Research Topics
Genomes and Genes | Gennady G YegutkinSummaryAffiliation: University of Turku Country: Finland Publications
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Publications
Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activitiesGennady G Yegutkin
MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
FASEB J 26:3875-83. 2012..In summary, we have identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides...
Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascadeGennady G Yegutkin
MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
Biochim Biophys Acta 1783:673-94. 2008..This review summarizes recent advances in this rapidly evolving field, with particular emphasis on the nucleotide-releasing and purine-converting pathways in the vasculature...- Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humansGennady G Yegutkin
MediCity Research Laboratory, University of Turku, National Public Health Institute, Turku, Finland
J Physiol 579:553-64. 2007..These findings provide a novel insight into the mechanisms underlying the enhanced risk of occlusive thrombus formation under exercising conditions... - Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in miceGennady G Yegutkin
MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
J Immunol 184:5112-20. 2010.... - Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cellsGennady G Yegutkin
MediCity Research Laboratory, University of Turku and National Institute of Health and Welfare, Tykistokatu 6A, 20520, Turku, Finland
Angiogenesis 14:503-13. 2011.... - Altered purinergic signaling in CD73-deficient mice inhibits tumor progressionGennady G Yegutkin
MediCity Research Laboratory, University of Turku, and National Institute of Health and Welfare, Turku, Finland
Eur J Immunol 41:1231-41. 2011.... 
Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivoCraig M Stolen
Department of Medical Microbiology, MediCity Research Laboratory, National Public Health Institute, Turku University, 20520 Turku, Finland
Immunity 22:105-15. 2005....- IFN-beta regulates CD73 and adenosine expression at the blood-brain barrierJussi Niemela
Department of Medical Microbiology, MediCity Research Laboratory, University of Turku, Turku, Finland
Eur J Immunol 38:2718-26. 2008..Upregulation of ecto-5'-nucleotidase and a subsequent increase in adenosine production might contribute to the beneficial effects of IFN-beta on MS via enhancing the endothelial barrier function... - Origins of serum semicarbazide-sensitive amine oxidaseCraig M Stolen
MediCity Research Laboratory, University of Turku and National Public Health Institute, Tykistokatu 6A, FIN 20520, Turku, Finland
Circ Res 95:50-7. 2004..An increased endothelial cell capacity for lymphocyte binding and altered expression of redox-sensitive proteins was also associated with the mTIEhVAP-1 transgene... - Different role of CD73 in leukocyte trafficking via blood and lymph vesselsAnnika Algars
MediCity Research Laboratory, University of Turku, Turku, Finland
Blood 117:4387-93. 2011..Instead, lymphocyte CD73 is intimately involved in lymphocyte migration via afferent lymphatic vessels... - IFN-beta protects from vascular leakage via up-regulation of CD73Jan Kiss
MediCity Research Laboratory, University of Turku, Department of Medical Microbiology, and Turku University Hospital, Department of Surgery, Finland
Eur J Immunol 37:3334-8. 2007..Moreover, IFN-beta treatment may be useful in alleviating vascular leakage induced by ischemia-reperfusion injury... - IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5'-nucleotidase) up-regulationJussi Niemela
MediCity Research Laboratory and Department of Medical Microbiology, Turku University, Turku, Finland
J Immunol 172:1646-53. 2004.... - Impaired ATP-induced coronary blood flow and diminished aortic NTPDase activity precede lesion formation in apolipoprotein E-deficient miceNathalie Mercier
Medicity Research Laboratory and the Department of Medical Microbiology, University of Turku, Turku, Finland
Am J Pathol 180:419-28. 2012.... - Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivoFumiko Marttila-Ichihara
University of Turku, and National Public Health Institute, Turku, Finland
Arthritis Rheum 54:2852-62. 2006..We undertook this study to determine the contribution of AOC3 and its oxidase activity to leukocyte trafficking into inflamed joints in vivo... - The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cellsGennady G Yegutkin
MediCity Research Laboratory, Turku University and National Public Health Institute, Tykistokatu 6A, FIN 20520 Turku, Finland
Biochem J 367:121-8. 2002.... - Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activityGennady G Yegutkin
MediCity Research Laboratory, University of Turku and National Public Health Institute, Tykistokatu 6A, Turku, 20520 Finland
Biosci Rep 28:189-94. 2008.... - Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complicationsCraig M Stolen
MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
FASEB J 18:702-4. 2004..These findings suggest that, although manipulation of VAP-1/SSAO has potential to serve as a therapeutic treatment in insulin-resistant conditions, care must be taken to fully understand its impact on obesity and vascular damage... - A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stressGennady G Yegutkin
MediCity Research Laboratory, , 20520 Turku, Finland
Eur J Immunol 34:2276-85. 2004..Moreover, the inhibitory peptide diminishes leukocyte interactions with endothelial cells under conditions of shear, and thus it may be useful to treat inflammatory conditions... - Soluble purine-converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactionsGennady G Yegutkin
MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, FIN 20520 Turku, Finland
FASEB J 17:1328-30. 2003.... - The detection of micromolar pericellular ATP pool on lymphocyte surface by using lymphoid ecto-adenylate kinase as intrinsic ATP sensorGennady G Yegutkin
MediCity Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, FIN 20520 Turku, Finland
Mol Biol Cell 17:3378-85. 2006..The ability of nonstimulated lymphocytes to maintain micromolar ATP halo might represent a novel route initiating signaling cascades within immunological synapses and facilitating leukocyte trafficking between the blood and tissues... - Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitisTiina Ujula
Turku PET Center, Turku University Hospital, Turku, Finland
Nucl Med Biol 36:631-41. 2009..Based on our previous studies, the most VAP-1-selective peptide (VAP-P1) was 1,4,7,10-tetraazacyclododecane-N',N'',N''',N-tetraacetic acid (DOTA)-conjugated, 68gallium (68Ga)-labeled (named [68Ga]DOTAVAP-P1) and evaluated preliminarily... - CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosisAndrey Mikhailov
Turku Centre for Biotechnology, University of Turku Abo Akademi University, Turku, Finland
J Immunol 181:464-75. 2008..We propose that CD73 is a component of multiresistance machinery, the transcription of which is activated under selective pressure of the immune system... - Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetesMarko Salmi
MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
Am J Pathol 161:2255-62. 2002..In conclusion insulin appears to regulate shedding or clearance of VAP-1, and an increase in sVAP-1 because of absolute or relative insulin deficiency may be directly involved in the pathogenesis of diabetic angiopathy... - Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitisGuido Beldi
Liver and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Hepatology 48:841-52. 2008..Deletion of CD39 is protective in [corrected] Con A-induced hepatitis. This study illustrates a [corrected] role for purinergic signaling in NKT-mediated mechanisms that result in liver immune injury... - ATP-consuming and ATP-generating enzymes secreted by pancreasGennady G Yegutkin
MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, FIN-2050 Turku, Finland
J Biol Chem 281:29441-7. 2006..This newly discovered richness of secreted enzymes underscores the importance of purine signaling between acini and pancreatic ducts lumen and implies regulation of the purine-converting enzymes release... - Adherent leukocytes prevent adenosine formation and impair endothelial barrier function by Ecto-5'-nucleotidase/CD73-dependent mechanismTiina Henttinen
MediCity Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, Finland
J Biol Chem 278:24888-95. 2003....