84. ncbi request reprint Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins
    Kirsi H Pietiläinen
    M Sc, Obesity Research Unit, Biomedicum Helsinki, C428a, P O Box 700, FIN 00029 HUS, Finland
    J Clin Endocrinol Metab 91:2776-81. 2006
    ..Both acquired and genetic factors regulate adipose tissue function...
  85. pmc Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey
    Anna Kotronen
    Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
    BMC Public Health 10:237. 2010
    ..We aimed at assessing the prevalences of NAFLD and AFLD, and to examine to what extent these conditions are associated with MetS and abnormal glucose tolerance...
  86. pmc Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    Anna Kotronen
    Department of Medicine, Division of Diabetes, Helsinki, Finland
    Diabetes 58:203-8. 2009
    ..To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver...
  87. ncbi request reprint FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study
    Anu Suomalainen
    Research Programmes Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland
    Lancet Neurol 10:806-18. 2011
    ..We investigated in a retrospective diagnostic study whether FGF-21 could be a biomarker for human mitochondrial disorders...
  88. pmc Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
    Saara Tikka
    Protein Chemistry Unit, Institute of Biomedicine Anatomy, University of Helsinki, Finland
    Brain 132:933-9. 2009
    ..Detection of GOM requires technically adequate biopsies and distinction of true GOM from fallacious deposits. If GOM is not found in the first vessel or biopsy, other vessels or additional biopsies should be examined...
  89. doi request reprint Liver fat and lipid oxidation in humans
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Liver Int 29:1439-46. 2009
    ..Studies in animals show that changes in hepatic fatty acid oxidation alter liver fat content. Human data regarding whole-body and hepatic lipid oxidation are controversial and based on studies of only a few subjects...