Gennady G Yegutkin

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    FASEB J 26:3875-83. 2012
  2. doi request reprint Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
    Biochim Biophys Acta 1783:673-94. 2008
  3. pmc Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, National Public Health Institute, Turku, Finland
    J Physiol 579:553-64. 2007
  4. doi request reprint Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    J Immunol 184:5112-20. 2010
  5. doi request reprint Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Institute of Health and Welfare, Tykistokatu 6A, 20520, Turku, Finland
    Angiogenesis 14:503-13. 2011
  6. doi request reprint Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 41:1231-41. 2011
  7. ncbi request reprint Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo
    Craig M Stolen
    Department of Medical Microbiology, MediCity Research Laboratory, National Public Health Institute, Turku University, 20520 Turku, Finland
    Immunity 22:105-15. 2005
  8. doi request reprint IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier
    Jussi Niemela
    Department of Medical Microbiology, MediCity Research Laboratory, University of Turku, Turku, Finland
    Eur J Immunol 38:2718-26. 2008
  9. ncbi request reprint Origins of serum semicarbazide-sensitive amine oxidase
    Craig M Stolen
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Tykistokatu 6A, FIN 20520, Turku, Finland
    Circ Res 95:50-7. 2004
  10. doi request reprint Different role of CD73 in leukocyte trafficking via blood and lymph vessels
    Annika Algars
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 117:4387-93. 2011

Collaborators

Detail Information

Publications26

  1. pmc Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    FASEB J 26:3875-83. 2012
    ..In summary, we have identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides...
  2. doi request reprint Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
    Biochim Biophys Acta 1783:673-94. 2008
    ..This review summarizes recent advances in this rapidly evolving field, with particular emphasis on the nucleotide-releasing and purine-converting pathways in the vasculature...
  3. pmc Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, National Public Health Institute, Turku, Finland
    J Physiol 579:553-64. 2007
    ..These findings provide a novel insight into the mechanisms underlying the enhanced risk of occlusive thrombus formation under exercising conditions...
  4. doi request reprint Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    J Immunol 184:5112-20. 2010
    ....
  5. doi request reprint Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Institute of Health and Welfare, Tykistokatu 6A, 20520, Turku, Finland
    Angiogenesis 14:503-13. 2011
    ....
  6. doi request reprint Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 41:1231-41. 2011
    ....
  7. ncbi request reprint Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo
    Craig M Stolen
    Department of Medical Microbiology, MediCity Research Laboratory, National Public Health Institute, Turku University, 20520 Turku, Finland
    Immunity 22:105-15. 2005
    ....
  8. doi request reprint IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier
    Jussi Niemela
    Department of Medical Microbiology, MediCity Research Laboratory, University of Turku, Turku, Finland
    Eur J Immunol 38:2718-26. 2008
    ..Upregulation of ecto-5'-nucleotidase and a subsequent increase in adenosine production might contribute to the beneficial effects of IFN-beta on MS via enhancing the endothelial barrier function...
  9. ncbi request reprint Origins of serum semicarbazide-sensitive amine oxidase
    Craig M Stolen
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Tykistokatu 6A, FIN 20520, Turku, Finland
    Circ Res 95:50-7. 2004
    ..An increased endothelial cell capacity for lymphocyte binding and altered expression of redox-sensitive proteins was also associated with the mTIEhVAP-1 transgene...
  10. doi request reprint Different role of CD73 in leukocyte trafficking via blood and lymph vessels
    Annika Algars
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 117:4387-93. 2011
    ..Instead, lymphocyte CD73 is intimately involved in lymphocyte migration via afferent lymphatic vessels...
  11. ncbi request reprint IFN-beta protects from vascular leakage via up-regulation of CD73
    Jan Kiss
    MediCity Research Laboratory, University of Turku, Department of Medical Microbiology, and Turku University Hospital, Department of Surgery, Finland
    Eur J Immunol 37:3334-8. 2007
    ..Moreover, IFN-beta treatment may be useful in alleviating vascular leakage induced by ischemia-reperfusion injury...
  12. ncbi request reprint IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5'-nucleotidase) up-regulation
    Jussi Niemela
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University, Turku, Finland
    J Immunol 172:1646-53. 2004
    ....
  13. doi request reprint Impaired ATP-induced coronary blood flow and diminished aortic NTPDase activity precede lesion formation in apolipoprotein E-deficient mice
    Nathalie Mercier
    Medicity Research Laboratory and the Department of Medical Microbiology, University of Turku, Turku, Finland
    Am J Pathol 180:419-28. 2012
    ....
  14. ncbi request reprint Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo
    Fumiko Marttila-Ichihara
    University of Turku, and National Public Health Institute, Turku, Finland
    Arthritis Rheum 54:2852-62. 2006
    ..We undertook this study to determine the contribution of AOC3 and its oxidase activity to leukocyte trafficking into inflamed joints in vivo...
  15. pmc The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells
    Gennady G Yegutkin
    MediCity Research Laboratory, Turku University and National Public Health Institute, Tykistokatu 6A, FIN 20520 Turku, Finland
    Biochem J 367:121-8. 2002
    ....
  16. doi request reprint Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Tykistokatu 6A, Turku, 20520 Finland
    Biosci Rep 28:189-94. 2008
    ....
  17. ncbi request reprint Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications
    Craig M Stolen
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
    FASEB J 18:702-4. 2004
    ..These findings suggest that, although manipulation of VAP-1/SSAO has potential to serve as a therapeutic treatment in insulin-resistant conditions, care must be taken to fully understand its impact on obesity and vascular damage...
  18. ncbi request reprint A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stress
    Gennady G Yegutkin
    MediCity Research Laboratory, Tykistokatu 6A, 20520 Turku, Finland
    Eur J Immunol 34:2276-85. 2004
    ..Moreover, the inhibitory peptide diminishes leukocyte interactions with endothelial cells under conditions of shear, and thus it may be useful to treat inflammatory conditions...
  19. ncbi request reprint Soluble purine-converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactions
    Gennady G Yegutkin
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, FIN 20520 Turku, Finland
    FASEB J 17:1328-30. 2003
    ....
  20. pmc The detection of micromolar pericellular ATP pool on lymphocyte surface by using lymphoid ecto-adenylate kinase as intrinsic ATP sensor
    Gennady G Yegutkin
    MediCity Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, FIN 20520 Turku, Finland
    Mol Biol Cell 17:3378-85. 2006
    ..The ability of nonstimulated lymphocytes to maintain micromolar ATP halo might represent a novel route initiating signaling cascades within immunological synapses and facilitating leukocyte trafficking between the blood and tissues...
  21. doi request reprint Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis
    Tiina Ujula
    Turku PET Center, Turku University Hospital, Turku, Finland
    Nucl Med Biol 36:631-41. 2009
    ..Based on our previous studies, the most VAP-1-selective peptide (VAP-P1) was 1,4,7,10-tetraazacyclododecane-N',N'',N''',N-tetraacetic acid (DOTA)-conjugated, 68gallium (68Ga)-labeled (named [68Ga]DOTAVAP-P1) and evaluated preliminarily...
  22. ncbi request reprint CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis
    Andrey Mikhailov
    Turku Centre for Biotechnology, University of Turku Abo Akademi University, Turku, Finland
    J Immunol 181:464-75. 2008
    ..We propose that CD73 is a component of multiresistance machinery, the transcription of which is activated under selective pressure of the immune system...
  23. pmc Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Am J Pathol 161:2255-62. 2002
    ..In conclusion insulin appears to regulate shedding or clearance of VAP-1, and an increase in sVAP-1 because of absolute or relative insulin deficiency may be directly involved in the pathogenesis of diabetic angiopathy...
  24. pmc Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis
    Guido Beldi
    Liver and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hepatology 48:841-52. 2008
    ..Hepatic NKT cells express most P2X and P2Y receptors; exceptions include P2X3 and P2Y11. Heightened levels of apoptosis of CD39 null NKT cells in vivo and in vitro appear to be driven by unimpeded activation of the P2X7 receptor...
  25. ncbi request reprint ATP-consuming and ATP-generating enzymes secreted by pancreas
    Gennady G Yegutkin
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, FIN 2050 Turku, Finland
    J Biol Chem 281:29441-7. 2006
    ..This newly discovered richness of secreted enzymes underscores the importance of purine signaling between acini and pancreatic ducts lumen and implies regulation of the purine-converting enzymes release...
  26. ncbi request reprint Adherent leukocytes prevent adenosine formation and impair endothelial barrier function by Ecto-5'-nucleotidase/CD73-dependent mechanism
    Tiina Henttinen
    MediCity Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, Finland
    J Biol Chem 278:24888-95. 2003
    ....