L Yavich

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi request reprint Mechanics of self-stimulation and dopamine release in the nucleus accumbens
    Leonid Yavich
    In Vivo Voltammetry Contract Research Laboratory, Department of Pharmacology and Toxicology, Kuopio University Hospital, Kuopio, Finland
    Neuroreport 18:1271-4. 2007
  2. ncbi request reprint Alpha2-adrenergic control of dopamine overflow and metabolism in mouse striatum
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Eur J Pharmacol 339:113-9. 1997
  3. ncbi request reprint Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
    Leonid Yavich
    In Vivo Voltammetry Contract Research Laboratory and Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:10196-209. 2007
  4. ncbi request reprint Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice
    Leonid Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    J Neurochem 99:724-32. 2006
  5. ncbi request reprint Noradrenaline overflow in mouse dentate gyrus following locus coeruleus and natural stimulation: real-time monitoring by in vivo voltammetry
    Leonid Yavich
    Department of Pharmacology and Toxicology, Universtiy of Kuopio, Kuopio, Finland
    J Neurochem 95:641-50. 2005
  6. ncbi request reprint Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein
    Leonid Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    Neurobiol Dis 20:303-13. 2005
  7. ncbi request reprint Spreading depression in the cortex differently modulates dopamine release in rat mesolimbic and nigrostriatal terminal fields
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    Exp Neurol 196:47-53. 2005
  8. ncbi request reprint Role of alpha-synuclein in presynaptic dopamine recruitment
    Leonid Yavich
    Department of Pharmacology and Toxicology, Clinical Research Centre Mediteknia, University of Kuopio, Finland
    J Neurosci 24:11165-70. 2004
  9. ncbi request reprint A new technique for measuring the temporal characteristics of the carbon fibre microelectrodes in in vivo voltammetry at millisecond time intervals
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    J Neurosci Methods 84:29-32. 1998
  10. ncbi request reprint Dopamine release from pharmacologically distinct storage pools in rat striatum following stimulation at frequency of neuronal bursting
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Brain Res 870:73-9. 2000

Detail Information

Publications17

  1. ncbi request reprint Mechanics of self-stimulation and dopamine release in the nucleus accumbens
    Leonid Yavich
    In Vivo Voltammetry Contract Research Laboratory, Department of Pharmacology and Toxicology, Kuopio University Hospital, Kuopio, Finland
    Neuroreport 18:1271-4. 2007
    ..Inclusion of this indicator solves the problem of large interindividual variation in self-stimulation currents and permits a new approach to studies on mechanisms and pathways involved in brain reward...
  2. ncbi request reprint Alpha2-adrenergic control of dopamine overflow and metabolism in mouse striatum
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Eur J Pharmacol 339:113-9. 1997
    ..but showed no effect itself. We suggest that alpha2-adrenoceptors in dopaminergic terminal fields in the mouse striatum are involved in the regulation of dopamine release at physiological stimulation frequencies...
  3. ncbi request reprint Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
    Leonid Yavich
    In Vivo Voltammetry Contract Research Laboratory and Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:10196-209. 2007
    ....
  4. ncbi request reprint Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice
    Leonid Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    J Neurochem 99:724-32. 2006
    ..The effects are essentially the same as previously reported for dopaminergic terminals in the striatum, indicating that the important role of alpha-synuclein in neurotransmitter mobilization is not limited to dopaminergic terminals...
  5. ncbi request reprint Noradrenaline overflow in mouse dentate gyrus following locus coeruleus and natural stimulation: real-time monitoring by in vivo voltammetry
    Leonid Yavich
    Department of Pharmacology and Toxicology, Universtiy of Kuopio, Kuopio, Finland
    J Neurochem 95:641-50. 2005
    ..This interference could be used, after appropriate filtration, for simultaneous recording from the same microelectrode of NA release and electrical activity of the hippocampus...
  6. ncbi request reprint Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein
    Leonid Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    Neurobiol Dis 20:303-13. 2005
    ..This is in agreement with the previously postulated involvement of alpha-synuclein in the turnover of transmitter vesicles and may explain the observed motor deficits in A30P mice...
  7. ncbi request reprint Spreading depression in the cortex differently modulates dopamine release in rat mesolimbic and nigrostriatal terminal fields
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    Exp Neurol 196:47-53. 2005
    ..e. the kind of neuropathology which may cause SD type phenomena also in human brain...
  8. ncbi request reprint Role of alpha-synuclein in presynaptic dopamine recruitment
    Leonid Yavich
    Department of Pharmacology and Toxicology, Clinical Research Centre Mediteknia, University of Kuopio, Finland
    J Neurosci 24:11165-70. 2004
    ..Reducing capacity of the storage pool in transgenic A30P mice led to paradoxical effects of l-dopa, which elevated dopamine release in response to single stimulation but decreased the refilling rate of the RRP...
  9. ncbi request reprint A new technique for measuring the temporal characteristics of the carbon fibre microelectrodes in in vivo voltammetry at millisecond time intervals
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    J Neurosci Methods 84:29-32. 1998
    ..49 +/- 0.1 microM/ms (M +/- SEM, n = 36, rise) and 0.051 +/- 0.003 microM/ms (n = 36, wash-out) on the half of amplitude of electrochemical response which was monitored by constant potential amperometry...
  10. ncbi request reprint Dopamine release from pharmacologically distinct storage pools in rat striatum following stimulation at frequency of neuronal bursting
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Brain Res 870:73-9. 2000
    ..Experiments using repeated stimulation at as low a frequency as 10-20 Hz, revealed that this phenomenon may take place under physiological conditions following bursting of dopamine neurones...
  11. ncbi request reprint Ethanol modulates evoked dopamine release in mouse nucleus accumbens: dependence on social stress and dose
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Eur J Pharmacol 401:365-73. 2000
    ..These data suggest that the stress of social defeat may have sensitised the machinery involved in dopamine release to ethanol, a process that may increase the reinforcing properties of this compound...
  12. ncbi request reprint Patterns of dopamine overflow in mouse nucleus accumbens during intracranial self-stimulation
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Neurosci Lett 293:41-4. 2000
    ..We conclude that the availability of a readily-releasable pool of DA in presynaptic terminals determined the pattern of dopamine overflow in the nucleus accumbens during ICSS in mice...
  13. ncbi request reprint Atipamezole, an alpha2-adrenoceptor antagonist, augments the effects of L-DOPA on evoked dopamine release in rat striatum
    Leonid Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Eur J Pharmacol 462:83-9. 2003
    ..We conclude that the rat caudate nucleus is more sensitive than the nucleus accumbens to the effects of L-DOPA, and the effects of L-DOPA treatment might be effectively enhanced by antagonism of alpha(2)-adrenoceptors...
  14. ncbi request reprint Brain reward in the absence of alpha-synuclein
    Mari Oksman
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    Neuroreport 17:1191-4. 2006
    ..The present work demonstrates that a lack of alpha-synuclein sensitized the brain reward system, implying that the levels of alpha-synuclein expression may predispose an individual to drug abuse or to a number of psychiatric diseases...
  15. doi request reprint Behavioural and neurochemical response of alpha-synuclein A30P transgenic mice to the effects of L-DOPA
    Mari Oksman
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Neuropharmacology 56:647-52. 2009
    ..These data show that A30P transgenic mice are more sensitive to the effects of L-DOPA at both behavioural and neurochemical level...
  16. doi request reprint Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference
    Anssi Pelkonen
    School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    J Neurochem 114:1168-76. 2010
    ..These results indicate that high expression of alpha-syn may contribute to the reduced DA overflow and the possible activation of re-uptake in the nucleus accumbens core of AA rats in comparison with ANA rats...
  17. doi request reprint Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine
    Jelena Mijatovic
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Finland
    J Neurochem 105:1716-25. 2008
    ....